细胞生物学与医学遗传学系
基础医学院
干细胞生物学和组织工程学方面
朱艳霞(Yanxia Zhu)副教授,博士,硕士研究生导师,深圳市海外高层次人才。主要从事干细胞生物学和组织工程学方面的研究工作。武汉大学硕士,牛津大学和大连理工大学联合培养博士,宾夕法尼亚大学再生医学博士后。以第一作和通讯作者发表SCI收录论文30余篇,EI收录论文8篇,他引共1000多次,其中一篇关于脂肪干细胞生物学特性的文章他引900多次;申请专利7项;主编教材两本,参编著作一本;作为核心成员参与国家重点研发项目1项,作为项目负责人获得国家项目2项,省级2项,市级项目多项;并获得2020年深圳市科技进步二等奖主要研究方向为脂肪干细胞生物学特性、iPS细胞重编程及定向分化、干细胞外泌体修复机制及其在组织工程中的应用,主要集中在软骨、骨和皮肤组织工程,本着集分子水平的基础理论研究和面向临床的转化研究于一体,以解决临床衰老和损伤组织修复再生问题。
1. 国家重点研发计划项目:“骨衰老发生机制及治疗策略”(2023YFC2509900),2023-2027;
2. 国家自然科学基金面上项目:“长效可控释氢对创面修复不同时期巨噬细胞极化的双向调控作用和机制研究”(82272292),2023.1-2026.12;
3. 国家自然科学基金青年项目:“基于iPS椎间盘退行性疾病模型的建立及机理研究”(81301597),2014-2016;
4. 广东省基础与应用基础研究基金项目:“可控释氢水凝胶的构建及其皮肤修复效应和机制研究”(2021A1515011155),2021.1-2023.12;
5. 广东省医学科学基金项目:“脂肪干细胞结合生物微环境模拟系统构建仿生髓核的实验研究”(A2018555),2018-2020;
6. 海外高层次人才创新创业项目:“电纺生物膜介导“三明治”样脂肪干细胞片层分泌外泌体促进表皮修复及其机制的研究”(KQJSCX20180328095512554)2019-2021;
7. 深圳市高端人才启动项目:“RNA激活和温敏技术在人工椎间盘组织构建中的应用”,2015-2017;
8. 深圳市基础研究面上项目:“长效可控释氢敷料通过双向调控巨噬细胞极化促进糖尿病创面修复的机制研究”(JCYJ20160422090807181),2022.10-2025.10
9. 深圳市基础研究项目: “生物微环境模拟体系结合脂肪干细胞构建仿生髓核的实验研究”(JCYJ20170818100526471),2018-2020;
10. 深圳市基础研究项目:“脂肪干细胞结合细胞片层技术构建皮肤复合组织的初步研究”(JCYJ20160422090807181),2016-2018;
11. 深圳市基础研究项目:“人工全椎间盘组织工程构建的实验研究”(JCYJ20150525092940984),2015-2017;
12. 深圳市基础研究项目: “以iPS为模型的椎间盘退行性变致病机理研究”(JCYJ20130326110154156),2013-2015。
13. 深圳市基础研究项目 负责人(2013-2014)“骨关节炎组织特异性干细胞表观遗传学调控机制的研究”(No:JCYJ20120821110533438)。
期刊论文(#表示共同第一作者,*表示通讯作者)
1. Zhu Yanxia, Jiang Qi, Jin Zhaokui, Chen Danyang, Xu Qingqing, Zeng Yue, Chen Jinchun, He Qianjun*. Two-Dimensional Mg2Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin. Adv. Healthc. Mater. 2023, 12(10): e2201705.
(IF 10.0,中科院1区,TOP期刊)
2. Zhu Yanxia, Liao Yuqi, Zhang Yuanyuan, Shekh Mehdihasan I., Zhang Jianhao, You Ziyang, Du Bing, Lian Cuihong*, He Qianjun*. Novel nanofibrous membrane-supporting stem cell sheets for plasmid delivery and cell activation to accelerate wound healing. Bioengineering & Translational Medicine, 2022, 7: e10244.
