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王雷

王雷 特聘教授

医学免疫学系

基础医学院

lei.wang@szu.edu.cn

深圳市南山区西丽学苑大道1066号

肿瘤免疫学

国家自然科学基金(海外)优秀青年。本科及硕士毕业于香港科技大学,博士毕业于美国加州大学河滨分校,美国希望之城国家医学中心博士后。长期聚焦肿瘤免疫方向,与临床医生紧密合作,运用单细胞以及空间原位多组学等深度免疫分析技术,结合生物信息学,从肿瘤微环境与免疫大环境互作的角度,探究肿瘤发生发展对患者全身性免疫系统的影响作用。已在Nature子刊、Cell子刊以及Lancet子刊等国际知名刊物发表多篇第一或通讯作者学术论文,主持国自然重大研究计划(免疫力数字解码)培育项目等国家级科研项目。

代表性论文

1. Wang L, Simons D, Lu X, Tu T, Solomon S, Wang R, Rosario A, Avalos C, Schmolze D, Yim J, Waisman J and Lee P. Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer. Nature Immunol, 2019, 20:1220-1230.

2. Wang L#*, Guo WH, Guo ZK, Yu JN, Tan JY, Simons D, Hu K, Liu XY, Zhou Q, Zheng YZ, Colt EA, Yim J, Waisman J, and Lee P*. PD-L1 is an IFNγ-independent maturation marker on tumor-associated macrophages and associates with good clinical outcome in human breast cancer. Cell Rep Med, 2024, 5:101420.

3. Wang L, Simons D, Lu X, Tu T, Avalos C, Chang A, Dribas F, Yim J, Waisman J and Lee P. Breast cancer induces systemic immune changes on cytokine signaling in peripheral blood monocytes and lymphocytes. EBioMedicine, 2020, 52(102631).

4. Wang L#, Miyahira A#, Simons D, Lu X, Chang A, Wang C, Suni M, Maino V, Dirbas F, Yim J, Waisman J and Lee P. IL-6 signaling in peripheral blood T cells predicts clinical outcome of breast cancer. Cancer Res, 2017, 77:1119-1126.

5. Wang L and Lee P. Systemic correlates of the tumor microenvironment. Cancer Treat Res, Springer Nature, 2020,180:97-109.  

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