BIOGRAPHICAL SKETCH

NAME: Xueqing Wu

POSITION TITLE: Professor, Consultant EDUCATION/TRAINING

A.Personal statement

Prof. Xueqing Wu has been engaged in basic and clinical research related to reproductive endocrinology for more than 25 years. Currently, she has presided more than 20 scientific projects. In recent years, her research mainly focus on the fields of reproductive health, gynecological oncology, new materials, and clinical application of new drugs in the Obstetrics gynecology. She has published more than 70 ariticles in Professional journals such as Reproduction, Reproductive Biology, Reproductive Biology and Endocrinology, Journal of Obstetrics & Gynecology, International Journal of Nanomedicine. In the meantime, she serves as a member of the Reproductive Health Committee of the China Maternal and Child Health Association, vice- chairman of the Reproductive Gynecology Department of the Primary Medical Association of Guangdong Province, vice-president of the obstetrics and Gynecology Branch of the Shenzhen Medical Association,

member of the British Society for Reproduction and infertility, member of the American Endocrine Society, and Editorial Board of the Journal of Reproductive Medicine (《生殖健康杂志》)

B. Positions and honors

1994-2000 Resident doctor and Assistant Lecturer，Department of Obstetrics ＆ Gynaecology, The first

affiliated hospital of Wenzhou Medical University.

2000-2010 Consultant and Lecturer, Department of Obstetrics ＆ Gynaecology, The first affiliated hospital  of Wenzhou Medical University.

2010-2012Consultant and Reader, Department of Obstetrics ＆ Gynaecology, The first affiliated hospital

of Wenzhou Medical University.

2012-2017Consultant and Professor, Department of Obstetrics ＆ Gynaecology, The first affiliated hospital of Wenzhou Medical University.

2017-NowConsultant and Professor, Department of Obstetrics ＆ Gynaecology, Shenzhen University

General Hospital

Honors

2016 Award for Medical and Health Science and Technology (Third award), Zhejiang province, (1/9) 2016 Award for Science and Technology Progress Award of Wenzhou City (Third award), Wenzhou, (1/6)

C.Representative publications (selected publications in recent five years  ( 5-10 篇)

1.Huilong Lin#, Laien Shen, Qi Lin, Chenle Dong, Baron Maswela, Gaby Sukma Illahi, Xueqing Wu*. SNHG5 enhances Paclitaxel sensitivity of ovarian cancer cells through sponging miR-23a. Biomedicine & Pharmacotherapy 2020. * corresponding authorship

2.Wu XQ#, Zhang SS#, Xu XX, Shen LE, Xu BY, Qu WZ, Zhuang WY, Locock K, Deighton M, Qu Y*. RAFT-derived polymethacrylates as a superior treatment for recurrent vulvovaginal candidiasis by targeting biotic biofilms and persister cells. Frontiers in Microbiology 2019. #first authorship

3.Zhou ZY#, Lin Q#, Xu XX, Gay SI, Dong CL, Wu XQ*. Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system. Reproductive Biology and Endocrinology, 2019. * corresponding authorship

4.Xu XX#, Zhang SS, Lin HL, Lin Q, Shen LE, Ansong E, Wu XQ*. Metformin promotes regeneration of the injured endometrium via inhibition of endoplasmic reticulum stress-induced apoptosis. Reproductive Science, 2019. * corresponding authorship

5.Ansong E, Arhin SK, Cai YY, Xu XX, Wu XQ*. Menstrual characteristics, disorders and associated risk factors among female international students in Zhejiang Province, China: a cross-sectional survey. BMC Women’s Health. 2019. * corresponding authorship

6.Xu XX#, Zhang SS#, Lin HL, Lin Q, Shen LE, Ansong E, Wu XQ*. Metformin promotes regeneration of the injured endometrium via inhibition of endoplasmic reticulum stress-induced apoptosis. Reproductive Science, 2018. * corresponding authorship

