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BIOGRAPHICAL SKETCH

NAME: Xueqing Wu

POSITION TITLE: Professor, Consultant EDUCATION/TRAINING

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A.Personal?statement

Prof. Xueqing Wu has been engaged in basic and clinical research related to reproductive endocrinology for more?than?25?years.?Currently,?she?has?presided?more?than?20?scientific?projects.?In?recent?years,?her?research mainly focus on the fields of reproductive health, gynecological oncology, new materials, and clinical application of new drugs in the Obstetrics gynecology. She has published more than 70 ariticles in Professional?journals?such?as?Reproduction,?Reproductive?Biology,?Reproductive?Biology?and?Endocrinology, Journal of Obstetrics & Gynecology, International Journal of Nanomedicine. In the meantime, she serves as a member of the Reproductive Health Committee of the China Maternal and Child Health Association, vice- chairman of the Reproductive Gynecology Department of the Primary Medical Association of Guangdong Province,?vice-president?of?the?obstetrics?and?Gynecology?Branch?of?the?Shenzhen?Medical?Association,

member of the British Society for Reproduction and infertility, member of the American Endocrine Society, and Editorial Board of the Journal of Reproductive Medicine (《生殖健康杂志》)

B. Positions and honors

1994-2000 Resident doctor and Assistant Lecturer，Department of Obstetrics ＆ Gynaecology, The first

affiliated hospital of Wenzhou Medical University.

2000-2010 Consultant and Lecturer, Department of Obstetrics ＆ Gynaecology, The first affiliated hospital ?of Wenzhou Medical?University.

2010-2012Consultant and Reader, Department of Obstetrics ＆ Gynaecology, The first affiliated?hospital

of Wenzhou Medical University.

2012-2017Consultant and Professor, Department of Obstetrics ＆ Gynaecology, The first affiliated hospital of Wenzhou Medical?University.

2017-NowConsultant and Professor, Department of Obstetrics ＆ Gynaecology, Shenzhen?University

General Hospital

Honors

2016 Award for Medical and Health Science and Technology (Third award), Zhejiang province, (1/9) 2016?Award?for?Science?and?Technology?Progress?Award?of?Wenzhou?City?(Third?award),?Wenzhou,?(1/6)

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C.Representative publications (selected publications in recent?five?years ?( 5-10?篇)

1.Huilong Lin#, Laien Shen, Qi Lin, Chenle Dong, Baron Maswela, Gaby Sukma Illahi, Xueqing Wu*. SNHG5 enhances Paclitaxel sensitivity of ovarian cancer cells through sponging miR-23a. Biomedicine & Pharmacotherapy 2020. * corresponding?authorship

2.Wu XQ#, Zhang SS#, Xu XX, Shen LE, Xu BY, Qu WZ, Zhuang WY, Locock K, Deighton M, Qu Y*. RAFT-derived polymethacrylates as a superior treatment for recurrent vulvovaginal candidiasis by targeting biotic biofilms and persister cells. Frontiers in Microbiology 2019. #first?authorship

3.Zhou ZY#, Lin Q#, Xu XX, Gay SI, Dong CL, Wu XQ*. Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system. Reproductive Biology and Endocrinology, 2019. * corresponding?authorship

4.Xu XX#, Zhang SS, Lin HL, Lin Q, Shen LE, Ansong E, Wu XQ*. Metformin promotes regeneration of the injured endometrium via inhibition of endoplasmic reticulum stress-induced apoptosis. Reproductive Science, 2019. * corresponding?authorship

5.Ansong E, Arhin SK, Cai YY, Xu XX, Wu XQ*. Menstrual characteristics, disorders and associated risk factors among female international students in Zhejiang Province, China: a cross-sectional survey. BMC Women’s Health. 2019. * corresponding?authorship

6.Xu XX#, Zhang SS#, Lin HL, Lin Q, Shen LE, Ansong E, Wu XQ*. Metformin promotes regeneration of the injured endometrium via inhibition of endoplasmic reticulum stress-induced apoptosis. Reproductive Science, 2018. * corresponding?authorship

