基础医学院

刘立忠
博士,副教授,硕士生导师,深圳市海外高层次人才

 

刘立忠博士教授,硕士生导师,深圳市海外高层次人才,深圳大学测试中心主任,深圳市医学会实验医学专业委员会委员。

邮箱liulz@szu.edu.cn

 

简介

主要从事糖尿病的发病机制、胰岛素信号的传导、胰岛β细胞的损伤和凋亡机制、脂代谢紊乱与肺癌发生发展关系的研究以及相关药物的开发工作。特别是在细胞骨架结构的动态变化、脂肪酸与葡萄糖转运蛋白的囊泡运输等方面积累了丰富的专业知识和实验操作经验。同时,应用现代细胞与分子生物学技术在细胞和动物水平进行抗肿瘤、抗糖尿病药物的筛选与评估,并在药理研究的基础上开发新的药物。主持和参与的课题分别来自国家自然科学基金面上项目、深圳市高层次人才和深圳市基础研究基金项目。承担多门研究生和本科生课程,近五年培养1名博士后及5名硕士研究生。

 

主持科研项目

1.国家自然科学基金面上项目“骨骼肌细胞中PKCzeta调控高脂诱导CD36转位的机制及其与胰岛素抵抗的关系研究 2016.01-2019.12,项目编号81570784。

2.深圳市基础研究项目“高脂诱导骨骼肌细胞胰岛素抵抗过程中脂肪酸转运蛋CD36异常分布的机制研究”2016.01-2019.12,项目编号JCYJ20150324141711688。

3.深圳高端人才科研启动项目“糖脂转运蛋白的分布对糖脂代谢稳态的影响”,2013.12-2015.12,项目编号8270000003

 

发表论文:

1. Li MY*, Liu LZ*, Li W, Ng CSH, Liu Y, Kong AWY, Zhao Z, Wang S, Qi H, Jia H, Yang S, Du J, Long X, Ho RLK, Chak ECW, Wan IYP, Mok TSK, Underwood MJ, Gali NK, Ning Z, Chen GG. Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis. J Exp Clin Cancer Res. 2019 Aug 16;38(1):359. (Co-first author)

2. Xin Q, Luo Q, Wu Z, Zhang J, Liu L*, Cheng Y*. New unsaturated lactones and a meroterpenoid fromGanoderma lucidum. Natural Product Communications. 2019 Jun; 14:1. (Co-corresponding author)

3. Xu H, Zhang T, Lu Y, Lin X, Hu X, Liu L, He Z, Wu X. Effect of chlorogenic acid covalent conjugation on the allergenicity, digestibility and functional properties of whey protein. Food Chem. 2019 Jun; 298:125024.

4. Xu H, Lu Y, Zhang T, Liu K, Liu L, He Z, Xu B, Wu X. Characterization of binding interactions of anthraquinones and bovine β-lactoglobulin. Food Chem. 2019 May 30; 281:28-35.

5. Yang D, Qin W, Shi X, Zhu B, Xie M, Zhao H, Teng B, Wu Y, Zhao R, Yin F, Ren P, Liu L, Li Z. Stabilized β-Hairpin Peptide Inhibits Insulin Degrading Enzyme. J Med Chem. 2018 Sep 27; 61(18):8174-8185.

6. Wu X, Lu Y, Xu H, Lin D, He Z, Wu H, Liu L, Wang Z. Reducing the allergenic capacity of β-lactoglobulin by covalent conjugation with dietary polyphenols. Food Chem. 2018 Aug 1;256:427-434.

7. Feng Y, Lv M, Lu Y, Liu K, Liu LZ, He Z, Wu K, Wang X, Zhang B, Wu X. Characterization of binding interactions between selected phenylpropanoid glycosides and trypsin. Food Chem. 2018 Mar; 243:118-124.

8. Zheng K, Jiang Y, Liao C, Hu X, Li Y, Zeng Y, Zhang J, Wu X, Wu H, Liu LZ, Wang Y, He Z. NOX2-mediated TFEB activation and vacuolization regulate lysosome-associated cell death induced by Gypenoside L, a saponin isolated from Gynostemma pentaphyllum. J Agric Food Chem. 2017 Aug; 65(31):6625-6637

9. Lu Y, Zhou W, Feng Y, Li Y, Liu K, Liu LZ, Lin D, He Z, Wu X. Acteoside and Acyl-Migrated Acteoside, Compounds in Chinese Kudingcha Tea, Inhibit α-Amylase In Vitro. J Med Food. 2017 Jun;20(6):577-585.

