苏文 副教授
病理学系
基础医学院
suwen@szu.edu.cn
脂滴在高血压、脂肪肝、糖尿病等代谢性疾病发病过程中的代谢调控机制和非酒精性脂肪性肝炎（NASH）新药研发
苏文，北京大学学士、北京大学病理生理学专业博士，北大优秀毕业生，南山区C类领航人才，深圳市孔雀人才C类人才。现为深圳大学助理教授，2015-2016年美国休斯顿核受体和细胞信号转导中心，美国瑞典三院院士-Jan-Ake Gustafsson实验室访问学者，阿斯利康-深圳大学肾脏病研究中心的成员。获国家博士后基金一等资助，国家自然科学基金青年基金，国家自然科学基金面上基金，深圳市基础项目等科研基金的资助。在国际上首次建立了正常人肝脏和脂肪脏的脂滴蛋白数据库，首次发现新型的脂滴相关蛋白HSD17B13参与人非酒精性脂肪肝和脂肪性肝炎的发生，为NASH的诊断和药物研发提供了新的靶点。目前以第一作者或通讯作者发表包括Naturecommun 2022，PNAS 2014、Am J Physiol Renal Physiol2017、Am J Physiol Endocrinol Metab2017在内的文章数篇，Am J Physiol Endocrinol Metab.审稿人，中国生理协会、美国糖尿病协会会员。
科研项目：
1.国家自然科学基金面上项目：新型肝特异性脂滴蛋白17β-HSD13在NAFLD发生中的作用及机制 （NO.81870405, 2018/1-2022/12, 60万) ；
2.广东省面上项目：17β-HSD13通过动态调控ATGL脂滴转位参与非酒精性脂肪性肝炎的发生 （2022/1-2024/12）
3. 深圳市基础研究项目（自由探索）：肾髓降压物质--髓质素（Medullipin）的分离和成分探索 （NO.JCYJ20170818144501119，2018/1-2020/9，48万）；
4. 深圳市基础研究项目（自由探索）：新型肝脂滴蛋白17β-HSD13通过调控脂代谢参与非酒精性脂肪性肝炎脂代谢紊乱及机制研究 （2021/8-2023/12，60万）；
5. 深圳市孔雀计划项目（ 2020.01-2022.12，270万）；
6. 国家自然科学基金青年项目：高血压大鼠肾髓间质细胞脂滴的蛋白质组学和脂质组学研究 （NO. 81500538, 2016/1-2018/12）
代表性成果：
1.Wen Su*, Sijin Wu, Yongliang Yang, Yanlin Guo, Haibo Zhang, Jie Su, Lei Chen, Zhuo Mao, Rongfeng Lan, Rong Cao, Chunjiong Wang, Hu Xu, Cong Zhang, Sha Li, Min Gao, Xiaocong Chen, Zhiyou Zheng, Bing Wang, Yi’ao Liu, Zuojun Liu, Zimei Wang, Baohua Liu, Xinmin Fan, Xiaoyan Zhang* & Youfei Guan*. Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice. Nat Commun 13, 6577 (2022). https://doi.org/10.1038/s41467-022-34299-1 (独立1作，共同通讯)
2.Su Wen, Wang Yang, Jia Xiao, Wu Wenhan, Li Linhai, Tian Xiaoyu, Li Sha, Wang Chunjiong, Xu Hu, Cao Jiaqi, Han Qifei, Xu Shimeng, Chen Yong, Zhong Yanfeng, Zhang Xiaoyan, Liu Pingsheng, Gustafsson JÅ, Guan Youfei. Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11437-42.
3.Su, Wen; Feng, Ming-Ji; Liu, Yuan; Cao, Rong; Liu, Yi-Ao; Tang, Jun-Yao; Pan, Ke; Lan, Rong-Feng; Mao, Zhuo. ZnT8 Deficiency Protects From APAP-Induced Acute Liver Injury by Reducing Oxidative Stress Through Upregulating Hepatic Zinc and Metallothioneins. Frontiers in pharmacology. 2021; 12:721471.
4.Sha Li, Chenghai Wang, Xiaxia Zhang, Wen Su*. Cytochrome P450 Omega-Hydroxylase 4a14 Attenuates Cholestatic Liver Fibrosis. Front Physiol. 2021 May 31;12:688259.
5.Yu Jingwei, Peng Jun, Luan Zhilin, Zheng Feng, Su Wen*. MicroRNAs as a Novel Tool in the Diagnosis of Liver Lipid Dysregulation and Fatty Liver Disease. Molecules. 2019 Jan 9;24(2). pii: E230.
