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基础医学院

王刚

 

2007年获北京大学博士学位,后在美国加州大学圣迭戈分校药理学院作博士后;2014年被深圳大学聘为医学院讲师。

 

教育经历:

学士,北京大学,生理学及生物物理学专业,2000年七月

博士,北京大学,生物物理学专业        ,2007年七月

 

工作经历:

2007年-2012年, 加州大学圣迭戈分校, 博士后

2013年-2014年,北京大学分子医学研究所, 科研人员 

2014年-至今   ,深圳大学,医学部医学院医学部,讲师

 

办公电话: 0755-86671993

Email: wangg@szu.edu.cn

 

研究方向

(1) 间质转化与心脏纤维化

(2)心力衰竭与心肌肥大

 

科研项目

1.主持项目

广东省自然科学基金项目“KCNE2表达下调引起心肌肥大的作用和机制研究”(编号2014A030313548),2015年1月-2018年01月。

国家自然科学基金面上项目“HIMF在心肌肥大发生中的作用与机制研究”(81670211),2017年1月-2020年12月。

 2.参与项目

 

代表性成果

论文(*表示通讯作者)

1)Santosh Kumar#, Gang Wang#, Na Zheng, Wanwen Cheng, Kunfu Ouyang,Hairuo Lin, Yulin Liao, Jie Liu* HIMF (Hypoxia-Induced Mitogenic Factor)-IL(Interleukin)-6 Signaling Mediates Cardiomyocyte-Fibroblast Crosstalk to Promote Cardiac Hypertrophy and Fibrosis. Hypertension. 2019 May;73(5):1058-1070.

2)Santosh Kumar#, Gang Wang#, Wenjuan Liu#, Wenwen Ding, Ming Dong, Na Zheng, Hongyu Ye, Jie Liu*.Hypoxia-Induced Mitogenic Factor Promotes Cardiac Hypertrophy via Calcium-Dependent and Hypoxia-Inducible Factor-1α Mechanisms. Hypertension. 2018 Aug;72(2):331-342.

3)Liu W#, Deng J#, Wang G#, Zhang C, Luo X, Yan D, Su Q, Liu J*.KCNE2 modulates cardiac L-type Ca2+ channel. J Mol Cell Cardiol. 2014 Jul; 72:208-218.

4)Liang X#, Wang G#, Lin L, Lowe J, Zhang Q, Bu L, Chen Y, Chen J, Sun Y, Evans SM*.HCN4 Dynamically Marks the First Heart Field and Conduction System Precursors. Circ Res. 2013;113: 399-407.

5)Wang G#, Zhu X#, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, Song R, Cao C, Zhang J, Wu C, Liu J*. Cheng H. Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart. Circ Res. 2010 Feb 5; 106(2):317-27.

6)Yao LJ#, Wang G#, Ou-Yang KF, Wei CL, Wang XH, Wang SR, Yao W, Huang HP, Luo JH, Wu CH, Liu J, Zhou Z, Cheng HP*. Ca2+ sparks and Ca2+ glows in superior cervical ganglion neurons.Acta Pharmacol Sin.2006 Jul;27(7):848-852.

7)Liu W#, Deng J#, Ding W#, Wang G, Shen Y, Zheng J, Zhang X, Luo Y, Lv C, Wang Y, Chen L, Yan D, Boudreau RL, Song LS, Liu J*. Decreased KCNE2 Expression Participates in the Development of Cardiac Hypertrophy byRegulation of Calcineurin-NFAT (Nuclear Factor of Activated T Cells) and Mitogen-ActivatedProtein Kinase Pathways. Circ Heart Fail. 2017 Jun;10(6). pii: e003960. doi: 10.1161/CIRCHEARTFAILURE.117.003960.

8)Liu WJ#, Deng JX#, Wang G, Gao KP, Lin ZX, Liu SY, Wang YH, Liu J*. Manipulation of KCNE2 expression modulates action potential duration and Ito and IK in rat and mouseventricular myocytes. Am J Physiol Heart Circ Physiol. 2015 Oct; 309(8):H1288-302.

9)Liang X, Zhang Q, Cattaneo P, Zhuang S, Gong X, Spann NJ, Jiang C, Cao X, Zhao X, Zhang X, Bu L, Wang G, Chen HS, Zhuang T, Yan J, Geng P, Luo L, Banerjee I, Chen Y, Glass CK, Zambon AC, Chen J, Sun Y, Evans SM*. Transcription factor ISL1 is essential for pacemaker development and function. J Clin Invest. 2015 Aug 3; 125(8):3256-68.

10)Xue Y, Ouyang K, Huang J, Zhou Y, Ouyang H, Li H, Wang G, Wu Q, Wei C, Bi Y, Jiang L, Cai Z, Sun H, Zhang K, Zhang Y, Chen J, Fu XD*. Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated microRNA Circuits. Cell. 2013 Jan 17; 152(1-2): 82-96.

11)Shen T, Aneas I, Sakabe N, Dirschinger RJ, Wang G, Smemo S, Westlund JM, Cheng H, Dalton N, Gu Y, Boogerd CJ, Cai CL, Peterson K, Chen J, Nobrega MA, Evans SM*.Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. J Clin Invest. 2011 Dec 1; 121(12):4640-54.

12)Efe JA, Hilcove S, Kim J, Zhou H, Ouyang K, Wang G, Chen J, Ding S*. Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol. 2011 Mar; 13(3):215-22.

13)Liang X, Sun Y, Ye M, Scimia MC, Cheng H, Martin J, Wang G, Rearden A, Wu C, Peterson KL, Powell HC, Evans SM*, Chen J*. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation. 2009 Aug 18; 120(7):568-76.