10. Yang S, Liu Y, Li MY, Ng CSH, Yang SL, Wang S, Zou C, Dong Y, Du J, Long X, Liu LZ, Wan IYP, Mok T, Underwood MJ, Chen GG. FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer. Mol Cancer. 2017 Jul;16(1):124-136

11. Song X, He J, Xu H, Hu XP, Wu XL, Wu HQ, Liu LZ, Liao CH, Zeng Y, Li Y, Hao Y, Xu CS, Fan L, Zhang J, Zhang HJ, He ZD. The antiviral effects of acteoside and the underlying IFN-γ-inducing action. Food Funct. 2016 Jul; 7(7):3017-30

12. Liao C, Zheng K, Li Y, Xu H, Kang Q, Fan L, Hu X, Jin Z, Zeng Y, Kong X, Zhang J, Wu X, Wu H, Liu LZ, Xiao X, Wang Y, He Z. Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. Oncotarget. 2016 Jul; 7(30):47387-47402

13. Zheng K, Liao C, Li Y, Fan X, Fan L, Xu H, Kang Q, Zeng Y, Wu X, Wu H, Liu LZ, Xiao X, Zhang J, Wang Y, He Z. Gypenoside L, Isolated from Gynostemma pentaphyllum, Induces Cytoplasmic Vacuolation Death in Hepatocellular Carcinoma Cells through Reactive-Oxygen-Species-Mediated Unfolded Protein Response. J Agric Food Chem. 2016 Mar 2; 64(8): 1702-11.

14. Li MY, Liu Y, Liu LZ, Kong AW, Zhao Z, Wu B, Long X, Wu J, Ng CS, Wan IY, Du J, Mok TS, Underwood MJ, Chen GG.  Estrogen receptor alpha promotes smoking-carcinogen-induced lung carcinogenesis via cytochrome P450 1B1. J Mol Med (Berl). 2015 Nov; 93(11):1221-33.

15. Liu LZ, Cheung SC, Lan LL, Ho SK, Chan JC, Tong PC. Microtubule network is required for insulin-induced signal transduction and actin remodeling. Mol Cell Endocrinol. 2013 Jan 5;365(1):64-74.

16. Cheung SC, Long X, Liu LZ, Liu Q, Lan L, Tong PC, Sun SS. Inhibition of human MCF-7 breast cancer cells and HT-29 colon cancer cells by rice-produced recombinant human insulin-like growth binding protein-3 (rhIGFBP-3). PLoS One. 2013 Oct 15;8(10):e77516.

17. Zhao HL, Sui Y, Qiao CF, Yip KY, Leung RK, Tsui SK, Lee HM, Wong HK, Zhu X, Siu JJ, He L, Liu LZ, Xu HX, Tong PC and Chan JC. Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression. Diabetes, 2012, 61(4): 933-43.

18. Cheung SC*, Liu LZ*, Lan LL, Liu QQ, Sun SS, Chan JC and Tong PC. Glucose lowering effect of transgenic human insulin-like growth factor-I from rice: in vitro and in vivo studies. BMC Biotechnol. 2011, 11(1): 37-47 (Co-first author)

19. Liu LZ, Cheung SC, Lan LL, Ho SK, Chan JC, Tong PC. The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK) - mediated glucose uptake in muscle cells.  Cell. Signal. 2010, 22(10): 1513-22.

20. Liu LZ, Cheung SC, Lan LL, Ho SK, Xu HX, Chan JC, Tong PC. Berberine modulates insulin signaling transduction in insulin-resistant cells. Mol. Cell. Endocrinol. 2010, 317: 148-153

21. Zhao HL, Liu LZ, Sui Y, Ho SK, Tam SK, Lai FM, Chan JC, Tong PC. Fatty acids inhibit insulin-mediated glucose transport associated with actin remodeling in rat L6 muscle cells. Acta Diabetol. 2010 Dec;47(4):331-9. Acta Diabetol.

22. He A, Liu X, Liu LZ, Chang Y, Fang F. How many signals impinge on GLUT4 activation by insulin?  Cell. Signal. 2007, 19 (1): 1-7.

23. Yang C, Yang Y, Gupta N, Liu X, He A, Liu LZ, Zuo J, Chang Y, Fang F. Pentaspan membrane glycoprotein, prominin-1, is involved in glucose metabolism and cytoskeleton alteration. Biochemistry (Mosc). 2007, 72(8): 854-862

24. Liu LZ, Zhao HL, Zuo J, Ho SK, Chan JC, Meng Y, Fang FD, Tong PC. PKCzeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells. Mol. Biol. Cell. 2006, 17:2322-2330.

25. Liu LZ, He AB, Liu XJ, Li Y, Chang YS, Fang FD. Protein Kinase C zeta and glucose uptake. Biochemistry (Mosc). 2006, 71(7): 701-706.