NAME: Huang, Bingsheng

POSITION TITLE:  Associate Professor, School of Biomedical Engineering, Health Science Centre, Shenzhen University

EDUCATION/TRAINING

INSTITUTION AND LOCATION	DEGREE (if applicable)	Completion Date MM/YYYY	FIELD OF STUDY
Tsinghua University, Beijing, China	B. Eng.	07/2004	Engineering Physics
Tsinghua University, Beijing, China	MA.Eng.	07/2006	Nuclear Science and Technology
The University of Hong Kong, China	MPhil.	08/2008	Diagnostic Radiology
The University of Hong Kong, China	Ph.D	12/2011	Diagnostic Radiology

 

A.   Personal Statement

My long-standing research interests lie in the application of advanced imaging techniques and image processing in cancer and brain disease. My team is currently focusing on liver cancer, nasopharyngeal carcinoma, epilepsy and other diseases. In particular, we want to explore how machine learning-based image processing techniques help to improve the diagnosis and treatment of affected patients, or help to predict the treatment response. Our research has been continuously supported by the National Natural Science Foundation in China (NSFC) with two regular grants, one Guangdong provincial grant, and three Shenzhen grants since 2014. We have published >30 papers in the peer-reviewed SCI journals. Our team currently consists of nine MSc candidates and >20 undergraduate students.

 

B.   Positions and Honors

Positions and Employment

10/2007 – 02/2008      Part-time Research Assistant, The University of Hong Kong, China

01/2012 – 07/2012      Senior Research Assistant, The University of Hong Kong, China

07/2012 – 02/2014      Postdoctoral Fellow, The University of Hong Kong, China

03/2014 – Present       Associate Professor, Shenzhen University, Shenzhen, China

 

Other Experience and Honors

1. Reviewer of European Radiology (Honored Reviewer of 2009, 2010): 2008 - present
2. Reviewer of NMR in Biomedicine: 2011 - present
3. Reviewer of Neuroradiology: 2012 - present
4. Reviewer of Journal of Computer Assisted Tomography: 2013 - present
5. Reviewer of Journal of Magnetic Resonance Imaging: 2013 - present
6. Shenzhen High-Class Overseas Intelligent (Class B): 2014
7. Reviewer of Current Cancer Drug Targets: 2015 - present
8. Reviewer of Biological Psychiatry: 2015 - present
9. Reviewer of American Journal of Neuroradiology: 2016 - present
10. Reviewer of Oncology Letters: 2016 - present

11.  Leading Editor of a Special Issue in Contrast Media & Molecular Imaging - Application of Image Processing Techniques in Molecular Imaging of Cancer (AIPT): 2016

 

C.   Contributions to Science (*: corresponding/co-corresponding author)

 

1.    Cancer Imaging

1)    Chan WK, Mak HK, Huang B, Yeung DW, Kwong DL, Khong PL. Nasopharyngeal carcinoma: relationship between 18F-FDG PET-CT maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis and TNM classification. Nuclear Medicine Communications. 2010 Mar;31(3):206-10.

2)    Winnie K.S. Chan, Dora Lai-Wan Kwong, David W.C. Yeung, Bingsheng Huang, Pek-Lan Khong. Prognostic Impact of Standardized Uptake Value of F-18 FDG PET-CT in Nasopharyngeal Carcinoma. Clinical Nuclear Medicine 2011 Nov;36(11):1007-11.

3)    Bingsheng Huang, Pek-Lan Khong, Dora Lai-Wan Kwong, Bortau Hung, Chun-Sing Wong, Ching-Yee Oliver Wong. Dynamic PET-CT studies for characterizing nasopharyngeal carcinoma metabolism: comparison of analytical methods. Nuclear Medicine Communications. 2012 Feb;33(2):191-7.

4)    Bingsheng Huang, Tao Chan, Dora Lai-Wan Kwong, Winnie Kit Sum Chan, Pek-Lan Khong. Nasopharyngeal Carcinoma: Investigation of Intratumoral Heterogeneity With FDG PET/CT. American Journal of Roentgenology. 2012 Jul;199(1):169-74.

