Name: Jianbing Jiang

Position: Associate Professor

E-Mail: jb.jiang@szu.edu.cn

Address: A1-518, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, No.1066, Xueyuan Avenue, Shenzhen, China. Post code: 518055.

Personal Statement:

Dr. Jianbing Jiang obtained his PhD degree in Leiden University of Netherlands with major of chemical biology in 2016. He came back to China to work as an assistant professor in the Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences. In 2017, he was recognized as a member of Class C of Shenzhen Overseas High-level talent Peacock Project and a member of Class C talent of Shenzhen Nanshan District. In July 2018, he was appointed as an assistant professor by the School of Medicine, Shenzhen University.In November 2019, he was appointed as a specially appointed associate researcher and master's supervisor. In March 2024, he was promoted to a long-term associate professor at Shenzhen University.

Dr. Jiang Jianbing's main research direction is the design and synthesis of molecular probes, as well as the identification and mechanism study of target proteins for the prevention and treatment of diseases by natural products of traditional Chinese medicine using activity based protein profiling. At present, I am leading one general project of Guangdong Natural Science Foundation , and as a sub project leader, I have participated in national key research and development plan projects (17 million yuan), national natural science foundation key projects (2.97 million yuan), and Shenzhen high-level talent peacock team projects (15 million yuan). As the project leader, I have led the completion of one National Natural Science Foundation youth project, one Guangdong Natural Science Foundation project, one Shenzhen Science and Technology Innovation Commission free exploration fund project, and one Shenzhen University research start-up project. As the first author or corresponding author, I have published over 20 SCI papers, including high-level research papers such as Nature Chemical Biology and ACS Central Science, and have been granted 2 national invention patents. At present, I am mainly responsible for teaching two courses: "Frontiers of Chemical Biology" for undergraduate students in pharmacy and "Medicinal Chemical Biology" for graduate students. I have also led one campus level educational reform project at Shenzhen University.

Research field:

1) Design and synthesis of activity-based probes;

2) Chemical biology studies of natural products of traditional Chinese medicine;

3) Chemical proteomics of gut microbiota.

Funding:

1. NSFC, 21807106, Jan.2019-Dec.2021, ¥30,0000;

2. Guangdong Natural Science Foundation, 2018A030310035,May 2018-Apr.2021,¥10,0000;

3. Shenzhen Science and Technology Commission Fund, JCYJ20180302145723601, Apr.2019-Mar.2021, ¥30,0000;

4. Guangdong Natural Science Foundation, 2018A030310035, Jan. 2025-Dec.2027,¥10,0000;

Selected Peer-reviewed Publications:

(1) Jianbing Jiang#; Diana Czuchry#; Yanxia Ru#; Huipai Peng#; Junfeng Shen; Teng Wang; Wenjuan Zhao; Weihua Chen; Sen-Fang Sui; Yaowang Li*; Nan Li*; Activity-based metaproteomics driven discovery and enzymological characterization of potential α-galactosidases in the mouse gut microbiome, Communications Chemistry, 2024, 7(1): 184.(IF=5.9)

(2) Wen-Jing Bi, Zhi-Xin Lan, Xue-Chun Wang, Yong-Xian Cheng*, Jian-Bing Jiang* Design and synthesis of photoaffinity-based probes for labeling β-glucuronidase, Bioorganic Chemistry, 2023, 141, 106909.(IF=5.1)

(3) Jianbing Jiang#, Ying Liu#, Shuxin Yang#, Huipai Peng, Jia-Wang Liu, Yong-Xian Cheng*, Nan Li*. Photoaffinity-Based Chemical Proteomics Reveals 7-Oxocallitrisic Acid Targets CPT1A to Trigger Lipogenesis Inhibition. ACS Medicinal Chemistry Letters 2021, 12 (12), 1905. (IF=4.4)

(4) Yingying Song#, Jianbing Jiang#, Yong-Ming Yan, Yong-Xian Cheng*. Isolation and identification of belamcandaoids A-N from Belamcanda chinensis seeds and their inhibition on extracellular matrix in TGF-beta1 induced kidney proximal tubular cells, Bioorganic Chemistry, 2021, 114, 105067. IF=5.1)

(5) Liang Wu#, Jianbing Jiang#, Yi Jin#, Wouter W Kallemeijn, Chi-Lin Kuo, Marta Artola, Wei Dai, Cas van Elk, Marco van Eijk, Gijsbert A van der Marel, Jeroen d C Codée, Bogdan I Florea, Johannes M F G aerts, Herman S Overkleeft*, Gideon J Davies*. Activity-based probes for functional interrogation of retaining beta-glucuronidases. Nature Chemical Biology, 2017, 13(8): 867-873. (IF=15.1)