主持科研项目
1.广东省自然科学基金-面上项目,2114050001863,黏着斑激酶FAK反馈增强IgE/FcεRI通路介导肥大细胞活化的机制研究、2021/01-2023/12,10万元,在研;
2.国家自然科学基金青年科学基金项目,81602595,STAT3/CDK6通路调控肝癌干细胞的静止期退出与自我更新的基础研究、2017/01-2019/12,17万元,结题;
3.广东省科技发展专项资金(公益研究与能力建设)项目:2017A020215069,抗精神病类药物pimozide在抑制肝癌细胞的静止期退出及预防肝癌发生的研究,2017/01-2018/12,10万元,结题;
4.深圳市基础研究项目,JCY20170818142053544,靶向CDK6基因逆转肝癌细胞的多药耐药性研究,2018/03-2020/02,30万元,结题;
5.广东省医学科研基金项目,A2019522,CDK6通过驱动肝癌细胞干细胞样特性在化疗耐药中的作用机制研究,2019/07-2021/06,1万元,结题;
代表性成果:
1.Chen JJ*, Zhang LN, Wang HN, Xie CC, Li WY, Gao P, Hu WZ, Zhao ZF, Ji K*. FAK inhibitor PF-431396 suppresses IgE-mediated mast cell activation and allergic inflammation in mice. Biochem Pharmacol. 2021; 192:114722. (IF5.858,第一作者兼共同通讯作者)
2.Wang HN#, Ji KM#, Zhang LN, Xie CC, Li WY, Zhao ZF, Chen JJ*. Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis. J Transl Med. 2021; 19(1):261. (IF5.531,独立通讯作者)
3.Zhang LN#, Ji KM#, Sun YT, Hou YB, Chen JJ*. Aurora kinase inhibitor tozasertib suppresses mast cell activation in vitro and in vivo. Br J Pharmacol. 2020; 177(12): 2848-2859. (IF 8.739,独立通讯作者)
4.Hou YB#, Zhang LN#, Wang HN, Zhao ZF, Sun YT, Ji KM*, Chen JJ*. The antipsychotic drug pimozide inhibits IgE-mediated mast cell degranulation and migration. Int Immunopharmacol. 2020; 84: 106500. (IF4.932,共同通讯作者)
5.Hou YB#, Ji KM#, Sun YT, Zhang LN, Chen JJ*. CDK4/6 inhibitor palbociclib suppresses IgE-mediated mast cell activation, J Transl Med. 2019; 17(1): 276. (IF4.124,独立通讯作者)
6.Cai ZL#, Chen JJ#, Zhang Z, Hou YB, He YS, Sun JL*, Ji KM*. Identification of immunodominant IgE binding epitopes of Der p 24, a major allergen of Dermatophagoides pteronyssinus. Clin Transl Allergy. 2019; 9:28. (IF5.129,共同第一作者)
7.Hu JY#, Chen JJ#, Ye LL, Cai ZL, Sun JL*, Ji KM*. Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE+ B cells. Clin Transl Allergy. 2018; 8:27. (IF 4.21, 共同第一作者)
用户登录
还没有账号?
立即注册