刘雪

Genome-wide CRISPRi screens for high-throughput fitness quantification and identification of determinants for dalbavancin susceptibility in Staphylococcus aureus

Cell Host & Microbe

20.6

付利

ATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8+ T cells

Nature Communications

14.7

许兴智

VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy

AUTOPHAGY

14.6

朱卫国

hnRNPA2B1 deacetylation by SIRT6 restrains local transcription and safeguards genome stability

Cell Death & Differentiation

13.7

于力

Bispecific CAR-T cells targeting CD19/20 in patients with relapsed or refractory B cell non-Hodgkin lymphoma: a phase I/II trial

Blood Cancer Journal

12.9

王雷

PD-L1-expressing tumor-associated macrophages are immunostimulatory and associate with good clinical outcome in human breast cancer

Cell Reports Medicine

11.7

许兴智

FOXP1 phosphorylation antagonizes its O-GlcNAcylation in regulating ATR activation in response to replication stress

EMBO Journal

9.5

朱卫国

DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair

PNAS

9.4

周景峰

Neratinib impairs function of m6A recognition on AML1-ETO pre-mRNA
and induces differentiation of t (8;21) AML cells by targeting HNRNPA3

Cancer Letters

9.1

朱卫国

Immune checkpoint reprogramming via sequential nucleic acid delivery strategy optimizes systemic immune responses for gastrointestinal cancer immunotherapy

Cancer Letters

9.1

吕德生

R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis

Cell Communication and Signaling

8.2

吕德生

CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism

cell reports

7.5

朱卫国

The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability

cell reports

7.5

许兴智

ULK1-dependent phosphorylation of PKM2 antagonizes O-GlcNAcylation and regulates the Warburg effect in breast cancer

ONCOGENE

6.9

朱卫国

Discovery of Novel PROTAC SIRT6 Degraders with Potent Effcacyagainst Hepatocellular Carcinoma

Journal of Medicinal Chemistry

6.8

于力

DNA methylation landscape reveals GNAS as a decitabine-responsive marker in patients with acute myeloid leukemia

NEOPLASIA

6.3

于力

Systemic tumor regression with synergy therapy: radiotherapy and CAR-T

Cell Death Discovery

6.1

于力

Complete remission of advanced pancreatic cancer induced by claudin18.2-targeted CAR-T cell therapy: a case report

Frontiers in Immunology

5.7

吕德生

The CK1e/SIAH1 axis regulates AXIN1 stability in colorectal cancer cells

Molecular Oncology

5

朱卫国

YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair

iScience

4.6

朱卫国

Chromatin lysine acylation: On the path to chromatin homeostasis and genome integrity

Cancer Science

4.5

许兴智

PTIP UFMylation promotes replication fork degradation in BRCA1-deficient cells

JOURNAL OF BIOLOGICAL CHEMISTRY

4

许兴智

USP11 deubiquitinates E-cadherin and maintains luminal fate of mammary tumor cells to suppress breast cancer

JOURNAL OF BIOLOGICAL CHEMISTRY

4

王雷

Immunological Mechanisms behind Anti-PD-1/PD-L1 Immune Checkpoint Blockade: Intratumoral Reinvigoration or Systemic Induction?

biomedicines

3.9

朱卫国

Caspase-4 in glioma indicates deterioration and unfavorable prognosis by affecting tumor cell proliferation and immune cell recruitment

Scientific Reports

3.8

刘琦

Bioorthogonal Diels-Alder Click Chemistry-based Pre-targeted PET Imaging Strategy for Monitoring Programmed Death-Ligand 1 Expression

ACS Omega

3.7

叶亮

MCM5 is a Novel Therapeutic Target for Glioblastoma

OncoTargets and Therapy

2.7

张素平

A human monoclonal antibody neutralizes SARS-CoV-2 Omicron variants by targeting the upstream region of spike protein HR2 motif

hLife

-

张素平

Immunotherapy shapes B-cell receptor repertoire to induce anti-tumor antibodies production in colon and lung cancer

Genome Instability & Disease

-

许兴智

MUS81 UFMylation at K400 promotes cell survival in response to camptothecin-induced replication stress

Genome Instability & Disease

-

叶亮

Identification of potential targets of chrysin in treating HSV‑1 infection: a network pharmacology study

Genome Instability & Disease

-