NAME: Zhang, Ming

POSITION TITLE: Associate Professor of Epidemiology; Department of Preventive Medicine, Shenzhen University Health Science Center

EDUCATION/TRAINING

A.   Personal Statement

My research interests lie in the epidemiology of cardiometabolic diseases, the relationship between polymorphisms in  genes, methylations in genes and metabolic syndrome (MS), and the components of MS and the closely related syndrome, type 2 diabetes mellitus etc.

B.   Positions and Honors

Positions and Employment

02/2014–11/2017: Assistant Professor, Department of Preventive Medicine, Shenzhen University Health Science Center, China

12/2017 – present: Associate Professor, Department of Preventive Medicine, Shenzhen University Health Science Center, China

C.   Research Support

Ongoing Research Support

NSFC (China) project (81402752)                01/01/2015 to 12/31/2017

Ming Zhang, PI                                                            ￥230,000 (direct cost)

Association study between gene (MFGE8 and CD36) polymorphism and metabolic syndrome risk and components of metabolic syndrome: a perspective nest case - control study of a Chinese Han population

Shenzhen Science and Technology Innovation Commission grant (JCYJ201404180914135622)                                                                                                           01/01/2015 to 012/31/2016

Ming Zhang, PI                                                            ￥200,000

Association study between CD36 gene polymorphism and metabolic syndrome risk and components of metabolic syndrome: a perspective nest case - control study of a Chinese Han population

NSFC (Guangdong Province) project (A2017181)                   06/01/2017 to 05/31/2019

Ming Zhang, PI                                                            ￥5,000 (direct cost)

Association study between TCFL2 gene methylation and dynamic change and type2 diabetes: a perspective nest case - control study of a Chinese Han population

Shenzhen Science and Technology Innovation Commission grant (JCYJ 20170302143855721)                                                                                                            06/01/2017 to 12/31/2019

Ming Zhang, PI                                                            ￥300,000

Association study between the environment, gene, the interactions and type2 diabetes based on the 10 years cohort

Shenzhen Science and Technology Innovation Commission grant                                                                                                                                                             01/01/2017 to 12/31/2019

Ming Zhang, PI                                                            ￥3,000,000

Study the comprehensive causes on the nested case control of type 2 diabetes mellitus.

D.   Peer-reviewed publications( ^# : co-first author, *: co- corresponding author)

1.    Haifei You, Jingzhi Zhao, Yujia Zhai, Lei Yin, Chao Pang, Xinping Luo, Ming Zhang, Jinjin Wang, Linlin Li, Yan Wang, Qian Wang, Bingyuan Wang, Yongcheng Ren, Dongsheng Hu. Association between low-density lipoprotein receptor-related protein 5 polymorphisms and type 2 diabetes mellitus in Han Chinese: A case-control study. Biomedical and Environmental Sciences 2015; 28(7): 510-517

