NAME: Dong Yun

POSITION TITLE: Assistant Professor of School of pharmaceutical Sciences, Health Science Center, Shenzhen University

EDUCATION/TRAINING

A.   Personal Statement

My long-standing research interests fall in molecular and pathological mechanisms of neurodegenerative disorders . During my PhD program, I mainly investigated the molecular and pathological mechanisms and potential therapeutic strategies against Alzheimer's disease (AD). Previous studies have demonstrate that tumor necrosis factor (TNF) played a major role in neurodegeneration, such as multiple sclerosis, brain ischemia. We focused on the role of TNF in AD and found that neuroprotection against AD can be mediated by inhibition of TNF receptor one (TNFR1) and TNFR2 activation. I have published 3 papers in the peer-reviewed professional journals, such as PNAS and Journal of Alzheimer's Disease. I had been in a position of  an assistant investigator to study AD-related neural circuits, specially alternation of cholinergic neural circuits in the early stage of AD at Shenzhen Institute of Advanced Technology, and 3 funds were supported by National Natural Science Foundation of China and Shenzhen government from 2016 to 2018. Since April 2018 to present, I am an assistant professor at School of Pharmaceutical Sciences, Health Science Center of Shenzhen University. 

B.   Positions and Honors

Positions and Employment

05/2016 – 04/2018      Assistant investigator, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

0 4 /201 8 – present      Assistant professor , School of pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China

International Meetings

1.    presentation, the 15th International Tumor Necrosis Factor Conference at the Handelsbeurs in Ghent, Belgium , May 20 - 23 th, 201 5 .

2.    poster, the 12th international Conference on Alzheimer's & Parkinson's Diseases in Nice, France, March 18-22th, 2015.

C.   Contributions to Science (*: corresponding/co-corresponding author)

Research Support

Ongoing Research Support

NSFC (China)  project (31700932)                          01/01/2018 to 12/31/2020

Yun Dong                                                              ￥250,000 (direct cost)

The role of TNF in the mechanism underlying NBM cholinergic neuronal damages in the early stage of AD

Shenzhen Science and Technology Innovation Commission grant (JCYJ20170307170742519)                                                                                                             25/05/2017 to 25/05/2019

Yun Dong,                                                             ￥300,000

Targeting TNFRs neuroprotects NBM cholinergic neurons and specific cholinergic neural circuits against AD

Chinese Academy of Sciences funds for Distinguished Young Scholar (Y7G0131001)  

                                                                             15/05/2017 to 15/05/2019

Yun Dong                                                   ￥100,000 (direct cost)

Neural circuits anatomy  of brain disorders

Peer-reviewed publications

1.      Y. Dong, R. Fischer, P.J.W. Naudé, O. Maier, C. Nyakas, M. Duffey, E.A. van der Zee, D. Dekens, W. Douwenga, A. Herrmann, E. Guenzi, R.E. Kontermann, K. Pfizenmaier, and U.L.M. Eisel. Essential protective role of TNFR 2 in neurodegeneration. PNAS. 113, 12304-12309 (2016).

2.      Y. Dong, D.W. Dekens, P.P. De Deyn, P.J.W. Naudé, U.L.M. Eisel, Targeting of tumor necrosis factor alpha receptors as a therapeutic strategy for neurodegenerative disorders. J. Antibodies. 4, 369-408 (2015).

3.      C.K. Mulder,  Y. Dong, H.F. Brugghe, H.A.M. Timmermans, W. Tilstra, J. Westdijk, E. van Riet, H. van Steeg, P. Hoogerhout, and U.L.M. Eisel, Immunization with small amyloid b-derived cyclopeptide conjugates diminishes amyloid b-induced neurodegeneration in mice. J. Alzheimer’s Disease. 52, 1111-1123 (2016).