生物医学工程学院

余夏夏
生物医学工程学院
医学信息工程
讲师
简介:

姓名:余夏夏

职位:讲师

邮箱:xiaxiayu@szu.edu.cn

  2015年获佐治亚州立大学计算机博士学位;2017年被深圳大学聘为讲师。研究方向主要包括:1)临床信息学:设计机器学习算法,对生物及医疗大数据进行筛选、学习、分析、和预测。在纽约州立大学生物医学信息学系任职期间,参与了纽约州医疗效率和支付系统改革项目,构建分析和预测模型,为医院、保险公司、及监管机构其提供决策支持。2)分子生物信息学及药物筛选:采用高分辨率三维蛋白晶体结构学和机器学习的方法,对HIV蛋白酶突变引发的抗药性进行了分析和预测。在国际期刊和会议上发表超过 20 篇文章,包括BMC Bioinformatics,BMC Gemonics,Journal of Biochemistry等。

    

研究方向

(1)临床电子病历数据分析与算法开发

(2)HIV蛋白酶耐药性预测与分析

(3)HIV药物筛选算法设计  

 

科研项目

 

代表性成果
   论文(*表示通讯作者)   

 

1.     Xin Chen, Yu Wang, Xiaxia Yu, Elinor Schoenfeld, Mary Saltz, Joel Saltz and Fusheng Wang. Large Scale Analysis of Opioid Poisoning Related Hospital Visits in New York State. AMIA Annual Symposium (2017), November 4-8, Washington DC, USA.

2.     Naiyun Zhou, Xiaxia Yu, Tianhao Zhao, Si Wen, Fusheng Wang, Wei Zhu, Tahsin Kurc, Allen Tannenbaum, Joel Saltz, Yi Gao. Evaluation of nucleus segmentation in digital pathology images through large scale image synthesis. SPIE Medical Imaging. International Society for Optics and Photonics (2017).

3.     ChenHsiang Shen, Xiaxia Yu, Robert W. Harrison, and Irene T. Weber. Automated prediction of HIV drug resistance from genotype data. BMC bioinformatic. 17, no. 8 (2016): 278.

4.     Joon H. Park, Jane M. Sayer, Annie Aniana, Xiaxia Yu, Irene T. Weber, Robert W. Harrison, and John M. Louis. Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme. Biochemistry 55, no. 16 (2016): 2390-2400.

5.     Xiaxia Yu, Irene T. Weber, and Robert W. Harrison. Identifying representative drug resistant mutants of HIV. BMC bioinformatics, 16, (2015).

6.     Chinua Umoja, Xiaxia Yu, and Robert Harrison. Fuzzy and uncertain learning techniques for the analysis and prediction of protein tertiary structures. Pattern Recognition in Computational Molecular Biology: Techniques and Approaches (2015): 190. Wiley.

7.     Xiaxia Yu, Irene T. Weber, and Robert W. Harrison. Prediction of HIV drug resistance from genotype with encoded three-dimensional protein structure. BMC genomics, 15, 2014.