Name：Jia-Jie Chen

Position：Associate Professor

E-mail：chenjj@szu.edu.cn

Personal Statement: 

Dr. Jia-Jie Chen received his Ph.D. in basic medicine from Sun Yat-sen  University in 2013 and then joined the Sun Yat-sen University Third Hospital for postdoctoral training. In 2015, Dr Chen joined the Shenzhen University Medical School as an assistant professor. In 2024, Dr. Chen joined the School of Basic Medical Sciences of Shenzhen University as an associate professor.

In the past few decades, Dr. Chen mainly teaches three undergraduate courses, including Biochemistry. His research focuses on targetd inhibition of mast cell activation to combat allergies and identification of novel house dust mite allergens. Dr. Chen has pointed out some molecular targets in promoting mast cell activation, such as the KAT6A, AURKA, PTK2, and FOS genes. His group has also completed the WHO/IUIS-approved naming of six novel house dust mite allergens (Der f5, Der f23, Der p24, Der f39, Der p39, and Der p40). Dr. Chen has published many papers in high impact academic journals such as Br J Pharmacol, Biochem Pharmacol, Clin Transl Allergy, and World Allergy Organ J etc. as a correspondent or co-corresponding author. Also, he has two approved patents,  one of which has been technically transferred.

Research Interests:

Regulation Mechanisms of Mast Cell Activation 

Targeted Inhibition of Mast Cell Activation 

Basic and Applied Research on House Dust Mite Allergens

Research Projects:

1. Guangdong Basic and Applied Basic Research Foundation (China) (2023A1515012935):  0101/2023 to 12/31/2025 ￥100,000

2. Natural Science Foundation of Shenzhen Municipality (China) (JCYJ20230808105312025):  1101/2023 to 11/30/2026 ￥300,000

3. Guangdong Basic and Applied Basic Research Foundation (China) (2021A1515011140):  0101/2021 to 12/31/2023 ￥100,000

4. Natural Science Foundation of Shenzhen Municipality (China) (JCY20170818142053544):  0301/2018 to 02/28/2020 ￥300,000

5. NSFC (China) Project (81602595):  01/01/2017 to 12/31/2019  ￥170,000

Selected Peer-reviewed Publications:

1. Zhang LN^#, Ji KM^#, Sun YT, Hou YB, Chen JJ*. Aurora kinase inhibitor tozasertib suppresses mast cell activation in vitro and in vivo. British J Pharmacol. 2020; 177(12): 2848-2859.

2. Jiao YX^#, Zhou YM^#, Zhou ZW, He Y, Liu S, Xu XT, Ji KM*, Chen JJ*. Histone acetylation alteration by KAT6A inhibitor WM-1119 suppresses IgE-mediated mast cell activation and allergic inflammation via reduction in AP-1 signaling. Biochem Pharmacol. 2025; 232:116732.

3. Chen JJ*, Zhang LN, Wang HN, Xie CC, Li WY, Gao P, Hu WZ, Zhao ZF, Ji KM*. FAK inhibitor PF-431396 suppresses IgE-mediated mast cell activation and allergic inflammation in mice. Biochem Pharmacol. 2021; 192:114722.

4. Zhou YM^#, Jiao YX^#, Fan JK, Zhang RX, Liu S, Xu XT, Zhu R*, Ji K*, Chen JJ*. Ubiquitin-specific protease 13 regulates FcεRI-mediated mast cell activation and allergic inflammation via SYK protein modulation. Int J Biol Macromol. 2025; 308(Pt 2):142302.

5. Zhou ZW^#, Ji KM^#, Zhu XY, Wu XY, Lin RT, Xie CC, Cai ZL,Chen JJ*. Natural isoflavone formononetin inhibits IgE mediated mast cell activation and allergic inflammation by increasing IgE receptors degradation. Food Funct. 2023; 14(6):2857-2869.