NAME: Xiao, Haitao

POSITION TITLE: Assistant Professor; School of Pharmaceutical Sciences, Health Science Center, Shenzhen University

EDUCATION/TRAINING

INSTITUTION AND LOCATION	DEGREE	Completion Date MM/YYYY	FIELD OF STUDY
Guizhou Medical University, Guiyang, China	B. P	07/2004	Pharmaceutical Science
Guizhou Medical University, Guiyang, China	Phar.M	05/2007	Chinese Medicine
Hong Kong Baptist University, Hong Kong, China	Ph.D.	05/2015	Chinese Medicine
Hong Kong Baptist University, Hong Kong, China	Postdoctoral	09/2017	Chinese Medicine

 

A.   Research Interests

My research focuses on the molecular characterization of anti-inflammatory or  immunomodulatory activities of Chinese medicines and the development of novel therapies for inflammatory bowel disease and viral diseases. My work mainly involves: 1) identifying the corresponding active compounds from complex herbal medicines through a bioactivity-guided fractionation procedure against specific disease-relevant molecular targets; 2) determining the therapeutic effects and the underlying mechanisms of Chinese medicines or active compounds in the treatment of inflammatory bowel disease and viral diseases; 3) translational studies of these active candidates described in (2). I have published > 30 peer-reviewed research papers in journals such as Mol Nutr Food Res, Oxid Med Cell Longev, Curr Med Chem, Sci Rep, J. Nat. Prod. My research has been financial supported by the National Natural Science Foundation in China (NSFC), the Science and Technology Fund of Guizhou province, and Shenzhen University.

 

B.   Positions and Honors

Positions and Employment

12 / 2007 – 05 / 2010       Lecturer, School of Pharmcy , Guizhou Medical University, Guiyang, China

06 /201 0 – 10 /2011      Visiting Research Scholar, Hong Kong Baptist University, Hong Kong, China

0 3 /201 3 – 12/201 3      Visiting Research Scientist, National Cancer Institute, National Institutes of Health, Maryland, USA

0 9 /2017 – present      Assistant Professor; School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China

 

Journal Reviewer

Scientific Reports

Phytomedicine

Pharmaceutical Biology

Natural Product Research

      Phytotheray Research

 

C.   Research Support

Ongoing Research Support

NSFC (China) regional project (81560676)                 01/01/2016 to 12/31/2019

Haitao Xiao, PI                                                                ￥390,000 (direct cost)

The role of GSK-3beta signaling in the imbalance of Th17/Treg in inflammatory bowel disease and the intervening effect of indirubin

 

Health Science Center, Shenzhen University             01/01/2018 to 12/31/2019

Haitao Xiao, PI                                                                 ￥100,000

The bidirectional regulating effects of indirubin on Th17/Treg in inflammatory bowel disease

 

New teacher research start-up funds, Shenzhen University (2018020)                                                        

Haitao Xiao, PI                                                               01/01/2018 to 12/31/2019

                                                                                            ￥60,000

Therapeutic effects of indirubin on DSS-induced colitis in mice

 

Completed Research Support

NSFC (China) young scholar project (21102025)    01/01/2012 to 12/31/2014

Haitao Xiao, PI                                                                ￥250,000

Pharmacodynamic components and action mechanisms of Semiaquilegia adoxoides against oxidative damage of  human lens epithelial cells

 

Science and technology fund of Guizhou province    01/01/2010 to 31/12/2012

Haitao Xiao, Co-PI                                                              ￥150,000

Quality evaluation of  Qi-Jiao-Shang-Bai capsule

Science and technology fund of Guizhou province    01/07/2009 to 31/06/2011

Haitao Xiao, PI                                                                ￥40,000

Pharmacodynamic components and protective mechanisms of Polygonum cuspidatum against against Aβ_1–42-induced SH-SY5Y cells  

 

 

D.   Peer-reviewed publications (*: corresponding author)

1.      Zhong LLD, Cheng CW, Kun W, Dai L, Hu DD, Ning ZW, Xiao HT, Lin CY, Zhao L, Huang T, Tian K, Chan KH, Lam TW, Chen XR, Wong CT, Li M, Lu AP, Wu JCY, Bian ZX. 2018. Efficacy of MaZiRenWan, a Chinese herbal medicine, in patients with functional constipation in a randomized controlled trial. Clin Gastroenterol Hepatol. pii: S1542-3565(18)30341-0.

2.      Jiao Peng, Ting-ting Zheng, Yue Liang, Li-fang Duan, Yao-dong Zhang, Li-Jun Wang, Guang-ming He, Hai-tao Xiao*. 2018. p-Coumaric acid protects human lens epithelial cells against oxidative stress-induced apoptosis by MAPK signaling. Oxid Med Cell Longev, 2018:1-7.

