NAME: Wu, Song

POSITION TITLE: Dean for Department of Urology Institute of Shenzhen University; Vice President of Shenzhen Luohu Hospital Group (The 3^rd? Affiliated? Hospital of Shenzhen University); President of Shenzhen Following Precision Medical Research Institute

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)

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A.?? Personal Statement

I? have committed myself to forefront research in the field of using precision medicine model in bladder cancer treatment and molecular mechanism. Iam the principal investigator of a National Key Research and Development Program of China (Project No. 2017YFA0105900) and a NSFC (China) (Project No. 81672533). I am also holding the post of the editorial board member of the following magazines: European Urology,? Journal of Urology, Cell Research, etc.. I have published 22 papers in international well-known magazines, such as Nature Genetics, European Urology, Cell Research, International Journal of Cancer and so on, and impact factor of his 6 papers reaches 15 points. I have obtained 6 national invention patents. Some honorary titles I have won are as follows: Forbes Under 30 Summit-Influential Elite in Asian Medical Treatment and Health, Guangdong Province branch of Youth Science and Technology Innovation Talents Plan Award, Shenzhen Youth Science and Technology Award, Shenzhen Luohu District High Level Medical Talent,? The National “May 1” Labor Medal.

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B.?? Positions and Honors

Positions and Employment

2009/08-2010/07 ??????Shenzhen Hospital of Peking University

2010/08-2011/05 ??????Affiliated Tumor Hospital of Sun Yat-sen University

2011/06-2012/05 ??????BGI-Shenzhen

2012/06-2015/03 ??????The First Affiliated Hospital of Shenzhen University

2015/03- Present ????????Academic Leader of Urology, Vice President, The Third AffiliatedHospital of ShenzhenUniversity

2015/05- Present????? President, Shenzhen Following Precision Medical Research Institute

2016/04- Present?????? Dean, Department of Urology Institute of Shenzhen University

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Other Experience and Honors

1.??? 2014/06-2018/06?? Committee member, Committee of Department of Urology And Reproduction of Guangdong Provincial Anticancer Association (GDACA)?

2.??? 2015/06-2018/06?? Vicechairman, Board of directors of Guangdong Provincial ?Urology And Reproduction Association

3.??? 2016/06-2019/06?? Youth committee member, the First Youth Committee of Urology Association of Chinese Medical Doctor Association (CMDA)

4.??? 2016/06-2021/06?? Vice chairman, Committee of Department of Precision Treatment of Tumors of Shenzhen Anticancer Association

5.??? 2016/07-2020/07?? Chairman, the First board of directors of Precision Medicine Association of Shenzhen Medical Doctor Association

6.??? 2017/07-2021/07?? Committee member, the Ninth Committee of Institute of Urology of Guangdong Provincial Institute of Medicine

7.??? The Chinese Medical Science and Technology Award (2014)

8.??? Chinese Outstanding Young Scientists Award (2014)

9.??? Guangdong Natural Science and Technology Award (2015)

10.? The Chinese Ministry of Education Outstanding Achievement Award(2015)

11.? Shenzhen Youth Science and Technology Award(2015)

12.? Guangdong Province branch of Youth Science and Technology Innovation Talents Plan Award(2015)

13.? Forbes Under 30 Summit-Influential Elite in Asian Medical Treatment and Health? (2016)

14.? The National “May 1” Labor Medal (2016)

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C.?? Contributions to Science (*: corresponding/co-corresponding author)

A full list of my publications? is enclosed at the end of this document.

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1.??? Study on urinary oncogene genomics

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2.??? Immunotherapy of tumor cell

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3.??? Research on stem cell

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4.??? Research on medical synthetic biology

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5.??? Urological minimally invasive surgery

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D.?? Research Support

Ongoing Research Support

National Key Research and Development Program of China ( 2017YFA0105900)

01/07/2017 to 12/31/2021

Song Wu, PI ?????????????????????????????????????????????????????????????? ￥5,370,000 (direct cost)

Mutation characteristics and evolution of bladder urothelial tissue stem cells

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NSFC general program ( 81672533)??????????????????? 01/01/2017 to 12/31/2020

Song Wu, PI ?????????????????????????????????????????????????????????????? ￥520,000 (direct cost)

Research on function of EP400 gene in bladder tumor recurrence and metastasis and molecular

Mechanisms

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Completed Research Support

NSFC (China) - Youth Science Foundation (81301740)?????? 01/01/2014 to 12/31/2016

????? Song Wu, PI ????????????????????????????????????????????????????????? ￥230,000 (direct cost)

Molecular mechanisms of DUSP-9 involved in the initiation and

progression study in renal cell carcinoma

863 project (2015AA020405)?????????? ?????????????????????? 01/01/2015 to 12/31/2017