2.  Jinjin Wang, Jingzhi Zhao, Jianfeng Zhang, Xinping Luo, Kaiping Gao, Ming Zhang, Linlin Li, Chongjian Wang, Dongsheng Hu. Association of canonical wnt/β-catenin pathway and type 2 diabetes: Genetic epidemiological study in Han Chinese. Nutrients 2015; 7(6): 4763-4777
3.  Yang Zhao#, Ming Zhang^#, Xinping Luo, Lei Yin, Chao Pang, Tianping Feng, Yongcheng Ren, Bingyuan Wang, Lu Zhang, Linlin Li, Hongyan Zhang, Xiangyu Yang, Chengyi Han, Dongting Wu, Jiaxiang Zhou, Yanxia Shen, Chongjian Wang, Jingzhi Zhao, Dongsheng Hu. Association of obesity categories and high blood pressure in a rural adult Chinese population. Journal of Human Hypertension 2016; 30(10): 613-618
4. Yongcheng Ren#, Ming Zhang^#, Jingzhi Zhao, Chongjian Wang, Xinping Luo, Jiatong Zhang, Tian Zhu, Xi Li, Lei Yin, Chao Pang, Tianping Feng, Bingyuan Wang, Lu Zhang, Linlin Li, Xiangyu Yang, Hongyan Zhang, Dongsheng Hu. Association of the hypertriglyceridemic-waist phenotype and type 2 diabetes mellitus among adults in China. Journal of Diabetes Investigation 2016; 7(5): 689-694
5.  Ming Zhang ^# , Hongyan Zhang#, Chongjian Wang, Yongcheng Ren, Bingyuan Wang, Lu Zhang, Xiangyu Yang, Yang Zhao, Chengyi Han, Chao Pang, Lei Yin, Yuan Xue, Jingzhi Zhao, Dongsheng Hu. Development and validation of a risk-score model for type 2 diabetes: A cohort study of a rural adult Chinese population. PLoS One 2016; 11(4): e152054
6.  Ming Zhang^#, Yang Zhao#, Guoan Wang, Hongyan Zhang, Yongcheng Ren, Bingyuan Wang, Lu Zhang, Xiangyu Yang, Chengyi Han, Chao Pang, Lei Yin, Jingzhi Zhao, Dongsheng Hu. Body mass index and waist circumference combined predicts obesity-related hypertension better than either alone in a rural Chinese population. Scientific Reports 2016; 6: 31935
7. Junmei Zhou, Ming Zhang*, Shu Wang, Bingyuan Wang, Chengyi Han, Yongcheng Ren, Lu Zhang, Hongyan Zhang, Xiangyu Yang, Yang Zhao, Dongsheng Hu. Association of the ADIPOQ rs2241766 and rs266729 polymorphisms with metabolic syndrome in the Chinese population: A meta-analysis. Biomedical and Environmental Sciences 2016; 29(7): 505-515
8.  Lu Zhang#, Ming Zhang^#, Jinjin Wang, Chongjian Wang, Yongcheng Ren, Bingyuan Wang, Hongyan Zhang, Xiangyu Yang, Yang Zhao, Chengyi Han, Junmei Zhou, Chao Pang, Lei Yin, Jingzhi Zhao, Xinping Luo, Dongsheng Hu. Association of TCF7L2 and GCG gene variants with insulin secretion, insulin resistance, and obesity in new-onset diabetes. Biomedical and Environmental Sciences 2016; 29(11): 814-817
9.  Chengyi Han#, Ming Zhang^#, Xinping Luo, Chongjian Wang, Lei Yin, Chao Pang, Tianping Feng, Yongcheng Ren, Bingyuan Wang, Lu Zhang, Linlin Li, Xiangyu Yang, Hongyan Zhang, Yang Zhao, Junmei Zhou, Zhihui Xie, Jingzhi Zhao, Dongsheng Hu. Secular trends in the prevalence of type 2 diabetes in adults in China from 1995 to 2014: A meta-analysis. Journal of Diabetes 2017; 9(5): 450-461
10.  Chengyi Han#, Ming Zhang^#, Xinping Luo, Chongjian Wang, Junmei Zhou, Lu Zhang, Yongcheng Ren, Bingyuan Wang, Xiangyu Yang, Hongyan Zhang, Yang Zhao, Yanxia Shen, Dongting Wu, Chao Pang, Lei Yin, Tianping Feng, Dongsheng Hu, Jingzhi Zhao. The association of resting heart rate and mortality by gender in a rural adult Chinese population: A cohort study with a 6-year follow-up. Journal of Public Health 2017; 25(1): 95-101
11.  Ming Zhang, Chengyi Han, Chongjian Wang, Jinjin Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Hongyan Zhang, Xiangyu Yang, Yang Zhao, Junmei Zhou, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Xinping Luo, Dongsheng Hu. Association of resting heart rate and cardiovascular disease mortality in hypertensive and normotensive rural Chinese. Journal of Cardiology 2017; 69(5): 779-784
