NAME: Yang, Chengbin

POSITION TITLE: Assistant Professor of Biomedical Engineering; Shenzhen University

EDUCATION/TRAINING

A.   Personal Statement

I obtained my Ph.D. degree in Electrical & Electronic Engineering from the Nanyang Technological University in 2018. My research interests are in the areas of (1) biodegradable polymer for gene therapy on cancer, (2) multifunctional nanoparticles for biomedical applications, and (3) biomaterials with drug controllable property. I have published 29 peer-reviewed papers in high-quality international journals, such as Nano Research, Nanoscale, Theranostics and Journal of Materials Chemistry B et. al. As PI, I have acquired one funding from the Natural Science Foundation of China.

B.   Positions and Honors

Positions and Employment

0 7 / 2012 – 12 / 2012       Project Management Officer , Shenzhen Beike Biotechnology, Shenzhen. China.

12/20 12 –01/201 5      Research Associate, Nanyang Technological University, Singapore.

04/201 8 – present     Assistant Professor , Shenzhen University, Shenzhen, China.

C.   Contributions to Science (*: corresponding/co-corresponding author)

1. Chengbin Yang, Kok Ken Chan, Wen-Jen Lin, Alana Mauluidy Soehartono, Guimiao Lin, Huiting Toh, Ho Sup Yoon, Chih-Kuang Chen, and Ken-Tye Yong. Biodegradable nanocarrier for siRNA co-delivery strategy increasing the chemosensitivity of pancreatic cancer cells to Gemcitabine. Nano Research, 2017, 10(9), 3049–3067.
2. Chengbin Yang ,   Nishtha Panwar,   Yucheng Wang,   Butian Zhang,  Maixian Liu,  Huiting Toh,   Ho Sup Yoon,   Swee Chuan Tjin,   Peter Han Joo Chong,   Wing-Cheung Law,   Chih-Kuang Chen and   Ken-Tye Yong.   Biodegradable charged polyester-based vectors (BCPVs) as an efficient non-viral transfection nanoagent for gene knockdown of the BCR–ABL hybrid oncogene in a human chronic myeloid leukemia cell line. Nanoscale, 2016, 17(8), 9405-9416.
3. Feng Yin, Chengbin Yang, Qianqian Wang, Shuwen Zeng, Rui Hu, Guimiao Lin, Jinglin Tian, Siyi Hu, Rong Feng Lan, Ho Sup Yoon, Fei Lu, Kuan Wang, Ken-Tye Yong. A light-driven therapy of pancreatic adenocarcinoma using gold nanorods-based nanocarriers for co-delivery of doxorubicin and siRNA. Theranostics, 2015; 5(8): 818–833. (Co-first author).
4. Chengbin Yang ,  Rui Hu, Tommy Anderson,   Yucheng Wang,  Guimiao Lin,   Wing-Cheung Law,   Wei-Jen Lin,   Quoc Toan Nguyen,   Hui Ting Toh,  Ho Sup Yoon,   Chih-Kuang Chen, Ken-Tye Yong. Biodegradable nanoparticle-mediated K-ras down regulation for pancreatic cancer gene therapy. Journal of Materials Chemistry B, 2015, 3, 2163-2172.
5. Rui Hu, Chengbin Yang, Yucheng Wang, Guimiao Lin, Wei Qin, Qingling Ouyang, Wing-Cheung Law, Quoc Toan Nguyen, Ho Sup Yoon, Xiaomei Wang, Ken-Tye Yong, Ben Zhong Tang. Aggregation-induced emission (AIE) dye loaded polymer nanoparticles for gene silencing in pancreatic cancer and their in vitro and in vivo biocompatibility evaluation. Nano Research, 2015, 8(5):1563-1576.
6. Nishtha Panwar, Chengbin Yang, Feng Yin, Ho Sup Yoon, Tjin Swee Chuan, Ken-Tye Yong. RNAi-based therapeutic nanostrategy: IL-8 gene silencing in pancreatic cancer cells using gold nanorods delivery vehicles. Nanotechnology, 2015, 26, 365101. (Co-first author).
