A. Personal Data

Mailing Address: A6-901, Shenzhen University Medical School, Shenzhen, Guangdong 518055, China

Tel: 0755-86930275 (office)

E-mail: Xingzhi.Xu@szu.edu.cn

B. Education　 　

B.Med., Shanghai Medical University, Shanghai, China (1992)

M.Sc., National University of Singapore, Singapore (1998)

Ph.D., University of South Carolina, Columbia, SC, USA (1999)

C. Positions and Honors　 　

Positions and Employment

1. Undergraduate research project, ABO blood grouping on hard tissues, completed at the Shanghai Institute of Forensic Sciences: Feb. 1992 - Jun. 1992.

2. Resident surgeon at the Department of General Surgery of Shanghai No.8 People's Hospital: Jul. 1992 - Oct. 1994.

3. Special research student at the Department of Biochemistry, NUS; research project, Expression of HIV-1 protease in different fusion forms: Nov. 1994 - Feb. 1995.

4. M.Sc. student at the Department of Zoology, Faculty of Science, National University of Singapore; research project, Molecular cloning and characterization of thyrotroph embryonic factor in zebrafish: Mar. 1995 - Aug. 1996

5. Ph.D. student at the Department of Pathology, School of Medicine, University of South Carolina, Columbia, South Carolina; dissertation project: Unique carboxyl termini of transforming growth factor-alpha precursors derived from alternative splicing mediate interactions with the intracellular domains of the ErbB receptors: Aug. 1996 –Aug. 1999.

6. Post-doctoral fellow at Dr. Lucia Pirisi’s laboratory at the Department of Pathology, School of Medicine, University of South Carolina, Columbia, South Carolina: Aug. 1999 to Dec. 1999.

7. Post-doctoral associate at Dr. David Stern’s laboratory at the Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut: Jan. 2000 to Aug. 2000.

8. The Leslie H. Warner fellow at Dr. David Stern’s lab, Yale University: Sep. 2000 to Aug. 2001.

9. The BCRP (Breast Cancer Research Program) fellow of the Congressionally Directed Medical Research Programs (CDMRP), Department of Defense, at Dr. David Stern’s lab, Yale University: Jul. 2001 to Jun. 2004

10. Beckman Fellow, the Arnold and Mabel Beckman Foundation, Division of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA: Jul. 2004 to Jun. 2006

11. Professor, Principal Investigator, College of Life Science, Capital Normal University, Beijing, China: July 2005-Dec. 2019

12. Founder & Director, Beijing Key Laboratory of DNA Damage Response, Capital Normal University, Beijing, China: 2011-2017

13. Visiting Professor, Van Andel Research Institute, Grand Rapids, MI, USA: Jan. – Mar. 2016

14. Adjunct professor, Department of Radiation Oncology, Rutgers University, NJ, USA: April 2016-June 2021

15. Professor, Vice Dean for Research & International Affairs, Shenzhen University School of Medicine, Shenzhen, China: May 2016-May 2019

16. Co-founder and vice director, Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University, China: Jan. 2017-present

17. Professor, Vice Dean for Graduate Studies & International Affairs, Shenzhen University School of Medicine, Shenzhen, China: May 2019-Dec 2022

18. Professor, Executive Dean, Shenzhen University Medical School, Shenzhen University, Shenzhen, China: Jan 2023-present

Other Experience and Honors

1. Founding director of the Shenzhen Society for Cell Biology: Jan. 2025-

2. Editor-in-Chief for Ageing and Cancer Research & Treatment: June 2025-

3. Associate Editor (AE) for Frontiers in Cell and Developmental Biology in Cell Growth and Division Section: April 2025-

4. Editorial board, NAR Cancer: 2020-present

5. Deputy Editor-in-Chief, Genome Instability & Disease (Springer Nature): 2020-present

6. Editorial board, DNA Repair: 2009-present

7. Guest editor, DNA Repair special issue (volume 11 issue 2, 2012): DNA damage research in China: 2012

8. Editorial board, Scientific Reports: 2014-present

9. NSFC review panel (Biochemistry & Molecular Biology): 2009-2016, 2018, 2020, 2024

10. NSFC review panel (Oncology): 2012, 2014, 2016, 2017, 2021

11. NSFC review panel (International Collaborative Program in Life Sciences): 2015

12. Executive director, Beijing Society for Cell Biology: 2009-2017

13. Vice director, Chinese Society for Cell Biology Signal Transduction Branch: 2016-2023

14. 2015 Distinguish Doctorate Alumni Award, University of South Carolina School of Medicine

D. Publications (*: corresponding/co-corresponding author; H index: 47)

1. Tao Qian, Xiong Liu, Feng Bai, Qiyue He, Yipei Xu, Jiayi Zhang, Shiwen Zhang, Shaoling Ye, Yuchan Wang, Bin Peng, Kapanova Gulnara, Jasur Rizaev, Wei-Guo Zhu, Xingzhi Xu*, Xin-Hai Pei*. 2026. USP11 deubiquitinates GATA3 to suppress the growth and metastasis of luminal-type breast cancers. J Biol Chem 2026 Jul 28:113371. doi: 10.1016/j.jbc.2026.113371

2. Xiangpeng Guo, Jieyi Hu, Shahzina Kanwal, Jianwen Yuan, Muqddas Tariq, Jingxia Zheng, Mingwei Sun, Yuanyuan Lu, Jingjing Wang, Mengling Jiang, Aiping Wang, Alvaro Castells-Garcia, Xiyuan Zheng, Bin Peng, Dongye Wang, Xiaofeng Wei, Tao Yang, Giacomo Volpe, Liang Wu, Md. Abdul Mazid, Wenjuan Li, Yiwei Lai, Dajiang Qin, Francesca Aguilo, Yu Zhou, Chuanyu Liu, Maria Pia Cosma, Xingzhi Xu, Emma Lundberg, Jan Mulder, Andrew P. Hutchins, Patrick H. Maxwell, Luciano Di Croce, Xiaofei Zhang*, Miguel A. Esteban*, Yuan Lv*. 2026. A framework for the exploration of subcellular compartmentalization of RNA-binding proteins. Nature Communications 17(1):5496. doi: 10.1038/s41467-026-71511-y

3. Aidos Bolatov*, Askhat Zhakupov, Malika Sapargaliyeva, Aizhan Abdikadirova, Xingzhi Xu, Mirgul Bayanova*. 2026. Cerebrospinal Fluid in Pediatric Neuro-Oncology: Molecular Diagnosis, Disease Monitoring, and Clinical Translation. Int J Mol Sci 27(11):5010. doi: 10.3390/ijms27115010.

4. Wen Zong, Jing Zhong, Xingzhi Xu*, Zhao-Qi Wang*. 2026. The 16^th International Symposium on DNA Damage Response & Human Disease (isDDRHD-2025). Ageing Cancer Res Treat 3:202603. https://doi.org/10.70401/acrt.2026.0013

5. Meiqian Jiang, Jiaxin Zhang, Jiankun He, Yu Miao, Linhui Wang, Haitao Zhong, Yingying Gong, Zhen Li, Li-Lin Du, Xingzhi Xu, Chunlai Chen, Alibek Ydyrys, Yisui Xia, Qinhong Cao, Huiqiang Lou*, Wenya Hou*. 2025. S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion. EMBO J doi: 10.1038/s44318-025-00641-8

6. Zheng Li, Xingxuan Wu, Liu Liu, Shaohong Rao, Yanting Liao, Mengting Liu, Bin Peng, Qiongdan Zhang, Yisui Xia, Yuanliang Zhai, Shunichi Takeda*, and Xingzhi Xu*(lead contact). 2025. MCM5 UFMylation regulates replication origin firing and fork progression. EMBO J https://doi.org/10.1038/s44318-025-00562-6

7. Xiyuan Zheng, Xinying Wu, Lei Wang, Haohong Ouyang, Yeltokova Damira, Bin Peng*, Xingzhi Xu*. 2025. S-Palmitoylation: An Oily Modification Guarding Genome Stability. DNA Repair (Amst). 153:103883. doi: 10.1016/j.dnarep.2025.103883

8. Weitao Jiang, Feng Bai, Guanrun Wang, Xiong Liu, Bin Peng, Xingzhi Xu, Guohui Nie, Wei-Guo Zhu, Bing Hu, Xin-Hai Pei. 2025. BRCA1 deficiency promotes DNA damage in cochlear hair cells with activation of ATM-p53 pathway independent of CHK2. Hearing Research Volume 465, September 2025, 109369.

9. Yisui Xia, Zhao-Qi Wang*, Xingzhi Xu*. 2025. DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA Damage Response & Human Disease (isDDRHD-2024). DNA Repair 2025 Jun 17:152:103860. doi: 10.1016/j.dnarep.2025.103860. 

10. Zheng Chen, Zheng Li, Ying Wang, Zaure Dushimova, Kapanova Gulnara, Shunichi Takeda, Zhongjun Zhou, Xingzhi Xu*. 2025. ISGylation: is our genome yearning for such a modification? Acta Biochimica et Biophysica Sinica

11. Christian Marx, Xiaobing Qing, Yamin Gong, Joanna Kirkpatrick, Kanstantsin Siniuk, Galina V. Beznoussenko, Gururaj Rao Kidiyoor, Murat Kirtay, Katrin Buder, Philipp Koch, Martin Westermann, Christopher Bruhn, Eric J. Brown, Xingzhi Xu, Marco Foiani, Zhao-Qi Wang*. 2025. DNA damage response regulator ATR licenses PINK1-mediated mitophagy. Nucleic Acids Research

12. Shibin Xu, Jingyu Zhang, Congwen Gao, Ziyi Xiong, Yamin Gong, Bao Chai, Hongxiang Chen, Xingzhi Xu*. 2025. FOXD3 promotes homologous recombination repair and genomic stability via facilitating MRE11-mediated DNA end resection. Acta Biochimica et Biophysica Sinica in press

13. Jie Li, Guangcan Shao, Bin Peng, Xingzhi Xu, Meng-Qiu Dong, Jing Li*. 2025. The Role of Polo-Like Kinase 1 (PLK1) O-GlcNAcylation in Mitosis. Methods Mol Biol 2874:127-137. doi: 10.1007/978-1-0716-4236-8_11.

