主持项目:
1. 国家自然科学基金面上项目(2024-2027):心肌梗死修复后期TGF-β2通过YAP/TAZ下调LYVE-1表达引起免疫细胞经淋巴管清除障碍的作用与机制研究。 RMB 490,000,No. 82370259。
2. 深圳市高等院校稳定支持计划项目(2024-2025):转录因子EB调节缺氧性肺动脉高压相关血管功能障碍的作用和机制研究。RMB 150,000, No. 89601170045.
3. 广东省基础与应用研究基金面上项目(2024-2026):淋巴管内皮转化生长因子β 2在心肌梗死后免疫细胞清除中的作用与机制研究。RMB 150,000。No. 2024A1515010994
4. 新引进高精尖缺人才科研启动费(2023-2025):RMB 1,990,000, No. 82700069224.
5. 深圳大学青年教师启动经费(2021)。RMB 150,000。(已结题)
6. 国家自然科学基金青年项目:转录因子EB通过抑制内皮-间充质细胞转化减轻慢性缺氧诱导的肺动脉高压(2021-2023),RMB240,000,No.82000056。(已结题)
代表性成果:
1. He L#, Chen Q, Wang L, Pu Y, Huang J, Cheng CK, Luo JY, Kang L, Lin X, Xiang L, Fang L, He B, Xia Y, Lui KO, Pan Y, Liu J, Zhang CL*, Huang Y*. Activation of Nrf2 inhibits atherosclerosis in ApoE-/- mice through suppressing endothelial cell inflammation and lipid peroxidation. Redox Biol. 2024 Aug;74:103229. (共同通讯作者)
2. Wu LY#, Song YJ#, Zhang CL*, Liu J. KV Channel-Interacting Proteins in the Neurological and Cardiovascular Systems: An Updated Review. Cells. 2023 Jul 20;12(14):1894. (通讯作者)
3. Wang MY#, Liu WJ#, Wu LY, Wang G*, Zhang CL*, Liu J. The Research Progress in Transforming Growth Factor-β2. Cells. 2023 Nov 30;12(23):2739. (通讯作者)
4. Zhao L#, Zhang CL#*, He L#, Chen Q, Liu L, Kang L, Liu J, Luo JY, Gou L, Qu D, Song WC, Lau CW, Ko H, Mok VCT, Tian XY, Wang L, Huang Y*. Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization. Diabetes. 2022 May 1;71(5):1099-1114. (共一兼共通讯)
5. He L#, Zhang CL#, Chen Q, Wang L, Huang Y*. Endothelial shear stress signal transduction and atherogenesis: From mechanisms to therapeutics. Pharmacol Ther. 2022 Feb 2;235:108152. (共同第一作者)
6. Zhao Q #, Zhang CL#, Xiang RL, Wu LL, and Li L*. CTRP15 derived from cardiac myocytes attenuates TGFβ1-induced fibrotic response in cardiac fibroblasts. Cardiovasc Drugs Ther. 2020 Oct;34(5):591-604. (共同第一作者)
7. Song W#, Zhang CL#, Gou L, He L, Gong YY, Dan Q, Zhao L, Jin N, Chan TF, Wang L, Tian XY, Luo JY* & Huang Y*. Endothelial TFEB Restrains IKK-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice. Arteriosclerosis, Thrombosis and Vascular Biology. 2019;39:719-730. (共同第一作者)
8. Zhang CL#, Zhao Q#, Liang H, Qiao X, Wang JY, Wu D, Wu LL*, and Li L*. Cartilage intermediate layer protein-1 alleviates pressure overload-induced cardiac fibrosis via interfering TGF-β1 signaling. J Mol Cell Cardiol. 2018, 116:135-144. (第一作者)
9. Zhang CL#, Feng H, Li L, Wang JY, Wu D, Hao YT, Wang Z, Zhang Y*, and Wu LL*. Globular CTRP3 promotes mitochondrial biogenesis in cardiomyocytes through AMPK/PGC-1α pathway. Biochimica et Biophysica Acta. 2017, 1861:3085-3094. (第一作者)
10. Zhang CL#, Chen ZJ, Feng H, Cao YP, Li L, Wang JY, Zhang Y*, and Wu LL*. C1q/tumor necrosis factor-related protein-3 enhances the contractility of cardiomyocyte by increasing calcium sensitivity. Cell Calcium. 2017, 66:90-97. (第一作者)
11. Zhang CL#, Xie S, Qiao X, An YM, Zhang Y, Li L, Guo XB, Zhang FC, and Wu LL*. Plasma endothelin-1 related peptides as the prognostic biomarkers for heart failure: A comprehensive meta-analysis. Medicine. 2017, 96(50):e9342. (第一作者)
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