3.      Hai-Tao Xiao, Bo Wen, Xiang-chun Shen, Zhao-xiang Bian. 2017. Potential of plant-based phenols for inflammatory bowel disease. Curr Med Chem. doi: 10.2174/0929867324666171009100900.

4.      Xia Y, Xiao HT(Co-first author), Liu K, Zhang HJ, Tsang SW. 2017. Resveratrol Ameliorates the Severity of Fibrogenesis in Mice with Experimental Chronic Pancreatitis. Mol Nutr Food Res. doi: 10.1002/mnfr.201700561.

5.      Xiao HT(Co-first author), Wen B, Ning ZW, Zhai LX, Liao CH, Lin CY, Mu HX, Bian ZX. 2017. Cyclocarya paliurus tea enhanced beta cell preseration through inhibition of apoptosis. Sci Rep.7(1): 9155.

6.      Zhao L, Xiao HT, Mu HX, Huang T, Lin ZS, Zhong LLD, Zeng GZ, Fan BM, Lin CY, Bian ZX. 2017, Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules. 22(7). pii: E1218.

7.      Mi H, Zhong L, Huang T, Lin CY. Zhao L, Hu DD, Xiao HT, Bian ZX, Liu FB. 2017. Chinese herbal medicine for ulcerative colitis:a systematic review protocol. World J Tradit Chin Med. 3(2):16-19.

8.      Wei W, Xiao HT(Co-first author), Bao WR, Ma DL, Leung CH, Han XQ, Ko CH, Lau CB, Wong CK, Fung KP, Leung PC, Bian ZX, Han QB. 2016. TLR-4 may mediate signaling pathways of Astragalus polysaccharide RAP induced cytokine expression of RAW264.7 cells. J Ethnopharmacol. 179:243-52.

9.      Bin Liang, Wei Wei, Jianta Wang, Ming-ming Zhang, Ran Xu, Fei Wu, Haitao Xiao*, Lei Tang*. 2016. Protective effects of Semiaquilegi aadoxoides n-butanol extract against hydrogen peroxide-induced oxidative stress in human lens epithelial cells.  Pharm Biol. 54(9):1656-63.

10.   Xun Song,Hai-Tao Xiao (Co-first author), Cheng-Hui Liao, Lu Li, Qiang-Rong Kang, Ying-Chun Jiang, Xiao-Peng Hu, Kai Zheng, Long Fan, Hong-Jie Zhang and Zhen-Dan He. 2016. Natural products: the master regulators of antiviral cytokines. Curr. Org. Chem. 21(999): 1-1.

11.   Chen X, Nie Y, Xiao HT, Bian Z, Scarzello AJ, Song NY, Anna TL, Yang D, Oppenheim JJ. 2016. TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis. Sci Rep. 6: 32834.

12.   Li YH, Zhang M, Fu HB, Xiao HT, Bian ZX. 2016. Pre-clinical toxicity of a combination of berberine and 5-aminosalicylic acid in mice. Food Chem Toxicol. 97:150-158.

13.   Li YH, Xiao HT, Hu DD, Fatima S, Lin CY, Mu HX, Lee NP, Bian ZX. 2016. Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL/6 mice by suppressing Th17 responses. Pharmacol Res. 110:227-239.

14.   Liu J, Xiao HT, Wang HS, Mu HX, Zhao L, Du J, Yang D, Wang D, Bian ZX, Lin SH. 2016. Halofuginone reduces the inflammatory responses of DSS-induced colitis through metabolic reprogramming. Mol Biosyst. 12(7):2296-303.

15.   Lin ZS, Ku CF, Guan YF, Xiao HT, Shi XK, Wang HQ, Bian ZX, Tsang SW, Zhang HJ. 2016.  Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis. Phytother Res. 30(4):663-70.

16.   Mu HX, Liu J, Fatima S, Lin CY, Shi XK, Du B, Xiao HT, Fan BM, Bian ZX. 2016.  Anti-inflammatory Actions of (+)-3'α-Angeloxy-4'-keto-3',4'-dihydroseselin (Pd-Ib) against Dextran Sulfate Sodium-Induced Colitis in C57BL/6 Mice. J Nat Prod. 79(4):1056-62.

17.   Sarwar S, Lin ZS, Ku CF, Guan YF, Xiao HT, Shi XK, Wang HQ, Bian ZX, Tsang SW, Zhang HJ. 2016. Protective effect of dihydro-resveratrol against lung injury in rats with cerulein-induced acute pancreatitis. Planta Med. 81(S 01):S1-S381.

