Name：Baohua Liu

Position：Distinguished Professor

E-mail：ppliew @szu.edu.cn

Personal Statement:

Professor Dr Baohua Liu is currently the Dean of Shenzhen University School of Basic Medical Sciences, and the Director of National Engineering Research Center for Biotechnology (Shenzhen). He earned his B.S. degree from Peking University, and Ph.D. degree at the University of Hong Kong. Dr Liu completed postdoctoral training at the University of Hong Kong and was promoted to Research Assistant Professor in 2011. In 2014, He joined Shenzhen University as a Distinguished Professor.

Dr Liu’s research focuses on the molecular mechanisms and intervention of aging, particularly, the epigenetic and metabolic regulation of aging, Organ-Talks that drive systemic aging, and therapeutic strategies that can slow down aging process. Dr Liu was the first to demonstrate that genome instability is a cause and hallmark of Hutchinson-Gilford progeria syndrome (HGPS) and revealed the Lamin A-Sirtuins axis as a central hub that couples primary cause of aging (genomic instability and epigenetic alterations) to the defective adaptive cellular response (metabolic reprogramming, inflammatory response, and circadian disruption). He has published more than 100 scientific papers, including Nature Medicine, Nature Metabolism, Cell Metabolism, Nature Aging, Science Advances and Nature Communications etc. Dr Liu’s research has been recognized with the National Outstanding Young Researcher Award (2021), the National Excellent Young Researcher Award (2014), and the National Young Talents Award (2013). Dr Liu also serves as the Chief Secretary of the Asian Society for Aging Research (ASAR) (2011-present), the vice Chairman of the Basic and Translational Branch of Chinese Geriatrics Society (2020-present), and the vice Chairman of the Chinese Society of Aging Biology (CSAB) (2021-present).

Research Interests:

Aging

Hutchinson-Gilford progeria syndrome

Sirtuins

Research Projects:

1. Nationa Key R&D Program of China (2024YFA0918700) : 12/01/2024-11/31/2029 ¥20000000.00

2. National Natural Science Foundation of China (82125012) : 01/01/2022-12/31/2026 ¥4000000.00

3. National Natural Science Foundation of China (32430048) : 01/01/2025-12/31/2029 ¥2170000.00

4. Shenzhen Medical Research Fund (C2406001) : 01/01/2025-12/31/2029 ¥14380000.00

Selected Peer-reviewed Publications:

1. Zuojun Liu, Minxian Qian, Xiaolong Tang, Wenjing Hu, Shimin Sun, Guo Li, Shuju Zhang, Fanbiao Meng, Xinyue Cao, Jie Sun, Cheng Xu, Bing Tan, Qiuxiang Pang4, Bosheng Zhao, Zimei Wang, Youfei Guan, Xiongzhong Ruan, and Baohua Liu*. SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis. Nature Metabolism, 2019, Nov;1(11):1141-1156.

2. Shimin Sun#, Yuan Meng#, Mingying Li#, Xiaolong Tang, Wenjing Hu, Weiwei Wu, Guo Li, Qiuxiang Pang, Wengong Wang, Baohua Liu*. CD133+ endothelial-like stem cells restore neovascularization and promote longevity in progeroid and naturally aged mice. Nature Aging. 2023 Nov; 3(11): 1401-1414.

3. Xiaolong Tang, Guo Li, Lei Shi, Fengting Su, Minxian Qian, Zuojun Liu, Yuan Meng, Shimin Sun, Ji Li3 & Baohua Liu*. Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis. Nature Communications, 2021, Aug 25;12(1):5058.

4. Jie Sun#, Ming Wang#, Yaqi Zhong#, Xuan Ma, Shimin Sun,Chenzhong Xu, Linyuan Peng, Guo Li, Liting Zhang, Zuojun Liu, Ding Ai & Baohua Liu*. A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice. Nature Communications. 2022 Nov 17;13(1):7028.

5. Shimin Sun, Weifeng Qin, Xiaolong Tang, Yuan Meng, Wenjing Hu, Shuju Zhang, Minxian Qian, Zuojun Liu, Xinyue Cao, Qiuxiang Pang, Bosheng Zhao1, Zimei Wang, Zhongjun Zhou, Baohua Liu*. Vascular endothelium-targeted Sirt7 gene therapy rejuvenates aging tissues and extends lifespan in Hutchinson-Gilford progeria model. Science Advances, 2020 Feb 19;6(8):eaay5556.