科研项目：APOBEC家族在DNA损伤修复中的表观遗传学调控
主持项目：
1. 2020.1-2023.12 国家自然科学基金面上项目，51万，主持
2. 2017.1-2019.12 国家自然科学青年基金，19 万，主持
1. Tian Y*, Yang B*, Qiu WN, et al. Endoplasmic reticulum-residential Nogo-B accelerates NAFLD-associated hepatocellular carcinogenesis mediated by metabolic reprogramming of oxidized LDL lipophagy. Nat Commun. 2019;10(1):3391.
2. Sun HY*, Yang WQ*, Tian Y*, et al. An inflammatory-CCRK circuitry drives mTORC1- dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma. Nat Commun. 2018;6;9(1):5214.
3. Tian Y*, Mok MT*, Yang P, et al. Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis. Cancers. 2016;20;8(8).
4. Tian Y, Wong VW, Wong GL, et al. Histone deacetylase 8 promotes insulin resistance and β-catenin activation in NAFLD-associated hepatocellular carcinoma. Cancer Res. 2015;75(22):4803-16.
5. Xu WH*, Hu HG*, Tian Y*, et al. Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis. Hepatology. 2014;60(2):648-60. 6. Tian Y, Wong VW, Chan HL, et al. Epigenetic regulation of hepatocellular carcinoma in non-alcoholic fatty liver disease. Semin Cancer Biol. 2013;23(6 Pt B):471-82.
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