Song Wu, PI???????????????????????????????????????????????????????????????? $300,000

Application of single cell genome sequencing in the diagnosis and treatment of pancreatic cancer

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E.??? Representative Publications (*: corresponding author)

1.????? Introduction to Precision Medicine, Chief Editor: Wu S, Sun Yat-sen University Press November, 2015, First Edition

2.????? Chong Li *, Song Wu, Zhao Yang*, Xiaolong Zhang*, Qi Zheng, Ling Lin, Zexiong Niu, Ruiqiang Li, Zhiming Cai, Lei Li，Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells[J]. Cell research.2016 IF=14.812

3.????? Wu S,?Huang P,?Li C,?Huang Y,?Li X,?Wang Y,?Chen C,?Lv Z,?Tang A,?Sun X,?Lu J,?Li W,?Zhou J,?Gui Y,?Zhou F,?Wang D,?Cai Z. Telomerase Reverse Transcriptase Gene Promoter Mutations Help Discern the Origin of Urogenital Tumors: A Genomic and Molecular Study. Eur Urol.?2014 Feb;65(2):274-7.??? IF=14.976

4.????? Wu S,?Chen J,?Dong P,?Zhang S,?He Y,?Sun L,?Zhu J,?Cheng Y,?Li X,?Tang A,?Huang Y,?Gui Y,?Liu C,?Yang G,?Zhou F,?Cai Z,?Wang R. Global gene expression profiling identifies ALDH2, CCNE1 and SMAD3 as potential prognostic markers in upper tract urothelial carcinoma. BMC Cancer.?2014 Nov 18;14:836.???? IF=3.265

5.????? Wu S, Lv Z, Zhu J, Dong P, Zhou F, Li X, Cai Z. Somatic Mutation of the Androgen Receptor Gene Is Not Associated with Transitional Cell Carcinoma: A “Negative” Study by Whole-exome Sequencing Analysis.? Eur Urol. 2013 Dec;64(6):1018-9.?? IF= 14.976

6.????? Wu S, Lv Z, Wang Y, Sun L, Jiang Z, Xu C, Zhao J, Sun X, Li X, Hu L, Tang A, Gui Y, Zhou F, Cai Z, Wang R.? Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma. PLoS One. 2013 Apr 25;8(4):e59936.???? IF=3.057

7.????? Wu S, Sun X, Zhu W, Huang Y, Mou L, Liu M, Li X, Li F, Zhang Y, Wang Z, Li W, Li Z, Tang A, Gui Y, Wang R, Cai Z, Wang D. Evidence for GAL3ST4 mutation as the potential cause of pectus excavatum. Cell research. 2012;22(12):1712-1715.???? IF=14.812

8.????? Wu S, Lai Y, He Y, Li X, Guan Z, Cai Z. Lower urinary tract destruction due to ketamine: a report of 4 cases and review of literature. Journal of addiction medicine. 2012;6(1):85-88. (第一作者) IF=2.065

9.????? Wu S, Wang Y, Sun L, Zhang Z, Jiang Z, Qin Z, Han H, Liu Z, Li X, Tang A, Gui Y, Cai Z, Zhou F.? Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma. BMC cancer. 2011;11:413.??? IF=3.265

10.?? Zhao Yang, Chong Li, Hongjie Liu, Xiaolong Zhang , Zhiming Cai, Liqin Xu, Jian Luo, Yi Huang, Luyun He, Chunxiao Liu, Song Wu*, Single-cell sequencing reveals variants in ARID1A, GPRC5A and MLL2 driving self-renewal of human bladder cancer stem cells. [J]. Eur Urol, 2016.IF=14.976

11.?? Chong Li*, Jihan Wang*, Junfeng Hao*, Baijun Dong*, Yi Li, Xiaoxiao Zhu, Juan Ding, Shuangchun Ren, Heping Zhao, Song Wu*, Yong Tian, Guo-Qing Wang Reduced cytosolic carboxypeptidase 6 (CCP6) level leads to accumulation of serum polyglutamylated DNAJC7 protein: A potential biomarker for renal cell carcinoma early detection [J]. Oncotarget, 2015.? IF= 5.008

12.?? Liu H,?Wu S*,?Duan L,?Zhu W,?Zhang S,?Hu X,?Jia W,?Yang G,?Liu C,?Li W,?Yang L,?Guo L,?Lin Y,?Wang Y,?He M,?Yang Z,?He Y,?Cai Z,?Wang D. Identification of a novel EXT1 mutation in patients with? hereditary multiple exostosis by exome sequencing. Oncol Rep.?2015 Feb;33(2):547-52. IF= 2.486???????

