NAME: Xu, Chenshu

POSITION TITLE: Assistant Professor, Pharmaceutical Sciences, Shenzhen University School of Medicine

EDUCATION/TRAINING

A.   Personal Statement

My research interests fall in (1) n uclear receptor mediated drug metabolism and drug interactions ; and (2) rational drug use in medical institutes. My r esearch has been supported by the National Natural Science Foundation in China (NSFC) , the State Education Ministry, the Natural Science Foundation of Guangdong Province, and the Shenzhen Science and Technology Innovation Commission since 2014. I have published nearly20 papers in peer-reviewed professional journals.

B.   Positions and Honors

Positions and Employment

07 / 201 2– 06 / 2015        Clinical Pharmacist, Pharmacy Department, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

0 9 /201 5 – present              Assistant Professor, Shenzhen University School of Medicine, Shenzhen, China

Other Experience and Honors

1.    2015 Outstanding Clinical Pharmacist, Society of Clinical Pharmacy, Chinese Medical Association

C.   Contributions to Science

1.    Nuclear receptor mediated drug metabolism and drug interactions.

2.    Rational drug use in medical institutes.

D.   Research Support

National Nature Science Foundation of China (81402998)                   

2015/01 to 2017/12

Chenshu Xu, PI                                                           ￥240,000

Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry

2015/01 to 2017/12

Chenshu Xu, PI                                                           ￥35,000

Natural Science Foundation of Guangdong Province (2015A030313059)

2015/08-2018/08

Chenshu Xu, PI                                                           ￥100,000

Shenzhen Science and Technology Innovation Commission grant (JCYJ20170818141722713)

2018/04 to 2020/03

Chenshu Xu, PI                                                           ￥300,000

Medical Scientific Research Foundation of Guangdong Province (B2014124),

2014/06-2016/05

Chenshu Xu, PI                                                           ￥10,000

Hospital pharmacy research grant of Guangdong Province (2013A25)

2013/01-2013/12

Chenshu Xu, PI                                                           ￥15,000

E.    Peer-reviewed publications (*: corresponding author)

1. Deng Y, Mo YF, Chen XM, Zhang LZ, Liao CF, Song Y, Xu C*. Effect of Ginkgo Biloba Extract on the Pharmacokinetics and Metabolism of Clopidogrel in Rats. Phytother Res. 2016 Nov; 30(11):1886-1892.
2. Xu C , Huang M, Bi H. PXR- and CAR-mediated herbal effect on human diseases. Biochim Biophys Acta. 2016 Sep; 1859(9):1121-9.
3. Tan H, Xu C (Co-first Author), Zeng H, Wang Y, Li Y, Fan X, Chen P, Jiang Y, Chen X, Huang M, Bi H. SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells. J Pharmacol Sci. 130(2):66-71; 2016.
4. Xu C , Wei B, Fu X, Luo M, Liu S, Li R, Ren B, Tang L. “Effect of Eclipta Prostrata on 11beta-hydroxysteroid Dehydrogenase in Rat Liver and Kidney”. Evid Based Complement Alternat Med. Volume 2014;2014:651053.
5. Deng R, Xu C (Co-first Author), Chen X, Chen P, Wang Y, Zhou X, Jin J, Niu L, Ying M, Huang M, Bi HC. “Resveratrol Suppresses the Inducible Expression of CYP3A4 through the Pregnane X Receptor”. J Pharmacol Sci. 126(2):146-54; (2014).
6. Cai Y, Xu C (Co-first Author), Chen P, Hu J, Hu R, Huang M, Bi H. “Development, validation, and application of a novel 7-day Caco-2 cell culture system”. J Pharmacol Toxicol Methods. 70(2):175-81; (2014).
7. Xu C , Wang X, Staudinger JL. “Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor”. Drug Metab Dispos. 37(7):1539-47; (2009).
8. Staudinger JL, Xu C, Biswas A, Mani S. “Post-translational modification of pregnane x receptor”. Pharmacol Res. 64(1):4-10; (2011).
9. Hu G, Xu C, Staudinger JL. “Pregnane X receptor is SUMOylated to repress the inflammatory response”. J Pharmacol Exp Ther. 335(2):342-50; (2010).
10. Staudinger JL, Xu C, Cui YJ, Klaassen CD.  “Nuclear receptor-mediated regulation of carboxylesterase expression and activity”. Expert Opin Drug Metab Toxicol. 6(3):261-71; (2010).
11. Lichti-Kaiser K, Xu C, Staudinger JL. “Cyclic AMP-dependent protein kinase signaling modulates pregnane x receptor activity in a species-specific manner”. J Biol Chem. 284(11):6639-49; (2008).
12. Zeng X, Li X, Xu C, Jiang F, Mo Y, Fan X, Li Y, Jiang Y, Li D, Huang M, Bi H.  “Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice”. Acta Pharm Sin B. 2017 Sep; 7(5):583-592.
13. Chen P, Zeng H, Wang Y, Fan X, Xu C, Deng R, Zhou X, Bi H, and Huang M. “Low Dose of Oleanolic Acid Protects Against Lithocholic Acid-induced Cholestasis in Mice: Potential Involvement of Nrf2 Mediated Up-regulation of Mrps”. Drug Metab Dispos. 42(5):844-52; (2014).
14. Xia Y, Chen J, Cao Y, Xu C, Li R, Pan Y, Chen X. “Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2”. Eur J Pharmacol. 714(1-3):105-11; (2013).
15. Xue XP, Qin XL, Xu C, Zhong GP, Wang Y, Huang M, Bi HC. “Effect of Wuzhi Tablet (Schisandra sphenanthera extract) on the Pharmacokinetics of Cyclosporin A in Rats”. Phytother Res. 27(8):1255-9; (2013).
16. Mo X, Wen Y, Ren B, Chen J, Xu C, Wang X, Huang M, Chen X. “Determination of erythrocyte methotrexate polyglutamates by liquid chromatography/tandem mass spectrometry after low-dose methotrexate therapy in Chinese patients with rheumatoid arthritis”. J Chromatogr B Analyt Technol Biomed Life Sci. 907:41-8; (2012).
17. Lichti-Kaiser K, Brobst D, Xu C, Staudinger JL. “A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein”. J Pharmacol Exp Ther. 331(1):65-76; (2009).
18. Bi HC, Zuo Z, Chen X, Xu CS, Wen YY, Sun HY, Zhao LZ, Pan Y, Deng Y, Liu PQ, Gu LQ, Huang ZY, Zhou SF, Huang M. “Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases”. Xenobiotica. 38(2):185-222; (2008).
19. Bi HC, Law FC, Zhong GP, Xu CS, Pan Y, Ding L, Chen X, Zhao LZ, Xu Q, Huang M. “Study of tanshinone IIA tissue distribution in rat by liquid chromatography-tandem mass spectrometry method”. Biomed Chromatogr. 21(5):473-9; (2007).