Name：Liang Ye

Position：Associate Professor

E-mail：liangyeszu@163.com

Personal Statement:

Dr. Liang Ye received her Ph.D. from the University of Freiburg, Germany, where he subsequently conducted postdoctoral research at the Institute of Virology. In 2016, Dr. Ye joined the Carlson International Cancer Center of Shenzhen University as an associate professor and principal investigator, then was appointed as a distinguished researcher, doctoral supervisor, and postdoctoral co-supervisor. Dr. Ye was awarded Guangdong Province Pearl River Talent Program Young Top Talent and Shenzhen Overseas Senior Talent.

Dr. Ye has long been committed to the research of viral infection and immune regulation mechanisms, as well as tumor immunology prevention and treatment. He has published over 30 papers as the first author or corresponding author in academic journals such as Nature Reviews Immunology, Nature Immunology, Journal of Virology, Journal of Immunology, and Theranostics. He has been granted four national invention patents as the first inventor and has presided over more than ten national, provincial, and municipal projects.

Research Interests:

Viral infection and immune regulation mechanism

Tumor immunology prevention and treatment

Research Projects:

1. National Natural Science Foundation of China, 2021-2025, host.

2. Guangdong Pearl River Talent Plan Young Talent Project, 2022-2025, host.

3. Guangdong Natural Science Foundation General Project, 2021-2023, host.

4. Guangdong Natural Science Foundation Youth Project, 2020-2023, host.

5. Guangdong Medical Science Foundation Project, 2021-2023, host.

6. Shenzhen High-Level Talent Scientific Research Start-Up Project, 2022-2024, host.

7. Shenzhen Science and Technology Plan Basic Research Project, 2015-2017, host.

8. Shenzhen Higher Education Institutions Stable Support Project, 2021-2023, host.

9. Shenzhen Excellent Science and Technology Innovation Talent Project, 2021-2023, host.

10. Shenzhen Medical Research Special Fund Project, 2024-2026, PI.

Selected Peer-reviewed Publications:

1. Ye L, Schnepf D, Becker J, Ebert K, Tanriver Y, Bernasconi V, Gad HH, Hartmann R, Lycke N, Staeheli P. Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin. Nature immunology. 2019, 20(5):593-601.

2. Ye L^#, Schnepf D^#, Staeheli P. Interferon-λ orchestrates innate and adaptive mucosal immune responses. Nature Reviews Immunology. 2019, 19(10): 614-25.

3. Cong J, Wu D, Dai H, Ma Y, Liao C, Li L, Ye L*, Huang Z*. Interleukin-37 exacerbates experimental colitis in an intestinal microbiome-dependent fashion. Theranostics. 2022, 12(11): 5204.

4. Wang X, Dong M, Wu X, Schnepf D, Thiel J, Sun W, Wolfrum C, Li S, Jin W*, Staeheli P*, Ye L*. Single-cell transcriptomics reveals a compartmentalized antiviral interferon response in the nasal epithelium of mice. Journal of Virology. 2025, e01413-24.

5. Hu H, Zhang Y, Zheng H, Zhao X, Ran W, Liao C, Lu M, Zhou J, Song X*, Ye L*. Thymic stromal lymphopoietin improves protective immunity of the SARS-CoV-2 subunit vaccine by inducing dendritic cell-dependent germinal center response. Journal of Virology. 2025, e02323-24.