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应颖

应颖 教授

生理学系

基础医学院

yingying@szu.edu.cn

深圳市南山区西丽学苑大道1066号

1)常见肿瘤及代谢性、神经退行性疾病发生发展中表观遗传调控异常的分子机制
2)消化道肿瘤及视网膜母细胞瘤的表观遗传治疗及耐药性机制

应颖,博士,教授,博士生导师,深圳市海外高层次B类人才,医学部基础医学院副院长兼生理学系副主任(主持学系工作)。2003年获英国伦敦大学学院(UCL)分子医学硕士学位,2007年获德国海德堡大学分子生物学博士学位。2008-2010获香港中文大学博士后研究基金资助,于香港中文大学医学院从事博士后研究工作。20109月加入深圳大学,现任深大医学部基础医学院教授。长期从事表观遗传变异所致的转录调控异常参与代谢性、神经退行性疾病及肿瘤的发生发展的分子机制及干预研究。主持国家自然科学基金4项,广东省自然科学基金2项,广东省高教厅优秀青年创新项目1项,深圳市基础研究项目多项。以第一或通讯作者(含共同)在Molecular Neurodegeneration, PNAS, Oncogene, Journal of Pathology等国际著名期刊上发表论文30篇。目前担任中国生理学会内分泌代谢专委会、整合生理学专委会、虚拟仿真与人工智能专委会委员;中国高等教育学会医学教育专业委员会理事会理事,广东省医学教育协会医药教师发展专业委员会副主任委员,广东省生物物理学会第八届理事会理事。

1) 国家自然科学基金面上项目:“P-tau驱动SAT1依赖性铁死亡促糖尿病视网膜神经节细胞丧失的作用机制研究”(82370833),2024年1-202712

2) 国家自然科学基金面上项目:“L1CAM表观遗传沉默介导的自噬流受阻在糖尿病视网膜tau蛋白病变中的作用机制研究”(82070978, 20211-202412

3) 国家自然科学基金面上项目:“14-3-3ζ介导CDK5GSK3β促tau蛋白过度磷酸化:糖尿病早期视网膜神经节细胞变性的新机制8167076020171-202012

4) 国家自然科学基金青年基金:GLP-1/beta-catenin/TCF信号通路对糖尿病鼠心肌细胞凋亡的保护作用与机制研究8120060220131-201512


1.      Huazhang Zhu#, Weizhen Zhang#Yingying Zhao#, Xing-sheng Shu#, Wencong Wang, Dandan Wang, Yangfan Yang, Zhijun He, Xiaomei Wang, Ying Ying*. GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions. Molecular Neurodegeneration 2018;13:62. (中科院大类1区,TOP期刊,IF: 18.879,通讯作者)

2.      Ying Ying, Wang Maolin, Chen Yongheng, Li Meiqi, Ma Canjie, Zhang Junbao, Huang Xiaoyan, Jia Min, Zeng Junhui, Wang Yejun, Li Lili, Wang Xiaomei, Tao Qian, Shu Xing-sheng*: Zinc finger protein 280C contributes to colorectal tumorigenesis by maintaining epigenetic repression at H3K27me3-marked loci. Proc Natl Acad Sci 2022;119:e2120633119.(中科院大类1区,TOP期刊,IF: 12.14,第一作者)

3. Ying Ying#, Yejun Wang#, Xiaoyan Huang, Yanmei Sun, Junbao Zhang, Meiqi Li, Junhui Zeng, Maolin Wang, Wenjun Xiao, Lan Zhong, Bo Xu, Lili Li, Qian Tao, Xiaomei Wang, Xing-sheng Shu*. Oncogenic HOXB8 is driven by MYC-regulated super-enhancer and potentiates colorectal cancer invasiveness via BACH1. Oncogene 2020;39:1004-1017. (中科院大类1区,TOP期刊,IF: 9.867,第一作者)

4. Xing-sheng Shu*, Yingying Zhao, Yanmei Sun, Lan Zhong, Yingduan Cheng, Yixiang Zhang, Kaile Ning, Qian Tao, Yejun Wang*, Ying Ying*PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer. Journal of Pathology 2018;244:36-48. 中科院大类1区,TOP期刊,IF: 9.883,通讯作者)

5. Junbao Zhang#Ying Ying#, Meiqi Li#, Maolin Wang, Xiaoyan Huang, Min Jia, Junhui Zeng, Canjie Ma, Yixiang Zhang, Chen Li, Xiaomei Wang,Xing-sheng Shu*. Targeted inhibition of KDM6 histone demethylases eradicates tumor-initiating cells via enhancer reprogramming in colorectal cancer. Theranostics 2020; 10:10016-10030.  (中科院大类1区,TOP期刊,IF: 11.556,并列第一作者)

6. Ying Ying*, Yilin Zhang*, Canjie Ma, Meiqi Li, Chaoyue Tang, Yangfan Yang, Junhui Zeng, Xiaoyan Huang, Junbo Yi, Xiaomei Wang, Zhendan He, Xing-sheng Shu*. Neuroprotective effects of ginsenoside Rg1 against hyperphosphorylated tau-induced diabetic retinal neurodegeneration via activation of IRS-1/Akt/GSK3β signaling. Journal of Agriculture and Food Chemistry 2019;67:8348-8360.中科院大类1区,TOP期刊,IF: 5.895,第一/通讯作者)