6.Su Wen, Cao Rong, Xiaoyan Zhang, Youfei Guan. Aquaporins in the Kidney: Physiology and Pathophysiology. Am J Physiol Renal Physiol. 2020 Jan 1;318(1): F193-F203.
7.Su Wen, Youfei Guan. Liver-Specific Overexpression of 17ß-HSD13 Causes Hepatic Steatosis in Mice. Diabetes May 2018. 67(Supplement 1):1871-P.
8.Peng Jun, Yu Jingwei, Xu Hu, Kang Chen, Shaul PW, Guan Youfei, Zhang Xiaoyan, Su Wen*. Enhanced Liver Regeneration After Partial Hepatectomy in Sterol Regulatory Element-Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability. Cell Physiol Biochem. 2018;47(2):784-799.
9.Su Wen, Mao Zhuo, Liu Yi’ao, Zhang Xiaoyan, Zhang Weizhen, Gustafsson JA, Guan Youfei. Role of HSD17B13 in the liver physiology and pathophysiology. Mol Cell Endocrinol. 2019 Jun 1; 489:119-125.
10.Wen Su, Shi-zheng Huang, Min Gao, Xiao-mu Kong, Jan-Ake Gustafsson, Su-juan Xu, Bing Wang, Feng Zheng, Nan-ping Wang, You-fei Guan, Xiao-Yan Zhang. Liver X Receptor β (LXRβ) Increases AQP2 Protein Level via a Post-transcriptional Mechanism in Renal Collecting Ducts. Am J Physiol Renal Physiol, 2017 Apr 1;312(4):F619-F628.
11.Su Wen#, Peng Jun#, Li Sha, Dai Yubing, Wang Chunjiong, Xu Hu, Gao Min, Ruan Xiongzhong, Gustafsson Jan-Åke, Guan Youfei, Zhang Xiaoyan. Liver X receptor α induces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c. Am J Physiol Endocrinol Metab. 2017 Apr 1;312 (4): E357-E367.
12.Su Wen, Cao Rong, He Yongcheng, Guan Youfei, Ruan Xiongzhong. Crosstalk of Hyperglycemia and Dyslipidemia in Diabetic Kidney Disease. Kidney Dis (Basel). 2017 Dec;3(4):171-180.
13. Yi-fei Miao#, Wen Su#, Yu-bing Dai, Wan-fu Wu, Bo Huang, Rodrigo P.A. Barros, Hao Nguyen, Laure Maneix, Youfei Guan, Margaret Warner*, Jan-Ake Gustafsson*. An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice, Scientific Reports, 2016, 6:38579.
14.Jingwei Yu, Wen Su, Xiaoyan Zhang, Feng Zheng, Youfei Guan. MicroRNAs in type 2 diabetes mellitus: Important for the pathogenesis but uncertain as biomarkers. J Diabetes.
15.Jing-Wei Yu, Jun Peng, Xiao-Yan Zhang, Wen Su*, You-Fei Guan*.Role of prostaglandin E 2 receptor EP4 in the regulation of adipogenesis and adipose metabolism. Sheng Li Xue Bao. 2019 Jun 25;71(3):491-496.
16.Sha Li, Wen Su, Xiao-Yan Zhang, You-Fei Guan. Arachidonic acid metabolism in liver glucose and lipid homeostasis. Sheng Li Xue Bao. 2021 Aug 25;73(4):657-664.
17.Zhuo Mao, Mingji Feng, Zhuoran Li, Minsi Zhou, Langning Xu, Ke Pan, Shaoxiang Wang, Wen Su, Weizhen Zhang.ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway.Diabetes. 2021 Jan;70(1):214-226.
18.Ling Guo, Chunhong Cui, Jiaxin Wang, Jifan Yuan, Qingyang Yang, Ping Zhang, Wen Su, Ruolu Bao, Jingchao Ran, Chuanyue Wu. PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth. Nat Commun. 2020 Oct 1;11(1):4913.
19.Zhuojun Zhang, Chen Zong, Mingyang Jiang, Han Hu, Xiaolei Cheng, Juhua Ni, Xia Yi, Bin Jiang, Feng Tian, Ming-Wen Chang, Wen Su, Lijun Zhu, Jinfan Li, Xueping Xiang, Congxiu Miao, Myriam Gorospe, Rafael de Cabo, Yali Dou, Zhenyu Ju, Jichun Yang, Changtao Jiang, Zhongzhou Yang, Wengong Wang. Hepatic HuR modulates lipid homeostasis in response to high-fat diet. Nat Commun. 2020 Jun 16;11(1):3067.
20.Bing Wang, Haibo Zhang, Zhilin Luan, Hu Xu, Yuanyi Wei, Xuejia Zhao, Miaomiao Xing, Xiaoxiao Huo, Jiayang Zhang, Wen Su, Youfei Guan, Xiaoyan Zhang.Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse liver.Exp Cell Res. 2020 May 1;390(1):111949.
