NAME: Zhu, Qinchang

POSITION TITLE: Assistant Professor of Pharmaceutical Sciences, Shenzhen University School of Medicine

EDUCATION/TRAINING

A.   Personal Statement

My research mainly focuses on virus-host interactions and antiviral studies of bio-functional molecules isolated from natural sources, especially molecules involved in Traditional Chinese Medicine (TCM). My interests also lie in probing drug targets against virus infection with bio-functional molecules.  My studies have focused on several viruses, including HSV, EV71, HBV, and influenza virus. I have published > 30 papers in peer-reviewed journals, and have jointly obtained five National Patents. As the Associate Editor and one of the major authors, I produce d a book to introduce the technology of isothermal nucleic acid amplification.

B.   Positions and Honors

Positions and Employment

07/2006–08/2010        Assistant Researcher, Laboratory of Virology and Immunology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

09/2016 – present       Assistant Professor, Laboratory of Natural Medicine, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen, China

Other Experience and Honors

1.    High-Level Overseas Talents of Shenzhen City: 01/2017-12/2021

2.    High-Level Talent in Nanshan District of Shenzhen:07/2017-06/2022

3.    Full doctoral scholarship from Japanese Government:  10/2010-09/2013

4.    Full master’s scholarship from Chinese Ministry of Education 09/2004– 06/2006

C.   Research Support

Ongoing Research Support

Shenzhen Science and Technology Innovation Commission grant (JCYJ20170818095732006)                                                                                                             04/01/2018 to 03/31/2020

Qinchang Zhu, PI                                                               ￥440,000

Discovery of a broad-spectrum drug target against hand-foot-mouth disease using pendulectin and its derivates as probes

Medical Scientific Research Foundation of Guangdong Province（A2018257）

07/01/2018 to 06/30/2020

Qinchang Zhu, PI                                                               ￥10,000

Discovery of  broad-spectrum drug targets against hand-foot-mouth disease

Natural Science Foundation of SZU  (20170901)  06/01/2017 to 05/31/2019

Qinchang Zhu, PI                                                                  ￥60,000

Discovery of a broad-spectrum drug target against hand-foot-mouth disease using active compounds as probes

Completed Research Support

973 project (China) (2009CB522300)                                       01/01/2009 to 08/30/2013

Qinchang Zhu, key member                                                            ￥2,700,000

Mechanism study of antiviral matters

D.   Peer-reviewed publications (*: corresponding author)

1.     Zhu Q., Amen, Y. M.，Ohnuki, K.，Shimizu, K. Anti-influenza effects of Ganoderma lingzhi: An animal study. Journal of Functional Foods, 34, 224-228, 2017

2.     Zhu Q., Kakino K., Nogami C., et al. An LC-MS/MS-SRM Method for Simultaneous Quantification of Four Representative Organosulfur Compounds in Garlic Products. Food Analytical Methods,1-7, 2016.

3.     Zhu, Q. , Bang, T.H., Ohnuki, K., Sawai, T., Sawai, K., Shimizu, K. Inhibition of Neuraminidase by Ganoderma Triterpenoids and Implications for Neuraminidase Inhibitor design. Sci Rep 10:1038, 2015

4.     Zhu, Q., Nakagawa, T., Kishikawa, A., Ohnuki, K., & Shimizu, K. In vitro bioactivities and phytochemical profile of various parts of the strawberry (Fragaria × ananassa var. Amaou). Journal of Functional Foods, 13, 38-49, 2015

5.     Zhu, Q., Yu Z., Kabashima, T., Yin, S., Dragusha, S., El-Mahdy, A., Ejupi, V., Shibata, T., Kai, M.. Fluorometric assay for phenotypic differentiation of drug-resistant HIV mutants. Sci Rep 5: 10323, 2015

6.     Zhu Q., Shibata T, Kabashima T, Kai M. Inhibition of HIV-1 protease expression in T cells owing to DNA aptamer-mediated specific delivery of siRNA, Eur J Med Chem, 56: 396-9, 08, 2012

7.     Zhu, Q., Liu, G., & Kai, M. DNA Aptamers in the Diagnosis and Treatment of Human Diseases. Molecules, 20(12), 20979-20997，2015

8.     Zhu, Q.^＃ , Tanaka, A.^＃, Tan, H., Horiba, H., Ohnuki, K., Mori, Y., Yamauchi, R., Ishikawa, H., Iwamoto, A., Kawahara, H. and Shimizu, K.. Biological activities and phytochemical profiles of extracts from different parts of bamboo (Phyllostachys pubescens). Molecules. 19, 8238-8260, 06, 2014

9.     Zhu Q., Wang Y, Liu YP, Zhang RQ, Li X, Su WH, Long F, Luo XD, Peng T.. Inhibition of enterovirus 71 replication by chrysosplenetin and penduletin, Eur J Pharm Sci, 44: 392-8, 09, 2011 

10.  Zhu Q . , Wang Y., Peng T.. Herpes simplex virus (HSV) immediate-early (IE) promoter-directed reporter system for the screening of antiherpetics targeting the early stage of HSV infection, J Biomol Screen, 15: 1016-20, 06, 2010

11.  Zhu Q., Ren Z, Zhang CL, Zhang MY, Liao HJ, Liu QY, Zhang PZ, Li JX, Hu CF, Wang HD, Wang YF. Silencing HSV1 gD expression in cultured cells by RNA interference, Chinese Journal of Virology, 23: 22-7, 09, 2007

12.  Ting Li，Libao Liu，Hongling Wu，Shaodan Chen，Qinchang Zhu，Hao Gao，Xiongtao Yu，Yi Wang， Wenhan Su，Xinsheng Yao，Tao Peng. Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb, Antiviral Research. 144:273-280, 2017