12.  Xuejiao Liu, Xinping Luo. Yu Liu. Xizhuo Sun, Chengyi Han, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Yang Zhao, Dongdong Zhang, Dongsheng Hu, Ming Zhang. Resting heart rate and risk of metabolic syndrome in adults: A dose-response meta-analysis of observational studies. Acta Diabetologica 2017; 54(3): 223-235
13.  Ming Zhang, Bingyuan Wang, Yu Liu, Xizhuo Sun, Xinping Luo, Chongjian Wang, Linlin Li, Lu Zhang, Yongcheng Ren, Yang Zhao, Junmei Zhou, Chengyi Han, Jingzhi Zhao, Dongsheng Hu. Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study. Cardiovascular Diabetology 2017; 16 (1): 30
14. Xuejiao Liu, Dongdong Zhang, Yu Liu, Xizhuo Sun, Chengyi Han, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Yang Zhao, Yuanyuan Shi, Dongsheng Hu, Ming Zhang*. Dose-response association between physical activity and incident hypertension: A systematic review and meta-analysis of cohort studies. Hypertension 2017; 69(5): 813-820
15.  Ming Zhang, Yang Zhao, Haohang Sun, Xinping Luo, Chongjian Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Chengyi Han, Hongyan Zhang, Xiangyu Yang, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu. Effect of dynamic change in body mass index on the risk of hypertension: Results from the Rural Chinese Cohort Study. International Journal of Cardiology 2017; 238: 117-122
16.  Lu Zhang, Jinjin Wang, Ming Zhang, Guo'an Wang, Yanxia Shen, Dongting Wu, Chongjian Wang, Linlin Li, Yongcheng Ren, Bingyuan Wang, Hongyan Zhang, Xiangyu Yang, Yang Zhao, Chengyi Han, Junmei Zhou, Chao Pang, Lei Yin, Jingzhi Zhao, Xinping Luo, Dongsheng Hu. Association of type 2 diabetes mellitus with the interaction between low-density lipoprotein receptor-related protein 5 (LRP5) polymorphisms and overweight and obesity in rural Chinese adults. Journal of Diabetes 2017; 9(11): 994-1002
17.  Yongcheng Ren, Yu Liu, Xizhuo Sun, Kunpeng Deng, Chongjian Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yang Zhao, Junmei Zhou, Chengyi Han, Hongyan Zhang, Xiangyu Yang, Xinping Luo, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Ming Zhang, Dongsheng Hu. Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study. Scientific Reports 2017; 7: 9072
18.  Yang Zhao, Ming Zhang, Xinping Luo, Chongjian Wang, Linin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Chengyi Han, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu. Association of 6-year waist circumference gain and incident hypertension. Heart 2017; 103(17): 1347-1352
19.  Yang Zhao, Haohang Sun, Bingyuan Wang, Ming Zhang, Xinping Luo, Yongcheng Ren, Junmei Zhou, Chengyi Han, Chongjian Wang, Linlin Li, Lu Zhang, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu. Impaired fasting glucose predicts the development of hypertension over 6 years in female adults: Results from the Rural Chinese Cohort Study. Journal of Diabetes and Its Complications 2017; 31(7): 1090-1095
20.  Yongcheng Ren, Ming Zhang, Xinping Luo, Jingzhi Zhao, Lei Yin, Chao Pang, Tianping Feng, Shu Wang, Bingyuan Wang, Hongyan Zhang, Xiangyu Yang, Dongsheng Hu. Secular trend of the leading causes of death in China from 2003 to 2013. African Health Sciences 2017; 17(2): 532-537
21.  Hongyan Zhang, Chongjian Wang, Yongcheng Ren, Bingyuan Wang, Xiangyu Yang, Yang Zhao, Chengyi Han, Junmei Zhou, Lu Zhang, Minjie Qin, Yujia Zhai, Chao Pang, Lei Yin, Jingzhi Zhao, Dongsheng Hu, Ming Zhang. A risk-score model for predicting risk of type 2 diabetes mellitus in a rural Chinese adult population: A cohort study with a 6-year follow-up. Diabetes/Metabolism Research and Reviews 2017; 33(7): e2911
22.  Dongdong Zhang, Xuejiao Liu, Yu Liu, Xizhuo Sun, Bingyuan Wang, Yongcheng Ren, Yang Zhao, Junmei Zhou, Chengyi Han, Lei Yin, Jingzhi Zhao, Yuanyuan Shi, Ming Zhang*, Dongsheng Hu*. Leisure-time physical activity and incident metabolic syndrome: a systematic review and dose-response meta-analysis of cohort studies. Metabolism 2017; 75: 36-44