7.Wang BQ#, Chen YY, Lan XX, Zhou ZY, Xu XX, Wu XQ*. The effect of neonatal immune challenge on reproduction by altering intraovarian kisspeptin/GPR54 system in the rat. Reprod Toxicol 2017. * corresponding?authorship

8.Zhang SS#, Xia WT, Xu J, Xu HL, Lu CT, Zhao YZ, Wu XQ*. Three-dimensional structure micelles of heparin-poloxamer improve the therapeutic effect of 17β-estradiol on endometrial regeneration for intrauterine adhesions in a rat model. Internationl Journal of Nanomedicine, 2017. * corresponding authorship

9.Wang Binqiao; Chen Yuanyuan; Lan Xiaoxiao; Zhou Qiangyong; Xu Xinxin; Wu Xueqing*. The effect of neonatal immune challenge on reproduction by altering intraovarian kisspeptin/GPR54 system in the rat, Reproductive Toxicology, 2017. * corresponding?authorship

10.Wu Xueqing#; Li Xiaofeng; Xia Weiting; Ye Bilu; O'Byrne, Kevin T.*. The effects of small litter rearing on ovarian function at puberty and adulthood in the rat, Reproductive Biology, 2016. #first authorship

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D.Research?support

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1.Treatment?of?Asherman?Syndrome?by?heparin-Poloxamer?temperature-controlled?hydrogel?entrapped

ESTRADIOL and its mechanism studies. The Foundation of Shenzhen Science and Technology Commissio(JCYJ20190808120807379)(￥300,000) ,2020.3-2023.2

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2.Long-term effects and meachanism of obesity on female hypothalamic-pituitary-ovarian?axis.

Guangdong?Province?Science?and?Technology?Innovation?Strategy?Special?Fund (overseas?famous?professor) (粤财科教 2019-182?号)( ￥20,000).2019.9-2020.12

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3.Investigation of the modulatory mechanism of the MAPK signalling pathway induced by kisspeptin in ovarian?dysfunction?in?PCOS.?The?National?Nature?Science?Foundation?of?China(81873822)?(￥570,000),

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2019.01-2022.12

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4.Mechanism?of?exercise?to?improve?reproductive?function?in?rats?induced?by?obesity ?through?ovary

kisspeptin/GPR54 system. The Foundation of Shenzhen Science and Technology Commissio(JCY20170818100355168)(￥450,000) ,2018.4-2020.3

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5.Research?on?the?application?of?multiple?simulation?teaching?aids?in?clinical?teaching, Guangdong?Province Clinical?Education?Base?Teaching?Reform?Research?Project(粤教高函 2019-3) (￥50,000) ,2018.1-2020.12

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6.The mechanism of modulation on follicular development and ovulation by the signal systme of ovarian kisspeptin/GRP54 in obesity. The Natural Science grant of Zhejiang Province (LY17H040009) (￥80,000), 2017.1-2019.12

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7.Wenzhou City High-level Talents Innovation Technology?Project Key Funding: Improvement?of

Reproductive Function of Obese Rats by Exercise of Ovary Kisspeptin/GPR5 System and Mechanism (￥40,000),2017.6-2020.6

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8.The prophylaInvestigation of the prolyphatice effect and the mechanism?of

temperature-regulated estradiol-heparin-poloxamer ydrogel in Asherman syndrome. (1/11). The Public Welfare ? Technology ?Project ? of ? Zhejiang ? Province(2016C37132)( ? ￥ ? ?60,000 ? ?） ? ?, 2016.1-2018.12

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9.The relationship between the autonomic innervation and reproductive loss in women . Wenzhou Science and Technology grant. (Y20140188)?（￥30,000）,2015.1-2017.12

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10.The clinical study of sex hormonal replacement therapy in perimenopausal?and

postmenopausal?women.?The?“Help?workers?and?agriculture?"activities?and?projects?for?less?developed?areas in Wenzhou. (￥15,000)?,2015.1-2017.12

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11.The long term effect on reproduction by endotoxin in female?rats.Scientific

Research Foundation for the Returned Overseas Chinese Scholars of Chinese Ministry of Education (No.2012-1707). (￥30,000) 2013.1-2015.12