
胡云龙 助理教授
病原生物学系
基础医学院
huyunlong@szu.edu.cn
感染与免疫
病原生物学博士,深圳大学助理教授,医学研究副研究员,深圳市高层次人才后备级。长期从事感染与免疫研究,致力于发掘感染性疾病诊断新型分子标识、结核病免疫治疗新策略和新型疫苗研究。主持国家自然科学基金、广东省自然科学基金、深圳市科创委基金和深圳大学启动项目等10项;发表SCI论文27篇,包括一作和通讯作者论文9篇;申请国家发明专利7项,获得国家发明专利授权4项。
主持课题:
广东省自然科学基金-省企联合面上项目,2022A1515220034,肺癌特异性循环miRNA分子标识的筛查及其临床应用研究,2022/11-2025/10,15万,在研,主持
深圳市科技计划基础研究面上项目,JCJY20210324094614038,靶向IL-1β特异性组蛋白修饰的结核病控制新策略研究,2021/10-2024/10,60万,在研,主持
深圳市科技计划基础研究面上项目,JCYJ20220530160207015,结核分枝杆菌下调巨噬细胞H3K4me3逃逸宿主免疫的作用和机制研究,2022/10-2025/10,15万,在研,主持
深圳大学人事处项目(科技)-青年教师科研启动经费,RC20240310,结核分枝杆菌操控磷脂酰肌醇PI3P/KDM5A信号轴逃逸宿主免疫的作用和机制研究,2024/11-2026/10,20万,在研,主持
北京大学深圳医院高水平医院建设项目,KYQD2022130,高水平科研启动金胡云龙,2022/06-2025/05,150万,结题,主持
国家自然科学基金青年项目,81800010,Ibrutinib增强巨噬细胞清除感染结核菌的作用和机制,2019/01-2021/12,21万,结题,主持
广东省自然科学基金面上项目,2020A1515010415,依鲁替尼增强宿主细胞清除感染结核菌的机制研究,2019/10-2022/09,10万,结题,主持
广东省自然科学基金-博士启动纵向协同,2018A030310642,TLR7和Wnt/beta-catenin信号通路双靶点药物设计及其抗肿瘤机制研究,2018/01-2020/12,10万,结题,主持
深圳市科技计划基础研究自由探索项目,JCYJ20180305163440858,新型免疫调节剂抗肿瘤作用及其机制研究,2018/03-2021/03,30万,结题,主持
深圳市科技创新计划创客创业项目,CKCY2017072015204636,用于细胞制剂规范化生产的高生物安全性细胞培养体系的构建,2018/07-2019/07,45万,结题,主持
发表论著(#第一作者,*通讯作者)
1. Yue Jiang#, Huilin Yang#, Zhenyu Wang, Dachuan Lin, Xinan Jiao, Yunlong Hu*, Jing Wang*. Persistent colonization of ciprofloxacin-resistant and extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198 in a patient with inflammatory bowel disease. Infection and Drug Resistance. 2024; 17:1459-1466.(Article,共同通讯,IF 3.92023)
2. Yunlong Hu, Zhihua Wen, Song Liu, Yi Cai, Jiubiao Guo, Yuzhong Xu, Dachuan Lin, Jialou Zhu, Dechang Li, Xinchun Chen. Ibrutinib suppresses intracellular mycobacterium tuberculosis growth by inducing macrophage autophagy. Journal of Infection. 2020; pii: S0163-4553(20)30115-8.(Article,第1作者,IF)
3. Yunlong Hu#,*, Li Tang#, Zhengyu Zhu, He Meng, Tingting Chen, Sheng Zhao, Zhenchao Jin, Zhulin Wang, Guangyi Jin*. A novel TLR7 agonist as adjuvant to stimulate high quality HBsAg-specific immune responses in an HBV mouse model. Journal of Translational Medicine. 2020; 4; 18(1):112.(Ariticle,共同第1作者,1/2,IF)
4. Peijun Tang#, Xingnian Chen#, Junchi Xu#, Yunlong Hu#, Zhijian Ye, Xiafang Wang, Yumei Xiao, Xinghua Shen, Jianping Zhang, Yanjun Feng, Cuilin Shi, Xin Yu, Lixian Yi, Xinchun Chen, Binfeng Lu, Ping Xu*, Zhongwen Sun*, and Meiying Wu*. Autologous cytokine-induced killer cell immunotherapy enhances chemotherapy efficacy against multidrug-resistant tuberculosis. Journal of Immunology Research. 2022; 17; 2022:2943113.(Article,共同第1作者,4/4,IF)
5. Yunlong Hu#, Hui Li#, Wenhui Li, Hongxue Meng, Yuzhuo Fan, Wenjing Li, Yuting Ji, Hong Zhao, Lei Zhang, Xiaoming Jin*, Fengmin Zhang*. The value of decreased plasma gelsolin levels in patients with systemic lupus erythematosus and rheumatoid arthritis in diagnosis and disease activity evaluation. Lupus. 2013; 22(14):1455-1461.(Article,共同第1作者,1/2,IF)