18.   Hai-Tao Xiao, Jiao Peng, Dong-Dong Hu, Cheng-Yuan Lin, Bin Du, Siu-Wai Tsang, Ze-si Lin, Xiao-Jun Zhang, J Feng-Ping Lueng, Quan-Bin Han, Zhao-Xiang Bian. 2015. Qing-Dai Powder ameliorates dextran sulfate sodium-induced acute colitis in mice and inhibits production of inflammatory mediators from macrophage. Chinese Medicine-UK, 10:29.

19.   Hai-Tao Xiao, Linda Zhong, Zhao-xiang Bian. 2015. Traditional Chinese Medicine Formulas for Irritable Bowel Syndrome Therapy - from ancient wisdoms to scientific understandings. Am J Chinese Med, 43(1):1-23.

20.   Li YH, Zhang M, Xiao HT, Fu HB, Ho A, Lin CY, Huang Y, Lin G, Bian ZX. 2015. Addition of Berberine to 5-Aminosalicylic Acid for Treatment of Dextran Sulfate Sodium-Induced Chronic Colitis in C57BL/6 Mice. PLoS One. 10(12):e0144101.

21.   Peng J, Tsang JY, Ho DH, Zhang R, Xiao HT, Li D, Zhu J, Wang F, Bian Z, Lui VC, Xu A, Tam PK, Lamb JR, Xia H, Chen Y. 2015. Modulatory effects of adiponectin on the polarization of tumor-associated macrophage. Int J Cancer. 137(4):848-58.

22.   Hai-Tao Xiao, Xiao-Lan Qi, Yan Liang, Cheng-Yuan Lin, Xia Wang, Zhi-Zhong Guan, Xiao-Yan Hao. 2014. Membrane permeability-guided identification of neuroprotective components from Polygonum cuspidatun. Pharm Biol. 52(3):356-61.

23.   Ya Hu, Hai-Tao Xiao, Ting-Chen Shi, O.M. Zack Howard, Joost J Oppenheim, Xin Chen. 2014. Progranulin promotes TNF-induced proliferation of mouse CD4⁺Foxp³⁺ regulatory T cells. Immunology, 142(2):193-201.

24.   Wen Zhang Chen, Ling Ling fan, Hai Tao Xiao, Ying Zhou, Wan Xiao, Jian Ta Wang, Lei Tang. 2014. First total synthesis of natural products of cajanolactone A and cajanonic acid A, ChinChemLett. 25(5): 749-751.

25.   Hai-Tao Xiao, Cheng-Yuan Lin, Derek H. H. Ho, Jiao Peng, Yan Chen, Siu-Wai Tsang, Michael Wong, Xiao-Jun Zhang, Man Zhang, Zhao-Xiang Bian. 2013. Inhibitory Effect of the Gallotannin Corilagin on Dextran Sulfate Sodium-Induced Murine Ulcerative Colitis. J. Nat. Prod. 76(11):2120-5.

26.   Hai-Tao Xiao, Siu-Wai Tsang, Hong-Yan Qin, Franky F. K. Choi, Zhi-Jun Yang, Quan-Bin Han, Hu-Biao Chen, Hong-Xi Xu, Hong Sheng, Ai-Ping Lu, Zhao-xiangBian. 2013. A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn. J Ethnopharmacol, 149, 499-505.

27.   Tsang Siu-Wai, Zhang Hong-jie, Lin Cheng-yuan, Xiao Hai-Tao, Wong Michael, Shang Hong-cai, Yang Zhi-Jun, Lu Ai-ping, Yung Ken Kin-Lam, Bian Zhao-xiang. 2013. Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis.PLoS One. 8(12):e82201

28.   Hong-Yan Qin,HaiTao Xiao, Justin CY Wu, Brian M Berman, Joseph JY Sung and ZhaoXiang Bian. 2012. Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats. World J Gastroenterol. 18(20): 2481-2492.

29.   Hong-Yan Qin, Hai-Tao Xiao, Fung-Ping Leung, Zhi-Jun Yang, Justin C. Y. Wu, Joseph J. Y. Sung, Hong-Xi Xu, Xu-Dong Tong, and Zhao-Xiang Bian. 2012. JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats. Evid Based Complement Alternat Med. 2012:239638.

30.   Zhao-xiang Bian, Shi-lin Chen, Chung-wah Cheng, Jun Wang, Hai-Tao Xiao, Hongyan Qin. 2012. Developing new drugs from annals of Chinese medicine. Acta Pharmaceutica Sinica B. 1, 1-7.

31.   Hai-Tao Xiao, Jiao Peng, Yan Liang, Jie Yang, XueBai, Xiao-Yan Hao, Fu-Mei Yang,  Qian-Yun Sun. 2010. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat. Prod. Res. 16:1-5.

