NAME: Shen, Yuanyuan

POSITION TITLE: Associate Professor of Biomedical Engineering, Shenzhen University School of Medicine

EDUCATION/TRAINING

A.   Personal Statement

My long-standing research interests fall in drug delivery and cancer therapy using ultrasound technology. Research in my lab has been continuously supported by seven grants from the National Natural Science Foundation in China (NSFC), the Chinese Postdoctoral Foundation, and the Shenzhen Science and Technology Planning Projects since 2010. I have published >20 papers in peer-reviewed professional journals. I am currently mentoring five MSc candidates.

B.   Positions and Employment

06/2012–12/2016        Lecturer, Department of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China

01/2017– present       Associate Professor, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China

C.   Research Support

Ongoing Research Support

Project of Department of Education of Guangdong Province (Grant No. 2016KTSCX123)     

01/2017 to 12/2018

Yuanyuan Shen, PI                                                            ￥100,000

Shenzhen Science and Technology Planning Project (JCYJ20160520175319943)        

13/02/2017 to 13/02/2019

Yuanyuan Shen, PI                                                            ￥300,000

Medical Scientific Research Foundation of Guangdong Province (A2017289)         

07/2017 to 12/2019

Yuanyuan Shen, PI                                                            ￥10,000

Completed Research Support

Chinese Postdoctoral Foundation (20100470903)

06/2010 to 12/2011

Yuanyuan Shen, PI                                                            ￥30,000

National Natural Science Foundation of China (81101171)

01/2012 to 12/2012

Yuanyuan Shen, PI                                                            ￥140,000

Shenzhen Science and Technology Planning Project (GJHS20120621153609166)

01/2013 to 12/2014

Yuanyuan Shen, PI                                                            ￥70,000

Shenzhen Science and Technology Planning Project (JCYJ20140828163634004)               

12/2014 to 12/2016

Yuanyuan Shen, PI                                                            ￥300,000

D.   Publications (*: corresponding author)

1.      Yuanyuan Shen, Zhaoke Pi, Fei Yan*, Chih-Kuang Yeh, Xiaojun Zeng, Xianfen Diao, Yaxin Hu, Siping Chen, Xin Chen*, Hairong Zheng, Enhanced delivery of paclitaxel liposomes using focused ultrasound with microbubbles for treating nude mice bearing intracranial glioblastoma xenografts, International Journal of Nanomedicine, 2017(12): 5613-5629.

2.      Haoming Lin, Xinyu Zhang, Yuanyuan Shen*, Yi Zheng, Yanrong Guo, Ying Zhu, Xianfen Diao, Tianfu Wang, Siping Chen, Xin Chen*, Model-dependent and model-independent approaches for evaluating hepatic fibrosis in rat liver using shearwave dispersion ultrasound vibrometry, Medical Engineering and Physics, 39: 66-72, 2017.

3.      Haoming Lin#, Yuanyuan Shen#, Xin Chen*, Ying Zhu, Yi Zheng, Xinyu Zhang, Yanrong Guo, Tianfu Wang, Siping Chen*, Viscoelastic properties of normal rat liver measured by ultrasound elastography: comparison with oscillatory rheometry. Biorheology, vol. 53, no. 5-6, pp. 193-207, 2016.

4.      Zhaoke Pi,Xin Chen, Fangfang Li, Yue Li, Weijian Huang, Yiling Chen, Fei Yan, Hairong Zheng, Yaxin Hu, Yuanyuan Shen*, Therapeutic effect of paclitaxel liposomes delivered by ultrasound with microbubbles on nude mice bearing intracranial glioblastoma xenografts monitored by bioluminescence imaging, IEEE Ultrasonic Symposium 2016, Tour, France, September 18-21, 2016.

5.      Yuanyuan Shen, Jinxuan Guo, Gaoshu Chen, Chien Ting Chin, Xin Chen, Jian Chen, Feng Wang, Shiguo Chen, Guo Dan*, Delivery of liposomes with different sizes to mice brain after sonication by focused ultrasound in the presence of microbubbles, Ultrasound in Medicine and Biology, 42(7): 1499-1511, 2016.

6.      Ying Zhu, Xin Chen, Xinyu Zhang, Siping Chen, Yuanyuan Shen*, Liang Song, Modeling the mechanical properties of liver fibrosis in rats. Journal of Biomechanics, 49:1461-1467 , 2016.

7.      Jinxuan Guo, Gaoshu Chen, Jian Chen, Chien Ting Chin, Yanyan Suo, Yuanyuan Shen*. Passive delivery of liposomes with different sizes to the mouse brain after blood brain barrier opening induced by focused ultrasound with microbubbles. IEEE Ultrasonic Symposium 2015, Taipei, Taiwan, October 21-24, 2015.

8.      Hao Yu, Zhongshi Lin, Liang Xu, Dalong Liu, Yuanyuan Shen*, Theoretical study of microbubble dynamics in sonoporation, Ultrasonics, 61: 136-144, 2015.

