NAME: Wang, Xiaodong

POSITION TITLE: Associate Professor

EDUCATION/TRAINING

A.   Personal Statement

My long-standing research interests fall in the antitumor mechanisms of small molecule compounds . Our lab is actively exploring the effect of small molecule compounds on immune activation, especially the application of adjuvants in gastric cancer treatment. I have completed one grant from the National Natural Science Foundation in China (NSFC) . I have published 6 papers as a first author in peer-reviewed professional journals.

B.   Positions and Honors

Positions and Employment

09 / 2010 – 12 / 2016        Lecturer, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China

09/2016-09/2017        Visiting Scholar, Moores Cancer Center, University of California, San Diego, CA, USA

0 1 /2 017 – present      Associate Professor, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China

C.   Research Support

Completed Research Support

NSFC (China) (81202396)                                          01/01/2013 to 12/31/2015

Xiaodong Wang                                                           ￥230,000

Gastric cancer vaccines based on TLR7 agonists

Shenzhen Scientific Project(JCYJ20130326112757843)         07/01/2013 to 06/30/2015

Xiaodong Wang                                                                                 ￥100,000

Gastric cancer vaccines based on TLR7 agonists

D.   Peer-reviewed publications

1. Wang, X.D., Li, C.Y., Jiang, M.M., Li, D., Wen, P., Song, X., Chen, J.D., Guo, L.X., Hu, X.P., Li, G.Q. et al. (2016) Induction of apoptosis in human leukemia cells through an intrinsic pathway by cathachunine, a unique alkaloid isolated from Catharanthus roseus. Phytomedicine, 23, 641-653.

2. Diao, Y.W., Wang, X.D., Wan, Y.Y., Zhong, J.J., Gao, D., Liu, Y., Gao, N.N., Li, W., Liu, B., Huang, X.P. et al. (2016) Antitumor activity of a novel small molecule TLR7 agonist via immune response induction and tumor microenvironment modulation. Oncol Rep, 35, 793-800. (co-first author)

3. Wang, X.D., Gao, N.N., Diao, Y.W., Liu, Y., Gao, D., Li, W., Wan, Y.Y., Zhong, J.J. and Jin, G.Y. (2015) Conjugation of TLR7 agonist to gastric cancer antigen MG7-Ag exerts antitumor effects. World J Gastroenterol, 21, 8052-8060.

4. Wang, X.D., Diao, Y.W., Liu, Y., Gao, N.N., Gao, D., Wan, Y.Y., Zhong, J.J. and Jin, G.Y. (2015) Synergistic apoptosis-inducing effect of aspirin and isosorbide mononitrate on human colon cancer cells. Mol Med Rep, 12, 4750-4758.

5. Wang, X.D., Ou, T.M., Lu, Y.J., Li, Z., Xu, Z., Xi, C., Tan, J.H., Huang, S.L., An, L.K., Li, D., Gu, L.Q. and Huang, Z.S. (2010) Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives. J Med Chem, 53, 4390-4398.

6. Wang, X.D., Gu, L.Q. and Wu, J.Y. (2007) Apoptosis-inducing activity of new pyrazole emodin derivatives in human hepatocellular carcinoma HepG2 cells. Biol Pharm Bull, 30, 1113-1116.