Associate Professor, Independent PI of International Cancer Center, Shenzhen University Health Science Center

In June 2019, I earned my PhD degree from the University of Freiburg, Germany. Afterwards, I joined the Institute of Virology at the Medical Center of the University of Freiburg to engage in post-doctoral scientific research. In June 2020, I joined Shenzhen University as an associate professor and the independent PI of International Cancer Center.

I have long been engaged in the research field of pathogen infection and host immunity, inflammatory diseases and cancer immunomodulation mechanisms. My research works have published in 17 peer-reviewed top journals including Nature Immunology, Nature Reviews Immunology, Journal of Virology, Journal of Immunology, eLife, International Journal of Pharmaceutics. Among them, there are 11 first author or corresponding author papers, with an impact factor of more than 130, an H-index of 11, and a citation rate of more than 560 times. My research project was supported by the Basic Research Program of Science and Technology Plan of Shenzhen, NSFC (China), the EU Seventh Framework Project, and the German Research Foundation (DFG). I obtained EU Marie Curie scholarship, and as the second core member of the German region in charge of the EU Seventh Framework Project ‘Universal influenza vaccine’. I also obtained the Summa Cum Laude, the highest honor of German PhD degree, and was awarded the 2019 Chinese Government Award for Outstanding Self-financed Students Abroad by the China Scholarship Council (500 students in worldwide/year). In addition, I have served as a special reviewer for many well-known international journals, a member of the International Cytokine Interferon Society and the editorial board of Austin Biology.

Research Interests:

1. Pathogen infection and host immunity

2.Immunomodulation networks mediated treatment in Cancer and inflammatory diseases

Research Projects:

The Basic Research Program of Science and Technology Plan of Shenzhen Project (No JCYJ20150324141711578)                                

Liang Ye, PI  

The effects and mechanisms of IL-10 regulated IL-33/ST2 pathways in rheumatoid Arthritis

07/2015 to /12/2017, ￥100,000                                                                                

Selected Peer-reviewed Publications:

1.  Lea MQ., Ye L#., Bernasconi V., Carpentier R., Fasquelle F., Lyck N., Staeheli P., Betbeder D. Prevention of influenza virus infection and transmission by intranasal administration of a porous maltodextrin nanoparticle-formulated vaccine. International Journal of Pharmaceutics. 2020, 582, 119348.

2.  Ye L., Schnepf D., Becker J., Ebert K., Tanriver Y., Bernasconi V., Henrik Gad H., Hartmann R., Lycke N., & Staeheli P. Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin. Nature Immunology. 2019, 20, 593–601. This paper was highly commented by Nature Immunology. 2019, 20, 522–524.

3. Ye L^#., Schnepf D^#., & Staeheli P. Interferon-λ orchestrates innate and adaptive immune responses at mucosal barriers. Nature Reviews Immunology. 2019, 19, 614-625.

4. Ye L., Ohnemus A., Ong Li C., Henrik H., Hartmann R., Lycke N., & Staeheli P. Type I and type III interferons differ in their adjuvant activities for influenza vaccines. Journal of Virology. 2019, 93, e01262-19.

5.  Ye L., Jiang B., Deng J., Du J., Xiong W., Guan Y., ... & Huang Z. IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17–Triggering Cytokine Production and Limiting Th17 Cell Proliferation. Journal of Immunology. 2015, 1401810.