副教授

邮箱：dongchunni@szu.edu.cn

       倪冬春博士，“百人计划”副教授，2020年获得瑞士巴塞尔大学博士学位，随后赴瑞士洛桑联邦理工学院（EPFL）从事博士后研究。2025年2月加入深圳大学医学部。倪冬春博士长期致力于功能性多肽、蛋白质设计及相关作用机制研究。通过整合人工智能、结构生物学和高通量筛选等技术，开发针对肿瘤耐药性和细菌耐药性的创新药物。其研究重点包括新型抗生素的发现、抗肿瘤药物的靶向设计及药理机制解析，旨在为临床耐药性问题提供突破性解决方案。已发表学术论文30余篇，包括Nature Structural & Molecular Biology、Science Advances、Nature Microbiology、Nature Communications、Molecular cell、Nature 、Plos Pathogens和PNAS等知名期刊。目前担任Engineering Microbiology青年编委；Nature、Nature Communications、Cell Research和Signal Transduction and Targeted Therapy 等期刊审稿人。

研究方向:

       1）创新型抗生素设计

       2）功能多肽、蛋白质设计

       3）创新型抗肿瘤靶向分子设计

代表性成果:

       1.Ekundayo B, Torre D, Beckert B, Nazarov S, Myasnikov A, Stahlberg H*, Ni D^#*. Structural insights into the regulation of Cas7-11 by TPR-CHAT. Nature Structural & Molecular Biology. 2023 Feb;30(2):135-9.

       2.Ni D*, Lu X, Stahlberg H, Ekundayo B. Activation mechanism of a short argonaute-TIR prokaryotic immune system. Science Advances. 2023 Jul 19;9(29)

       3.Ekundayo, B., Arullampalam, P., Gerber, C., Haemmerli, A. F., Guichard, S., Boukenna, M., ... & Ni, D. (2024). Identification of a Binding Site for Small Molecule Inhibitors Targeting Human TRPM4. Nature Communications, 2025-01.

       4.Sedzicki, J. #, Ni, D^#, Lehmann, F., Stahlberg, H., & Dehio, C. (2024). Structure-function analysis of the cyclic β-1, 2-glucan synthase from Agrobacterium tumefaciens. Nature Communications, 15(1), 1844

       5.Ni D, Turelli P, Beckert B, Nazarov S, Uchikawa E, Myasnikov A, Pojer F, Trono D, Stahlberg H, Lau K. Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range. PLoS Pathogens. 2023 Apr 5;19(4): e1011206.

       6.Fenwick C#, Turelli P#, Ni D^#, Perez L, Lau K, Herate C, Marlin R, Lana E, Pellaton C, Raclot C, Esteves-Leuenberger L. Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys. Nature Microbiology. 2022 Sep;7(9):1376-89.

       7.Sedzicki J#, Ni D^#, Lehmann F, Wu N, Zenobi R, Jung S, Stahlberg H, Dehio C. Mechanism of cyclic β-glucan export by ABC transporter Cgt of Brucella. Nature Structural & Molecular Biology. 2022 Dec;29(12):1170-7.

       8.Botte M, Ni D^#, Schenck S, Zimmermann I, Chami M, Bocquet N, Egloff P, Bucher D, Trabuco M, Cheng RK, Brunner JD. Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation. Nature communications. 2022 Apr 5;13(1):1826.

       9.Cimmino Lorenzo#, Duarte Américo G#, Dongchun Ni^#, Ekundayo Babatunde, Pereira Inês A.C., Stahlberg Henning, Holliger Christof, Maillard Julien. Structural of the membrane-bound menaquinol:organohalide oxidoreductase complex. Nature Communications 2023 Nov 14, 7038.

       10.Gainza, P., Wehrle, S., Van Hall-Beauvais, A., Marchand, A., Scheck, A., Harteveld, Z., Buckley, S., Ni, D., Tan, S., Sverrisson, F. and Goverde, C., George F. Gao …&  & Correia, B. Ef. De novo design of protein interactions with learned surface fingerprints. Nature, 2023. pp.1-9.