NAME: Wu, Haiqiang,

POSITION TITLE: Associate Professor of Medicinal Chemistry; Shenzhen University School of Medicine

EDUCATION/TRAINING

A.   Personal Statement

Research interests:

(1) Purification, identification, synthesis and mechanisms of natural components targeting complex diseases. (2) Design, synthesis, screening and mechanisms of anti-AD leading compounds.

B.   Positions and Honors

Positions and Employment

09/2007 – 12/2013      Associate Professor, College of Life Science, Shenzhen University, Shenzhen, China

09/2016 – 08/2017      Visiting Scientist, UCLA, Los Angeles, USA

01/2014 – present              Associate Professor, Shenzhen University School of Medicine, Shenzhen, China

C.   Research Support

Ongoing Research Support

NSFC (China) (81573288)                                          01/01/2016 to 12/31/2019

Haiqiang Wu, PI                                                          ￥500,000 (direct cost)

Synthesis, discovery and mechanistic study of novel Glutaminyl cyclase inhibitiors

Shenzhen Science and Technology Innovation Commission grant (JCYJ20170302144938485)                                                                                                             06/01/2017 to 05/31/2019

Haiqiang Wu, PI                                                          ￥400,000

Synthesis and anti-AD effects of new Glutaminyl cyclase inhibitors

D.   Peer-reviewed publications (*: corresponding author)

1.      Haiqiang Wu*. 2017. Can small molecule inhibitors of glutaminyl cyclase be used as a therapeutic for Alzheimer’s disease? Future Med. Chem. 9(17): 1979–1981

2.      Manman Li, Yao Dong, Xi Yu, Yue Li, Yongdong Zou, Yizhi Zheng, Zhendan He, Zhigang Liu, Junmin Quan, Xianzhang Bu, Haiqiang Wu*. 2017. Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer's Disease. J Med Chem. 60(15): 6664-6677.

3.      Manman Li, Yao Dong, Xi Yu, Yongdong Zou, Yizhi Zheng, Xianzhang Bu, Junmin Quan, Zhendan He, Haiqiang Wu*. 2016. Inhibitory effect of flavonoids on human glutaminyl cyclase. Bioorganic & Medicinal Chemistry. 24(10): 2280-2286.

4.      Hai-qiang Wu, Fang Zhang, Neil Williamson, Jie Jian, Liao Zhang, Ze-qiu Liang, Jin-yu Wang, Lin-kun An, Alan Tunnacliffe, Yi-zhi Zheng. 2014. Effects of Secondary Metabolite Extract from Phomopsis occulta on β-Amyloid Aggregation. PLOS ONE, 9(10): e109438.