13.   Amen, Yhiya，Zhu, Qinchang，Tran, Hai-Bang，Afifi, Mohamed S，Halim, Ahmed F，Ashour, Ahmed，Fujimoto, Ryoji，Goto, Takahiro，Shimizu, Kuniyoshi, Rho-kinase inhibitors from adlay seeds. Nat Prod Res, DOI:10.1080/14786419.2017.1354183, 2017

14.   Kohno, Toshitaka，Hai-Bang, Tran，Zhu, Qinchang，Amen,Yhiya，Sakamoto, Seiichi，Tanaka, Hiroyuki Morimoto, Satoshi，Shimizu,Kuniyoshi，Tubulin polymerization-stimulating activity of Ganoderma triterpenoids.，J Nat Med，2017.01.11，71（2）：457-462

15.  Yin, Sheng，Kabashima, Tsutomu，Zhu, Qinchang，Shibata, Takayuki，Kai, Masaaki，Fluorescence assay of dihydroorotate dehydrogenase that may become a cancer biomarker，Scientific Reports，2017.1.13，7

16.  Amen, Yhiya，Zhu, Qinchang，Tran, Hai-Bang，Afifi, Mohamed S，Halim, Ahmed F，Ashour, Ahmed，Shimizu, Kuniyoshi，Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds: insights on discovery of natural Rho-kinase inhibitors.，J Nat Med，2017.01.10，71（2）：380~388

17.  Zaki, Ahmed，Ashour, Ahmed，Mira, Amira，Kishikawa, Asuka，Nakagawa,Toshinori，Zhu, Qinchang，Shimizu, Kuniyoshi，Biological Activities of Oleanolic Acid Derivatives from Calendula officinalis Seeds，Phytotherapy Research，2016.5.01，30（5）：835~841

18.  Amen Y M, Zhu Q., Afifi M S, et al. New cytotoxic lanostanoid triterpenes from Ganoderma lingzhi. Phytochemistry Letters, 2016, 17: 64-70.

19.   Mira A, Alkhiary W, Zhu Q., et al. Improved Biological Activities of Isoepoxypteryxin by Biotransformation. Chemistry & Biodiversity, 2016, 13(10): 1307-1315

20.  Amen, Y. M., Zhu, Q., Tran, H. B., Afifi, M. S., Halim, A. F., Ashour,  A., & Shimizu, K. Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells. Journal of natural medicines, 1-6. 2016

21.  Zaki, A., Ashour, A., Mira, A., Kishikawa, A., Nakagawa, T.,Zhu, Q., & Shimizu, K. (2016). Biological Activities of Oleanolic Acid Derivatives from Calendula officinalis Seeds. Phytotherapy Research.

22.  El-Mahdy, A. F., Shibata, T., Kabashima, T., Zhu, Q., & Kai, M. Delivery of siRNA using siRNA/cationic vector complexes encapsulated in dendrimer-like polymeric DNAs. RSC Advances, 5(41), 32775-32785, 2015

23.  Nakagawa, T., Zhu, Q., Ishikawa, H., Ohnuki, K., Kakino, K., , & Yatagai, M. Multiple uses of Essential Oil and By-Products from Various Parts of the Yakushima Native Cedar (Cryptomeria Japonica). Journal of Wood Chemistry and Technology, 36(1), 42-55, 2016

24.  Kishikawa, A., Ashour, A., Zhu, Q., Yasuda, M., Ishikawa, H. and Shimizu, K.. Multiple Biological Effects of Olive Oil By-products such as Leaves, Stems, Flowers, Olive Milled Waste, Fruit Pulp, and Seeds of the Olive Plant on Skin. Phytother Res, doi: 10.1002/ptr.5326, 03, 2015

25.   Ejupi, V., Dragusha, S., Kabashima, T., Zhu, Q., El-Mahdy, A. F., Yin, S.& Kai, M. (2015). Spectrofluorometric Assays of Human Collagenase Activity Using Native Collagen and Acetyl-Peptide Substrates. Advances in Enzyme Research, 3(01), 19.

26.   Chen, S. D., Li, T., Gao, H.,Zhu, Q., Lu, C.J., Wu, H.L., Peng, T., Yao, X.S. Anti HSV-1 flavonoid derivatives tethered with houttuynin from Houttuynia cordata, Planta Med , 79, 1742-1748, 11, 2013

27.  Chen SD, Gao H, Zhu Q, Wang YQ, Li T, Mu ZQ, Wu HL, Peng T, Yao XS. Houttuynoids A-E, Anti-Herpes Simplex Virus Active Flavonoids with Novel Skeletons from Houttuynia cordata. Org Lett, 14: 1772-5, 03, 2012

28.  Wang Y, Wang Q, Zhu Q., Zhou R, Liu J, Peng T. Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children, J Clin Virol, 52: 107-12, 07, 2011

29.  Zhu Y-C, Wang G, Yang X-L, Luo D-Q, Zhu Q-C, Peng T, Liu J-K. Agrocybone, a novel bis-sesquiterpene with a spirodienone structure from basidiomycete Agrocybe salicacola, Tetrahedron Letters, 51: 3443-5, 04, 2010

30.     Zhe R, Mei-Ying Z, Kitazato K, Kobayash N, Qin-Chang Zhu, Pei-Zhuo Z, Zhi-Rong Y, Yi-Fei W. Effect of siRNA on HSV-1 plaque formation and relative expression levels of UL39 mRNA, Arch Virol, 153: 1401-6, 06, 2008