6. Tingting Chen#, Yunlong Hu#, Bing Liu, Xinping Huang, Qin Li, Ningnign Gao, Zhenchao Jin, Tieliu Jia, Deyin Guo*, Guangyi Jin*. Combining thioridazine and loratadine for the treatment of gastrointestinal tumor. Oncology Letters. 2017; 14(4):4573-4580.(Article,共同第1作者,2/2,IF)
7. Tingting Chen#, Yunlong Hu#, Xiaotan Lin#, Xinping Huang, Bing Liu, Peggy Leung, Sunon Chan, Deyin Guo*, Guangyi Jin*. Dopamine signaling regulates the projection patterns in the mouse chiasm. Brain Research. 2015; 1625:324-336.(Article,共同第1作者,2/3,IF)
8. Yunlong Hu#, Tingting Chen#, Song Liu#, Bing Liu, Hongxue Meng, Lei Zhang, Di Sun, Yong Dai, Deyin Guo, Xiaoming Jin, Guangyi Jin*, Fengmin Zhang*. Gelsolin deposits in renal tissues of the patients with lupus nephritis. International Journal of Clinical and Experimental Pathology. 2016; 9(5):5413-5420. (Article,共同第1作者,1/3,IF)
9. Tingting Chen#, Yunlong Hu#, Bing Liu, Xinping Huang, Ningning Gao, Zhenchao Jin, Tieliu Jia, Deyin Guo*, Guangyi Jin*. Synthetic toll-like receptor 7 agonist as a conjugated adjuvant enhances the Th1 typeimmunogenicity of influenza virus vaccine. International Journal of Clinical and Experimental Pathology. 2016; 9(4):4790-4795.(Article,共同第1作者,2/2,IF)
10. Kehong Zhang, Yuzhong Xu, Yunlong Hu, Xinchun Chen. Nutritional supplementation for tuberculosis prevention: the rations trial. The lancet 2024 Oct 19;404(10462):1523-1524. (Correspondence, 共同作者,第3, IF 98.4)
11. Fuxiang Li, Chuanzhi Zhu, Yue Zhang, Fanhui Kong, Ximeng Zhang, Liping Pan, Hongyan Jia, Liang Fu, Yunlong Hu, Guofang Deng, Qianting Yang, Xinchun Chen, Yi Cai. Granzyme A as biomarker for diagnosis in tuberculous pleural effusion. JCI insight. 2024 Dec 6; 9(23):e185307. (Article,共同作者,第9,IF)
12. Zhaodong Li, Yunlong Hu, Wenfei Wang, Fa Zou, Jiahuan Yang, Wei Gao, Siwan Feng, Guanghuan Chen, Chenyan Shi, Yi Cai, Guofang Deng, Xinchun Chen. Assessing the risk of TB progression: Advances in blood-based biomarker research. 2024 Dec 26:292:128038. (Review,共同作者,第2,IF)
13. Ximeng Zhang, Guanggui Ding, Xirui Yang, Hailin Lu, Yuzhong Xu, Yunlong Hu, Song Liu, Huihua Zhang, Kaisong Huang,Guofang Deng, Taosheng Ye, Qing Yu, Yi Cai, Shuixiang Xie, Wenfei Wang, Xinchun Chen. Myriocin enhances the clearance of M. tuberculosis by macrophages through the activation of PLIN2.mSphere.2024 Jun 26:e0025724. (Article,共同作者,第6,IF)
14. Zhaodong Li, Yunlong Hu, Wenfei Wang, Fa Zou, Jiahuan Yang, Wei Gao, Siwan Feng, Guanghuan Chen, Chenyan Shi, Yi Cai, Guofang Deng, Xinchun Chen X. Integrating pathogen- and host-derived blood biomarkers for enhanced tuberculosis diagnosis: a comprehensive review. Front Immunol. 2024:15:1438989. (Review,共同作者,第2,IF)