21.Meiling Jin, Yihong Lai, Peili Zhao, Qian Shen, Wen Su, Yue Yin, Weizhen Zhang.Effects of peptidoglycan on the development of steatohepatitis. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158595.
22.Hu Xu, Shengnan Du, Bingying Fang, Chaojie Li, Xiao Jia, Senfeng Zheng, Sailun Wang, Qingwei Li, Wen Su, Nanping Wang, Feng Zheng, Lihong Chen, Xiaoyan Zhang, Jan-Åke Gustafsson, Youfei Guan.VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8457-8462.
23.Zhuo Mao, Hui Lin, Wen Su, Jinghui Li, Minsi Zhou, Zhuoran Li, Beibei Zhou, Qing Yang, Mingyan Zhou, Ke Pan, Jinhan He, Weizhen Zhang. Deficiency of ZnT8 Promotes Adiposity and Metabolic Dysfunction by Increasing Peripheral Serotonin Production. Diabetes. 2019 Jun;68(6):1197-1209.
24.Bowen Xing, Jian Ma, Zongzhe Jiang, Zijie Feng, Sunbin Ling, Katy Szigety, Wen Su, Longmei Zhang, Ruirui Jia, Yanmei Sun, Lin Zhang, Xiangchen Kong, Xiaosong Ma, Xianxin Hua. GLP-1 signaling suppresses menin's transcriptional block by phosphorylation in β cells. J Cell Biol. 2019 Mar 4;218(3):855-870.
25.Zhuo Mao, Qing Yang, Wenzhen Yin, Wen Su, Hui Lin, Mingji Feng, Ke Pan, Yue Yin, Weizhen Zhang. ETV5 regulates GOAT/ghrelin system in an mTORC1-dependent manner. Mol Cell Endocrinol. 2019 Apr 5; 485:72-80.
26.Xiaoyan Zhang, Sha Li, Yunfeng Zhou, Wen Su, Xiongzhong Ruan, Bing Wang, Feng Zheng, Margaret Warner, Jan-Åke Gustafsson, and Youfei Guan. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3181-3185.
27.Bo Huang, Ryan Butler, Yifei Miao, Yubing Dai, Wanfu Wu, Wen Su, Yoshiaki Fujii-Kuriyama, Margaret Warner, and Jan-Åke Gustafsson. Dysregulation of Notch and ERα signaling in AhR-/- male mice. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7614-9.
28.Yu-bing Dai,a Yi-fei Miao, Wan-fu Wu, Yu Li, Francesca D'Errico, Wen Su, Alan R. Burns, Bo Huang, Laure Maneix, Margaret Warner, and Jan-Åke Gustafsson. Ablation of Liver X receptors α and β leads to spontaneous peripheral squamous cell lung cancer in mice. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7614-9.
29.Wan-fu Wu, Laure Maneix, Jose Insunza, Ivan Nalvarte, Per Antonson, Juha Kere, Nancy Yiu-Lin Yu, Virpi Tohonen, Shintaro Katayama, Elisabet Einarsdottir, Kaarel Krjutskov, Yu-bing Dai, Bo Huang, Wen Su, Margaret Warner, and Jan-Åke Gustafsson. Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate. Proc Natl Acad Sci U S A. 2017 May 9;114(19): E3816-E3822.
30.Yunfeng Zhou, Jingwei Yu, Jia Liu, Rong Cao, Wen Su, Sha Li, Shiqi Ye, Chenggang Zhu, Xiaolin Zhang, Hu Xu, Hua Chen, Xiaoyan Zhang, Youfei Guan. Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice. Biochim Biophys Acta. 2018 Mar; 1864(3):860-870.
31.Chunjiong Wang, Yujing Chi, Jing Li, Sha Li, Wen Su. FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis. Hepatology,2013;
32.Su Wen, Xu Huamin, Kang Jihogn, Guan Youfei. The function of 17beta-hydroxysteroid dehydrogenase family. Sheng Li Ke Xue Jin Zhan. 2014 Feb;45(1):27-31.
主要学术贡献：在国际上首次建立了正常人肝脏和脂肪脏的脂滴蛋白数据库，首次发现新型的脂滴相关蛋白HSD17B13参与人非酒精性脂肪肝和脂肪性肝炎的发生，为NASH的诊断和药物研发提供了新的靶点,其关于肝脏脂滴的研究成果发表于美国科学院院刊（PNAS 2014）并被评为当期亮点文章，并于2018年被新英格兰杂志（NEJM）在大规模人群上得到验证。
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