副教授

邮箱：liu_qi@szu.edu.cn

2011年9月获得德国海德堡大学放射治疗学博士学位，2023年2月入职深圳大学医学部，担任卡尔森国际肿瘤中心副教授，曾在美国哈佛大学医学院和加州大学旧金山分校担任博士后研究员和项目科学家。刘琦博士长期从事放射医学与癌症精准医疗的临床前研究，科研方向包括DNA损伤反应、细胞死亡模式、放射敏化与防护、肿瘤生物学特点与药物靶点等；回国后主要从事分子靶向性肿瘤放射诊疗学研究，利用加速器或核素产生的光子、电子、质子、中子、重离子等射线应用于癌症的分子靶向放疗或在体分子影像技术。刘琦博士项目执行经验丰富，曾领导多项科研课题，与世界的知名学者专家合作，取得了多项重要研究成果，发表在Science Translational Medicine、Clinical Cancer Research、Oncogene等国际著名学术期刊上，目前已经发表SCI论文40余篇。刘博士担任多个国际知名学术期刊的审稿专家和放射学临床研究期刊的编辑，是国际放射研究协会、美国癌症研究协会和放射肿瘤学协会、中华放射肿瘤专业委员会、广东省药学会委员。

研究方向：

1.分子靶向性肿瘤放射诊疗学

2.DNA损伤修复的分子机制

3.抗肿瘤药物药理学

主持项目：

1.国家自然科学基金委面上项目，可替换的非同源末端连接的DNA修复模式在口咽癌精准诊疗中的功能及分子机制研究，项目批准号82073007， 2021.01-2024.12。

代表性成果:

1. Qi Liu, Luis Palomero, Jade Moore, Ines Guix, Roderic Espin, Alvaro Aytés, Jian-Hua Mao, Amanda G. Paulovich, Jeffrey R. Whiteaker, Richard G. Ivey, George Iliakis, Daxian Luo, Anthony J. Chalmers, John Murnane, Miquel Angel Pujana, Mary Helen Barcellos-Hoff: “Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types”. Science Translational Medicine.10 Feb 2021: Vol. 13, Issue 580.

2. Qi Liu, Lin Ma, Trevor Jones, Luis Palomero, Miquel A. Pujana, Haydeliz Martinez-Ruiz, Patrick Ha, John Murnane, Isabel Cuartas, Joan Seoane, Michael Baumann, Annett Linge, Mary Helen Barcellos-Hoff: “Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End-Joining”. Clinical Cancer Research. 2018 Dec 1; 24(23):6001-6014.

3.Qi Liu, Liliana Gheorghiu, Michael Drumm, Rebecca Clayman, Alec Eidelman, Matthew F. Wszolek, Aria Olumi, Adam Feldman, Meng Wang, Lynnette Marcar, Deborah E. Citrin, Chin-Lee Wu, Cyril H. Benes, Jason A. Efstathiou and Henning Willers: “PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53”. Oncogene, 2018 May; 37(21):2793-2805.

4.Qi Liu, Genwen Chen, Jade Moore, Ines Guix, Dimitris Placantonakis, Mary Helen Barcellos-Hoff: “Exploiting Canonical TGFβ Signaling in Cancer Treatment”. Molecular Cancer Therapeutics, 2022 Jan;21(1):16-24.

5.Qi Liu, Frank Schneider,Lin Ma, Frederik Wenz and Carsten Herskind: “Relative Biologic Effectiveness (RBE) of 50 kV X-rays Measured in a Phantom for Intraoperative Tumor-Bed Irradiation”. Int J Radiat Oncol Biol Phys, 85(4):1127-33; 2013, Mar 15. Issue Highlights.

6. Qi Liu*, Meng Wang*, Ashley M. Kern, Saman Khaled, Jing Han, Beow Y.Yeap, Theodore S. Hong, Jeff Settleman, Cyril H. Benes, Kathryn D. Held, Jason A. Efstathiou, and Henning Willers: “Adapting a Drug Screening Platform to Discover Associations of Molecular Targeted Radiosensitizers with Genomic Biomarkers”. Mol Cancer Res, 2015 Apr;13(4):713-20.

7. Qi Liu, Priyanjali Ghosh, Nicole Magpayo, Mauro Testa, Shikui Tang, Liliana Gheorghiu, Peter Biggs, Harald Paganetti, Jason A. Efstathiou, Hsiao-Ming Lu, Kathryn D. Held, and Henning Willers: “Lung Cancer Cell Line Screen Links Fanconi Anemia/BRCA Pathway Defects to Increased Relative Biological Effectiveness of Proton Radiation”. Int J Radiation Oncol Biol Phys, 2015 Apr1, 91(5):1081-9.

8. Qi Liu, Tracy S. A. Underwood, Jong Kung, Meng Wang, Hsiao-Ming Lu, Harald Paganetti, Kathryn D. Held, Theodore S. Hong, Jason A. Efstathiou, and Henning Willers: “Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation”. Int J Radiation Oncol Biol Phys, 2016 May 1, 95(1):78-85.

9. Jing Xiang, Lin Ma, Zheng Gu, Hongjun Jin, Hongbin Zhai, Qiushi Ren^#,Qi Liu^#: “A Boronated Derivative of Temozolomide Showing Enhanced Efficacy in Boron Neutron Capture Therapy of Glioblastoma”. Cells, 2022, Mar 31;11(7):1173.

10. Nan Zuo, Lin Ma, Tianyang Liu, Weitao Hu, Yupeng Luo, He Meng, Qiushi Ren, Yongqiang Deng, Lanlan Wei^#, Qi Liu^#: “Human papillomavirus associated XPF deficiency increases alternative end joining and cisplatin sensitivity in head and neck squamous cell carcinoma”. Oral Oncology, 2023 Mar 28;140:106367.