23.  Chengyi Han, Yu Liu, Xizhuo Sun, Xinping Luo, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Yang Zhao, Dongdong Zhang, Xuejiao Liu, Ming Zhang, Dongsheng Hu. Prediction of a new body shape index and body adiposity estimator for development of type 2 diabetes mellitus: The Rural Chinese Cohort Study. British Journal of Nutrition 2017; 118(10): 771-776
24.  Junmei Zhou, Yongcheng Ren, Chongjian Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yang Zhao, Chengyi Han, Hongyan Zhang, Xiangyu Yang, Xinping Luo, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu, Ming Zhang. Association of change in waist circumference and dyslipidemia risk: The Rural Chinese Cohort Study. Diabetes/Metabolism Research and Reviews 2018; 34(1): e2949
25.  Bingyuan Wang, Ming Zhang, Shu Wang, Chongjian Wang, Jinjin Wang, Linlin Li, Lu Zhang, Yongcheng Ren, Chengyi Han, Yang Zhao, Junmei Zhou, Guo'an Wang, Yanxia Shen, Dongting Wu, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Xinping Luo, Dongsheng Hu. Dynamic status of metabolically healthy overweight/obesity and metabolically unhealthy and normal weight and the risk of type 2 diabetes mellitus: A cohort study of a rural adult Chinese population. Obesity Research and Clinical Practice 2018; 12(1): 61-71
26.  Ming Zhang, Junmei Zhou, Yu Liu, Xizhuo Sun, Xinping Luo, Chengyi Han, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Yang Zhao, Dongdong Zhang, Xuejiao Liu, Dongsheng Hu. Risk of type 2 diabetes mellitus associated with plasma lipid levels: The rural Chinese cohort study. Diabetes Research and Clinical Practice 2018; 135: 150-157
27.  Xu Chen, Yu Liu, Xizhuo Sun, Zhaoxia Yin, Honghui Li, Kunpeng Deng, Cheng Cheng, Leilei Liu, Xinping Luo, Ruiyuan Zhang, Feiyan Liu, Qionggui Zhou, Chongjian Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yang Zhao, Junmei Zhou, Chengyi Han, Hongyan Zhang, Xiangyu Yang, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Ming Zhang, Dongsheng Hu. Comparison of body mass index, waist circumference, conicity index, and waist-to-height ratio for predicting incidence of hypertension: The Rural Chinese Cohort Study. Journal of Human Hypertension 2018; 32(3): 228-235
28.  Dongdong Zhang, Ruiyuan Zhang, Yu Liu, Xizhuo Sun, Zhaoxia Yin, Honghui Li, Yang Zhao, Bingyuan Wang, Yongcheng Ren, Cheng Cheng, Xuejiao Liu, Dechen Liu, Feiyan Liu, Xu Chen, Leilei Liu, Qionggui Zhou, Yihan Xiong, Qihuan Xu, Jiali Liu, Shihao Hong, Ziyang You, Dongsheng Hu, Ming Zhang. CD36 gene variants is associated with type 2 diabetes mellitus through the interaction of obesity in rural Chinese adults. Gene  2018; 659: 155-159
29.  Bingyuan Wang, Ming Zhang, Yu Liu, Xizhuo Sun, Lu Zhang, Chongjian Wang, Linlin Li, Yongcheng Ren, Chengyi Han, Yang Zhao, Junmei Zhou, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu. Utility of three novel insulin resistance-related lipid indices for predicting type 2 diabetes mellitus among people with normal fasting glucose in rural China. Journal of Diabetes 2018 Jan 11. doi: 10.1111/1753-0407.12642
30. YangZhao, YuLiu,HaohangSun,XizhuoSun,ZhaoxiaYinm,HonghuiLi,YongchengRen,,DongdongZhang,XuejiaoLiu,DechenLiu,RuiyuanZhang,FeiyanLiu,XuChen,LeileiLiu,ChengCheng,QiongguiZhou,DongshengHu, Ming Zhang. Association of long-term dynamic change in body weight and incident hypertension: The RuralChinese Cohort Study. Nutrition. 2018 Mar 20;54:76-82. doi: 10.1016/j.nut.2018.02.020. [Epub ahead of print]
31. Feiyan Liu, Hongyan Zhang, Yu Liu, Xizhuo Sun, Zhaoxia Yin, Honghui Li, Kunpeng Deng, Yang Zhao, Bingyuan Wang, Yongcheng Ren, Lu Zhang, Junmei Zhou,; Chengyi Han, Xuejiao Liu, Dongdong Zhang, Guozhen Chen,; Shihao Hong, Chongjian Wang, Dongsheng Hu, Ming Zhang, Sleep duration interacts with lifestyle risk factors and health status to alter risk of all-cause mortality: the rural Chinese cohort study J Clin Sleep Med 2018 May 15;14(5):857-865. doi: 10.5664/jcsm.7124.