代表性研究成果

1)Santosh Kumar^#, Gang Wang^#, Na Zheng, Wanwen Cheng, Kunfu Ouyang,Hairuo Lin, Yulin Liao, Jie Liu^* HIMF (Hypoxia-Induced Mitogenic Factor)-IL(Interleukin)-6 Signaling Mediates Cardiomyocyte-Fibroblast Crosstalk to Promote Cardiac Hypertrophy and Fibrosis.Hypertension. 2019 May;73(5):1058-1070.

2)Santosh Kumar^#, Gang Wang^#, Wenjuan Liu^#, Wenwen Ding, Ming Dong, Na Zheng, Hongyu Ye, Jie Liu*.Hypoxia-Induced Mitogenic Factor Promotes Cardiac Hypertrophy via Calcium-Dependent and Hypoxia-Inducible Factor-1α Mechanisms.Hypertension. 2018 Aug;72(2):331-342.

3)Liu W^#, Deng J^#, Wang G^#, Zhang C, Luo X, Yan D, Su Q, Liu J*.KCNE2 modulates cardiac L-type Ca²⁺ channel.J Mol Cell Cardiol. 2014 Jul;72:208-218.

4)Liang X^#, Wang G^#, Lin L, Lowe J, Zhang Q, Bu L, Chen Y, Chen J, Sun Y, Evans SM*.HCN4 Dynamically Marks the First Heart Field and Conduction System Precursors. Circ Res. 2013;113:399-407.

5)Wang G^#, Zhu X^#, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, Song R, Cao C, Zhang J, Wu C, Liu J*. Cheng H. Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.Circ Res. 2010 Feb 5;106(2):317-27.

6)Yao LJ^#, Wang G^#, Ou-Yang KF, Wei CL, Wang XH, Wang SR, Yao W, Huang HP, Luo JH, Wu CH, Liu J, Zhou Z, Cheng HP*. Ca²⁺ sparks and Ca²⁺ glows in superior cervical ganglion neurons.Acta Pharmacol Sin.2006 Jul;27(7):848-852.

7)Wenjuan Liu, Gang Wang, Cuicui Zhang, Wenwen Ding, Wanwen Cheng, Yizhi Luo, Chaoliang Wei, Jie Liu ^* MG53, a Novel Regulator of KChIP2 and Ito,f, Plays a Critical Role in Electrophysiological Remodeling in Cardiac Hypertrophy.Circulation. 2019 Apr 30;139(18):2142-2156.

8)Liu W^#, Deng J^#, Ding W^#, Wang G, Shen Y, Zheng J, Zhang X, Luo Y, Lv C, Wang Y, Chen L, Yan D, Boudreau RL, Song LS, Liu J*. Decreased KCNE2 Expression Participates in the Development of Cardiac Hypertrophy byRegulation of Calcineurin-NFAT (Nuclear Factor of Activated T Cells) and Mitogen-ActivatedProtein Kinase Pathways. Circ Heart Fail. 2017 Jun;10(6). pii: e003960. doi: 10.1161/CIRCHEARTFAILURE.117.003960.

9)Liu WJ^#, Deng JX^#, Wang G, Gao KP, Lin ZX, Liu SY, Wang YH, Liu J*. Manipulation of KCNE2 expression modulates action potential duration and Ito and IK in rat and mouseventricular myocytes. Am J Physiol Heart Circ Physiol. 2015 Oct;309(8):H1288-302.

10)Liang X, Zhang Q, Cattaneo P, Zhuang S, Gong X, Spann NJ, Jiang C, Cao X, Zhao X, Zhang X, Bu L, Wang G, Chen HS, Zhuang T, Yan J, Geng P, Luo L, Banerjee I, Chen Y, Glass CK, Zambon AC, Chen J, Sun Y, Evans SM*.Transcription factor ISL1 is essential for pacemaker development and function.J Clin Invest. 2015 Aug 3; 125(8):3256-68.

11)Xue Y, Ouyang K, Huang J, Zhou Y, Ouyang H, Li H, Wang G, Wu Q, Wei C, Bi Y, Jiang L, Cai Z, Sun H, Zhang K, Zhang Y, Chen J, Fu XD*.Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated microRNA Circuits.Cell. 2013 Jan 17; 152(1-2): 82-96.

12)Shen T, Aneas I, Sakabe N, Dirschinger RJ, Wang G, Smemo S, Westlund JM, Cheng H, Dalton N, Gu Y, Boogerd CJ, Cai CL, Peterson K, Chen J, Nobrega MA, Evans SM*.Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function.J Clin Invest. 2011 Dec 1;121(12):4640-54.

13)Efe JA, Hilcove S, Kim J, Zhou H, Ouyang K, Wang G, Chen J, Ding S*.Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy.Nat Cell Biol. 2011 Mar;13(3):215-22.

14)Liang X, Sun Y, Ye M, Scimia MC, Cheng H, Martin J, Wang G, Rearden A, Wu C, Peterson KL, Powell HC, Evans SM*, Chen J*.Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality.Circulation. 2009 Aug 18;120(7):568-76.