14. Xuefei Zhu*, Congwen Gao, Bin Peng, Jingwei Xue, Donghui Xia, Liu Yang, Jiexiang Zhang, Xinrui Gao, Yilin Hu, Shixian Lin, Peng Gong*, Xingzhi Xu*. 2025. FOXP1 phosphorylation antagonizes its O-GlcNAcylation in regulating ATR activation in response to replication stress. EMBO J 44(2):457-483. doi: 10.1038/s44318-024-00323-x

15. Tao Qian, Feng Bai, Shiwen Zhang, Yuping Xu, Yuchan Wang, Shuping Yuan, Xiong Liu, Yaru Du, Bin Peng, Wei-Guo Zhu, Xingzhi Xu*, Xin-Hai Pei*. 2024. USP11 deubiquitinates E-cadherin and maintains luminal fate of mammary tumor cells to suppress breast cancer. J Biol Chem 300(10):107768. doi: 10.1016/j.jbc.2024.107768.

16. Weitao Jiang, Guanrun Wang, Feng Bai, Bing Hu, Yang Xu, Xingzhi Xu, Guohui Nie, Wei-Guo Zhu, Fangyi Chen, Xin-Hai Pei*. 2024. BRCA1 promotes repair of DNA damage in cochlear hair cells and prevents hearing loss. J Neurosci 44(42):e0132242024. doi: 10.1523/JNEUROSCI.0132-24.2024.

17. Qunsong Tan, Xingzhi Xu*. 2024. MUS81 UFMylation at K400 promotes cell survival in response to camptothecin-induced replication stress. Genome Instability & Disease 5(4):154–163.

18. Yunhui Li, Lei Li, Xinshu Wang, Fei Zhao, Yuntong Yang, Yujuan Zhou, Jiyuan Zhang, Li Wang, Zeshan Jiang, Yuanyuan Zhang, Yuping Chen, Chenming Wu, Ke Li, Tingting Zhang, Ping Wang, Zhiyong Mao, Weiguo Zhu, Xingzhi Xu, Shikang Liang, Zhenkun Lou, Jian Yuan*. 2024. USP25 Elevates SHLD2-Mediated DNA Double-Strand Break Repair and Regulates Chemoresponse in Cancer. Adv Sci (Weinh) 11(28):e2403485. doi: 10.1002/advs.202403485.

19. Yefei Luo, Jia Li, Xiaoman Li, Haodong Lin, Zuchao Mao, Zhanzhan Xu, Shiwei Li, Chen Nie, Xiao Albert Zhou, Junwei Liao, Yundong Xiong, Xingzhi Xu, Jiadong Wang*. 2024. The ARK2N-CK2 complex initiates transcription-coupled repair through enhancing the interaction of CSB with lesion-stalled RNAPII. PNAS in press

20. Xuejie Wang, Feng Bai, Xiong Liu, Bin Peng, Xingzhi Xu, Hongquan Zhang, Li Fu, Wei-Guo Zhu, Bin Wang, Xin-Hai Pei*. 2024. GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer. BMC Biology 

21. Qunsong Tan, Xingzhi Xu*. 2024. PTIP UFMylation promotes replication fork degradation in BRCA1-deficient cells. J Biol Chem

22. Zibin Zhou, Xiyuan Zheng, Jianxin Zhao, Aiyun Yuan, Zhuan Lv, Guangcan Shao, Bin Peng, Meng-Qiu Dong, Quan Xu*, Xingzhi Xu*, Jing Li*. 2024. ULK1-dependent phosphorylation of PKM2 antagonizes O-GlcNAcylation and regulates the Warburg effect in breast cancer. Oncogene 

23. Yamin Gong, Zhifeng Wang, Wen Zong, Ruifeng Shi, Wenli Sun, Sijia Wang, Bin Peng, Shunichi Takeda, Zhao-Qi Wang, Xingzhi Xu*. PARP1 UFMylation ensures the stability of stalled replication forks. PNAS, in press

24. Zhifeng Wang, Shuhui Xiong, Zhaoyi Wu, Xingde Wang, Yamin Gong, Wei-Guo Zhu, Xingzhi Xu*. 2024. VCP/p97 UFMylation stabilizes Beclin1 and facilitates the initiation of autophagy. Autophagy, in press

25. Peipei Wang, Juntao Lin, Xiangyang Zheng, Xingzhi Xu*. 2024. RNase P: Beyond Precursor tRNA Processing. Genomics Proteomics & Bioinformatics qzae016, https://doi.org/10.1093/gpbjnl/qzae016

26. Jun Zhang, Feng Chen, Ming Tang, Wenchao Xu, Yuan Tian, Zhichao Liu, Yuxin Shu, Hui Yang, Qian Zhu, Xiaopeng Lu, Bin Peng, Xiangyu Liu, Xingzhi Xu, Monika Gullerova, Wei-Guo Zhu. 2024. The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability. Cell Rep 43(2):113779. doi: 10.1016/j.celrep.2024.113779.2

27. Yuqin Zhao, Kaiping Hou, Youhang Li, Shuailin Hao, Yu Liu, Yinan Na, Chao Li, Jian Cui, Xingzhi Xu, Xiaohua Wu, Hailong Wang*. 2023. Human HELQ regulates DNA end resection at DNA double-strand breaks and stalled replication forks. Nucleic Acids Res gkad940. doi: 10.1093/nar/gkad940.

28. Xingde Wang, Xingzhi Xu*, Zhifeng Wang*. 2023. The Post-Translational Role of UFMylation in Physiology and Disease. Cells 12(21),2543. doi: 10.3390/cells12212543

29. Jie Li, Xiangxiang Liu, Bin Peng, Tingting Feng, Wen Zhou, Li Meng, Shanshan Zhao, Xiyuan Zheng, Chen Wu, Shian Wu, Xing Chen, Xingzhi Xu*, Jianwei Sun*, Jing Li*. 2023. O-GlcNAc has crosstalk with ADP-ribosylation via PARG. J Biol Chem 105354. doi: 10.1016/j.jbc.2023.105354.

30. Congwen Gao, Honglin Zhu, Peng Gong, Chen Wu, Xingzhi Xu*, Xuefei Zhu*. 2023. The functions of FOXP transcription factors and their regulation by post-translational modifications. Biochim Biophys Acta Gene Regul Mech doi: 10.1016/j.bbagrm.2023.194992. 

31. Jun Zhang, Feng Chen, Yuan Tian, Wenchao Xu, Qian Zhu, Zhenhai Li, Lingyu Qiu, Xiaopeng Lu, Bin Peng, Xiangyu Liu, Haiyun Gan, Baohua Liu, Xingzhi Xu, Wei-Guo Zhu. 2023. PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair. Nat Struct Mol Biol doi: 10.1038/s41594-023-01107-3

32. Donghui Xia, Xuefei Zhu, Ying Wang, Peng Gong, Hong-Shu Su*, Xingzhi Xu*. 2023. Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy. Biosci Rep doi: 10.1042/BSR20222591

33. Zheng Li, Yanting Liao, Chen Tang, Linli Xu, Bin Peng, Xingzhi Xu*. 2023. RBM14 promotes DNA end resection during homologous recombination repair. Acta Biochim Biophys Sin (Shanghai) 2023 Aug 10. doi: 10.3724/abbs.2023104. 

34. Xingxuan Wu, Zheng Li, Zhao-Qi Wang, Xingzhi Xu*. 2023. The neurological and non-neurological roles of the primary microcephaly-associated protein ASPM. Front. Neurosci. 17:1242448. doi: 10.3389/fnins.2023.1242448. 

35. Lingyu Qiu, Wenchao Xu, Xiaopeng Lu, Feng Chen, Yongcan Chen, Yuan Tian, Qian Zhu, Xiangyu Liu, Yongqing Wang, Xin-Hai Pei, Xingzhi Xu, Jun Zhang, Wei-Guo Zhu. 2023. The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair. Nucleic Acids Res 2023 Jul 28; gkad631. doi: 10.1093/nar/gkad631.

36. Jiaxin Zhang#, Lili Li#, Yu Miao, Xiaojing Liu, Haitao Sun, Meiqian Jiang, Xiaoli Li, Zhen Li, Cong Liu, Baohua Liu, Xingzhi Xu, Qinhong Cao, Wenya Hou, Chunlai Chen, Huiqiang Lou*. 2023. Symmetric control of sister chromatid cohesion establishment. Nucleic Acids Research, 51(10):4760-4773. doi: 10.1093/nar/gkad146 

37. Jing-Qiang Huang #, Ling-Xin Duan #, Qiu-Yu Liu #, He-Feng Li, Ao-Ping Hu, Jun-Wei Song, Chuxuan Lin, Bingsheng Huang, Da Yao, Bin Peng, Yehong Sun, Yuxin Wen, Lin Yang, Xingzhi Xu, Li-Yun Gong*. 2023. Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhancing GSK3β Ser9 autophosphorylation independent of its kinase activity in non-small-cell lung cancer. Oncogene 42(15):1233-1246. doi: 10.1038/s41388-023-02645-2.

38. Sheng Yan#, Bin Peng#, Shifeng Kan#, Guangcan Shao, Zhikai Xiahou, Xiangyan Tang, Yong-Xiang Chen, Meng-Qiu Dong, Xiao Liu*, Xingzhi Xu*, Jing Li*. 2023. Polo-like kinase 1 (PLK1) O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma. Journal of Biological Chemistry 299(2):102887. doi: 10.1016/j.jbc.2023.102887.

39. Guangrong Zhu, Xiangyang Zheng, Zhifeng Wang* and Xingzhi Xu*. 2022. Post-translational modifications by lipid metabolites during the DNA damage response and their role in cancer. Biomolecules 12(11):1655. doi: 10.3390/biom12111655.

