特聘教授，博士生导师

邮箱：delu@szu.edu.cn

1998年获得加拿大多伦多大学博士学位，现为深圳大学医学部特聘教授，深圳大学国际肿瘤中心PI。已在多个研究领域获得原创性研究成果，1997年，鉴定了第一个原核生物的锌转运蛋白；2004年，首次发现Wnt信号通路在慢性淋巴细胞白血病中被激活，并已鉴定多个新颖的Wnt信号通路抑制剂,其中一项有关盐霉素对肿瘤干细胞的抑制机理研究被顶级科学杂志Nature Medicine选作研究亮点加以介绍。2016年，首次报道灵菌红素通过阻断Wnt信号通路，抑制肿瘤的生长；2018年，首次揭示了佛波酯TPA激活Wnt/β-catenin信号通路，诱导肿瘤形成的新颖机理。2019年，鉴定了盐霉素抑制结直肠癌干细胞的新颖机理;2020年，发现含硫金属铱配合物通过靶向Wnt/β-catenin信号通路，表现出明显的拮抗乳腺癌和乳腺癌干细胞的活性。2021年，首次发现TMEM97激活Wnt信号通路参与乳腺癌发生发展的新颖机理。2023年，发现神经干细胞分化诱导剂ISX９是一个新颖的Wnt激活剂，该分子通过与Axin结合，激活Wnt信号通路，促进毛发生长。

迄今已发表70多篇科学论文，论文已被引用超过3500次，其中作为第一作者或通讯作者的论文引用已超过2000次，并已申请多项发明专利。担任多个知名期刊PNAS、Blood、Leukemia、Clinical Cancer Research及Molecular Cancer Research等的审稿专家。

研究方向:

肿瘤信号通路、肿瘤干细胞和抗肿瘤新药的研发

主持项目：

1. 国家自然科学基金委员会, 面上项目, 31970739, 佛波酯TPA通过调控酪蛋白激酶1δ/ε在激活Wnt信号通路和促进皮肤癌形成中的分子机制研究, 2020-01-01 至 2023-12-31, 58万元, 在研, 主持

2.  深圳大学, 基础研究（重点项目）, 20191231132915092, 基2020N107肺癌、肠癌发病机制及诊疗新靶 点研究, 2020-11 至 2023-11, 200万元, 在研, 主持

3.  深圳大学, 广东省自然科学基金-面上项目, 2020A1515010340, 三吡咯环衍生物通过阻断Wnt信号抑制 乳腺癌及乳腺癌干细胞活性的研究, 2019-10 至 2022-09, 10万元, 在研, 主持

4.  深圳大学, 基础研究（自由探索）, 20170220175114658, Fzd7在乳腺癌发病中的机制及其靶向治疗, 2017-01 至 2019-05, 40万元, 结题, 主持

代表性成果:

1.Huan Li, Danlan Zhang, Qiuxia Fu, Shang Wang, Zhongyuan Wang, Xin Zhang, Xin Chen, Xiaoyu Zhu, Na An, Yun Chen, Liang Zhou, Desheng Lu*, Na Zhao*. YBX1 as an oncogenic factor in T-cell acute lymphoblastic leukemia.Blood Adv. 2023 Jun 20; 7(17):4874-4885.

2.Sapna Sayed, Jiaxing Song, Ling Wang, Tobias Achu Muluh, Boxin Liu, Zhixian Lin, Yun Tang, Zijie Su, Huan Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Guangqian Zhou, Qi Sun, Desheng Lu*. Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β-catenin signalling and promotes hair regrowth.British J of Pharmacology 2023 Jan 31; 180(13):1748-1765.

3.Huifang Zhu, Zijie Su, Jiong Ning, Liang Zhou, Lifeng Tan, Sapna Sayed, Jiaxing Song, Zhongyuan Wang, Huan Li, Qi Sun, Shanshan Liu, Ou Sha, Feng Leng, Xianxiong Chen, Desheng Lu*.Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer.Cell Death Dis. 2021 Oct 6; 12(10):912.

4.Zhongyuan Wang, Liang Zhou, Yejun Wang, Quanzhou Peng, Huan Li, Xin Zhang, Zijie Su, Jiaxing Song, Qi Sun, Sapna Sayed, Shanshan Liu, Desheng Lu*. The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer. Theranostics2021; 11(9):4421-4435.

5. Qi Sun, Yi Wang, Qiuxia Fu, Ai Ouyang, Shanshan Liu, Zhongyuan Wang, Zijie Su, Jiaxing Song, Qianling Zhang, Pingyu Zhang, Desheng Lu*. Sulfur-coordinated organoiridium(III) complexes exert anti-breast cancer activity via inhibiting Wnt/β-catenin signaling.Angew Chem Int Ed Engl. 2021 Feb 23; 60(9):4841-4848.

6. Ling Wang, Ke Deng, Liang Gong, Liang Zhou, Sapna Sayed, Huan Li, Qi Sun, Zijie Su, Zhongyuan Wang, Shanshan Liu, Huifang Zhu, Jiaxing Song*, Desheng Lu*.Chlorquinaldol targets the β-catenin and T-cell factor 4 complex and exerts anti-colorectal cancer activity.Pharmacol Res. 2020 May 30; 159:104955.

7. Tao Feng, Liang Zhou, Zhongyuan Wang, Chunxiao Li, Yifan Zhang, Jing Lin*, Desheng Lu*, Peng Huang*. Dual-stimuli responsive nanotheranostics for mild hyperthermia enhanced inhibition of Wnt/β-catenin signaling.Biomaterials. 2020 Feb; 232:119709.

8. Zhongyuan Wang, Liang Zhou, Yanpeng Xiong, Shubin Yu, Huan Li, Jiaoyang Fan, Fan Li, Zijie Su, Jiaxing Song, Qi Sun, Shan-Shan Liu, Yuqing Xia, Liang Zhao, Shiyue Li, Fang Guo, Peng Huang, Dennis A Carson*, Desheng Lu*. Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/TCF complex. British J of Pharmacology2019 Sep; 176(17):3390-3406.

9. Zijie Su; Jiaxing Song; Zhongyuan Wang; Liang Zhou; Yuqing Xia; Shubin Yu; Qi Sun; Shan-S han Liu; Liang Zhao; Shiyue Li; Lei Wei; Dennis A. Carson*; Desheng Lu*; Tumor promoter TPA activates Wnt/beta-catenin signaling in a casein kinase 1-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115: 7522-7531.

10. Zhongyuan Wang; Bo Li; Liang Zhou; Shubin Yu; Zijie Su; Jiaxing Song; Qi Sun; Ou Sha; Xiaomei Wang; Wenqi Jiang; Karl Willert; Lei Wei; Dennis A.Carson*; Desheng Lu*; Prodigiosin inhibits Wnt/beta-catenin signaling and exerts anticancer activity in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(46):13150-13155.