13.?? Y. Lin, Z. Yang, A. Xu, P. Dong, Y. Huang, H. Liu, F. Li, H. Wang, Q. Xu, Y. Wang, D. Sun, Y. Zou, X. Zou, Y. Wang, D. Zhang, H. Liu, X. Wu, M. Zhang, Y. Fu, Z. Cai, C. Liu, and S.Wu*. PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3b/CTNNB1 signaling pathway. Sci Rep. 2015 Mar.?? IF=5.228

14.?? Yingying He，Qin Wang，Meng Zhang，Bo Wang，Zuying Xiong，Qiong Luo，Song Wu*. Abdominal Aortic Dissection in a Patient With Autosomal Dominant Polycystic Kidney Disease After Starting Peritoneal Dialysis[J]. Urology Case Reports, 2014, 2(4): 123-125..?

15.?? Huang Y, Gao S, Wu S*, Song P, Sun X, Hu X, Zhang S, Yu Y, Zhu J, Li C, Qin Z, Xie L, Yao Q, Tang A, Li Z, Guo G, Wan S, Dong P, Sun L, Li W, Wang D, Gui Y, Yang H, Zhou F, Zhang X, Cai Z. Multilayered molecular profiling supported the monoclonal origin of metastatic renal cell carcinoma[J]. International Journal of Cancer, 2014, 135(1): 78-87.? IF=5.531

16.?? Meng Zhang&, Hu Xiong&, Lu Fang, Wei Lu, Xun Wu, Yong-Qiang Wang, Zhi-Ming Cai*, Song Wu*. Meta-Analysis of the Association between H63D and C282Y Polymorphisms in HFE and Cancer Risk [J]. Asian Pacific journal of cancer prevention: APJCP, 2014, 16(11): 4633-4639.

17.?? ]Meng Zhang&, Hu Xiong&, Lu Fang&, Wei Lu, Xun Wu, Zhan-Sen Huang, Yong-Qiang Wang, Zhi-Ming Cai*, Song Wu*. Paraoxonase 1 (PON1) Q192R Gene Polymorphism and Cancer Risk: A Meta-Analysis Based on 30 Publications[J]. Asian Pacific journal of cancer prevention: APJCP, 2015, 16(10): 4457.

18.?? Yu Fu, Youcheng Lin, Zhao Yang, Guosheng Yang, Gaoyuan Li, Yuejia Liu, Xi Tan, Yi Huang, Xun Wu, Yongqiang Wang, Hu Xiong, Meng Zhang,Lu Fang, Yukun Ge, Jun Zeng, Yangke Cai,? Jian Bai, Song Wu*. FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis[J]. Medical Oncology, 2015, 32(8): 1-9.. IF=2.486

19.?? Xun Wu,Youcheng Lin, Liping Shi, Yi Huang, Caiyong Lai,Yongqiang Wang, Meng Zhang,Shupeng Wang, Baoli Heng,Ganshen Yu,Xinghua Du,Lu Fang,Yu Fu,Jie Chen,Zexiong Guo,Zexuan Su, Song Wu*. Upregulation of centromere protein H is associated with progression of renal cell carcinoma[J]. Journal of Molecular Histology, 2015, 46(4-5): 377-385. . IF=2.221

20.?? Zhang SQ, Dong P, Zhang ZL, Wu S*, Guo SJ, Yao K, Li YH, Liu ZW, Han H, Qin ZK, Cai ZM, Li XX, Zhou FJ. Renal plasmacytoma: Report of a rare case and review of the literature.Oncol Lett. 2013 Jun;5(6):1839-1843.??? IF=1.482

21.?? Guo G*, Sun X*, Chen C*, Wu S, Huang P, Li Z, Dean M, Huang Y, Jia W, Zhou Q, Tang A, Yang Z, Li X, Song P, Zhao X, Ye R, Zhang S, Lin Z, Qi M, Wan S, Xie L, Fan F, Nickerson ML, Zou X, Hu X, Xing L, Lv Z, Mei H, Gao S, Liang C, Gao Z, Lu J, Yu Y, Liu C, Li L, Fang X, Jiang Z, Yang J, Li C, Zhao X, Chen J, Zhang F, Lai Y, Lin Z, Zhou F, Chen H, Chan HC, Tsang S, Theodorescu D, Li Y, Zhang X, Wang J, Yang H, Gui Y, Wang J, Cai Z. Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nature genetics. 2013 Dec;45(12):1459-63.???? IF=31.616

22.?? Guo G, Gui Y, Gao S, Tang A, Hu X, Huang Y, Jia W, Li Z, He M, Sun L, Song P, Sun X, Zhao X, Yang S, Liang C, Wan S, Zhou F, Chen C, Zhu J, Li X, Jian M, Zhou L, Ye R, Huang P, Chen J, Jiang T, Liu X, Wang Y, Zou J, Jiang Z, Wu R, Wu S, Fan F, Zhang Z, Liu L, Yang R, Wu H, Yin W, Liu Y, Peng H, Jiang B, Feng Q, Li C, Xie J, Lu J, Kristiansen K, Li Y, Zhang X, Li S, Wang J, Yang H, Cai Z. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nature genetics. 2012;44(1):17-19.??? IF=31.616