7. Xing-sheng Shu#, Yilin Zhang#, Meiqi Li, Xiaoyan Huang, Yangfan Yang, Junhui Zeng, Yingying Zhao, Xiaomei Wang, Weizhen Zhang, Ying Ying*. Topical ocular administration of the GLP-1 receptor agonist liraglutide arrests hyperphosphorylated tau-triggered diabetic retinal neurodegeneration via activation of GLP-1R/Akt/GSK3β signaling. Neuropharmacolocy 2019;153:1-12. (中科院大类2区,IF: 5.25,通讯作者)

8. Kostadin Dimov Rolev, Xing-sheng Shu*Ying Ying*. Targeted pharmacotherapy against neurodegeneration and neuroinflammation in early diabetic retinopathy. Neuropharmacolocy 2021;187:1-12. (中科院大类2区,IF: 5.25,通讯作者)

9. Maolin Wang#, Xing-sheng Shu#, Meiqi Li, Yiling Zhang, Youli Yao, Xiaoyan Huang, Jianna Li, Pengfei Wei, Zhendan He*, Jun Lu*Ying Ying*A novel strategy conjugating PD-L1 polypeptide with Doxorubicin alleviates chemotherapeutic resistance and enhances immune response in colonc cancer. Frontiers in Oncology 2021;11:1. (中科院大类2区,IF: 6.244,通讯作者)

10. Xing-sheng Shu#*, Huazhang Zhu#, Xiaoyan Huang#, Yangfan Yang, Dandan Wang, Yilin Zhang, Weizhen Zhang, Ying Ying*Loss of β-catenin via activated GSK3β causes diabetic retinal neurodegeneration by instigating a vicious cycle of oxidative stress-driven mitochondrial impairment.Aging-US 2020; 12(13):13437-13462. (中科院大类2区,IF: 5.682,通讯作者)

11. Yingying Zhao, Huazhang Zhu, Yangfan Yang, Yiming Ye, Youli Yao, Xiaoyan Huang, Yixiang Zhang, Xing-sheng Shu, Xianxiong Chen, Yatao Yang, Junxian Ma, Le Cheng, Xiaomei Wang, Ying Ying*. AQP1 suppression by ATF4 triggers trabecular meshwork tissue remodelling in ET-1-induced POAG.Journal of Cellular and Molecular Medicine2020:6:3469-3480. (中科院大类2区,IF: 5.31,通讯作者)

12. Yixiang Zhang#, Yingduan Cheng#, Zhaoxia Zhang#, Zhongyuan Bai, Hongtao Jin, Xiaojing Guo, Xiaoyan Huang, Meiqi Li, Maolin Wang, Xing-sheng Shu*, Yeqing Yuan*, Ying Ying*.  CDCA2 Inhibits Apoptosis and Promotes Cell Proliferation in Prostate Cancer and Is Directly Regulated by HIF-1α Pathway.Frontiers in Oncology 2020;10:725. (中科院大类2区,IF: 6.244,通讯作者)

13. Ying Y#, Xue R#, Yang Y, Zhang SX, Xiao H, Zhu H, Li J, Chen G, Ye Y, Yu M, Liu X, Zhong Y. Activation of ATF4 triggers trabecular meshwork cell dysfunction and apoptosis in POAG.Aging-US 2021 ;13(6):8628-8642. (中科院大类2区,IF: 5.682,通讯作者)

14. Dandan Wang#Huazhang Zhu#Shiwei LiJiaming YangYang XiaoQiangrong KangChenyang LiYunshi ZhaoYong ZengYan LiJian ZhangZhendan He*, Ying Ying*. Crude saponins of panax notoginseng have neuroprotective effects to inhibit palmitate-triggered endoplasmic reticulum stress-associated apoptosis and loss of postsynaptic proteins in staurosporine differentiated RGC-5 retinal ganglion cells. Journal of Agriculture and Food Chemistry 2016;64:1528-1539. 中科院大类1区,TOP期刊,IF: 5.895,通讯作者)

15. Xing-sheng Shu#, Dandan Wang#, Yingying Zhao#, Yanmei Sun, Xiaopeng Hu, Xiaoyan Huang, Junhui Zeng, Chenyang Li, Yan Li, Yong Zeng, Xiaomei Wang, Zhendan He*, and Ying Ying*. Extract from Moringa oleifera seeds suppresses the epithelial-mesenchymal transition-mediated metastasis of gastric cancer by targeting the metastatic suppressor NDRG1. Journal of Functional Foods 2018;50:93-103. (中科院大类2区,IF: 4.64,通讯作者)

16. Ying Ying#*Huazhang Zhu#Zhen LiangXiaosong Ma, Shiwei Li. GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway. Journal of Molecular Endocrinology 2015,55:245-262.(中科院大类2区,IF: 5.098,第一/通讯作者)

17. Youli Yao#Ying Ying#, Qiyu Deng, Wenjiang Zhang, Huazhang Zhu, Zhenglong Lin, Shengli Zhang, Junxian Ma, Yingying Zhao. Noninvasive 40-Hz light flicker ameliorates Alzheimer’s-associated rhythm disorder via regulating central circadian clock in mice. Frontiers in Physiology 2020;11:294. (中科院大类2区,IF: 4.566,并列第一作者)


  应颖教授实验室团队成员合影 

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