代表性成果

1. Yue Xiao, Wenjing Ma, Weiwei Hu, Qianqian Di, Xibao Zhao, Xingyu Ma, Xinyi Chen, Ping Sun, Han Wu, Zherui Wu, Weilin Chen^*. Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation. Mol. Oncol. 2021 Apr 2. doi: 10.1002/1878-0261.12958.

2. Xingyu Ma^#, Xiaoli Li^#, Qianqian Di, Xibao Zhao, Ruihan Zhang, Yue Xiao, Ping Sun, Haimei Tang, Jiazheng Quan, Weilie Xiao*, Weilin Chen*. Natural molecule Munronoid I attenuates LPS-induced acute lung injury by promoting the K48-linked ubiquitination and degradation of TAK1. Biomedicine & Pharmacotherapy, 2021 Apr. 111543

3. Qianqian Di ^‡, Xibao Zhao^‡, Ruihan Zhang ^‡, Xingyu Ma, Xinxin Liang, Xiaoli Li, Junbo Gao, Haimei Tang, Weilin Chen^*, Weilie Xiao^* Novel clerodane-type diterpenoid Cintelactone A suppresses lipopolysaccharide -induced inflammation by promoting ubiquitination and proteasomal degradation of TRAF6. Pharmacological Research  2021 Feb;164:105386.

4. Hongrui Li^#, Jiazheng Quan^#, Xibao Zhao, Jing Ling, Weilin Chen*. USP14 negatively regulates RIG-I-mediated IL-6 and TNF-α production by inhibiting NF-κB activation. Mol Immunol. 2021 Jan;130:69-76.

5. Yue Xiao^#, Qi Huang^#, Zherui Wu, Weilin Chen*. Roles of Protein Ubiquitination in Inflammatory Bowel Disease. Immunobiology. 2020 Nov;225:152026

6. Ping Sun ,Yue Xiao, Qianqian Di,Wenjing Ma, Xingyu Ma, Qingqing Wang,Weilin Chen*. Transferrin receptor-targeted PEG-PLA Polymeric Micelles for Chemotherapy against Glioblastoma multiforme. International Journal of  Nanomedicine.  2020 Sep:15 6673–6688

7. Qianqian Di, Huihui Zhu, Debing Pu, Xibao Zhao, Xiaoli Li*, Xingyu Ma, Weilie Xiao*, Weilin Chen*. The natural compound Cirsitakaoside enhances antiviral innate responses against vesicular stomatitis virus in vitro and in vivo. Int Immunoph. 2020 Sep;86:106783

8. Xi-Bao Zhao, Fei-Yang Ji, Hong-Rui Li, Hui-Hui Zhu, Zi-Zhao Zhao, Jing Ling, Qian-Qian Di , Xing-Yu Ma, Wei-Lin Chen*. P22077 Inhibits LPS-induced Inflammatory Response by Promoting K48-linked Ubiquitination and Degradation of TRAF6. Aging-US. 2020 Jun;12:103309.

9. Qin FY^＃, Zhang HX^＃, Di QQ^＃, Wang Y, Yan YM, Chen WL*, Cheng YX*. Ganoderma cochlear Metabolites as Probes to Identify a COX-2 Active Site and as in Vitro and in Vivo Anti-Inflammatory Agents. Org Lett. 2020 Apr 3;22(7):2574-2578.

10.  Li H, Zhao Z, Ling J, Pan L, Zhao X, Zhu H, Yu J, Xie B, Shen J, Chen W*. USP14 promotes K63-linked RIG-I deubiquitination and suppresses antiviral immune responses. Eur J Immunol. 2019 Jan;49(1):42-53.

11. Huihui Zhu^＃, Debing Pu^＃, Qianqian Di^＃, Xibao Zhao, Feiyang Ji, Hongrui Li, Zizhao Zhao, Junbo Gao, Weilie Xiao*, Weilin Chen*.Cirsitakaoside isolated from Premna szemaoensis reduces LPS-induced inflammatory responses in vitro and in vivo. Int Immunoph. 2018;59:384-390

12. Jiafeng Ge^＃, Weiwei Hu^＃, Hui Zhou, Juan Yu, Chongran Sun and Weilin Chen*. Ubiquitin carboxyl-terminal hydrolase isozyme L5 inhibits human glioma cell migration and invasion via downregulating SNRPF. Oncotarget, 2017, 8 (69): 113635-113649 

13. Xibao Zhao, Debing Pu, Zizhao Zhao, Huihui Zhu, Hongrui Li, Yaping Shen, Xingjie Zhang, Ruihan Zhang, Jianzhong Shen, Weilie Xiao * and Weilin Chen *. Teuvincenone F Suppresses LPS-Induced Inflammation and NLRP3 Inflammasome Activation by Attenuating NEMO Ubiquitination. Front. Pharmacol. 2017 Aug 23; 8:565

14. Zhao X, Zhu H, Yu J, Li H, Ge J, Chen W*. c-Cbl-mediated ubiquitination of IRF3 negatively regulates IFN-β production and cellular antiviral response. Cell Signal. 2016 ;28(11):1683-1693

15.Zhao X, Shen Y, Hu W, Chen J, Wu T, Sun X, Yu J, Wu T, Chen W*. DCIR negatively regulates CpG-ODN-induced IL-1β and IL-6 production. Mol Immunol. 2015; 68(2):641-647

16. Chen W^＃, Han C^＃, Xie B^＃, Hu X, Yu Q, Shi L, Wang Q, Li D, Wang J, Zheng P, Liu Y, Cao X. Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation. Cell. 2013 ;152(3):467-78.