23.?? Gui Y, Guo G, Huang Y, Hu X, Tang A, Gao S, Wu R, Chen C, Li X, Zhou L, He M, Li Z, Sun X, Jia W, Chen J, Yang S, Zhou F, Zhao X, Wan S, Ye R, Liang C, Liu Z, Huang P, Liu C, Jiang H, Wang Y, Zheng H, Sun L, Liu X, Jiang Z, Feng D, Wu S, Zou J, Zhang Z, Yang R, Zhao J, Xu C, Yin W, Guan Z, Ye J, Zhang H, Li J, Kristiansen K, Nickerson ML, Theodorescu D, Li Y, Zhang X, Li S, Wang J, Yang H, Cai Z. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nature genetics. 2011;43(9):875-878. ?????IF=31.616

24.?? Lai Y, Wu S, Ni L, Chen Z, Li X, Yang S, Gui Y, Guan Z, Cai Z, Ye J. Ketamine-associated urinary tract dysfunction: an underrecognized clinical entity. Urol Int. 2012;89(1):93-6.? (Co-first author)? IF=1.313

25.?? Li Z, Huang Y, Li H, Hu J, Liu X, Jiang T, Sun G, Tang A, Sun X, Qian W, Zeng Y, Xie J, Zhao W, Xu Y, He T, Dong C, Liu Q, Mou L, Lu J, Lin Z, Wu S, Gao S, Guo G, Feng Q, Li Y, Zhang X, Wang J, Yang H, Wang J, Xiong C, Cai Z, Gui Y. Excess of Rare Variants in Genes that are Key Epigenetic Regulators of Spermatogenesis in the Patients with Non-Obstructive Azoospermia. Sci Rep. 2015 Mar 5;5:8785.? IF=5.578

26.?? Dong P, Liu ZW, Li XD, Li YH, Yao K, Wu S, Qin ZK, Han H, Zhou FJ. Risk actors for relapse in patients with clinical stage I testicular nonseminomatous germ cell tumors. Med Oncol. 2013 Mar;30(1):494.? IF= 2.634

27.?? Zhang SQ, Wu S, Yao K, Dong P, Li YH, Zhang ZL, Li XX, Zhou FJ Retroperitoneal schwannoma mimicking metastatic seminoma: case report and literature review. Chin J Cancer. 2013 Mar;32(3):149-52.? IF=2.155

28.?? Lv ZJ, Wu S*, Dong P, Yao K, He YY, Gui YT, Zhou FJ, Liu ZW, Cai ZM. Clinical outcomes in patients with stage I non-seminomatous germ cell cancer. Asian J Androl. 2013 Jul;15(4):558-63.?????? IF=2.596

29.?? Zhu J, Jiang Z, Gao F, Hu X, Zhou L, Chen J, Luo H, Sun J, Wu S, Han Y, Yin G, Chen M, Han Z, Li X, Huang Y, Zhang W, Zhou F, Chen T, Fa P, Wang Y, Sun L, Leng H, Sun F, Liu Y, Ye M, Yang H, Cai Z, Gui Y, Zhang X. A systematic analysis on DNA methylation and the expression of both mRNA and microRNA in bladder cancer. PloS one. 2011;6(11):e28223.? IF=3.057

30.?? Shupeng Wang, Xiang Wang, Wu S. Progress in the study of the metabolism of renal cell carcinoma. Chinese Journal of Department of Urology, 2015,36(3).

31.?? Meng Zhang, Yitian Wang, Liangfu Xie, Zhiming Cai, Wu S. Tumor immune library research to promote cancer vaccine research, Life Science, 2015, 27(2): 120-126.

32.?? Meng Zhang，Anbang He, Zhiming Cai，Wu S. Progress of the research on the human germ cell tumor of the testis. Chinese Journal of Andrology, 2015,21(4):363-370.

33.?? Yitian Wang, Meng Zhang, Bo Wang, Zhiming Cai1*, Wu S. Research progress of telomerase reverse transcriptase in tumor of the urinary system. Life Science, 2014, 26(8): 804-809.

34.?? Meng Zhang, Zeyu Yang, Liangfu Xie, Zhiming Cai*, Wu S. The development of targeted therapy in renal cell cancer genomics. Life Science, 2014, 26(8): 814-822.

35.?? Wu S, Zhiming Cai*. Progress of single tumor cell sequencing. Life Science, 2011,23(1):136-139.

Contact

Email: wusong@szu.edu.cn

Office Tel: 0755-82202540