(IF 10.711,中科院1区,TOP期刊)
3. Chen Shenqiang#, Zhu Yanxia#, Xu Qingqing, Jiang Qi, Chen Danyang, Chen Ting, Xu X, Jin Zhaokui, He Qianjun*. Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing. Nature Communications. 2022, 13: 5684.
(IF 17.694,中科院1区,TOP期刊)
4. Dong Ming#, Chen Deng#, Zhu Yanxia#, Yang Shishu, Kumar S, Zhang R, Zhou Y, Yang Z, Zheng N, Zhu Ting, Xiang J, Liu Yan, Kang Ling*, Liu Jie*. Impaired regulation of MMP2/16–MLCK3 by miR-146a-5p increased susceptibility to myocardial ischaemic injury in aging mice. Cardiovasc. Res. 2022, 119 (3) :786-801.
(IF 13.081,中科院1区,TOP期刊)
5. Wang Yingshuai#, Zhu Yanxia#, Zhao Penghe, Wei Bin, Fan Mingjian, Chen Danyang, Jin Zhaokui, He Qianjun*. A nanoconcrete welding strategy for constructing high-performance wound dressing. Bioactive materials, 2022, 14:31-41.
(IF 18.9,中科院1区,TOP期刊)
6. Amirian Jhaleh, Zeng Yue, Shekh Mehdihasan I., Gaurav Sharma, Florian.J. Stadler, Song Jun, Du Bing*, Zhu Yanxia*. In-situ crosslinked hydrogel based on amidated pectin/oxidized chitosan as potential wound dressing for skin repairing. Carbohydrate Polymers, 2021, 251:117005.
(IF 9.381,中科院1区,TOP期刊)
7. Mehdihasan I. Shekh, Jhaleh Amirian, Florian J. Stadler, Du Bing*, Zhu Yanxia*. Oxidized chitosan modified electrospun scaffolds for controllable release of acyclovir. Int. J. Biol. Macromol. 2020, 151:787–796.
(IF 6.953,中科院1区,TOP期刊)
8. Dai Weifeng#, Zhu Yanxia#, Qin Fuying,Chang Junlei, Zeng Yue, Wang Jigang, Zhang Yuanyuan, Cheng Yongxian*. Skeletal meroterpenoids from Ganoderma petchii mushrooms that potentially stimulate umbilical cord mesenchymal stem cells. Bioorganic Chemistry, 2020, 97: 103675.
(IF 5.275,中科院1区,TOP期刊)
9. Liu Kaixin#, Zhu Yanxia#, Yan Yongming, Zeng Yue, Jiao Yubo, Qin FY, Liu Jiawang, Zhang Yuanyuan, Cheng Yongxian*. Discovery of Populusone, a Skeletal Stimulator of Umbilical Cord Mesenchymal Stem Cells from Populus euphratica Exudates. Org Lett. 2019, 21(6):1837-1840.
(IF 6.555,中科院1区,TOP期刊)
10. Liu Jiawang, Zhang Mingyu, Yan Yongming, Wei Xiaoyi, Dong Lu, Zhu Yanxia*, and Cheng Yongxian*. Characterization of Sesquiterpene Dimers from Resina Commiphora That Promote Adipose-Derived Stem Cell Proliferation and Differentiation. The Journal of Organic Chemistry. 2018,83, 2725−2733.
(IF 4.805,中科院2区,TOP期刊)
7. Zhu Y*, Liang Y, Zhu H, Lian C, Gu H, Zou X, Zhou G, Yu X*. Generation and Functional Characterization of Induced Pluripotent Stem Cells (iPSCs) from Human Intervertebral Disc Nucleus Pulposus Cells. Oncotarget, 2017, 8(26): 42700-42711.