7. Guimiao Lin, Chengbin Yang, Rui Hu, Chih-Kuang Chen, Wing-Cheung Law, Tommy Anderson, Butian Zhang, Quoc Toan Nguyen, Hui Ting Toh, Ho Sup Yoon, Chong Cheng, Ken-Tye Yong. Interleukin-8 gene silencing on pancreatic cancer cells using biodegradable polymer nanoplexes. Biomaterials Science, 2014, 2 (7), 1007-1015. (Co-first author).
8. Chengbin Yang, Xucheng Mo, Jingzhang Lv, Xiaoyu Liu, Meichun Yuan, Ming Dong, Li Li, Xinping Luo, Xinmin Fan, Zhe Jin, Zhigang Liu, Jie Liu. Lipopolysaccharide enhances FcεRI-mediated mast cell degranulation by increasing Ca²⁺ entry through store-operated Ca2⁺ channels: implications for lipopolysaccharide exacerbating allergic asthma. Experimental physiology, 2012, 97(12):1315-1327
9. Weiyi He, Chengbin Yang, Lixin Xia, Meizhen Zhao, Rong-Ti Ge, Haizheng Huang, Qiongmei Ji, Pingchang Yang, Zhigang Liu. CD4⁺ T cells from food allergy model are resistant to TCR-dependent apoptotic induction. Cytokine, 2014, 68(1):32-39. (Co-first author).
10. Bo Yang, Chengbin Yang, Ping Wang, Jianjie Li, H Huang, Q Ji, Jie Liu, Zhigang Liu. Butian Zhang, Chengbin Yang, Yuan Gao, Yue Wang, Chengfei Bu, Siyi Hu, Liwei Liu, Hilmi Volkan Demir, Junle Qu, Ken-Tye Yong. Engineering Quantum Dots with Different Emission Wavelengths and Specific Fluorescence Lifetimes for Spectrally and Temporally Multiplexed Imaging of Cells. Nanotheranostics, 2017, 1(1):131-140.
11. Fong-Chuen Loo, Chengbin Yang, Hing Lun Tsang, Pui-Man Lau, Ken-Tye Yong, Ho-Pui Ho, Siu-Kai Kong. An Aptamer Bio-barCode (ABC) Assay Using SPR, RNase H, and Probes with RNA and Gold-Nanorod for Anti-cancer Drug Screening. Analyst, 2017, DOI: 10.1039/C7AN01026E.
12. Jianwei Liu, Chengbin Yang, Jing Liu, Rui Hu, Yazhuo Hu, Hongyan Chen, Wing-Cheung Law, Mark T. Swihart, Ling Ye, Kuan Wang, Ken-Tye Yong. Effects of Cd-based Quantum Dot Exposure on the Reproduction and Offspring of Kunming Mice over Multiple Generations. Nanotheranostics, 2017,1(1):23-37.
13. Liying Hong, Tai-Lok Cheung, Nanxi Rao, Qingling Ouyang, Yue Wang, Shuwen Zeng, Chengbin Yang, Dang Cuong, Peter Han Joo Chong, Liwei Liu, Wing-Cheung Law, Ken-Tye Yong. Millifluidic synthesis of cadmium sulfide nanoparticles and their application in bioimaging. RSC Advances, 2017, 7 (58), 36819-36832.
14. Guimiao Lin, Chih-Kuang Chen, Feng Yin, Chengbin Yang, Jinglin Tian, Ting Chen, Gaixia Xu, Chunxiao He, Marie Chia-Mi Lin, Jie Wang, Fei Lu, Xiaomei Wang and Ken-Tye Yong. Biodegradable nanoparticles as siRNA carriers for in vivo gene silencing and pancreatic cancer therapy. Journal of Materials Chemistry B. 2017, 5(18), 3327-3337.
15. Yucheng Wang, Bo Wu, Chengbin Yang, Maixian Liu, Tze Chien Sum, Ken-Tye Yong. Synthesis and Characterization of Mn: ZnSe/ZnS/ZnMnS Sandwiched QDs for Multimodal Imaging and Theranostic Applications. Small, 2016, 12(4), 534-546.
16. Tai-Lok Cheung, Liying Hong, Nanxi Rao, Chengbin Yang, Libo Wang, Wenn Jing Lai, Peter Han Joo Chong, Wing-Cheung Law, Ken-Tye Yong. The non-aqueous synthesis of shape controllable Cu₂-_xS plasmonic nanostructures in a continuous-flow millifluidic chip for the generation of photo-induced heating. Nanoscale, 2016, 8(12), 6609-6622.
