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基础医学院

李春满
助理教授

 

姓名:李春满


职位:助理教授


邮箱cli@szu.edu.cn


简介:

  长期从事细胞内囊泡转运研究,在EMBO J、Cell Reports、 Journal of biological Chemistry等杂志发表论文20余篇。 主持国家自然科学面上基金1项、深圳市科创委自由探索基金1项。

 

 

研究方向

(1)细胞内囊泡转运

(2)脂代谢调控

 

科研项目

主持项目

1.国家自然科学基金面上项目(31771567):转运蛋白颗粒复合体II与小G蛋白对哺乳动物细胞内脂滴调控及参与肝纤维化病理进程的机理研究,2018/01/01-2021/12/31;

2.深圳市科技创新委员会自由探索项目(JCYJ20180305163436194):小G蛋白Rab43通过调控Hedgehog信号通路影响肝星形胶质细胞活化的机制研究,2019/03/16-2021/03/15;

代表性成果

(1) Zhe Wei#, Maoxiang Zhang#Chunman Li#, Wei Huang, Yi Fan, Jianhui Guo, Mostafa Khater, Mitsunori Fukuda, Zheng Dong, Gang Hu, and Guangyu Wu*.

Specific TBC Domain-Containing Proteins Controlthe ER-Golgi-Plasma Membrane Trafficking of GPCRs. Cell Reports. 2019 Jul 9;28(2):554-566. (#共同第一作者)

(2) Chunman Li, Zhe Wei, Yi Fan, Wei Huang, Yunchao Su, Honglin Li, Zheng Dong, Mitsunori Fukuda, Mostafa Khater, Guangyu Wu*. The GTPase Rab43 controls the anterograde ER-Golgi trafficking and sorting of GPCRs. Cell Reports. 2017, 21(4):1089-1101.

(3) Huju Chi#, Chunman Li#, Flora Sha Zhao, Li Zhang, Tzi Bun Ng*, Guangyi Jin*, Ou Sha*. Anti-tumor Activity of Toll-Like Receptor 7 Agonists. Frontiers in Pharmacology, 2017, 8:304. (#共同第一作者)

(4) Chunman Li, Meiqi Zeng, Huju Chi, Jing Shen, Tzi-Bun Ng, Guangyi Jin, Desheng Lu, Xinmin Fan, Bilian Xiong, Zhangang Xiao*, Ou Sha*. Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CT-MPR on the cell surface. Oncotarget, 2017, 8(16):26460-26470.

(5) Chunman Li, Xiaomin Luo, Shan Zhao, Gavin KY Siu, Yongheng Liang, Hsiao Chang Chan, Ayano Satoh, Sidney SB Yu*. COPI–TRAPPII activates Rab18 and regulates its lipid droplet association, The EMBO Journal, 2017, 36, 441 ~ 457 

(6) Chunman Li, Sidney S. B. Yu*. Rab proteins as regulators of lipid droplet formation and lipolysis, Cell Biology International, 2016, 40(10): 1026 ~ 1032 

(7) Junfei Niu#, Chunman Li#, Haihui Wu, Xianling Feng, Qingning Su, Shihe Li, Lihong Zhang, David Tai Wai Yew, Eric Yu Pang Cho*, Ou Sha*. Propidium iodide (PI) stains Nissl bodies and may serve as a quick marker for total neuronal cell count, Acta Histochemica,2015, 117(2): 182 ~ 187

(8) Chunman Li*, Sidney Yu. A perspective from transport protein particle: Vesicle tether and human diseases, Acta Physiologica Sinica, 2014, 66(1): 1 ~ 6

(9) Chunman Li, Yi Fan, Tien-Hung Lan, Nevin A. Lambert, Guangyu Wu*. Rab26 Modulates the Cell Surface Transport of α2-Adrenergic Receptors from the Golgi, The Journal of Biological Chemistry, 2012, 287(51): 42784 ~ 42794