40. Fu-Cheng Wang, Bin Peng, Ting-Ting Ren, Shao-Peng Liu, Jing-Rui Du, Zi-Hao Chen, Ting-Ting Zhang, Xiaoyang Gu, Mo Li, Sheng-Li Cao*, Xingzhi Xu*. 2022. A 1,2,3-triazole derivative of quinazoline exhibits anti-tumor activity by tethering RNF168 to SQSTM1/P62. Journal of Medicinal Chemistry 65(22):15028-15047

41. Xuefei Zhu, Xiang-Yang Zheng, Peng Gong*, Xingzhi Xu*. 2022. Regulation of ATR-CHK1 signaling by ubiquitination of CLASPIN. Biochem Soc Trans 50(5):1471-1480. doi: 10.1042/BST20220729

42. Yuqin Zhao, Shuailin Hao, Wenchi Wu, Youhang Li, Kaiping Hou, Yu Liu, Wei Cui, Xingzhi Xu, Hailong Wang*. 2022. Lysine Crotonylation: An Emerging Player in DNA Damage Response. Biomolecules 12,1428. https://doi.org/10.3390/biom12101428

43. Xingxuan Wu#, Shibin Xu#, Peipei Wang, Zhao-Qi Wang, Hongxiang Chen, Xingzhi Xu*(lead contact), Bin Peng*. 2022. ASPM promotes ATR-CHK1 activation and stabilizes stalled replication forks in response to replication stress. PNAS 119(40):e2203783119. doi: 10.1073/pnas.2203783119 

44. Ningda Xu#, Yue Liu#, Shanshan Nai#, Yong Tao#, Yuehe Ding, Lemei Jia, Qizhi Geng, Jie Li, Yujing Bai, Gong-Hong Wei, Meng-Qiu Dong, Linyi Luo, Mingwei Zhao, Xingzhi Xu, Xiao-Xin Li*, Jing Li*, Lvzhen Huang*. 2022. UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair. Invest Ophthalmol Vis Sci 63(10):7. doi: 10.1167/iovs.63.10.7.

45. Shuailin Hao, Ya Wang, Yuqin Zhao, Wen Gao, Wei Cui, Youhang Li, Jian Cui, Yu Liu, Lixiu Lin, Xingzhi Xu, Hailong Wang*. 2022. Dynamic switching of crotonylation to ubiquitination of H2A at lysine 119 attenuates transcription–replication conflicts caused by replication stress. Nucleic Acids Research 50(17):9873-9892. doi: 10.1093/nar/gkac734.

46. Yingying Meng, Guliang Wang, Hongjuan He, Kin H. Lau, Allison Hurt, Brianna J. Bixler, Andrea Parham, Seung-Gi Jin, Xingzhi Xu, Karen M. Vasquez, Gerd P. Pfeifer & Piroska E. Szabó. 2022. Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome. Nature Cell Biology 24(7):1141-1153. 

47. Qiang Lv, Shuang Han, Lei Wang, Jinchan Xia, Peng Li, Ruoyang Hu, Jinzheng Wang, Lei Gao, Yuli Chen, Yu Wang, Jing Du, Fang Bao, Yong Hu, Xingzhi Xu, Wei Xiao, Yikun He*. 2022. TEB/POLQ plays dual roles in protecting Arabidopsis from NO-induced DNA damage. Nucleic Acids Research 50(12):6820-36

48. Zheng Li, Shaohong Rao, Chunwei Song, Min Zhu, Hongchang Zhao,  Shuping Yuan, Bin Peng, Xingzhi Xu*. 2022. Ubiquitin carboxyl‑terminal hydrolase 11 promotes autophagy by de‑ubiquitinating and stabilizing Beclin‑1. Genome Instability & Disease 3(1): 47-55

49. Xuefei Zhu, Jingwei Xue, Xing Jiang, Yamin Gong, Congwen Gao, Ting Cao, Qian Li, Lulu Bai, Yuwei Li, Gaixia Xu, Bin Peng, Xingzhi Xu*. 2022. TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination. Nucleic Acids Research 50(3):1517-1530. doi: 10.1093/nar/gkac011.

50. Kaibin Yang, Shiting Song, Yafei Zhang, Siting Shen, Xingzhi Xu, Zhicao Yue*. 2022. The programmed gene expression change in mouse skin after ultraviolet radiation damage. Experimental Dermatology 31(6):862-868

51. Junwei Song, Jing Zhu, Xing-Xuan Wu, Ting Tu, Jingqinag Huang, Guanzi Chen, Liyin Liang, Chunhui Zhou, Xingzhi Xu, and Li-Yun Gong*. 2021. GOLPH3/CKAP4 promotes metastasis and tumorigenicity by enhancing the secretion of exosomal WNT3A in non-small cell lung cancer. Cell Death Diseases 12(11):976. doi: 10.1038/s41419-021-04265-8

52. Ruifeng Shi, Wenya Hou, Zhao-Qi Wang, Xingzhi Xu*. 2021. Biogenesis of iron-sulfur clusters and their role in DNA metabolism. Front. Cell Dev. Biol. 9:735678. doi: 10.3389/fcell.2021.735678

53. Jun Zhang#, Xiaopeng Lu#, Sara MoghaddamKohi, Lei Shi*, Xingzhi Xu*, Wei-Guo Zhu*. 2021. Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair. DNA Repair 107:103206. doi: 10.1016/j.dnarep.2021.103206

54. Bin Peng*, Ruifeng Shi, Jing Bian, Yuwei Li, Peipei Wang, Hailong Wang, Ji Liao, Wei-Guo Zhu, Xingzhi Xu*. 2021. PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair. Nucleic Acids Research 49(13): 7554–7570

55. Jianping Ren#, Yan Wu#, Ya Wang#, Yuqin Zhao, Youhang Li, Shuailin Hao, Lixiu Lin, Shuyuan Zhang, Xingzhi Xu, Hailong Wang*. 2021. CtIP suppresses primary microRNA maturation and promotes metastasis of colon cancer cells in a xenograft mouse model. J Biol Chem 296:100707. doi: 10.1016/j.jbc.2021.100707. 

56. Shibin Xu#, Xingxuan Wu#, Peipei Wang, Sheng-Li Cao*, Bin Peng*, Xingzhi Xu*. 2021. ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability. iScience 24(6): 102534

57. Qian Zhu, Qiaoyan Yang, Xiaopeng Lu, Hui Wang, Lili Tong, Zheng Li, Ge Liu, Yantao Bao, Xingzhi Xu, Luo Gu, Jian Yuan, Xiangyu Liu, and Wei-Guo Zhu*. 2021. SETD2-mediated H3K14 trimethylation promotes ATR activation and stalled replication fork restart in response to DNA replication stress. Proc Natl Acad Sci U S A 118(23): e2011278118

58. Hongchang Zhao#, Zhifeng Wang#, Min Zhu#, Ji Liao & Xingzhi Xu*. 2021.  USP11 suppresses CHK1 activation by deubiquitinating CLASPIN. Genome Instability & Disease 2(3): 184–194

59. Shibin Xu#, Xingxuan Wu#, Bin Peng*, Sheng‑Li Cao*, Xingzhi Xu*. 2020. Primary microcephaly with an unstable genome. Genome Instability & Disease 1(5): 235-264

60. Fanbiao Meng, Minxian Qian, Bin Peng, Xiaohui Wang, Linyuan Peng, Kang Zheng, Zuojun Liu, Xiaolong Tang, Shuju Zhang, Shimin Sun, Xinyue Cao, Qiuxiang Pang, Bosheng Zhao, Wenbin Ma, Zhou Songyang, Bo Xu, Wei-Guo Zhu, Xingzhi Xu*, Baohua Liu*. 2020. Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiate the DNA damage response and repair. eLife 9:e55828. doi: 10.7554/eLife.

61. Xiangyu Liu*, Muhammad Irfan, Xingzhi Xu, Chi-Yen Tay & Barry J. Marshall*. 2020. Helicobacter pylori infection induced genome instability and gastric cancer. Genome Instability & Disease volume 1(3):129–142

62. Xiaolong Tang, Guo Li, Fengting Su, Yanlin Cai, Lei Shi, Yuan Meng, Zuojun Liu, Jie Sun, Ming Wang, Minxian Qian, Zimei Wang, Xingzhi Xu, Yong-Xian Cheng, Wei-Guo Zhu, Baohua Liu*. 2020. HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration. Nucleic Acids Research 48(6):2912-2923

63. Fu-Cheng Wang, Bin Peng, Sheng-Li Cao* Hong-Yun Li, Xiao-Li Yuan, Ting-Ting Zhang, Ruifeng Shi, Zhuqing, Li, Ji Liao, Hailong Wang, Jing Li, Xingzhi Xu*. 2020. Synthesis and cytotoxic activity of chalcone analogues containing a thieno[2,3-d]pyrimidin-2-yl group as the A-ring or B-ring. Bioorganic Chemistry 94:103346. doi: 10.1016/j.bioorg.2019.103346

64. Xiaopeng Lu, Ming Tang, Qian Zhu, Qiaoyan Yang, Zhiming Li, Yantao Bao, Ge Liu, Tianyun Hou, Yafei Lv, Ying Zhao, Haiying Wang, Yang Yang, Zhongyi Cheng, He Wen, Baohua Liu, Xingzhi Xu, Luo Gu, Wei-Guo Zhu*. 2019. GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival. Nucleic Acids Research, 47(21):10977-10993 (NAR breakthrough paper)

65. Nai S, Shi Y, Ru H, Ding Y, Geng Q, Li Z, Dong MQ, Xu Xingzhi, Li Jing*. 2019. Chk2-dependent phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) regulates centrosome maturation. Cell Cycle 18(20): 2651-2659

66. Yang Q, Liao M, Wang W, Zhang M, Chen Q, Guo J, Peng B, Huang J, Liu H, Yahagi A, Xu Xingzhi, Ishihara K, Cooper A, Chen X*, Cai Y*. 2019. CD157 confers host resistance to mycobacterium tuberculosis via TLR2-CD157-PKCzeta-induced reactive oxygen species production. MBio. 2019 Aug 27;10(4). pii: e01949-19. doi: 10.1128/mBio.01949-19

67. Sabapathi N, Sabarimurugan S, Madurantakam Royam M, Kumarasamy C, Xingzhi Xu, Xu G, Jayaraj R*. 2019. Prognostic Significance of FOXC1 in Various Cancers: A Systematic Review and Meta-Analysis. Mol Diagn Ther 23(6):695-706  

68. Shuyuan Zhang, Shuailin Hao, Zhiyu Qiu, Ya Wang, Yuqin Zhao, Youhang Li, Wen Gao, Yan Wu, Chang Liu, Xingzhi Xu, Hailong Wang*. 2019. Cadmium disrupts the DNA damage response by destabilizing RNF168. Food Chem Toxicol 2019 Jul 31:110745. doi: 10.1016/j.fct.2019.110745.

