BIOGRAPHICAL SKETCH

NAME: Xiaodong Cai

POSITION TITLE: Professor of Neurosurgery, Postgraduate Tutor, Postdoctoral Tutor, Director of the Functional Neurosurgery Department, The First Affiliated Hospital of Shenzhen University/Shenzhen Second People’s Hospital, Director of Canada McGill University MNI/H - Shenzhen Functional Brain Disease Center.

EDUCATION/TRAINING

A. Personal statement

Director of the Functional Neurology and Neurosurgery Department Shenzhen Second People’s Hospital

B. Positions and honors

Positions

1997–2005Attending neurosurgeon at the Brain Center of The First Affiliated Hospital of Shenzhen University/Shenzhen Second People’s Hospital (SZSPH)

2006–2009Assistant Professor of Neurosurgery at SZSPH

2009–PresentProfessor of Neurosurgery at SZSPH

2012–PresentDirector of Functional Neurosurgery at SZSPH

           Director of Shenzhen Parkinson’s disease and Other Movement Disorders Center

           Vice Chair of the Shenzhen Association of Neurosurgeons

           Member of the Chinese Neuromodulation Society.

2014–PresentDirector of the MNI – Shenzhen Functional Brain Diseases Center

Honors

C. Representative publications (selected publications in last 5 years; 5–10)

1.Xiaodong Cai, Xin Chen, Song Wu, Wenlan Liu, Xiejun Zhang, Doudou Zhang, Sijie He, Bo Wang, Mali Zhang, Yuan Zhang, Zongyang Li, Kun Luo, Zhiming Cai, and Weiping Li. Homozygous mutation of VPS16 gene is responsible for an autosomal recessive adolescent-onset primary dystonia. Scientific Reports. 2016, 12(6),25834 (IF=5.578).

2.Xiaodong Cai (CRASH trial collaborators). Effect if intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury(MRC CRASH trial):randomized placebo-controlled trial. Lancet 2004, 364:1321-28.

3.Xiaodong Cai (CRASH trial collaborators).Final result of MRC CRASH ,a randomized placebo-controlled trial of intravenous corticosteroid in adult with head injury-outcomes at 6 months. Lancet 2005, 365:1957-59.

4.Xiaodong Cai, Yongzhong Gao, Weiping Li. Use of selective thalamotomy for various kinds of movement disorder. Chin J Stereotact Funct Neurosurg, 2009, 22(3):134-136.

5.Xiaodong Cai, Yongzhong Gao, Weiping Li. Stereotactic Intracystic Irradiation Treatment of Cystic and Cystosolid Craniopharyngioma. West China Journal. 2009, 24(7):1621-1622.

6.Xiaodong Cai, Yongzhong Gao, Weiping Li. Stereotactic Biopsy of Brain Lesions. West China Journal. 2009, 24(7):1816-1817.

7.Xiaodong Cai, Chihiro Ohye , Tohru Shibazaki. Thalamotomy with Vim and Vo as Targets for PD and Other Movement Disorders. Journal of Occupational Health and Damage. 2004,119(13):167-169.

8.Ding fu Li , Xiaodong Cai, Yi Lei. MRI duiding stereotactic orientation and radiofrequency derogation to selected thalamic nuclei in 12 patients with Writer’s Cramp. Chin J Stereotact Funct Neurosurg. 2009, 22(6):346-350.

9.Doudou Zhang, Hai Lin, Jiali Liu, Zesi Liu, Jie Yan, Xiaodong Cai. Electrode reconstruction assists postoperative contact selection in deep brain stimulation. World Neurosurgery. 2019, 125:e442-e447.

10.Hai Lin, Peng Na, Doudou Zhang, Jiali Liu, J. Xiaodong Cai, Weiping Li. Brain connectivity markers for the identification of effective contacts in subthalamic nucleus deep brain stimulation. Human Brain Mapping. 41(8):2028-2036.

D. Research support

Ongoing projects (RMB)

1.基金英文名 (项目编号) 2018–2022负责人英文名, ￥金额

2.Study on pathogenesis of dystonia based on stem cell model (No. JCYJ20180228162928828), 2018–2021, Xiaodong Cai, ￥5000003.

3.Establishment and application of pluripotent stem cell model in patients with brain diseases (No. JCYJ20180507183628543), 2019–2022, Zhoucun Shang; Xiaodong Cai,￥3000000

4.Clinical application and mechanism of deep brain stimulation in the treatment of chronic neuropathic pain (No. GJHZ20180930110402104), 2019–2021, Luming Li; Xiaodong Cai, ￥500000