5)    Feng ST, Cui M, Gao J, Wu B, Sha W, Huang B*. Image-derived arterial input function in dynamic PET-CT: a method using both PET and CT images. Journal of Computer Assisted Tomography. 2012 Nov;36(6):762-7. (*corresponding author).

6)    Huang B, Wong CS, Whitcher B, Kwong DL, Lai V, Chan Q, Khong PL. Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Characterising Nasopharyngeal Carcinoma: Comparison of Semi-Quantitative and Quantitative Parameters and Correlation with Tumour Stage. European Radiology 2013 Feb 2. Jun;23(6):1495-502.

7)    Gong NJ, Wong CS, Chu YC, Guo H, Huang B, Chan Q. Increasing the accuracy of volume and ADC delineation for heterogeneous tumor on diffusion-weighted MRI: correlation with PET/CT. International Journal of Radiation Oncology * Biology * Physics 2013 Oct 1;87(2):407-13.

8)    Lai V, Lee V, Li X, Fong DYT, Lam KO, Huang B, Chan Q, Khong PL. Nasopharyngeal carcinoma: comparison of diffusion and perfusion characteristics between different tumour stages using intravoxel incoherent motion MR imaging. European Radiology 2013 Aug. [Epub ahead of print].

9)    Hanwei Chen; Jinzhao Jiang; Junling Gao; Dan Liu; Jan Axelsson; Minyi Cui; Nan-Jie Gong; Shi-Ting Feng; Liangping Luo; Bingsheng Huang*. Tumor Volumes Measured from Static and Dynamic 18F-FDG PET-CT Scan: Comparison of Different Methods Using MRI As Gold Standard. Journal of Computer Assisted Tomography 38 (2), 209-215. (*corresponding author).

10) Pek-Lan Khong, Bingsheng Huang, Elaine Yuen Phin Lee, Winnie Kit Sum Chan, Yok-Lam Kwong. Mid-Treatment 18F-FDG PET-CT Scan for Early Response Assessment of SMILE Therapy in NK/T-Cell Lymphoma: A Prospective Study from a Single Center. Journal of Nuclear Medicine 2014 May 12;55(6):911-916.

11) Bingsheng Huang,Ching-Yee Oliver Wong,Vincent Lai, dora Lai Wan Kwong,Pek-Lan Khong. Prognostic Value of 18F-FDG PET-CT in Nasopharyngeal Carcinoma:Is Dynamic Scanning Helpful? BioMed Research International. 2015;2015:582614.

12) Jinzhao Jiang, Bingsheng Huang, Guo Bin, Shihui Chen, Fei Feng, Liqiu Zou. An experimental study on the assessment of rabbit hepatic fibrosis by using magnetic resonance T1ρ imaging. Magnetic Resonance Imaging. 2015 Oct 24. pii: S0730-725X(15)00254-4.

13) Bingsheng Huang, Dora Lai Wan Kwong, Vincient Lai, Queenie Chan, Brandon Whitcher, Pek-Lan Khong. Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Regional Nodal Metastasis in Nasopharyngeal Carcinoma: Correlation with Nodal Staging. Contrast Media & Molecular Imaging. 2017

14) Vincent Lai, Victor Ho Fun Lee, Ka On Lam, Bingsheng Huang, Queenie Chan and Pek Lan Khong. Intravoxel incoherent motion MR imaging in nasopharyngeal carcinoma: Comparison and correlation with dynamic contrast enhanced MR imaging. 2017 In Press.

15) Yong Xue; Shihui Chen; Jing Qin; Yong Liu; Hanwei Chen; Bingsheng Huang*. Application of Deep Learning in Automated Analysis of Molecular Images in Cancer: A Survey. Contrast Media & Molecular Imaging. 2017 Oct 15;2017:9512370.

16) Bingsheng Huang*; Guoyan Zheng; Ziyue Xu; Shengxiang Rao; SilunWang. Application of Image Processing Techniques in Molecular Imaging of Cancer. Contrast Media & Molecular Imaging. 2017 Nov.

17) Liangliang Chen;Yufeng Ye;Hanwei Chen; Shihui Chen; Jinzhao Jiang;Guo Dan;Bingsheng Huang*.Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Differentiating between Primary Tumor, Metastatic Node and Normal Tissue in Head and Neck Cancer. Current Medical Imaging Reviews. 2017, 14.