69. Bai Y, Wang W, Li S, Zhan J, Li H, Zhao M, Zhou XA, Li S, Li X, Huo Y, Shen Q, Zhou M, Zhang H, Luo J, Sung P, Zhu WG, Xingzhi Xu, Wang J*. 2019. C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex. Mol Cell 75(6):1299-1314

70. Zhifeng Wang, Yamin Gong, Bin Peng, Ruifeng Shi, Dan Fan, Hongchang Zhao, Min Zhu, Haoxing Zhang, Zhenkun Lou, Jianwei Zhou*, Wei-Guo Zhu, Yu-Sheng Cong*, Xingzhi Xu*. 2019. MRE11 UFMylation promotes ATM activation. Nucleic Acids Research 47(8):4124-4135 

71. Zheng Li, Xingzhi Xu*. 2019. Post-Translational Modifications of the Mini-Chromosome Maintenance Proteins in DNA Replication. Genes (Basel). 2019 Apr 30;10(5). pii: E331. doi: 10.3390/genes10050331. 

72. Ming Tang#, Zhiming Li#, Chaohua Zhang, Xiaopeng Lu, Bo Tu, Ziyang Cao, Yinglu Li, Yongcan Chen, Lu Jiang, Hui Wang, Lina Wang, Jiadong Wang, Baohua Liu, Xingzhi Xu, Haiying Wang, Wei-Guo Zhu. 2019. SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair. Science Advances EAAV1118

73. Xue Han, Bin Peng, Bei-Bei Xiao, Sheng-Li Cao*, Chao-Rui Yang, Wen-Zhu Wang, Fu-Cheng Wang, Hong-Yun Li, Xiao-Li Yuan, Ruifeng Shi, Ji Liao, Hailong Wang, Jing Li, Xingzhi Xu*. 2019. Synthesis and evaluation of chalcone analogues containing a 4-oxoquinazolin-2-yl group as potential anti-tumor agents. European Journal of Medicinal Chemistry 162:586-601 

74. Lianzhong Zhang, Zhenzhen Wang, Ruifeng Shi, Xuefei Zhu, Jiahui Zhou, Bin Peng, Xingzhi Xu*. 2018. RNF126 Quenches RNF168 Function in the DNA Damage Response. Genomics Proteomics Bioinformatics 16:428-438.

75. Hailong Wang*, Zhiyu Qiu, Bo Liu, Yan Wu, Jianping Ren, Yaqing Liu, Ya Wang, Yuqin Zhao, Shuailin Hao, Zheng Li, Bin Peng, Xingzhi Xu*. 2018. PLK1 targets CtIP to promote microhomology-mediated end joining. Nucleic Acids Research 46(20):10724-10739

76. Zhiming Li, Yinglu Li, Ming Tang, Bin Peng, Xiaopeng Lu, Qiaoyan Yang, Qian Zhu, Tianyun Hou, Meiting Li, Chaohua Liu, Lina Wang, Xingzhi Xu, Ying Zhao, Haiying Wang, Yang Yang and Wei-Guo Zhu*. 2018. Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair. Cell Research 28(7):756-770 

77. Chao-Rui Yang, Bing Peng, Sheng-Li Cao*, Ting-Ting Ren, Wei Jiang, Fu-Cheng Wang, You-Shan Li, Guo Wang, Zheng Li, Shi-Bin Xu, Ji Liao, Hai-Long Wang, Jing Li, Xingzhi Xu*. 2018. Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position. European Journal of Medicinal Chemistry 154:324-340

78. Xiaomei Hu, Zhe Li, Yuehe Ding, Qizhi Geng, Zhikai Xiahou, Huanwei Ru, Meng-Qiu Dong, Xingzhi Xu, and Jing Li*. 2018. Chk1 modulates the interaction between myosin phosphatase targeting protein 1 (MYPT1) and protein phosphatase 1cβ (PP1cβ). Cell Cycle 17(4):421-427

79. Liu X, Zong W, Li T, Wang Y, Xu X, Zhou ZW, Wang ZQ*. 2017. The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis. EMBO J. 36:3666-3681 

80. Jie Tian, Yingxin Shi, Shanshan Nai, Qizhi Geng, Leiliang Zhang, Gong-Hong Wei, Xingzhi Xu*, and Jing Li*. 2017. Ataxin-10 is involved in Golgi membrane dynamics. J Genet Genomics 44:549-552

81. Zhe Li, Xueyan Li, Shanshan Nai, Qizhi Geng, Ji Liao, Xingzhi Xu* and Jing Li*. 2017. Checkpoint kinase 1-induced phosphorylation of O-linked β-N-acetylglucosamine transferase regulates the intermediate filament network during cytokinesis. Journal of Biological Chemistry 292:19548-19555 

82. Xueyan Li, Shanshan Nai, Yuehe Ding, Qizhi Geng, Bingtao Zhu, Kai Yu, Wei-Guo Zhu, Meng-Qiu Dong, Xiao-Dong Su, Xingzhi Xu* & Jing Li*. 2017. Polo-like kinase 1 (PLK1)-dependent phosphorylation of methylenetetrahydrofolate reductase (MTHFR) regulates replication via histone methylation. Cell Cycle 16(20):1933-1942

83. Zhifeng Wang, Wei-Guo Zhu, Xingzhi Xu*. 2017. Ubiquitin-like modifications in the DNA damage response. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 803–805: 56–75

84. Qiaoyan Yang, Qian Zhu, Xiaopeng Lu, Yipeng Du, Linlin Cao, Changchun Sheng, Tianyun Hou, Meiting Li, Zhiming Li, Chaohua Liu, Di Wu, Xingzhi Xu, Lina Wang, Haiying, Ying Zhao, Yang Yang, Wei-Guo Zhu*. 2017. G9a coordinates with the RPA complex to promote DNA damage repair and cell survival. Proc Natl Acad Sci U S A 114(30):E6054-E6063. 

85. Wang H*, Peng B, Pandita RK, Engler DA, Matsunami RK, Xu X, Hegde PM, Butler BE, Pandita TK, Mitra S, Xu B, Hegde ML*. 2017. Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis. Oncotarget 2017 Mar 15. doi: 10.18632/oncotarget.16225

86. Bin Peng, Ruifeng Shi, Weiwei Jiang, Yue-He Ding, Meng-Qiu Dong, Wei-Guo Zhu, Xingzhi Xu*. 2017. Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis. Cell BioScience 7:15. DOI 10.1186/s13578-017-0142-x. 

87. Hu L, Li X, Liu Q, Xu J, Ge H, Wang Z, Wang H, Wang Z, Shi C, Xu X, Huang J, Lin Z, Pieper RO*, Weng C*. 2017. UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy. Oncogene 2017 Feb 23; 36(8):1145-1156. 

88. Ming Tang, Xiaopeng Lu, Chaohua Zhang, Changzheng Du, Linlin Cao, Tianyun Hou, Zhiming Li, Bo Tu, Ziyang Cao, Yinglu Li, Yongcan Chen, Lu Jiang, Hui Wang, Lina Wang, Baohua Liu, Xingzhi Xu, Jianyuan Luo, Jiadong Wang, Jin Gu, Haiying Wang and Wei-Guo Zhu*. 2017. Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity of human colorectal cancer. Theranostics 7(5): 1346-1359.

89. Hailong Wang* and Xingzhi Xu*. 2017. Microhomology-mediated end joining: new players join the team. Cell BioScience 7:6. doi: 10.1186/s13578-017-0136-8

90. You-Shan Li, Bin Peng, Li Ma, Sheng-Li Cao*, Lu-Lu Bai, Chao-Rui Yang, Chong-Qing Wan, Hao-Jie Yan, Pan-Pan Ding, Zhong-Feng Li, Ji Liao, Ying-Ying Meng, Hai-Long Wang, Jing Li, Xingzhi Xu*. 2017. Synthesis, crystal structures and antitumor activity of two platinum(II) complexes with methyl hydrazinecarbodithioate derivatives of indolin-2-one. European Journal of Medicinal Chemistry 127:137-146.

91. Zhong J, Li X, Cai W, Wang Y, Dong S, Yang J, Zhang J, Wu N, Li Y, Mao F, Zeng C, Wu J, Xu X, Sun ZS*. 2017. TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function. Nucleic Acids Research 45(2):672-684. 

92. Meng-Wen Hu, Tie-Gang Meng, Zong-Zhe Jiang, Ming-Zhe Dong, Heide Schatten, Xingzhi Xu*, Zhen-Bo Wang*, Qing-Yuan Sun*. 2016. Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity. PLoS Genet. 12(12), e1006513. doi: 10.1371/journal.pgen.1006513. 

93. Zhang Y, Yang CR, Tang X, Cao SL*, Ren TT, Gao M, Liao J, Xu X*. 2016. Synthesis and antitumor activity evaluation of quinazoline derivatives bearing piperazine-1-carbodithioate moiety at C4-position. Bioorg Med Chem Lett. 26(19), 4666-70. 