15. Jun Wang, Jinyong Huang, Yunlong Hu, Qianwen Guo, Shasha Zhang, Jinglin Tian, Yanqin Niu, Ling Ji, Yuzhong Xu, Peijun Tang, Yaqin He, Yuna Wang, Shuya Zhang, Hao Yang, Kang Kang, Xinchun Chen, Xinying Li, Deming Gou. Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification. Nature Communications. 2024; 15(1):156.(Article,共同作者,第3,IF 14.7)
16. Dachuan Lin, Lei Liu, Mingxia Zhang, Yunlong Hu, Qianting Yang, Jiubiao Guo, Yongchao Guo, Youchao Dai, Yuzhong Xu, Xinchun Chen, Zheng Zhang, Kaisong Huang. Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected patients. Science China-Life Science. 2020; 63(4):606-609.(Correspondence,共同作者,第4,IF)
17. Tianqi Dai, Yunlong Hu, Fulian Lv, Tatsuhiko Ozawa, Xin Sun, Jingjing Huang, Xiaojian Han, Hiroyuki Kishi, Atsushi Muraguchi, Aishun Jin. Analysis of the clinical significance of DCLK1+ colorectal cancer using novel monoclonal antibodies against DCLK1. Oncotargets and Therapy. 2018; 11:5047-5057.(Article,共同作者,第2,IF)
18. Dachuan Lin, Lei Liu, Mingxia Zhang, Yunlong Hu, Qianting Yang, Jiubiao Guo, Youchao Dai, Yuzhong Xu, Yi Cai, Xinchun Chen, Kaisong Huang, Zheng Zhang. Evaluations of the serological test in the diagnosis of 2019 novel coronavirus (SARS-CoV-2) infections during the COVID-19 outbreak. European Journal of Clinical Microbiology and Infectious Diseases. 2020; 39(12):2271-2277.(Ariticle,共同作者,第4,IF)
19. Liu Jia, Lei Cao, Junze Qu, Tingting Chen, Zijie Su, Yunlong Hu, Ying Wang, Mingdong Yao, Wenhai Xiao, Chun Li, Bo Li, Yingjin Yuan. NVD-BM-mediated genetic biosensor triggers accumulation of 7-dehydrocholesterol and inhibits melanoma via Akt1/NF-κB signaling. Aging-US. 2020; 12(14):15021-15036.(Article,共同作者,第6,IF)
20. Dong Gao, Juan Zeng, Xiaodong Wang, Yu Liu, Wang Li, Yunlong Hu, Ningning Gao, Yuwen Diao, Zhulin Wang, Wenqi Jiang, Jinhua Chen, Guangyi Jin. Conjugation of weak ligands with weak antigens to activate TLR-7: A step toward better vaccine adjuvants. European Journal of Medicinal Chemistry. 2016; 120:111-120.(Article,共同作者,第6,IF)
21. Bing Liu, Xinping Huang, Yunlong Hu, Tingting Chen, Boya Peng, Ningning Gao, Zhenchao Jin, Tieliu Jia, Na Zhang, Zhulin Wang, Guangyi Jin. Ethacrynic acid improves the antitumor effects of irreversible epidermal growth factor receptor tyrosine kinase inhibitors in breast cancer. Oncotargets. 2016; 7(36):58038-58050.(Article,共同作者,第3,IF)
22. Aimei Li, Wuqi Song, Jun Qian, Yujun Li, Junming He, Qingmeng Zhang, Wenhui Li, Aixia Zhai, Wenping Kao, Yunlong Hu, Hui Li, Jing Wu, Hong Ling, Zhaohua Zhong , Fengming Zhang*. MiR-122 modulates type I interferon expression through blocking suppressor of cytokine signaling 1. International Journal of Biochemistry & Cell Biology. 2013, 45(4):858-865.(Article,共同作者,第9,IF)