32.   Hai-Tao Xiao, Bin Liu, Xiao-Yan Hao, Xiao-Sheng Yang, Qian-Yun Sun. 2009. Chemical Constituents from Saussureadeltoidea. Chem. Nat. Compd. 4, 458-459.

33.   Fanyan Meng, Guoying Zuo, Xiaoyan Hao,HaiTao Xiao, Jiquan Zhang, Guili Xu. 2009. Antifungal activity of the benzo[c]phenanthridine alkaloids from Chelidonium majus Linn against resistant clinical yeast isolates. J Ethnopharmacol, 3, 494-496.

34.   Min Liu, Hai-Tao Xiao, Hong-Ping He, Xiao-Yan Hao. 2008. A novel lignanoid and norbisabolane seaquiterpenoids from Glochidion puberum. Chem. Nat. Compd., 5, 588-590.

35.   Hai-Tao Xiao, Hong-Ping He, Jiao Peng, Yue-Hu Wang, Xian-Wen Yang, Xu-Jia Hu, Xiao-Yan Hao, Xiao Jiang Hao. 2008. Two New Norbisabolane Sesquiterpenoid Glycosides from Glochidion coccineum. J. Asian Nat. Prod. Res. 10, 1-5.

36.   Hai-Tao Xiao, Xiao-Yan Hao, Xian-Wen Yang, Yue-Hu Wang, Yang Lu, Yan Zhang, SuoGao, Hong-Ping He, and Xiao-Jiang Hao. 2007. Bisabolane-type Sesquiterpenoids from the Rhizomes of Glochidion coccineum. Helv. Chim. Acta. 1,164-170.

37.   Xian-Wen Yang, Jun-Song Wang, Yue-Hu Wang, Hai-Tao Xiao, Xu-Jia Hu, Shu-Zhen Mu, Xiao-Jiang Hao. 2007. Tarennane and Tarennone, Two Novel Chalcone Constituents from Tarenna attenuata. Planta Med. 73, 496-498.

38.   Xian-Wen Yang, Jun-Song Wang, Yan-Lin Ma, Hai-Tao Xiao, Yi-Qing Zuo, Hua Li, Hong-Ping He, Ling Li, and Xiao-Jiang Hao. 2007. Bioactive phenols from the leaves of Baccaure aramiflora. Planta Med. 73, 1415-1417.

39.   Xian-Wen Yang, Pei-Ji Zhao, Yan-Lin Ma, Hai-Tao Xiao, Yi-Qing Zuo, Hong-Ping He, Ling Li, and Xiao-Jiang Hao. 2007. Mixed Lignan-Neolignans from Tarenna attenuata.J. Nat. Prod. 4, 521-52

 

E.    National and International patents

1.      Zhao-xiang Bian, Hai-tao Xiao, Shi-lin Chen, Da-jian Yang, Hong-xi Xu, Ai-ping Lu, Albert Sun-Chi Chen. Bioactive Fractions and Compounds from Polygonum genus, their Use in Anti-diarrhea and the Method of Preparation. (US 61/662,354, filed date: 2013/3/15).

2.      Zhao-xiang Bian, Hong-yanQin, Hai-tao Xiao, Albert Sun-Chi Chan, Hong-xi Xu, Shi-lin Chen, Da-jian Yang. Method for preventing or treating enterochromaffin cell hyperplasia-related diseases by quercetin administration. (US 2013/0210907, filed date: 2013/2/14).

3.      Zhao-xiang Bian, Phyllis Siu-Wai Tsang, Ai-ping Lu, Hai-tao Xiao, Hong-yan Qin, Albert Sun-Chi Chen, Hong-xi Xu, Shi-lin Chen, Da-jian Yang. Method of Using Rhein for Treating Fibrotic conditions and Tumors (US 13/831,990, filed date: 2013/3/15)，authorized.

4.      Guan Zhi-Zhong, Luo Jun, Xiao Hai-tao, Qi Xiao-lan. Preparation of traditional Chinese medicine for senile dementia (China patent: CN101269179 B), authorized.

5.      Tang Lei, Hou fu-cai, Wang Jian-ta, Xiao haitao, Guo zonghua. Preparation of a kind of anemone extract (China patent: CN101773553 B), authorized

6.      Hao Xiao-yan, Xiao hai-tao, Ye lan, Li Li, Liang Yan, Li Qian, Hu Zhao-yang. Preparation of a drug for senile dementia (China patent: CN102335227 B), authorized.

7.      Hao Xiao-yan, Xiao hai-tao, Qi Xiao-lan. The application of emodin-8-O-β-D-glucoside in the preparation of drugs and health products for the treatment of synaptic dysfunction (China patent: CN102764265 A).