94. Jing Li* and Xingzhi Xu*. 2016. DNA double-strand break repair: a tale of pathway choices. Acta Biochim Biophys Sin (Shanghai) 48(7), 641-6 (review) 

95. Ying Wei and Xingzhi Xu*. 2016. UFMylation: A Unique & Fashionable Modification for Life. Genomics Proteomics Bioinformatics 14(3), 140-6 (review) 

96. Jie Tian, Qizhi Geng, Y Ding, Ji Liao, Meng-Qiu Dong, Xingzhi Xu*, Jing Li*. 2016. O-GlcNAcylation Antagonizes Phosphorylation of Cdh1 (CDC20 homologue 1). Journal of Biological Chemistry 291(23), 12136-44

97. Pan-Pan Ding, Man Gao, Bei-Bei Mao, Sheng-Li Cao*, Cui-Huan Liu, Chao-Rui Yang, Zhong-Feng Li, Ji Liao, Hongchang Zhao, Zheng Li, Jing Li, Hailong Wang, Xingzhi Xu*. 2016. Synthesis and biological evaluation of quinazolin-4(3H)-one derivatives bearing dithiocarbamate side chain at C2-position as potential antitumor agents. European Journal of Medicinal Chemistry 108, 364-373 

98. Meng-Wen Hu, Zhen-Bo Wang, Yan Teng, Zong-Zhe Jiang, Xue-Shan Ma, Ning Hou, Xuan Cheng, Heide Schatten, Xingzhi Xu*, Xiao Yang*, Qing-Yuan Sun*. 2015. Loss of protein phosphatase 6 in oocytes causes failure of meiosis II exit and impaired female fertility. Journal of Cell Science 128(20), 3769-3780

99. Bin Peng, Jing Wang, Yuan Hu, Hongli Zhao, Wenya Hou, Hongchang Zhao, Hailong Wang, Ji Liao, Xingzhi Xu*. 2015. Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage. Nucleic Acids Research 43(12), 5936-5947 

100. Jie Tian, Chuan Tian, Yuehe Ding, Zhe Li, Qizhi Geng, Zhikai Xiahou, Jue Wang, Wenya Hou, Ji Liao, Meng-Qiu Dong, Xingzhi Xu*, and Jing Li*. 2015. Aurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis. Scientific Reports 5, 8360. doi: 10.1038/srep08360 

101. Yingying Meng, Xingzhi Xu, Ji Liao*. 2015. ZBTB transcription factors and tumorigenesis. Chinese Bulletin of Life Sciences 27(4):477-485 (in Chinese with an abstract in English)

102. S He, Y Zhang, Pei Wang, Xingzhi Xu, K Zhu, W Pan, W Liu, K Cai, J Sun, W Zhang, X Jiang*. 2015. Multiplexed microfluidic blotting of proteins and nucleic acids by parallel, serpentine microchannels. Lab Chip 15(1), 105-12

103. Min Zhu, Hongchang Zhao, Ji Liao, and Xingzhi Xu*. 2014. HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability. Nucleic Acids Research 42(21), 13074-13081

104. Hongchang Zhao, Min Zhu, Gelin Dou, Hongli Zhao, Bingtao Zhu, Jing Li, Ji Liao, Xingzhi Xu*. 2014. BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response. Cell Cycle 13(11), 1777-87. 

105. Bingtao Zhu, Zhikai Xiahou, Heyu Zhao, Bin Peng, Hongchang Zhao, and Xingzhi Xu*. 2014. MTHFR promotes heterochromatin maintenance.  Biochemical and Biophysical Research Communications 447, 702-706 

106. Gao M, Wei W, Li MM, Wu YS, Ba Z, Jin KX, Li MM, Liao YQ, Adhikari S, Chong Z, Zhang T, Guo CX, Tang TS, Zhu BT, Xingzhi Xu, Mailand N, Yang YG, Qi Y, Danielsen JM. 2014. Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination. Cell Research 24(5), 532-41. 

107. Dongyun Liu, Xiaoli Deng, Chongzhen Yuan, Lin Chen, Yusheng Cong*, and Xingzhi Xu*. 2014. The Werner syndrome protein positively regulates XLF transcription. Molecular Medicine Reports 9, 1648-1652

108. Bo Liu, Rixin Cong, Bin Peng, Bingtao Zhu, Gelin Dou, Haiyan Ai, Xiaodong Zhang, Zhenghe Wang, Xingzhi Xu*. 2014. CtIP is required for DNA damage-dependent induction of P21. Cell Cycle 13, 90-95. 

109. Bin Peng, Jing Wang, Yuan Hu, Xingzhi Xu*. 2014. Serine/threonine protein phosphatases in DNA damage response. Chinese Bulletin of Life Sciences 26(11):1120-1135 (in Chinese with an abstract in English)

110. WooKee Min, Christopher Bruhn, Paulius Grigaravicius, Zhong-Wei Zhou, Fu Li, Anja Krüger, Bénazir Siddeek, Karl-Otto Greulich, Oliver Popp, Chris Meisezahl, Cornelis F. Calkhoven, Alexander Bürkle, Xingzhi Xu, and Zhao-Qi Wang*. 2013. Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S phase checkpoint. Nature Communications 4, 2993. 

111. Jing Li*, Xiaoqian Liu, Ji Liao, Jie Tian, Jue Wang, Xin Wang, Jiezhong Zhang and Xingzhi Xu*. 2013. MYPT1 sustains centromeric cohesion and the spindle-assembly checkpoint. Journal of Genetics and Genomics 40(11), 575-578

112. Li MM, Nilsen A, Shi Y, Fusser M, Ding YH, Fu Y, Liu B, Niu Y, Wu YS, Huang CM, Olofsson M, Jin KX, Lv Y, Xu XZ, He C, Dong MQ, Rendtlew Danielsen JM, Klungland A, Yang YG. 2013. ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. Nature Communications 4, 1832. 

113. Sheng-Li Cao*, Ying Han, Chong-Zhen Yuan, Yao Wang, Zhi-Kai Xiahou, Ji Liao, Rui-Ting Gao, Bei-Bei Mao, Bao-Li Zhao, Zhong-Feng Li, Xingzhi Xu*. 2013. Synthesis and antiproliferative activity of 4-substituted-piperazine-1-carbodithioate derivatives of 2,4-diaminoquinazoline. European Journal of Medicinal Chemistry 64, 401-409. 

114. HH Lin, WY Wu, SL Cao*, J Liao, L Ma, M Gao, ZF Li, Xingzhi Xu*. 2013. Synthesis and antiproliferative evaluation of piperazine-1-carbothiohydrazide derivatives of indolin-2-one. Bioorg. Med. Chem. Lett. 23, 3304-3307. 

115. WY Wu, SL Cao*, BB Mao, J Liao, ZF Li, HB Song, Xingzhi Xu*. 2013. Synthesis and antiproliferative evaluation of hybrids of indolin-2-one and quinazoline-4(3H)-one linked via imine bond. Lett. Drug Des. Discov. 10, 61-66. 

116. Bingtao Zhu, Xiaoli Deng, Yifan Sun, Lin Bai, Zhikai Xiahou, Yusheng Cong, and Xingzhi Xu*. 2012. Nampt is involved in DNA double-strand repair. Chinese Journal of Cancer 31(8), 392-298. 

117. Jinping Liu, Linli Xu, Jianing Zhong, Ji Liao, Jing Li and Xingzhi Xu*. 2012. Protein phosphatase PP4 is involved in NHEJ-mediated repair of DNA double-strand breaks. Cell Cycle 11(14), 2643-49 (Commentary on Cell Cycle 11(14), 2590 and 11(19), 3535) 

118. Jinping Liu（本研究室的博士生）, Shukun Luo, Hongchang Zhao, Ji Liao, Jing Li, Chunying Yang, Bo Xu, David F. Stern, Xingzhi Xu* and Keqiong Ye*. 2012. Structural mechanism of the phosphorylation-dependent dimerization of MDC1 forkhead-associated domain. Nucleic Acids Research 40(9), 3898-3912 (featured article) 

119. Xingzhi Xu* & Wei Xiao. 2012. DNA damage research in China (editorial). DNA Repair 11(2), 101

120. Cao SL*, Xu H, Wang Y, Liao J, Zhang JJ, Li ZF, Guo YW, Li XR, Cui XM, Xingzhi Xu*. 2012. Synthesis and Cytotoxic Evaluation of Quinazolin-4(3H)-one Derivatives Bearing Thiocarbamate, Thiourea or N-Methyldithiocarbamate Side Chains. Med Chem. 8(2), 163-73 

121. Bo Liu, Xingzhi Xu*. 2011. Serine/threonine protein phosphatases in DNA damage response. Chinese Sci Bull 56, 3122–3131 (review)

122. Jing Li, Jue Wang, Wenya Hou, Zhiyi Jing, Chuan Tian, Yi Han, Ji Liao, Meng-Qiu Dong and Xingzhi Xu*. 2011. Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis. Cell Cycle 10(17), 2946-2958 (cover image) 

123. Liu Y, Liao J, Xu Y, Chen W, Liu D, Ouyang T, Li J, Wang T, Fan Z, Fan T, Lin B, Xingzhi Xu, Xie Y. 2011. A recurrent CHEK2 p.H371Y mutation is associated with breastcancer risk in Chinese women. Hum Mutat 32, 1000-1003 

124. Jianing Zhong, Ji Liao, Xing Liu, Pei Wang, Jinping Liu, Wenya Hou, Bingtao Zhu, Lu Yao, Jinsheng Wang, Jing Li, Jeremy M. Stark, Yuntao Xie, Xingzhi Xu*. 2011. Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks. Cell Cycle 10(9), 1411-1419

125. Xingzhi Xu*, Martin Eilers, Wei Xiao, Li-Lin Du, Alexander Bürkle, Lisa Wiesmüller, Zhao-Qi Wang. 2011. The first Sino-German Symposium on DNA Repair and Human Diseases. DNA Repair 10(3), 349-54

126. Sheng-Li Cao*, Yao Wang, Lin Zhu, Ji Liao, Yan-Wen Guo, Lin-Lin Chen, Hong-Qin Liu, and Xingzhi Xu*. 2010. Synthesis and in vitro cytotoxic activity of (2-methyl-4(3H)-quinazolinon- 6-yl)methylcarbamodithioic acid esters. European Journal of Medicinal Chemistry 45(9), 3850-3857 

127. Xu Li, H. Helen Lin, Hanqing Chen, Xingzhi Xu, Hsiu-Ming Shih and David K. Ann. 2010. SUMOylation of KAP1, a transcriptional co-repressor, is regulated by Ser/Thr phosphatase PP1. Science Signaling 3(119), ra32 

128. Jing Li*, Jue Wang, Hong Jiao, Ji Liao, Xingzhi Xu*. 2010. Cytokinesis and Cancer: Polo Loves ROCK’n’ Rho(A). Journal of Genetics and Genomics 37(3), 159-172 (review) 