18) Yufeng Ye; Yuzhen Xu; Zhewei Chen;Dexiang Liu;Martin Wai-Ming Law;Qiaoliang Li; Bingsheng Huang*. Deep learning-based tumor segmentation in dynamic contrast-enhanced MRI of head and neck cancer. Oncotarget. Accepted.

 

2.    Neuroimaging

1)    Gao Y, Zhang Y, Wong CS, Wu PM, Zhang Z, Gao J, Qiu D, Huang B*. Diffusion Abnormalities in Temporal Lobes of Children with Temporal Lobe Epilepsy: A Preliminary Diffusional Kurtosis Imaging Study with Comparison with Diffusion Tensor Imaging. NMR in Biomedicine 2012 Dec;25(12):1369-77. (*corresponding author)

2)    Jibiao Zhang , Xueling Zhu, Xiang Wang, Junling Gao , Huqing Shi, Bingsheng Huang, Weijun Situ, Jinyao Yi, Xiongzhao Zhu, Shuqiao Yao. Increased Structural Connectivity in Corpus Callosum in Male Conduct-disordered Adolescents. Journal of the American Academy of Child and Adolescent Psychiatry. 2014 Apr;53(4):466-475.e1.

3)    Jibiao Zhang, Junling Gao, Huqing Shi, Bingsheng Huang, Xiang Wang, Weijun Situ, Weixiong Cai, Jinyao Yi, Xiongzhao Zhu, Shuqiao Yao. Sex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder. BioMed Research International. 2014;2014:673165.

4)    Yali Jiang, Xiao Guo, Jibiao Zhang, Junling Gao, Xiang Wang, Weijun Situ, Jinyao Yi, Xiaocui Zhang, Xiongzhao Zhu, Shuqiao Yao, Bingsheng Huang*. Abnormalities of Cortical Structures in Adolescent-Onset Conduct Disorder. Psychological Medicine. 2015 Dec;45(16):3467-79.

5)    Yali Jiang, Weixiang Liu, Qingsen Ming, Yidian Gao, Ren Ma, Xiaocui Zhang, Weijun Situ, Xiang Wang, Shuqiao Yao, Bingsheng Huang . Disrupted Topological Patterns of Large-Scale Network in Conduct Disorder. Scientific Reports. 2016; 2016: 37053.

6)    Li, Xiangmin; Peng, Zhenpeng; Zhou, Xuhui; Dong, Zhi; Yan, Chaogui; Huang, Bingsheng; Cui, Min-Yi; Feng, Shi-Ting. Preoperative and Follow up Multi-Detector Row CT Angiography (MDCTA) in the Evaluation of Interrupted Aortic Arch (IAA). Current Medical Imaging Reviews, Volume 12, Number 3, August 2016, pp. 205-212(8)

7)    Guo Bin, Tianfu Wang, Hongwu Zeng, Xiaoming He, Feng Li, Jian Zhang, Bingsheng Huang*. Patterns of Gray Matter Abnormalities in Idiopathic Generalized Epilepsy: A Meta-Analysis of Voxel-Based Morphology Studies. PLoS One. 2017 Jan 6;12(1):e0169076.

 

3.    Radiation Protection in Medical Imaging

1)    Huang B, Law MW, Khong P L. Whole Body PET-CT Scan: Estimation of Radiation Dose and Cancer Risk. Radiology 2009 Apr;251(1):166-74.

2)    Huang B, Law MW, Mak HK, Kwok SP, Khong PL. Pediatric CT coronary angiography using 64-slice CT with ECG-modulated tube current: radiation dose and cancer risk. American Journal of Roentgenology 2009 Aug;193(2):539-44. Available for CME credit: http://www.arrs.org/education/cert/index.cfm

3)    Huang B, Li J, Law MW, Zhang J, Shen Y, Khong PL. Radiation dose and cancer risk in retrospectively and prospectively ECG-gated coronary angiography using 64-slice MDCT. British Journal of Radiology 2010 Feb;83(986):152-8.

4)    Feng ST, Law MW, Huang B, Ng S, Li ZP, Meng QF, Khong PL. Radiation dose and cancer risk from pediatric CT examinations on 64-slice CT: A phantom study. European Journal of Radiology 2010 Nov;76(2):e19-23.

