邢少军,博士,深圳大学特聘教授, 国家级人才,病原生物学系主任。2005年本科毕业于山东大学,2010年博士毕业于中国科学院生物物理所感染与免疫中心。曾工作于中国医学科学院病原生物学研究所、美国爱荷华大学微生物与免疫学系。主要从事免疫细胞分化及功能的转录调控和表观修饰研究。以第一作者或通讯作者(含共同)在Nat Immunol, Immunity, J Exp Med, J Immunol, JAIDS, Clin Transl Med, Front Oncol等发表文章8篇。目前主持包括国家自然科学基金(面上项目)在内的多项科研项目。担任广东省组织器官区域免疫与疾病重点实验室学术委员会委员,广东省免疫学会理事,广东省免疫学会青年委员会常务委员等。
实验室主要围绕机体对感染的免疫应答调控,从分子、细胞及动物等不同水平,多学科交叉开展工作。目前的主要研究方向:
(1)感染免疫及肿瘤免疫的免疫调控
(2)免疫细胞的表观修饰、代谢调控及其干预策略研究
代表性成果(* 第一或共同第一作者;#,通讯或共同通讯作者)
1. Pin Zhao*, Samiullah Malik, Shaojun Xing# Epigenetic Mechanisms Involved in HCV-Induced Hepatocellular Carcinoma (HCC) Front Oncol . 2021 Jul 15;11:677926. doi: 10.3389/fonc.2021.677926.
2. Siyang Yu*, Jianghong An*, Xuejiao Liao*, Haiyan Wang*, Fen Ma, Dapeng Li, Aimin Li, Weilong Liu, Siwei Zhang, Mingfeng Liao, Lei Liu#, Juanjuan Zhao#, Shaojun Xing#, Lanlan Wei#, Zheng Zhang# Distinct kinetics of immunoglobulin isotypes reveal early diagnosis and disease severity of COVID-19: A 6-month follow-up. Clin Transl Med2021;11(3):e342. doi: 10.1002/ctm2.342.
3. Xing S*, Gai K*, Li X, Shao P, Zeng Z, Zhao X, Zhao X, Chen X, Paradee WJ, Meyerholz DK, Peng W, Xue HH Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. J Exp Med2019. 216(4): 847-866.
4. Shaojun Xing, Peng Shao, Fengyin Li et al. Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity. J Exp Med 2018, 215(8): 2211-2226.
5. Jiao Y-M*, Yang H-G*, Huang H-H, Tu B, Xing S-J, Mao L, Xia W, He R, Zhang J-Y, Xu R-N, Jin L, Shi M, Xu Z, Qin E-Q, Wang X-C, Wu H, Ye L and Wang F-S (2017) Dichotomous Roles of Programmed Cell Death 1 on HIV-Specific CXCR5+ and CXCR5− CD8+ T Cells during Chronic HIV Infection. Front. Immunol. 2017.8:1786.
6. Shan Q*, Zeng Z*, Xing S, Li F, Hartwig SM,et al . The transcription factor Runx3 guards cytotoxic CD8(+)effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol. 2017. 18(8): 931-939.
7. Zhe Xu*, Shaojun Xing*, Qiang Shan et al Cutting Edge: beta-Catenin-Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions.J Immunol. 2017. 198(9): 3404-3409. (co-first author).
8. Bing He*, Shaojun Xing*, Changya chen et al CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections. Immunity. 2016;45(6):1341-1354. (co-first author).
9. Shaojun Xing*, Fengyin Li*, Zhouhao Zeng*, Yunjie Zhao, Shuyang Yu, et al Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity. Nat Immunol. 2016;17(6):695-703.
10. Choi YS*, Gullicksrud JA*, Xing S et al LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6 Nat Immunol. 2015;16(9):980-90.
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