NAME: Hu, Ming-Hao

POSITION TITLE: Assistant Professor of Medicinal Chemistry, School of Pharmaceutical Sciences, Shenzhen University

EDUCATION/TRAINING

A.   Personal Statement

My research interests fall in discovery of fluorescent probes for bioimaging, andI am also interested in development oflead compounds for cancer therapy. Indeed, I am always focus ing on the areaof nucleic acid, especially G-quadruplexes. Several distinct compounds targeting particular G-quadruplexeswere developed, including c-MYC G-quadruplex, multimeric G-quadruplex, hybrid telomeric G-quadruplex and so on.

B.   Positions and Honors

Positions and Employment

07/2017 – present      Assistant Professor, Shenzhen University, Shenzhen, China

Organizing International Meetings

None

Other Experience and Honors

None

C.   Contributions to Science (*: corresponding/co-corresponding author)

1.      Hu, M.-H.^#; Wang, Y.-Q.^# (contributed equally); Yu, Z-Y; Hu, L-N; Ou, T.-M.; Chen, S.-B.*; Tan, J.-H.*; Discovery of a new four-leaf clover-like ligand as a potent c-MYC transcription inhibitor specifically targeting the promoter G-quadruplex., Journal of Medicinal Chemistry, 2018, 61, 2447–2459.

2.      Hu, M.-H.; Chen, S.-B.; Wang, B.; Ou, T.-M.; Gu, L.-Q.; Tan, J.-H.; Huang, Z.-S. Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole. Nucleic Acids Research, 2017, 45, 1606-1618.

3.      Hu, M.-H.; Chen, S.-B.; Wang, Y.-Q.; Zeng, Y.-M.; Ou, T.-M.; Li, D.; Gu, L.-Q.; Huang, Z.-S.; Tan, J.-H. Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole. Biosensors & Bioelectronics, 2016, 83, 77-84.

4.      Hu, M.-H.; Chen, X.; Chen, S.-B.; Ou, T.-M.; Yao, M.; Gu, L.-Q.; Huang, Z.-S.; Tan, J.-H. A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology. Scientific Reports, 2015, 5, 17202.

5.      Hu, M.-H.^#; Guo, R.-J. ^# (contributed equally); Chen, S.-B.; Huang, Z.-S.; Tan, J.-H. Development of an engineered carbazole/thiazole orange conjugating probe for G-quadruplexes. Dyes and Pigments, 2017, 137, 191-199.

6.      Hu, M.-H.; Chen, S.-B.; Guo, R.-J.; Ou, T.-M.; Huang, Z.-S.; Tan, J.-H.Development of a highly sensitive fluorescent light-up probe for G-quadruplexes. Analyst, 2015, 140, 4616-4625.

7.      Wang, Y.-Q.^#; Hu, M.-H.^# (contributed equally); Guo, R.-J.; Chen, S.-B.*; Huang, Z.-S.; Tan, J.-H.*; Tuning the selectivity of a commercial cyanine nucleic acid dye for preferential sensing of hybrid telomeric G-quadruplex DNA. Sensors and Actuators B: Chemical, 2018, 266, 187–194.

8.      Chen, S.-B.; Hu, M.-H.; Liu, G.-C.; Wang, J.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.; Tan, J.-H. Visualization of NRAS RNA G-quadruplex structures in cells with an engineered fluorogenic hybridization probe. Journal of the American Chemical Society, 2016, 138, 10382-10385.

9.      Chen, S.-B.; Wu, W.-B.; Hu, M.-H.; Ou, T.-M.; Gu, L.-Q.; Tan, J.-H.; Huang, Z.-S. Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes. Chemical Communications, 2014, 50, 12173-12176.

Zhuo, S.-T.; Li, C.-Y.; Hu, M.-H.; Chen, S.-B.; Yao, P.-F.; Huang, S.-L., Ou, T.-M.; Tan, J.-H.; An, L.-K.; Li, D.; Gu, L.-Q.; Huang, Z.-S. Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II. Organic & Biomolecular Chemistry, 2013, 11, 3989-4005.

D.   Research Support

None