Name：Xing Liu

Position：Professor

E-mail：xingliu1@szu.edu.cn

Personal Statement:

Dr. Xing Liu is currently a Professor in the Department of Pathogen Biology, Shenzhen University Medical School. He was honored with the title of Jiangsu Distinguished Professor and received the Jiangsu Distinguished Youth Fund. Dr. Liu earned his Ph.D. from Nanjing Agricultural University in 2015 and completed postdoctoral training at the University of Illinois at Chicago from 2016 to 2020. From 2020 to 2024, he served as Associate Professor and later Professor at Nanjing Agricultural University

Dr. Liu's research primarily focuses on viral infection and the mechanisms of pathogenesis. He has published 27 SCI papers as first or corresponding author in high-impact journals such as PNAS, Autophagy, PLoS Pathogens, mBio, and Journal of Virology. He also holds one authorized international invention patent and two national patents. In addition, Dr. Liu has contributed to three academic books, including serving as Deputy Editor for the Principles of Virology, a national undergraduate textbook under China’s 14th Five-Year Plan.

Research Interests:

Entry mechanisms and host tropism of large DNA viruses (Herpesviruses, Poxviruses, etc.)

Immune evasion and pathogenesis of large DNA viruses

Antiviral drugs, oncolytic viruses, and live-vector vaccines

Research Projects:

1. NSFC (China) Project (32272985):  01/01/2023 to 12/31/2026  ￥540,000

2. Jiangsu Distinguished Youth Fund (BK20230039): 09/01/2023 to 08/31/2026 ￥1,500,000

Selected Peer-reviewed Publications:

1. Xing Liu, Dhiraj Acharya, Eric Krawczyk, Chase Kangas, Michaela U. Gack., Bin He*. Herpesvirus-Mediated Stabilization of ICP0 Expression Neutralizes Restriction by TRIM23. Proc Natl Acad Sci USA.2021 Dec 21; 118 (51): e2113060118.2.

2. Zicheng Ma. Juan Bai. Chenlong Jiang, Huixin Zhu, Depeng Liu, Mengjiao Pan, Xianwei Wang, Jiang Pi, Ping Jiang*, Xing Liu*. Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering cGAS degradation through TOLLIP-mediated selective autophagy. Autophagy.2023 May;19(5):1512-1532.

3. Zhe Sun^#, Zicheng Ma^#, Wandi Cao, Chenlong Jiang, Lei Guo, Kesen Liu, Yanni Gao, Juan Bai, Jiang Pi, Ping Jiang*, Xing Liu*. Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation. PLoS Pathogens. 2025 Jan 13:21(1): e1012872.

4. Feifei Diao, chenlong Jiang, Yangyang Sun, Yanni Gao, Juan Bai, Hans Nauwynck, Xianwei Wang, Yuanqi Yang, Ping Jiang*, Xing Liu*. Porcine reproductive and respiratory syndrome virus infection triggers autophagy via ER stress-induced calcium signaling to facilitate virus replication. PLoS Pathogens. 2023 Mar 27; 19(3): e1011295.

5. Xing Liu, Yijie Ma, Kathleen Voss, Michiel van Gent, Ying Kai Chan, Michaela U. Gack, Michael Gale Jr, Bin He*. The herpesvirus accessory protein γ134.5 facilitates viral replication by disabling mitochondrial translocation of RIG-I. PLoS Pathogens. 2021 Mar 26;17(3):e1009446.