129. Pauline Douglas, Greg Moorhead, Xingzhi Xu and Susan Lees-Miller. 2010. Choreographing the DNA Damage Response: PP6 joins the dance. Cell Cycle 9(7), 1221-1222 

130. Shuang Lv, Wenjuan Bu, Hong Jiao, Bo Liu, Lin Zhu, Hongchang Zhao, Jing Li, Ji Liao, Xingzhi Xu*. 2010. LSD1 is required for chromosome segregation during mitosis. Eur. J. Cell Biol. 89(7), 557-563

131. P. Douglas, J. Zhong, R. Ye, G.B. Moorhead, Xingzhi Xu*, S.P. Lees-Miller*. 2010. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and dephosphorylates g-H2AX. Mol Cell Biol 30(6), 1368-1381

132. H. Wang, A. Zhao, L. Chen, X. Zhong, J. Liao, M. Gao, M. Cai, D.H. Lee, J. Li, D. Chowdhury, Y.G. Yang, G.P. Pfeifer, Y. Yen, Xingzhi Xu*. 2009. Human RIF1 encodes an anti-apoptotic factor required for DNA repair. Carcinogenesis 30(8), 1314-1319

133. Xiaoying Zhang, Dongyun Liu, Shuang Lv, Haibo Wang, Xueyan Zhong, Bo Liu, Bo Wang, Ji Liao, Jing Li, Gerd P. Pfeifer and Xingzhi Xu*. 2009. CDK5RAP2 is required for spindle checkpoint function. Cell Cycle 8(8), 1206-1216

134. Wang, A. Zhao, L. Sun, X. Zhong, J. Zhong, H. Wang, M. Cai, J. Li, Y. Xu, J. Liao, J. Sang, D. Chowdhury, G.P. Pfeifer, Y. Yen, and Xingzhi Xu*. 2008. Protein phosphatase PP4 is overexpressed in human breast and lung tumors. Cell Research 18, 974-977

135. Chowdhury*, Xingzhi Xu*, X. Zhong, F. Ahmed, J. Zhong, J. Liao, D. Dykxhoorn, D. Weinstock, G.P. Pfeifer, and J. Lieberman*. 2008. A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Molecular Cell 31, 33-46

136. L. Wang, G. Zhu, D. Yang, Q. Li, Y. Li, Xingzhi Xu, D. He, C. Zeng. 2008. The spindle function of CDCA4. Cell Motility and the Cytoskeleton 65, 581-593

137. X. Zhong, G.P. Pfeifer, and Xingzhi Xu*. 2006. Microcephalin Encodes a Centrosomal Protein. Cell Cycle 5, 457-458. (Cover image) 

138. X. Zhong, M. Liu, A. Zhao, G.P. Pfeifer, and Xingzhi Xu*. 2005. The Abnormal Spindle-like, Microcephaly-associated (ASPM) Gene Encodes a Centrosomal Protein. Cell Cycle 4, 1227-1229

139. T. Rauch, X. Zhong, G.P. Pfeifer, and Xingzhi Xu*. 2005. 53BP1 is a positive regulator of the BRCA1 promoter. Cell Cycle 4, 1078-1083

140. L.M. Tsvetkov, R.T. Tsekova, Xingzhi Xu, and D.F. Stern. 2005. The Plk1 Polo Box Domain Mediates a Cell Cycle and DNA Damage Regulated Interaction with Chk2. Cell Cycle 4, 609-617

141. Xingzhi Xu* , J.H. Lee, and D.F. Stern*. 2004. Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. Journal of Biological Chemistry 279, 34091-34094 (Accelerated Publication; Papers of the Week)

142. Xingzhi Xu and D.F. Stern. 2003. NFBD1/MDC1 regulates ionizing radiation-induced focus formation of DNA checkpoint signaling and repair factors. FASEB Journal 17, 1842-1848

143. Xingzhi Xu and D. F. Stern. 2003. NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways. Journal of Biological Chemistry 278, 8795-8803

144. L.M. Tsvetkov, Xingzhi Xu, J. Li, and D.F. Stern. 2003. Polo like kinase 1 and Chk2 interact and Co-localize to centrosomes and the midbody.  Journal of Biological Chemistry 278, 8468-8475

145. Xingzhi Xu, L.M. Tsvetkov, and D.F. Stern. 2002. Chk2 activation and phosphorylation-dependent oligomerization. Molecular and Cellular Biology 22, 4419-4432

146. Xingzhi Xu, K.F. Kelleher, J Liao, K. E. Creek, and L. Pirisi. 2000. Unique carboxyl-terminal sequences of wild-type and alternatively spliced variant forms of transforming growth factor-a precursors mediate specific interactions with ErbB4 and ErbB2. Oncogene 19, 3172-3181

147. J. Liao, Xingzhi Xu, and M.J. Wargovich. (2000) Direct re-probing with anti-b-actin antibody as an internal control for Western Blotting analysis. BioTechniques 28, 216-218

148. Xingzhi Xu, J Liao, K. E. Creek, and L. Pirisi. (1999) Human keratinocytes and tumor-derived cell lines express alternatively spliced forms of transforming growth factor-alpha (TGF-alpha) mRNA encoding precursors lacking carboxy-terminal valine residues. Oncogene 18, 5554-5562

149. Liang, Xingzhi Xu, A. J. Chin, N. V. Balasubramaniyan, M. A. L. Teo, T. J. Lam, E. S. Weinberg and R. Ge. (1998) Cloning and characterization of vascular endothelial growth factor (VEGF) from zebrafish, Danio rerio. Biochimica et Biophysica Acta 1397, 14-20

150. Xingzhi Xu, L. Liu, K.C.Y. Wong, and R. Ge. (1998) Cloning and characterization of two isoforms of the zebrafish thyrotroph embryonic factor (tef-alpha and tef-beta). Biochimica et Biophysica Acta 1395, 13-20

151. M. Wan, M. Takagi, B.N. Loh, Xingzhi Xu, and T. Imanaka. (1996) Autoprecessing - an essential step for the activation of HIV-1 protease. Biochemical Journal 316, 569-573

152. Xingzhi Xu*, J. Liao, H. Fang, M. Li, and Z. Liu. (1993) ABO blood grouping on dental tissue. Journal of Forensic Sciences 38, 956-960

153. Xingzhi Xu* and Z. Liu. (1993) Discussion of H substance in urine. Journal of Forensic Sciences 38, 8-9.

E. Research Support

Completed Research Support

Leslie H. Warner Fund, Yale Cancer Center                       09/01/2000 to 08/31/2001

PI                                                                                          $30,000

Mechanisms of Chk2 activation in response to DNA damage

Goal: To understand mechanisms of Chk2 in response to DNA damage through functional interactions with the Mre11 complex and other Chk2-interacting proteins.

Breast Cancer Research Program, DOD (DAMD 17-01-1-0465)   

                                                                                              07/01/2001 to 06/30/2004

PI                                                                                           $150,000

Mechanisms of Chk2 activation in response to DNA damage

Goal: To understand mechanisms of Chk2 in response to DNA damage through functional interactions with the Mre11 complex and other Chk2-interacting proteins.

The Arnold and Mabel Beckman Foundation                    07/01/2004 to 06/30/2006

PI                                                                                        $360,000

DNA damage checkpoint signaling

Goal: To investigate functions of Mcph1 in DNA damage-induced checkpoint signaling pathways. 

NSFC (China) (30570371)  01/01/2006 to 12/31/2008

PI Y300,000

NFBD1 in DNA damage checkpoint control

NSFC (China) (90608014) 01/01/2007 to 12/31/2009

PI Y450,000

NFBD1 in the spindle checkpoint control

Beijing Municipal Support for Creative Teams 01/01/2007 to 12/31/2009

PI Y1,500,000

Stress-induced cell cycle checkpoints

NSFC (China)-CIHR (Canada) (30711120570 )          01/01/2008 to 12/31/2010

PI                                                                                  ￥450，000

The protein phosphatase PP6 in the DNA damage response

Beijing Municipal Commission of Education(KZ200810028014) 01/01/2008 to 12/31/2010

PI                                                                                  ￥500，000

The protein phosphatases involved in the cell cycle checkpoint control

NSFC (China) (31071190) 01/01/2011 to 12/31/2013

PI Y350,000

Functional characterization of the lysine-specific demethylase LSD1

Beijing Municipal Commission of Education(PHR20110508) 01/01/2011 to 12/31/2013

PI                                                                                  ￥3,000,000

DNA damage response and cancer

NSFC (China) key project (31130017) 01/01/2012 to 12/31/2016

PI Y2,900,000

Functional characterization of protein phosphatases in DSB repair

NSFC-ISF joint project (31461143012) 10/01/2014 to 09/30/2017

PI Y2,000,000

Novel ubiquitin-driven branches of the DNA damage response

973 project (China) (2013CB911002) 01/01/2013 to 12/31/2017

PI Y4,400,000

Functional characterization of proteins involved in DNA damage response

NSFC (China) key project (31530016) 01/01/2016 to 12/31/2020

PI Y2,780,000 (direct cost)

Molecular mechanisms of the coordination of phosphorylation and ubiquitination in ATR-dependent CHK1 activation

973 subproject (China) (2015CB910601) 01/01/2015 to 12/31/2019

PI Y1,450,000

Sensing and transduction of DNA damage signal

Shenzhen S&T Commissions (JCYJ20170412112009742) 07/01/2017 to 06/30/2020

PI Y3,000,000

Mechanistic investigation of novel metal complexes in cancer therapy

NSFC-DFG joint project (31761133012) 01/01/2018 to 12/31/2020

PI Y1,800,000 (direct cost)

PARP1 UFMylation in the replication stress response

Shenzhen S&T Commissions (JCYJ20180507182213033) 04/01/2019 to 03/31/2022

PI Y3,000,000

Screening and mechanistic investigation of novel anti-cancer lead compounds derived from the non-peptide small molecules in insects

Active Research Support

NSFC (China) joint key grant (U24A20740) 01/01/2025 to 12/31/2028

PI Y2,600,000 (direct cost)

Checkpoint kinase CHK1-promoted Fe-S cluster biogenesis in nucleus overcomes cancer radiochemotherapeutic resistance

Shenzhen Medical Research Special Fund Program (D2403014) 01/01/2025 to 12/31/2027

PI Y3,000,000

Development of novel molecular-glue compounds to overcome paclitaxel resistance and its neuropathic pain

NSFC (China) program project (32090031) 01/01/2021 to 12/31/2025

PI Y5,800,000 (direct cost)

Biochemical mechanisms of DNA replication initiation and fork stability

Shenzhen S&T Commissions (JCYJ20220818095616035) 11/01/2022 to 10/31/2025

PI Y2,000,000

Study on the mechanism of small molecule targeted anti-tumor action of Chinese medicine 

Mechanistic investigation of anti-cancer small molecules derived from Chinese herbs

 F. Trainees

1. 2006-present: have trained 15 PhD students and 74 MSc students, 19 PhD candidates and 16 MSc candidates are under training.

