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王乃涛

王乃涛 特聘教授

生理学（生理学和药理学系）

wangnaitao@szu.edu.cn 

1.解析肿瘤发生的表观遗传机制；
2.开发新型肿瘤治疗策略；

王乃涛，深圳大学医学部教授、博士生导师，国家海外高层次青年人才。研究方向聚焦于转录因子和表观遗传修饰在癌症发生中的功能与分子机制，在Nature Genetics、Journal of Clinical Investigation、Science Advances等期刊发表多篇研究论文。

根据实验室发展需要，现面向海内外高薪诚聘优秀青年人才，包括百人计划助理教授、预聘-长聘助理教授、副研究员、博士后，同时招收博士、硕士研究生。欢迎生物医学相关方向、具有理想和热情的青年人才加入。

请将个人简历（包括主要教育和工作经历、研究背景、代表性论文等）发送至wangnaitao@szu.edu.cn，邮件标题请注明“王乃涛团队招聘+应聘岗位+姓名”。

国家自然科学基金优秀青年科学基金项目（海外），2026.01-2028.12

1. Wang N#*, Li D#, Zhang T#, Pachai MR, Schoeps DM, Bao Y, Cho WH, Khudoynazarova MN, Kristoff K, Liu M, Tang L, Janjigian YY, Chi P*, Chen Y*. Loss of Kmt2c/d promotes gastric cancer and confers vulnerability to mTORC1 and PD1 inhibition. J Clin Invest. 2026 May 12;. doi: 10.1172/JCI194462. PubMed PMID: 42118591.

2. Li D#*, Wang N#, Guo W#, Owiredu J#, Cho WH, Schoeps D, Cheng S, Zhang H, Chan UI, Wong CK, Callychurn VR, Wang H, Kang W, Fan N, Pasolli HA, Sharma A, Gopalan A, Barbieri CE, Gao D*, Chi P*, Chen Y*. Cell-Autonomous AR Dependence in Luminal Prostatic Epithelium Governs Survival and Lineage Plasticity. bioRxiv. 2026 Feb 16;. doi: 10.64898/2026.02.13.705807. PubMed PMID: 41757036.

3. Wang N#, Pachai MR#, Li D#, Lee CJ, Warda S, Khudoynazarova MN, Cho WH, Xie G, Shah SR, Yao L, Qian C, Wong EWP, Yan J, Tomas FV, Hu W, Kuo F, Gao SP, Luo J, Smith AE, Han M, Gao D, Ge K, Yu H, Chandarlapaty S, Iyer GV, Rosenberg JE, Solit DB, Al-Ahmadie HA, Chi P*, Chen Y*. Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A-menin to bivalent promoters. Nat Genet. 2025 Jan;57(1):165-179. doi: 10.1038/s41588-024-02015-y. PubMed PMID: 39806204.

4. Li D#, Zhan Y#, Wang N#, Tang F, Lee CJ, Bayshtok G, Moore AR, Wong EWP, Pachai MR, Xie Y, Sher J, Zhao JL, Khudoynazarova M, Gopalan A, Chan J, Khurana E, Shepherd P, Navone NM, Chi P*, Chen Y*. ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer. Sci Adv. 2023 Apr 5;9(14):eadc9446. doi: 10.1126/sciadv.adc9446. PubMed PMID: 37018402.

5. Wang N#, Hakimi AA, Chen Y*. XL-ing at Induction of Apoptosis in Kidney Cancer through Inhibition of BCL-XL.  Clin Cancer Res. 2022 Nov 1;28(21):4600-4602. doi: 10.1158/1078-0432.CCR-22-2104. PubMed PMID: 35984355.

6. Wang N#, Dong BJ#, Quan Y, Chen Q, Chu M, Xu J, Xue W, Huang YR, Yang R*, Gao WQ*. Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status. Stem Cell Reports. 2016 May 10;6(5):668-678. doi: 10.1016/j.stemcr.2016.04.007. PubMed PMID: 27167157.

7. Wang N#, Yao M, Xu J, Quan Y, Zhang K, Yang R*, Gao WQ*. Autocrine Activation of CHRM3 Promotes Prostate Cancer Growth and Castration Resistance via CaM/CaMKK-Mediated Phosphorylation of Akt. Clin Cancer Res. 2015 Oct 15;21(20):4676-85. doi: 10.1158/1078-0432.CCR-14-3163. PubMed PMID: 26071486.

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