9.      Yuanyuan Shen, Aili Zhang, Jinxuan Guo, Guo Dan, Siping Chen and Hao Yu*, Fluorescence imaging of Evans blue extravasation into mouse brain induced by low frequency ultrasound with microbubble, Bio-Medical Materials and Engineering, 2014, 24(6): 2831-2838.

10.   Yuanyuan Shen, Tianfu Wang, Chien Ting Chin, Xianfen Diao and Siping Chen*, Interaction Between Microbubble and Elastic Microvessel in Low Frequency Ultrasound Field Using Finite Element Method, Chinese Science Bulletin, 58(3): 291-298, 2013.

11.   Yuanyuan Shen, Tianfu Wang and Siping Chen*, The Mechanical Effects of Microbubble Oscillation on Elastic Vessel Wall Under Ultrasonic Excitation with Different Frequencies using Finite Element Method, World Congress on Medical Physics and Biomedical Engineering, May 26-31, 2012, Beijing, China, IFMBE Proceedings 39: 1085-1088, 2013.

12.   Yuanyuan Shen, Tianfu Wang, Xianfen Diao and Siping Chen*, Numerical Analysis of Interaction Between Microbubble and Elastic Microvessel in Low Frequency Ultrasound Field Using Fluid Solid Interaction Method, IEEE-EMBS International Conference on Biomedical and Health Informatics,Hongkong, 5-7 Jan. 2012: 733- 736.

13.   Yuanyuan Shen, Aili Zhang*, Study of Alternate Cooling and Heating Treatment Induced Tumor Microvasculature Injury, Chinese Science Bulletin, Vol.55, No.2: 172−178, January 2010.

14.   Yuanyuan Shen, Aili Zhang, and Lisa X. Xu*, A Study on Mechanical study on tumor microvascular damage induced by alternate cooling and heating treatment, ASME journal of Thermal Science and Engineering Applications, Vol.1, No.3: 10-18, September 2009.

15.   Yuanyuan Shen, Aili Zhang, and Lisa X. Xu*, Mechanical study on tumor microvessel damage induced by alternate cooling and heating treatment, Proceedings of the ASME 2009 Summer Bioengineering Conference, accepted, Lake Tahoe, U.S.A., 2009.

16.   Yuanyuan Shen, Ping Liu, Aili Zhang, and Lisa X. Xu*, Study on tumor microvasculature damage induced by alternate cooling and heating, Annals of Biomedical Engineering, Vol.36, No.8, pp. 1409-1419, August 2008.

17.   Yuanyuan Shen, Ping Liu, Aili Zhang, and Lisa X. Xu*, Tumor microvasculature response to alternated cold and heat treatment, Proceedings of the 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, pp. 6797-6800, Shanghai, China, 2005.

18.   Ying Zhu, Yi Zheng, Yuanyuan Shen, Xin Chen, Xinyu Zhang, Haoming Lin,Yanrong Guo, Tianfu Wang, Siping Chen, Analyzing and modeling rheological behavior of liver fibrosis in rats using shear viscoelastic moduli, Journal of Zhejiang University SCIENCE B, 2014 Apr;15(4):375-81.

19.   Qing Zhu, Yuanyuan Shen, Aili Zhang and Lisa X. Xu, Numerical Study of the Influence of Water Evaporation on Radiofrequency Ablation. BioMedical Engineering OnLine, 2013, 12:127.

20.   Xin Chen, Yuanyuan Shen, Yi Zheng, Haoming Lin ,Yanrong Guo, Ying Zhu, Xinyu Zhang, Tianfu Wang, Siping Chen, Quantification of Liver Viscoelasticity with Acoustic Radiation Force: A Study of Hepatic Fibrosisin a Rat Model, Ultrasound in Medicine and Biology, Vol. 39, No. 11:2091-2102, 2013.

21.   Ying Zhu, Yuanyuan Shen, Xin Chen, Haoming Lin, and Siping Chen, Rheological Behavior Analysis of Liver Fibrosis in Rats, International Journal of Bioscience, Biochemistry and Bioinformatics, Vol. 3, No. 3: 229-231, 2013.

22.   Ying Zhu, Yuanyuan Shen, Xin Chen, Haoming Lin, Tianfu Wang and Siping Chen, Rheological Properties Analysis of Rats Liver in Fibrosis Stages, Journal of Shenzhen University Science and Engineering, Vol. 30, No. 2: 216-220, 2013.

23.   Xin Chen, Yanrong Guo, Yi Wang, Yuanyuan Shen, Haoming Lin, Ying Zhu, Yi Zheng, Tianfu Wang, Siping Chen, Ultrasonic radiation force elastography system for measuring tissue viscoelasticity: an in vitro study on phantom and rat liver, Journal of Shenzhen University Science and Engineering, Vol. 30, No. 1: 54-59, 2013.