17. Yucheng Wang, Chengbin Yang, Rui Hu, Hui Ting Toh, Xin Liu, Guimiao Lin, Feng Yin, Ho Sup Yoon, Ken-Tye Yong. Assembling Mn: ZnSe quantum dots-siRNA nanoplexes for gene silencing in tumor cells. Biomaterials Science, 2015, 3 (1), 192-202.
18. Butian Zhang, Yucheng Wang, Chengbin Yang, Siyi Hu, Yuan Gao, Yiping Zhang, Yue Wang, Hilmi Volkan Demir, Liwei Liu, Ken-Tye Yong. Composition effect on the optical properties of aqueous synthesized Cu-In-S and Zn-Cu-In-S quantum dot nanocrystals. Physical Chemistry Chemical Physics, 2015, 17, 25133-25141.
19. Danny Jian Hang Tng, Peiyi Song, Rui Hu, Chengbin Yang, Cher Heng Tan, Ken-Tye Yong. Standalone Lab-on-a-Chip Systems toward the Evaluation of Therapeutic Biomaterials in Individualized Disease Treatment. ACS Biomaterials Science & Engineering, 2015, 1 (11), 1055–1066.
20. Feng Yin, Butian Zhang, Shuwen Zeng, Guimiao Lin, Jinglin Tian, Chengbin Yang, Kuan Wang, Gaixia Xu, Ken-Tye Yong. Folic acid-conjugated organically modified silica nanoparticles for enhanced targeted delivery in cancer cells and tumor in vivo. Journal of Materials Chemistry B, 2015, 3, 6081-6093.  
21. Danny Jian Hang Tng, Peiyi Song, Guimiao Lin, Alana Mauluidy Soehartono, Guang Yang, Chengbin Yang, Feng Yin, Cher Heng Tan, Ken-Tye Yong. Synthesis and characterization of multifunctional hybrid-polymeric nanoparticles for drug delivery and multimodal imaging of cancer. International Journal of Nanomedicine, 2015, 10, 5771–5786.
22. Siyi Hu, Shuwen Zeng, Butian Zhang, Chengbin Yang, Peiyi Song, Tng Jian Hang Danny, Guimiao Lin, Yucheng Wang, Tommy Anderson, Philippe Coquet, Liwei Liu, Xihe Zhang, and Ken-Tye Yong.  Preparation of biofunctionalized quantum dots using microfluidic chips for bioimaging. Analyst, 2014,139 (18), 4681-4690.
23. Tommy Anderson, Rui Hu, Chengbin Yang, Ho Sup Yoon and Ken-Tye Yong. Pancreatic cancer gene therapy using siRNA-functionalized single walled carbon nanotubes (SWNTs) nanoplex. Biomaterials Science. 2014,2 (9), 1244-1253.
24. Danny Jian Hang Tng, Peiyi Song, Rui Hu, Chengbin Yang, Ken-Tye Yong. High reliability nanosandwiched Pt/Ti multilayer electrode actuators for on-chip biomedical applications. Analyst, 2014, 139(2), 407-415.
25. Butian Zhang, Rui Hu, Yucheng Wang, Chengbin Yang, Xin Liu, Ken-Tye Yong. Revisiting the principles of preparing aqueous quantum dots for biological applications: the effects of surface ligands on the physicochemical properties of quantum dots. RSC Advances, 2014, 4(27), 13805-13816.
26. Bo Yang, Jianjie Li, Jijuan Cao, Chengbin Yang, Jie Liu, Qiongmei Ji, Zhigang Liu. Polydatin attenuated food allergy via store-operated calcium channels in mast cell. World journal of gastroenterology, 2013, 19(25), 3980–3989.
27. Meichun Yuan, Jianjie Li, Jingzhang Lv, Xucheng Mo, Chengbin Yang, Xiangdong Chen, Zhigang Liu, Jie Liu. Polydatin (PD) inhibits IgE-mediated passive cutaneous anaphylaxis in mice by stabilizing mast cells through modulating Ca 2⁺ mobilization. Toxicology and applied pharmacology, 2012, 264(3), 462-469.

D.   Research Support

Completed Research Support

NSFC (China) project           01/01/2015 to 12/31/2017

Yang Chengbin, PI                                                                     ￥230,000

Investigation into the mechanism by which SIT down-regulate ADAM10 on B cells to inhibit food allergy