7.Wang BQ#, Chen YY, Lan XX, Zhou ZY, Xu XX, Wu XQ*. The effect of neonatal immune challenge on reproduction by altering intraovarian kisspeptin/GPR54 system in the rat. Reprod Toxicol 2017. * corresponding authorship

8.Zhang SS#, Xia WT, Xu J, Xu HL, Lu CT, Zhao YZ, Wu XQ*. Three-dimensional structure micelles of heparin-poloxamer improve the therapeutic effect of 17β-estradiol on endometrial regeneration for intrauterine adhesions in a rat model. Internationl Journal of Nanomedicine, 2017. * corresponding authorship

9.Wang Binqiao; Chen Yuanyuan; Lan Xiaoxiao; Zhou Qiangyong; Xu Xinxin; Wu Xueqing*. The effect of neonatal immune challenge on reproduction by altering intraovarian kisspeptin/GPR54 system in the rat, Reproductive Toxicology, 2017. * corresponding authorship

10.Wu Xueqing#; Li Xiaofeng; Xia Weiting; Ye Bilu; O'Byrne, Kevin T.*. The effects of small litter rearing on ovarian function at puberty and adulthood in the rat, Reproductive Biology, 2016. #first authorship

D.Research support

1.Treatment of Asherman Syndrome by heparin-Poloxamer temperature-controlled hydrogel entrapped

ESTRADIOL and its mechanism studies. The Foundation of Shenzhen Science and Technology Commissio(JCYJ20190808120807379)(￥300,000) ,2020.3-2023.2

2.Long-term effects and meachanism of obesity on female hypothalamic-pituitary-ovarian axis.

Guangdong Province Science and Technology Innovation Strategy Special Fund (overseas famous professor) (粤财科教 2019-182 号)( ￥20,000).2019.9-2020.12

3.Investigation of the modulatory mechanism of the MAPK signalling pathway induced by kisspeptin in ovarian dysfunction in PCOS. The National Nature Science Foundation of China(81873822) (￥570,000),

2019.01-2022.12

4.Mechanism of exercise to improve reproductive function in rats induced by obesity  through ovary

kisspeptin/GPR54 system. The Foundation of Shenzhen Science and Technology Commissio(JCY20170818100355168)(￥450,000) ,2018.4-2020.3

5.Research on the application of multiple simulation teaching aids in clinical teaching, Guangdong Province Clinical Education Base Teaching Reform Research Project(粤教高函 2019-3) (￥50,000) ,2018.1-2020.12

6.The mechanism of modulation on follicular development and ovulation by the signal systme of ovarian kisspeptin/GRP54 in obesity. The Natural Science grant of Zhejiang Province (LY17H040009) (￥80,000), 2017.1-2019.12

7.Wenzhou City High-level Talents Innovation Technology Project Key Funding: Improvement of

Reproductive Function of Obese Rats by Exercise of Ovary Kisspeptin/GPR5 System and Mechanism (￥40,000),2017.6-2020.6

8.The prophylaInvestigation of the prolyphatice effect and the mechanism of

temperature-regulated estradiol-heparin-poloxamer ydrogel in Asherman syndrome. (1/11). The Public Welfare   Technology  Project   of   Zhejiang   Province(2016C37132)(   ￥    60,000    ）    , 2016.1-2018.12

9.The relationship between the autonomic innervation and reproductive loss in women . Wenzhou Science and Technology grant. (Y20140188) （￥30,000）,2015.1-2017.12

10.The clinical study of sex hormonal replacement therapy in perimenopausal and

postmenopausal women. The “Help workers and agriculture "activities and projects for less developed areas in Wenzhou. (￥15,000) ,2015.1-2017.12

11.The long term effect on reproduction by endotoxin in female rats.Scientific

Research Foundation for the Returned Overseas Chinese Scholars of Chinese Ministry of Education (No.2012-1707). (￥30,000) 2013.1-2015.12