5)    Wong Chun-Sing; Huang Bingsheng; Sin Ho-Kwan; Wong Wai-Lam; Yiu Ka-Ling; Chu Yiu Ching, Tiffany. A questionnaire study assessing local physicians, radiologists and interns' knowledge and practice pertaining to radiation exposure doses related to radiological imaging. European Journal of Radiology 2012 Mar;81(3):e264-8.

6)    Sin Ho-Kwan; Wong Chun-Sing; Huang Bingsheng; Yiu Ka-Ling; Wong Wai-Lam; Chu Yiu Ching Tiffany. Assessing local patients’ knowledge and awareness on radiation doses and risks associated with radiological imaging – A Questionnaire Study. Journal of Medical Imaging and Radiation Oncology. 2013 Feb;57(1):38-44.

 

D.   Research Support

Ongoing Research Support

Guangdong Provice Medical Research Fundind (No. B2016031) , 07/01/2016 to 6/30/2018

Bingsheng Huang, PI                                                 project approval but not funding.

"Automatic Lesion Segmentation of Hepatocellular Carcinoma based on Machinie Learning and Spectral CT"

 

Shenzhen Municipal Scheme for Basic Research (No. JCYJ20160429181451546)                                                                                      01/01/2018 to 12/31/2020

Bingsheng Huang, Co-I                                                    ￥500,000 (direct cost)

“The effects and mechanisms of temporary spinal cord stimulation for herpetic pain”

 

Shenzhen Municipal Scheme for Basic Research (No. JCYJ20160307114900292),                                              01/01/2017 to 12/31/2018

Bingsheng Huang, PI                                                              ￥3,000,000

" Technical Research on the diagnosis and treatment of nasopharyngeal carcinoma based on intelligent image processing "

 

Shenzhen Municipal Scheme for Basic Research (No. JCYJ20170303160116960),                                                     07/01/2017 to 06/30/2020

Bingsheng Huang, Co-I                                                    ￥15,000 (direct cost)

 "A multi-parametric MRI study of cognitive impairment in frontal lobe epilepsy"

Completed Research Support

Shenzhen High-caliber Personnel Research Funding OR Seed Funding from Scientific and Technical Innovation Council of Shenzhen Government              01/01/2015 to 12/31/2017

Bingsheng Huang, PI                                                         ￥4,500,000

“Application of advanced medical imaging techniques in research of cancer and brain disorders”

 

Special Funding Scheme for Supporting The Innovation and Research of Shenzhen High- caliber Overseas Intelligents (No. KQCX20140519103243534)           01/01/2015 to 12/30/2016

Bingsheng Huang, PI                                                          ￥600,000

“Estimation of Radiation Risk and Research of Low-dose Scanning Protocol in Medical Imaging”

 

Young Investigator Research Program of Shenzhen University,                                                                                 07/01/2014 to 06/30/2015

Bingsheng Huang, PI                                                         ￥60,000

“Application of DKI and MPRAGE in the Functional and Morphological Analysis of Children Brain with Epilepsy”

 

Young Investigator Program, NSFC (No. 81301273), 01/01/2014 to 12/31/2016

Bingsheng Huang, PI                                                               ￥230,000

"Dynamic PET-CT and Dynamic Contrast-Enhanced MRI in Treatment Monitoring and Prognosis of Nasopharyngeal Carcinoma"

 

Small Project Funding, The University of Hong Kong (No. 201209176182), 01/01/2013 to 12/31/2015

Bingsheng Huang, PI                                                              HK$ 77,119

"Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Locoregional Nodal Metastasis of Nasopharyngeal Carcinoma"

 

Young Investigator Program, NSFC (No. 81201074), 01/01/2013 to 12/31/2015

Bingsheng Huang, Co-I (NO.3)                                         ￥230,000

"Perfusion MRI and 18F-Chlorotoxin PET double-modality imaging of glioma"

 

Small Project Funding of The University of Hong Kong (No. 200907176188),  01/01/2009 to 12/31/2011

Bingsheng Huang, Co-I (NO.2)                                         HK$ 60,000

 “Dynamic FDG-PET-CT imaging for the evaluation of nasopharyngeal carcinoma (NPC): a pilot study”