8. Zhu Y*, Tan J, Zhu H, Lin G, Yin F, Wang L, Song K, Wang Y, Zhou G, Yi W*. Development of Kartogenin-conjugated chitosan-hyaluronic acid hydrogel for nucleus pulposus regeneration. Biomaterials Science, 2017, 5:784-791.
9. Yanxia Zhu*, Xiaomin Wu, Yuhong Liang, Kedong Song, Xuenong Zou, Guangqian Zhou*. Induced pluripotent stem cell derived chondrocytes restore knee function in rat osteoarthritis model. BMC Biotechnology, 2016, 16(1): 78-88.
10. Yanxia Zhu#, Kedong Song#, Siyu Jiang#, Jinglian Chen, Lingzhi Tang, Siyuan Li, Jiangli Fan, Yiwei Wang, Jiaquan Zhao, Tianqing Liu*. Numerical simulation of mass transfer and three-dimensional fabrication of tissue engineered cartilages based on chitosan/gelatin hybrid hydrogel scaffold in a rotating bioreactor,Appl Biochem Biotechnol, 2016, 179(459):1-17.
11. Kedong Song#, Liying Li#, Zhu Yanxia#, Zeren Jiao, Mayasari Lim, Meiyun Fang, Fangxin Shi, LingWang, Tianqing Liu*. Three-dimensional dynamic fabrication of engineered cartilage based on chitosan/gelatin hybrid hydrogel scaffold in a spinner fask with a special designed steel frame. Materials Science and Engineering. 2015, 55: 384-392.
12. Kedong Song#, Wenfeng Li#, Yanxia Zhu#, Meiyun Fang, Fangxin Shi, LingWang, Tianqing Liu*. Dynamic fabrication of tissue engineering bone substitutes based on derived cancelious bone scaffold in a spinner flask bioreactor system. Appl Biochem Biotechnol. 2014, 174(4): 1331-1343.
13. Yanxia Zhu, Zhuxin Dong, Uchechukwu C. Wejinya, Kaiming Ye*. Determination of Mechanical Properties of Soft Tissue Scaffolds by Atomic Force Microscopy Nanoindentation. Journal of Biomechanics. 2011, 44(13): 2356-2361.
14. Yanxia Zhu, Tianqing Liu*, Xuehu Ma, et al. Enhancement of ADSC Differentiation in Scaffolds with IGF-1 Gene Impregnation under Dynamic Microenvironment. Stem Cells and Development. 2010, 19(10): 1-10.
1. 朱艳霞,余小平。一种三明治样多细胞片层的制备方法。2014,中国专利,专利号:201410632650.8。(已授权)
2. 朱艳霞,谭杰,易伟宏,周光前。可注射水凝胶及其制备方法。2015,中国专利,专利号:201510334402.X。(已授权)
3. 朱艳霞,周光前。一种髓核细胞分离纯化方法。2016,中国专利,专利号:201610371318.X。
4. 朱艳霞。含干细胞因子的明胶-透明质酸-壳聚糖电纺膜制备方法。2018,中国专利,专利号:201810450212.8。
5. 廉翠红,朱艳霞,张远远。外泌体的提取方法。 2018,中国专利,专利号: 201811373858.7。
6. 何前军,朱艳霞,蒋奇。硅化镁二维纳米片的制备方法及其应用、释氢水凝胶创面敷料的制备方法及其应用。2022,中国专利,专利号:202210076555.9。(已授权)
7. 朱艳霞,杜冰。一种凝血酶修饰的止血膜及其制备方法。2022,中国专利,专利号:202211009502.1。
1. 《系统理论及应用》,科学出版社,2018年。(参编)
2. 《组织学与胚胎学》,人民卫生出版社,2020年。(副主编)
3. 《组织胚胎学英语词汇和复习思维导图》,湖北科技出版社,2024年。(副主编)
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