23. Yunjun Li, Wuqi Song, Jing Wu, Qingmeng Zhang, Junming He, Aimei Li, Jun Qian, Aixia Zhai, Yunlong Hu, Wenping Kao, Lanlan Wei, Fengming Zhang*, Dakang Xu*. MAVS-mediated host cell defense is inhibited by Borna disease virus. International Journal of Biochemistry & Cell Biology. 2013, 45(8):1546-1555.(Article,共同作者,第,IF)
24. Wuqi Song, Wenping Ka, Aixia Zhai, Jun Qian, Yujun Li, Qingmeng Zhang, Hong Zhao, Yunlong Hu, Hui Li, Fengming Zhang*. Borna disease virus nucleoprotein inhibits type I interferon induction through the interferon regulatory factor 7 pathway. Biochemical and Biophysical Research Communications. 2013, 438(4):619-623.(Article,共同作者,第8,IF)
25. Song Liu, Xianliang Hou, Sui W G, Lu, Q J, Yunlong Hu, Yong Dai. Direct measurement of B-cell receptor repertoire's composition and variation in systemic lupus erythematosus. Genes and Immunity. 2017; 18(1): 22-27.(Article,共同作者,第5,IF)
26. Song Liu, Jiangang Bi, Yunlong Hu, Donge Tang, Bo Li, Peng Zhu, Wujian Peng, Dong Du, Huiyan He, Jun Zeng, Yong Dai. Targeted next generation sequencing identified novel loss-of-function mutations in MERTK gene in Chinese patients with retinitis pigmentosa. Molecular Genetics & Genomic Medicine. 2019,7(4):e00577.(Article,共同作者,第3,IF)
27. Wenhui Li, Hui Li, Wuqi Song, Yunlong Hu, Yanhong Liu, Rong Da, Xiaobei Chen, Yang Li, Hong Ling, Zhaohua Zhong, Fengming Zhang*. Differential diagnosis of systemic lupus erythematosus and rheumatoid arthritis with complements C3 and C4 and C reactive protein. Experimental and Therapeutic Medicine 2013, 6(5):1271-1276.(Article,共同作者,第4,IF)
28. 李德昌,张明霞,林大川,胡云龙,温志华,刘圣泽,徐羽中,黄开松,张政,陈心春。新型冠状病毒ELISA试剂盒灵敏度和特异度评价。深圳大学学报理工版。2020,3(37):224-226。
29. 陈婷婷,胡云龙,刘兵,李琴,贾铁留,郭德银,靳广毅。Toll 样受体 7 小分子激动剂偶联流感病毒灭活疫苗的研究。中国医药导报。2016,3(13):26-31。
30. 陈婷婷,胡云龙,刘兵,王晓东,郭德银,靳广毅。Sirt1 基因的研究进展。 中国医药导报.2015; 12(12)45-50.
31. 张娜,靳广毅,晋贞超,刘兵,彭博雅,高宁宁,胡云龙,唐黎。Toll 样受体7激动剂T7-利尿酸偶合物联合ROR1具有更强的抗乳腺癌作用。细胞与分子免疫学杂志. 2016; 7:876-880.
32. 王垚,苏丽菊,李辉,刘彦虹,翟爱霞,考文萍,吴静,李文辉,胡云龙,钟照华,张凤民*。 系统性红斑狼疮患者血清特异性噬菌体 7 肽的筛选、鉴定及其意义。中华微生物和免疫学杂志. 2010; 30(7):665-669.
专利和应用:
陈心春,胡云龙,蔡毅,张惠华,杨浩。与活动性肺结核有关的miRNA标志物及其应用。2022,中国,发明专利,ZL202111614198.9,发明授权。
陈心春,蔡毅,张惠华,胡云龙。与抗结核疗效评估有关的miRNA标志物及其应用。2022,中国,发明专利,ZL202111614140.4,发明授权。
陈心春,张惠华,胡云龙,蔡毅。与非结核性肺炎有关的血浆miRNA标志物及其应用。2022,中国,发明专利,ZL202111610560.5,发明授权。
靳广毅,王竹林,胡云龙,刘兵。化合物 I 和化合物 II 及其制备方法和应用。2016,中国,发明专利,ZL201510786141.5,发明授权。
靳广毅,王竹林,胡云龙,唐黎,刘冰。免疫激动剂和组合物及其应用以及组合物的制备方法。2017,中国,发明专利,专利号CN107281483A,发明公开。
靳广毅,王竹林,唐黎,胡云龙。用于制备乙肝疫苗的组合物及其制备方法和应用。2017,中国,发明专利,专利号CN107281484A,发明公开。
Guangyi Jin, Zhulin Wang, Zhengyu Zhu, Li Tang, Yunlong Hu. Composition for preparing hepatitis B vaccine, preparation method therefor, and application thereof. WO2018219266 (A1), PCT patent.
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