1. Human papillomavirus-mediated carcinogenesis and tumor progression | Fadi Abboodi, Nella C. Delva, Jennifer Emmel, Ariana Renrick, Phillip Buckhaults, Carolyn E. Banister, Kim E. Creek & Lucia Pirisi

High-risk human papillomaviruses (HPVs) are a leading cause of cervical and oropharyngeal cancer. Now, Lucia Pirisi and colleagues have reviewed the mechanisms and cellular pathways underlying how HPVs promote carcinogenesis. They focus their analysis on the interactions between the HPV E6 and E7 oncoproteins with p53 and pRB, respectively. Drawing on their own research experience, Pirisi et al. propose a pivotal role for p53 in HPV-mediated transformation throughout cancer development.  

High-risk human papillomaviruses (HPV)是引起宫颈癌和口咽癌等癌症的主要病因。在这篇综述里，南卡罗来纳大学医学院的Lucia Pirisi和她的同事介绍了HPV引起细胞癌变的主要机制和细胞通路，尤其是HPV E6 and E7蛋白分别与p53和pRB的相互作用，帮助我们更好的理解HPV和一些癌症的关系。

Lucia Pirisi教授：https://www.researchgate.net/profile/Lucia-Pirisi

全文下载：https://link.springer.com/article/10.1007/s42764-021-00038-x

2. The post translational modification of key regulators of ATR signaling in DNA replication | Yuping Chen & Jian Yuan

ATM and ATR signaling is essential for ensuring precision during DNA replication and safeguarding stability of the genome. Here, Yuping Chen and Jian Yuan outline the various post-transcriptional modifications (PTMs) that occur during ATR signaling transduction and how these might impact on DNA replication. The researchers hope that improving our understanding of these complex PTMs will shed more light on how DNA replication is regulated.

ATM和ATR是DNA复制过程中两条重要的调节通路，对维持基因组稳定非常重要。在这篇综述里，同济大学医学院的袁健和他的同事向我们重点介绍了在DNA复制过程中ATR通路的各种转录后修饰，有助于我们更好地了解DNA复制信号通路的复杂机制。

袁健 教授：https://med.tongji.edu.cn/info/1406/4515.htm

全文下载：https://link.springer.com/article/10.1007/s42764-021-00036-z

3. Nuclear envelope integrity, DNA replication, damage repair and genome stability | Wenjun Pu, Haihui Zhang, Peiwu Qin & Lin Deng

The nuclear envelope (NE) helps ensure genome integrity and stability. Indeed, perturbations to NE integrity have been associated with various diseases and genome instability. In this review, Lin Deng and colleagues first describe the interactions that occur between NE components and DNA replication and repair factors. Then they summarize the potential triggers of NE loss and the cellular consequences. The researchers hope that further research in this area will ultimately lead to improvements in the diagnosis and treatment of related diseases, such as cancers and laminopathies.  

The nuclear envelope (NE) 在维持基因组完整性和稳定性发挥重要作用。在这篇综述里，深圳湾实验室的邓麟和他的同事描述了NE成分与DNA复制和修复因子之间的相互作用，总结了NE丢失的触发因素及其细胞后果，对癌症和椎板病等相关疾病的诊断和治疗提供参考。

邓麟研究员： https://www.szbl.ac.cn/scientificresearch/researchteam/387.html

全文下载：https://link.springer.com/article/10.1007/s42764-021-00039-w

4. Repair of programmed DNA lesions in antibody class switch recombination: common and unique features | Yafang Shang & Fei-Long Meng

Antibody class switch recombination (CSR) permits the transformation of antibodies produced by B cells from one type to another. Such immune diversification allows for the elimination of pathogens through programmed DNA lesions at antigen receptor genes. In this review, Yafang Shang and Fei-long Meng compare the mechanism of antibody CSR to programmed DNA damage repair. They highlight the most recent advances in understanding DNA repair/replication coordination. Then, they elaborate on the application of CSR in end-joining, resection and translation synthesis assays. 

类开关重组（CSR）是一种可以使B细胞所生产的抗体从一种类型转变成另一种类型的生物学机制，保证了免疫的多样性。在免疫多样化中，一般的DNA修复机制可用于将程序化的DNA损伤转化为具有共同和独特特征的基因突变或重组事件。在这篇综述里，中科院上海细胞生化所的孟飞龙和他的同事以抗体CSR为例，介绍了程序化DNA损伤修复中的共同和独特的特征，对我们了解该领域的最新进展提供参考。 

孟飞龙研究员：http://people.ucas.ac.cn/~0041174

全文下载：https://link.springer.com/article/10.1007/s42764-021-00035-0

5. SIRT7–SREBP1 restrains cancer cell metabolic reprogramming by upregulating IDH1 | Fengting Su, Xiaolong Tang, Guo Li, Andreas Koeberle & Baohua Liu

SIRT7 is a key regulator of tumorigenesis but the underlying mechanisms are unclear. Now, Baohua Liu and colleagues have found that both SIRT7 and IDH1 are downregulated in breast cancer cells. They go on to show that SIRT7 is essential for enhancing IDH1 expression via SREBP1. Interestingly, SIRT7 insufficiency results in suppressed lipogenesis and gluconeogenesis and promoted glycolysis. The overall consequence is that cancer cells can rapidly proliferate due to the Warburg effect. It thus seems that the SIRT7–IDH1 axis contributes to cancer cell metabolic reprogramming and thus might constitute a point of therapeutic intervention.

SIRT7是已知的重要的肿瘤调控因子之一。在这篇文章里，深圳大学的刘宝华和他的同事报道了SIRT7–IDH1轴调节癌细胞的代谢重编程，并揭示α-KG参与其调控的机制，为肿瘤治疗提供新思路。

刘宝华教授：https://med.szu.edu.cn/Item/365.aspx

全文下载：https://link.springer.com/article/10.1007/s42764-021-00031-4