所属科室：深圳大学总医院血液肿瘤科   

职称：副主任医师

职务：科副主任

诊疗特长

造血干细胞移植；白血病精准诊疗；骨髓瘤；淋巴瘤；各种类型贫血；恶性血液病CAR-T细胞治疗；噬血细胞综合征；骨髓增生异常综合征等血液病。

详细介绍

王立新，副主任医师，深圳大学总医院血液肿瘤科副主任。毕业于第二军医大学，在解放军总医院获得博士学位。曾在中国人民解放军海军总医院工作20余年。2009年美国俄亥俄州立大学访问学习一年，2014年于全国最大造血干细胞移植中心北京大学人民医院血液科进修半年。主持自然科学基金1项，参与科技部新药创制重大专项1项。以第一或通信作者发表SCI论文6篇，研究成果曾被Nature、Cell、Nature review drug discovery等杂志引用。主要研究方向为恶性血液病的表观调控化疗与细胞免疫治疗，长期专注于白血病精准诊疗及预后分层研究，熟悉造血干细胞移植后并发症的处理，近年致力于恶性血液病的CAR-T细胞治疗探索。

社会主要任职：

1.中国研究型医院学会血液病精准诊疗专业委员会常务委员

2.深圳市医学会肿瘤免疫治疗专业委员会常务委员

代表性论著：

1.Wang Z, Xiao Y, Guan W, Wang M, Chen J, Zhang L, Li Y, Xiong Q, Wang H, Wang M, Li Y, Lv N, Li Y, Wang L, Yu L. Acute myeloid leukemia immune escape byepigenetic CD48 silencing. Clin Sci (Lond). 2020 Jan 31;134(2):261-271. doi:10.1042/CS20191170. PMID: 31922199.

2.Wang LX, Chen X, Jia M, Wang S, Shen J. Arthritis of large joints shown as a rare clinical feature of cytokine release syndrome after chimeric antigen receptor T cell therapy: A case report. Medicine (Baltimore). 2018 Apr;97(16):e0455. doi: 10.1097/MD.0000000000010455. PubMed PMID: 29668614

3.Ma Y, Shen J, Wang LX. Successful treatment of high-risk myelodysplastic syndrome with decitabine-based chemotherapy followed by haploidentical lymphocyte infusion: A case report and literature review. Medicine (Baltimore). 2018 Apr;97(16):e0434.

4.Jing Y, Jin X, Wang L, Dou L, Wang Q, Yao Y, Lian S, Zhou J, Zhu H, Yao Z, Gao L, Wang L, Li Y, Bai X, Fang M, Yu L. Decitabine-based chemotherapy followed by haploidentical lymphocyte infusion improves the effectiveness in elderly patients with acute myeloid leukemia. Oncotarget. 2016 Aug 10. doi:10.18632/oncotarget.11183.

5.*Wang L, Liu JQ, Talebian F, Liu Z, Yu L, Bai XF. IL-10 enhances CTL-mediated tumor rejection by inhibiting highly suppressive CD4(+) T cells and promoting CTL persistence in a murine model of plasmacytoma. Oncoimmunology. 2015 May 13;4(7):e1014232.

6.*Li-Xin Wang, Zhen-Yang Mei, Ji-Hao Zhou, Yong-Hui Li, Jing-Xin Li, Yu-Shi Yao, Xiao-Ning Gao, Min-Hang Zhou, Meng-Meng Jiang, Li Gao, Yi Ding, Xue-Chun Lu, Jin-Long Shi, Xu-Feng Luo, Li-Li Wang, Chunfeng Qu , Xue-Feng Bai, and Li Yu. Low-Dose Decitabine Treatment Induces CD80 Expression in Cancer Cells and Stimulates Tumor-Specific Cytotoxic T cell Response. PloS One. May 9;8(5):e62924. 2013.

7.*L.X. Wang, F. Talebian, J.-Q. Liu, M. Khattabi, L. Yu & X.F. Bai. IL-10 Contributes to the Suppressive Function of Tumour-Associated Myeloid Cells and Enhances Myeloid Cell Accumulation in Tumours. Scand J Immunol.75(3):273-81. 2012 .

8. Lixin Wang, Jin-Qing Liu, Xue-Feng Bai. Tumor Expression of CD200 Inhibits IL-10 Production by Tumor Associated Myeloid Cells and Prevents Tumor Immune Evasion of CTL Therapy. European Journal of Immunology. 2010，40（9）： 2569–2579.