1. Roles of Claspin in regulation of DNA replication, replication stress responses and oncogenesis in human cells | Hao-Wen Hsiao, Chi-Chun Yang & Hisao Masai

The Atr-claspin-chk1 pathway has an important role in stabilizing DNA replication forks and coping with DNA replication stagnation. In this review, Professor Hisao Masai and colleagues from the University of Tokyo introduce to us how claspin interacts with various kinases and replication factors. They then explain how the formed ATR-Claspin-Chk1 pathway regulates DNA replication. This review serves as an excellent resource to improve our understanding of how DNA replication is tightly regulated.

ATR-Claspin-Chk1通路对稳定DNA复制叉和应对DNA复制停滞起着至关重要的作用，在这篇综述里，日本东京大学的Hisao Masai教授向我们介绍了Claspin如何与多种激酶和复制因子相互作用， 形成的ATR-Claspin-Chk1通路如何调控DNA复制，帮助我们更好地理解DNA复制调控过程，以及为癌症诊断治疗提供了参考。

Hisao Masai教授：https://www.k.u-tokyo.ac.jp/pros-e/person/hisao_masai/hisao_masai.htm

全文下载：https://link.springer.com/article/10.1007/s42764-021-00049-8

2. The emergence of a unified mechanism in the Fanconi anemia pathway| Xinlin Xu, Rong Guo & Dongyi Xu

Fanconi anemia (FA) is a rare genetic disease that causes physical abnormalities, organ defects, and is associated with an increased risk of certain cancers. Mutations in around 15 genes can cause Fanconi anemia, the proteins of which are involved in the FA pathway. In this review, Professor Dongyi Xu and his team at Peking University summarize the various genes and regulatory factors involved in the FA pathway. They put forward a potential endogenous etiology of FA, and speculate on emerging treatments for this debilitating disease.

范可尼贫血 (FA) 是一种罕见的遗传性疾病，在这篇综述里，北京大学的徐冬一教授团队总结了FA 通路的各类基因及调控因素，并提出了FA症状的潜在内源性病因，为FA治疗提供参考和新思路。

徐冬一教授：http://www.bio.lb.pku.edu.cn/teacher_dis_oa.php?cid=208&&teaid=85

全文下载：https://link.springer.com/article/10.1007/s42764-021-00053-y

3. The role of telomere dysfunction in genomic instability and age-related diseases | Lu Xu, Kexiong Zhang & Yu-Sheng Cong

The telomere is a unique structure located at the end of a chromosome; it gradually shortens with each cell division. Telomere shortening or dysfunction can lead to genomic instability and is associated with various diseases, including cancer, cardiovascular diseases and neurodegenerative diseases. In this review, Professor Yusheng Cong and colleagues at Hangzhou Normal University update us on the latest progress made in understanding telomere regulation and explain the relationship between telomere imbalance and age-related diseases.

端粒是位于染色体末端的特殊结构，会随着每一次细胞分裂而逐渐缩短。端粒缩短或功能障碍会导致基因组不稳定，并与多种疾病有关，包括癌症、心血管疾病和神经退行性疾病。在这篇综述里，杭州师范大学的丛羽生教授向我们介绍了端粒调节的最新进展，帮助我们了解端粒失调与衰老以及年龄相关疾病的关系。

丛羽生教授：https://www.hznu.edu.cn/c/2013-10-31/340190.shtml

全文下载：https://link.springer.com/article/10.1007/s42764-021-00052-z

4. ¹H NMR-based assay for lysine demethylase LSD1 and its application to inhibitor screening | Hui Wang, Minghui Shu, Xiaofan Li, Wei-Guo Zhu, He Wen & Zebin Mao

Lysine-specific demethylase 1 (LSD1) is an enzyme with oxidative activity. With the assistance of flavin adenine dinucleotide, it can catalyze the production of formaldehyde and induce various cancers. In this primary research article, Dr.He Wen (Shenzhen University), Professor Zebin Mao (Peking University) and colleagues introduce a method based on nuclear magnetic resonance to detect the enzymatic activity of LSD1. This method can be performed in a reaction buffer without any extraction step, to achieve a time-dependent absolute quantification. Going forward, this assay might improve the detection efficiency of LSD1 and thus aid the development of LSD1 inhibitors.

赖氨酸特异性脱甲基酶1(LSD1)是一类具有氧化活性的酶，在黄素腺嘌呤二核苷酸 (FAD)的协助下，可在体内催化产生甲醛，进而诱发各种癌症。深圳大学的文赫博士与北京大学的毛泽斌教授团队介绍了一种基于NMR检测 LSD1 酶活性的方法，该方法可在反应缓冲液中进行，无需任何提取步骤，实现时间依赖的绝对定量，并可用于酶抑制剂筛选，有助于提高LSD1检测效率与 LSD1 抑制剂的开发。

毛泽斌 教授：

https://sbms.bjmu.edu.cn/jsdw/bssds/d7aa598ed1f04cad93941d297fcf893e.htm

文赫助理教授：https://med.szu.edu.cn/Item/3127.aspx

全文下载：https://link.springer.com/article/10.1007/s42764-021-00051-0