Name：Qianqian Di

Position：Assistant Professor

E-mail：diqianqian@szu.edu.cn

Personal Statement:

Dr. Qianqian Di recerived her Ph.D. from Southern Medical University in 2017, and then joined the Department of Immunology of Shenzhen University School of Medicine. Dr. Di has focused on the study of immunological mechanisms of immune inflammation and autoimmune diseases, particularly psoriasis pathogenesis. Dr. Di has published many papers in academic journals such as AUTOPHAGY, CELL MOL IMMUNOL, PHARMACOL RES as a (co-)first author.

Research Interests:

immune inflammation

autoimmune diseases

infection immunology

Research Projects:

1. National Natural Science Foundation of China (32000668): 01/01/2021 to 12/31/2023  ￥240,000

2. Guangdong Basic and Applied Basic Research Foundation (2023A1515012070): 01/01/2023 to 12/31/2025 ￥100,000

3. Guangdong Basic and Applied Basic Research Foundation (2019A1515110146): 01/01/2020 to 12/31/2022 ￥100,000

4. Shenzhen Science and Technology Innovation Program (JCYJ20220531102005011): 10/01/2022 to 10/31/2025 ￥300,000

Selected Peer-reviewed Publications:

1. Di Q^#, Zhao X^#, Tang H, Li X, Xiao Y, Wu H, Wu Z, Quan J, Chen W^*. USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent autophagy. Autophagy. 2023, 19(3):873-885.

2. Zhao X^#, Di Q^#, Chen J, Ling J, Quan J, Zhao Z, Li H, Chen S, Li X, Guo X, Wu H, Xiao Y, Chen W^*. The USP43/RNF2 axis negatively regulates antiviral innate immunity by promoting TBK1 ubiquitination and degradation. Cell Death Differ. 2025, Online ahead of print.

3. Di Q^#, Zhao X^#, Lin J^#, Li X, Li X, Tang H, Zhang R, Xiao W^*, Chen W^*. Novel clerodane-type diterpenoid Cintelactone A suppresses lipopolysaccharide-induced inflammation by promoting ubiquitination, proteasomal degradation of TRAF6. Pharmacol Res. 2021, 164: 105386.

4. Di Q^#, Zhao X^#, Lin J^#, Li X, Li X, Tang H, Zhang R, Xiao W^*, Chen W^*.A new acid isolated from V. negundo L. inhibits NLRP3 inflammasome activation and protects against inflammatory diseases. Front Immunol. 2023, 14:1174463.

5. Zhao X^#, Di Q^#, Liu H^#, Quan J, Ling J, Zhao Z, Xiao Y, Wu H, Wu Z, Song W, An H^*, Chen W^*. MEF2C promotes M1 macrophage polarization and Th1 responses. Cell Mol Immunol. 2022, 19(4): 540-553.