2. The PhD candidate Mr. Haibo Wang, graduated in 2009, received the Scholar-in-training Award from the AACR in 2009.

3. The PhD candidate Mr. Jianing Zhong, graduated in 2010, received the Scholar-in-training Award from the AACR in 2010, who became a full professor at the Gannan Medical University in 2023.

4. Dr. Jinping Liu, who graduated in 2012, became a full professor at the Sun Yat-sen University Cancer Center in 2023.

G. Organizer/co-organizer of international meetings

1. Co-organizer, the 3^rd International Conference on Biomedical and Environmental Sciences & Technology: DNA Repair and Cancer Intervention (icBEST-2010)), May 9-12^th, 2010, Beijing. 

2. Founder and Organizer, the 1^st Sino-German Symposium on DNA Repair & Human Disease）, Oct. 8-13^th, 2010, Beijing.

3. Co-organizer, the International Meeting (Jena-Beijing) on Molecular Signatures of Adaptive Stress Response, Nov. 25-26^th, 2010, Jena, Germany

4. Organizer, the International Meeting (Beijing-Jena) on Molecular Signatures of Adaptive Stress Response, Oct. 10-11^th, 2011, Beijing

5. Co-organizer, the 2^nd Sino-German Symposium on DNA Repair & Human Disease), Oct. 16-21^st, 2011, Mainz, Germany

6. Founder and Organizer, the 3^rd International Symposium on DNA Damage Response & Human Disease (isDDRHD), Oct. 13-14^th, 2012, Beijing

7. Co-organizer, the International Meeting (Jena-Beijing) on Molecular Signatures of Adaptive Stress Response, Feb. 28^th-Mar. 1^st, 2013, Jena, Germany

8. Organizer, the 4^th International Symposium on DNA Damage Response & Human Disease (isDDRHD), Oct. 19-20^th, 2013, Beijing 

9. General Secretary, the 5^th International Conference on Biomedical and Environmental Sciences & Technology: DNA Damage Response and Cancer (icBEST-2014)); Organizer, the 5^th International Symposium on DNA Damage Response & Human Disease (isDDRHD); Oct. 16-19^th, 2014, Beijing

10. Co-organizer, the International Meeting (Jena-Beijing) on Molecular Signatures of Adaptive Stress Response, Sept. 20^th-22^nd, 2015, Dresden-Jena, Germany

11. Co-organizer, the 16^th Ataxia Telangiectasia Workshop (ATW) in conjunction with the 6^th International Symposium on DNA Damage Response & Human Disease (isDDRHD), Oct. 11-14^th, 2015, Beijing 

12. Co-organizer, the 6^th International Conference on Biomedical and Environmental Sciences & Technology: DNA Damage Response and Cancer (icBEST-2016)) and the 7^th International Symposium on DNA Damage Response & Human Disease (isDDRHD); Oct. 14-17^th, 2016, Chengdu

13. Organizer, the 8th International Symposium on DNA Damage Response & Human Disease (isDDRHD), Oct. 28-29^th, 2017, Shenzhen

14. Organizer, the 1st international symposium on Radiation Therapeutics & Biology (isRTB-2017), Oct. 31^st-Nov. 1^st, 2017, Shenzhen

15. Organizer, the 7th International Conference on Biomedical and Environmental Sciences & Technology: DNA Damage Response and Cancer (icBEST-2018) and the 9th International Symposium on DNA Damage Response & Human Disease (isDDRHD); Nov. 1-4^th, 2018, Shenzhen 

16. Co-organizer, the 2^nd international symposium on Radiation Therapeutics & Biology, isRTB-2018, Nov. 10-12^th, 2018, Kyoto, Japan

17. Co-organizer, the 9^th International Meeting (Jena-Shenzhen) on Molecular Signatures of Adaptive Stress Response, Sept. 29^th – Oct. 3^rd, 2019, Lepzig-Jena, Germany

18. Co-organizer, the 10^th International Symposium on DNA Damage Response & Human Disease (isDDRHD), Nov. 6-10^th, 2019, Shenzhen, China

19. Co-organizer, the 11^th International Symposium on DNA Damage Response & Human Disease (isDDRHD), Nov. 6-7^th, 2020, Shenzhen, China

20. Co-organizer, the 12^th International Symposium on DNA Damage Response & Human Disease (isDDRHD), Oct. 22-24^th, 2021, Shanghai, China

21. Co-organizer, the 13^th International Symposium on DNA Damage Response & Human Disease (isDDRHD), Dec. 9-11^th, 2022, Shenzhen, China

22. Co-organizer, the 14^th International Symposium on DNA Damage Response & Human Disease (isDDRHD), Nov. 3-5^th, 2023, Shenzhen, China

23. Co-organizer, the 20^th Ataxia Telangiectasia Workshop (ATW) in conjunction with the 15^th International Symposium on DNA Damage Response & Human Disease (isDDRHD), Oct. 17-20^th, 2024, Shenzhen, China (www.isddrhd.com) 

24. Co-organizer, the 16^th International Symposium on DNA Damage Response & Human Disease (isDDRHD), Oct. 17-20^th, 2025, Qingdao, China (www.isddrhd.com)

H. Invited presentations

1. University of Southern California School of Pharmacy, Jan. 20th, 2006: Functional characterization of the primary microcephaly genes

2. Annual meeting of the Beijing Society for Cell Biology, May 12th, 2007: Cell cycle checkpoint, genome instability, and cancer

3. 2nd International Conference on Frontiers in Biomedical and Environmental Health Sciences: DNA Repair and Cancer Biology，April 16-20, 2008，Linquan Villa, Hangzhou, Chin: A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication

4. National Institute of Biological Sciences, June 10th, 2008: Functional characterization of protein phosphatase PP4

5. Institute of Biophysics, Chinese Academy of Sciences, June 12th, 2008: Protein phosphatases and cell cycle checkpoint control

6. Southern Alberta Cancer Research Institute, University of Calgary, Calgary, Alberta, Canada, April 24, 2009: Primary microcephaly genes in cell cycle checkpoint controls.

7. City of Hope National Medical Center/Beckman Research Institute, Duarte, CA, USA, 12-09-2009: Dephosphorylation of g-H2AX by protein phosphatases

8. 3^rd International Conference on Frontiers in Biomedical and Environmental Health Sciences, May 2010，Beijing, China: Secretary General and session co-chairs

9. First Sino-German Symposium on DNA Repair and Human Disease, Beijiing, China, Oct. 9th, 2010: Ser/Thr Protein Phosphatases in DNA Repair

10. 2010 International Conference on Translational Medicine in Cancer, Hangzhou, China, Oct. 21st: Protein Phosphatases and Tumorigenesis

11. International Meeting on Molecular Signatures of Adaptive Stress Responses, Jena, Germany, Nov. 25-26, 2010: Protein phosphatases in DNA damage response

12. Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, Dec. 10th, 2010: DNA damage response and cancer

13. Institute of Toxicology, University of Mainz, Mainz, Germany, Feb. 25^th, 2011: DNA damage response

14. Society of Chinese Bioscientists in America-The 13^th SCBA International Symposium, Apr. 28^th, 2011: Protein phosphatases in DNA damage response & tumorigenesis

15. 2nd Sino-German Symposium on DNA Repair and Human Disease, Mainz, Germany, Oct. 16-20th, 2011: Protein Phosphatases in DNA Damage Response

16. 4^th icBEST, Guangzhou, April 18^th, 2012: PP4 and MDC1 in DNA Damage Response

17. 3^rd international symposium on DNA Damage Response & Human Disease (isDDRHD), Beijing, Oct. 13-14^th, 2012: Post-translational modifications DNA damage response

18. 2012 IWRS: International Workshop Series on Radiation Science-Radiation Induced Biological Effects & Repair, Nov. 13-14^th, 2012, National Taiwan University, Taibei:  Post-translational modifications DNA damage response

19. 3^rd Jena-Beijing meeting on Molecular Signatures of Adaptive Stress Responses, Jena, Germany, Feb. 28^th to Mar. 1^st, 2013: BCL10 regulates RNF8/RNF168-mediated ubiquitination in DNA damage response

20. 13^th SCBA, Xi’an, July 18-22, 2013, (session co-chairs) DNA repair & genome instability research in China

21. University of Michigan School of Medicine, Aug. 23^rd, 2013: BCL10 regulates RNF8/RNF168-mediated ubiquitination in DNA damage response

22. 4^th international symposium on DNA Damage Response & Human Disease (isDDRHD), Beijing, Oct. 19-20^th, 2013: BCL10 regulates RNF8/RNF168-mediated ubiquitination in DNA damage response

23. Annual meeting of the Beijing Society of Biochemistry & Molecular Biology, Dec. 7th, 2013: Reversible ubiquitination-driven DNA damage response

24. Mayo Clinic Department of Radiation Oncology, Rochester, MN, Dec. 12^th, 2013: Reversible ubiquitination-driven DNA damage response

25. State University of New York at Albany Department of Biology, Albany, NY, Dec. 13^th, 2013: Reversible ubiquitination-driven DNA damage response

26. University of California at Davis Comprehensive Cancer Center, Davis, CA, Feb. 13^th, 2014: Ubiquitination-driven DNA damage response

27. 5^th icBEST/5^th international symposium on DNA Damage Response & Human Disease (isDDRHD), Beijing, Oct. 17-19^th, 2014, title of the presentation: Reversible ubiquitination modulates DNA damage response

28. University of South Carolina School of Medicine, Columbia, SC, March 5^th, 2015, title of the presentation: Reversible ubiquitination modulates CHK1 activation through targeting CLASPIN

29. The first CGI (Center for Genomic Integrity) Symposium, Ulsan National Institute of Science & Technology, Ulsan, Korea, May 27-29^th, 2015, title of the presentation: Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage 

30. The Tomass Lindahl Conference on DNA Repair, Oslo, Norway, June 16-20^th, 2015, title of the presentation: Reversible ubiquitination of CLASPIN modulates CHK1 activation

31. 14^th SCBA, Taipei, June 26-29^th, 2015, (session chair) DNA replication & genome instability research in China

32. 14^th SCBA, Taipei, June 26-29^th, 2015, title of the presentation: Reversible ubiquitination of CLASPIN modulates CHK1 activation

33. Taipei Medical University, Taipei, Taiwan, June 29^th, 2015, title of the presentation: Reversible ubiquitination modulates DNA damage response 

34. Department of Radiation Oncology University of Texas Southwestern Medical Center at Dallas, August 20^th, 2015, title of the presentation: Phosphorylation and ubiquitination coordinate DNA damage response

35. The Methodist Hospital Department of Radiation Oncology, Houston, TX, August 21^st, 2015, title of the presentation: Phosphorylation and ubiquitination coordinate DNA damage response

36. 5^th Jena-Beijing meeting on Molecular Signatures of Adaptive Stress Responses, Jena-Dresden, Germany, Sept. 22^nd, 2015, title of the presentation: Phosphorylation and ubiquitination coordinate DNA damage response

37. 16^th Ataxia-Telangiectasia Workshop and 6^th isDDRHD, Beijing, China, Oct. 14^th, 2015, title of the presentation: Reversible ubiquitination in the replication stress response

38. Van Andel Research Institute Center for Epigenetics, Grand Rapids, MI, USA, Feb. 17^th, 2016, title of the presentation: Ubiquitination of TIPIN/CLASPIN modulates CHK1 activation

39. The 2016 Cold Spring Harbor Asia Conference “DNA metabolism, genomic stability & diseases”, Suzhou, June 13-17^th, 2016, title of the presentation: CALSPIN deubiquitination modulates ATR-dependent CHK1 activation in response to replication stress

40. The 32^nd RBC International Symposium “Growing Edge of Radiation biology, from principles to applications”, Kyoto University, Kyoto, September 1-2, 2016, title of the presentation: Reversible ubiquitination modulates ATR-dependent CHK1 activation

41. 6^th icBEST/7^th international symposium on DNA Damage Response & Human Disease (isDDRHD), Chengdu, Oct. 14-17th, 2016, title of the presentation: Reversible ubiquitination modulates ATR-dependent CHK1 activation

42. 16^th SCBA, Hangahou, June 29^th to July 2^nd, 2017, title of the presentation: BCL10 is a prognostic marker for breast invasive ductal carcinoma

43. Shandong Normal University College of Life Sciences, Jinan, Shandong, China, May 28^th, 2018, title of the presentation: Post-translational modifications modulate the DNA damage response

44. Shanghai Jiaotong University School of Medicine, Shanghai, China, May 29^th, 2018, title of the presentation: Post-translational modifications modulate the DNA damage response

45. The 2018 Cold Spring Harbor Asia Conference “DNA metabolism, genomic stability & diseases”, Suzhou, June 11-15^th, 2018, title of the presentation: UFMylation modulates the DNA damage response

46. Fudan University Jinshan Hospital, Shanghai, China, July 9^th, 2018, title of the presentation: Post-translational modifications modulate the DNA damage response Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA, August 17^th, 2018, title of the presentation: Post-translational modifications modulate the DNA damage response

47. The 6th International Experimental biology & Medicine Conference and the 4^th International Regenerative Medicine & Health Industry Forum, Chengdu, Sichuan, Oct. 19-21, 2018, chair of the session “Assessing the toxicity of hazardous wastes & food contaminates”

48. The 3^rd International Symposium of Epigenetic Mechanism & Human Health, SUSTech, Shenzhen, China, Oct. 23-26, title of the presentation: Homeostasis of CLASPIN ubiquitination controls CHK1 activation in response to replication stress

49. The 7^th icBEST and the 9^th isDDRHD, Shenzhen, China, Nov. 1-4, 2018, title of the presentation: MRE11 UFMylation promotes ATM activation 

50. The 2^nd international symposium on Radiation Therapeutics & Biology, isRTB-2018, Nov. 10-12^th, 2018, Kyoto, Japan, title of the presentation: MRE11 UFMylation promotes ATM activation

51. The 12^th Biennial Conference of the Chinese Biological Investigators Society (CBIS，华人生物学家协会), Dec. 22-24^th, 2018, Kylin Villa, Shenzhen, title of the presentation: MRE11 UFMylation promotes ATM activation

52. College of Life Sciences Xiamen University, Jan. 2^nd, 2019, title of the presentation: MRE11 UFMylation promotes ATM activation

53. Department of Pharmacology, Case Western Reserve University School of Medicine, Feb. 12^th, 2019, title of the presentation: Post-translational modifications modulate the DNA damage response. 

54. Chinese Society for Cell Biology annual meeting, section chair, April 11^th, 2019, Tianjin, title of the presentation: UFMylation in the DNA Damage Response

55. Kazahstan Medical University (KSPH), April 16^th, 2019, Almaty, title of the presentation: DNA damage response & cancer therapy

56. Institute for Quantitative Biosciences University of Tokyo, April 22^nd, 2019, title of the presentation: UFMylation in the DNA Damage Response18^th Ataxia-Telangiectasia Workshop, Houston Methodist Hospital, Houston, USA, May 1-4^th, 2019, title of the presentation: MRE11 UFMylation promotes ATM activation 

57. Tomas Lindahl International Forum on DNA Repair & Disease, May 18^th, 2019, Shenzhen, China, title of the presentation: UFMylation in the DNA damage response 

58. Hebei Medical University, Shijiazhuang, China, May 28^th, 2019, title of the presentation: UFMylation in the DNA damage response 

59. IMCB, Singapore, June 25^th, 2019, title of the presentation: UFMylation in the DNA damage response 

60. 3^rd Ubiquitin & Protein Homeostasis Symposium, Shenzhen, SUSTech, July 22^nd, 2019, title of the presentation: UFMylation in the DNA damage response 

61. 17^th SCBA, Kunming, July 27^th, 2019, title of the presentation: UFMylation protects genome stability

62. Hebei University, Baoding, Sept. 20^th, 2019, title of the presentation: Post-translational modifications modulate genome stability

63. 9^th Lepzig-Jena-Shenzhen International Meeting on Adaptive Stress Response, Lepzig-Jena, Sept. 29-Oct. 2, 2019, co-organizer, title of the presentation: UFMylation protects genome stability 

64. 16^th Annual Meeting of the Chinese Society for Therapeutics & Radiation Oncology (CSTRO), Shenzhen, Oct. 12, 2019, title of the presentation: Post-translational modifications modulate chemo/radiosensitivity

65. The 10^th isDDRHD, Shenzhen, China, Nov. 8-10^th, 2019, title of the presentation: 10 years of DDR research club and beyond

66. The 11^th isDDRHD, Shenzhen, China, Nov. 6-7^th, 2020, title of the presentation: Polo-like kinases in the DNA damage response

67. International Association of Advanced Materials (IAAM）Fellow Lecture (Webinar), Shenzhen, January 28^th, 2021, title of the presentation: Development of anti-cancer lead compounds targeting genome homeostasis

68. 2021 Annual Meeting of Chinese Society for Cell Biology, April 12-16, Chongqing, co-organizer of the session: Chromatin homeostasis & human disease, title of the presentation: PARP1 and CHK1 coordinate PLK1 kinase activity during the DNA damage response 

69. The 12^th isDDRHD, Shanghai, China, Oct. 22-24^th, 2021, title of the presentation: TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination

70. The 2021 Cold Spring Harbor Asia Conference “DNA metabolism, genomic stability & human disease”, Suzhou, Nov. 22-26^th, 2021, title of the presentation: TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination

71. The 2021 Guangzhou-Shenzhen Cancer Research Symposium & the 3^rd Shenzhen University International Cancer Center Annual Meeting, Shenzhen, Dec. 3-4^th, 2021, title of the presentation: TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination

72. Shenzhen Bay Laboratory, Shenzhen, March 17^th, 2022, title of the presentation: How to ensure or disrupt genome integrity?

73. 29^th meeting of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) in conjunction with 2022 Annual Meeting of Chinese Society for Biochemistry & Molecular Biology (online), Oct. 20^th, 2022, Title of the [presentation: Ubiquitination of CLASPIN regulates the ATR-CHK1 checkpoint signaling

74. The 13^th isDDRHD, Shenzhen, China, Nov. 6-7^th, 2022, title of the presentation: A dithiocarbamate derivative of 2-aminoquinazolin-4(3H)-one promotes BUB3-BUBR1 interaction to overcome taxane chemoresistance

75. 19^th Ataxia-Telangiectasia Workshop, Kyoto, Japan, March 2-5^th, 2023, title of the presentation: Mycobacterium tuberculosis infection-induced activation of cytosolic ATM contains host defense by phosphorylating STING

76. Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena, Germany， March 16^th, 2023, title of the presentation: Primary microcephaly with an unstable genome 

77. 2023 Annual Meeting of Chinese Society for Cell Biology, Suzhou, April 13^th, 2023, title of the presentation: Primary microcephaly with an unstable genome

78. Chinese Agriculture University, Beijing, April 21^st, 2023, title of the presentation: ATR-CHK1 signaling pathway as the guardian of genome integrity

79. Columbia University School of Medicine, New York, May 18^th, 2023, title of the presentation: Regulation of the ATR-CHK1 checkpoint signaling

80. The 14^th isDDRHD, Shenzhen, China, Nov. 3-5^th, 2023, title of the presentation: ATM activation induced by Mycobacterium tuberculosis infection