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高成

高成 “百人计划”助理教授

药剂学

药学院

chenggao@szu.edu.cn

深圳大学药学院A1-116室

(1)细胞原基材料的胞外、细胞膜和胞内组装
(2)细胞原基材料中和效应和中和治疗
(3)细胞原基材料靶向识别和药物递送

深圳大学“百人计划”助理教授,特聘研究员,博士生导师,独立PI。本科和硕士毕业于武汉理工大学,博士毕业于澳门大学,并在澳门大学从事博士后和研究助理教授工作。研究工作聚焦于细胞原基材料的结构组装和生物效应研究,以第一和通讯作者身份在Sci. Adv.(2篇)、Matter、Nat. Commun.(3篇)、Cell Rep. Med.、J. Am. Chem. Soc.、Adv. Mater.、Mater. Today(2篇)、ACS Nano、Adv. Funct. Mater.、Nano Lett.(2篇)、J. Control. Release等发表20余篇论文,相关研究工作被Nat. Rev. Cardiol.和Matter等选为研究亮点进行专题评论。主持国家自然科学基金和澳门科学技术发展基金等10余项科研项目,获澳门自然科学二等奖(2022年)和澳门技术发明三等奖(2020年),担任Chinese Chemical Letters(中国化学快报,中科院一区)编委会委员,以及ACS Nano、Adv. Sci.、Chem. Eng. J.、ACS Appl. Bio Mater.、等期刊审稿人。

教学工作:

本科生课程《药物新剂型与新技术》、《生物制药学》和《药学导论》

研究生课程《药剂学》

招聘信息(常年):

招收博士后,欢迎具有生物、化学、材料、药学和医学等专业背景的同学联系,竭诚支持每位同学的职业发展!

(1)国家自然科学基金面上项目,2024-01至2027-12,在研,主持

(2)深圳市医学研究专项资金项目,2024-01至2026-12,在研,主持

(3)广东省自然科学基金面上项目,2022-11至2025-10,在研,主持

(4)深圳市自然科学基金面上项目,2024-11至2027-11,在研,主持

(5)深圳市自然科学基金面上项目,2021-10至2024-10,结题,主持

(6)国家自然科学基金青年项目,2021-01至2023-12,结题,主持

(7)广东省自然科学基金青年项目,2020-10至2023-09,结题,主持

(8)深圳大学高水平人才引育启动项目,2024-04至2026-03,在研,主持

1. Cheng Gao#, Ruifeng Luo#, Cheryl HT Kwong#, Jinwei Liu#, Mian Tang, Beibei Xie, Tianshun Duan, and Ruibing Wang*. Cancer vaccine from intracellularly gelated tumor cells functionalized with CD47 blockage and damage-associated molecular pattern exposure. Cell Reports Medicine, 2025, in press.

2. Mian Tang, Zhiqing Yang, Xingchen Tang, He Ma, Beibei Xie, Jiang-Fei Xu, Cheng Gao*, David Bardelang, Ruibing Wang*. Hypoxia-Initiated Supramolecular Free Radicals Induce Intracellular Polymerization for Precision Tumor Therapy. Journal of the American Chemical Society, 2025, 147, 3488-3499.

3. Siyao Gu, Xiaona Zhao, Fang Wan, Dayong Gu*, Weidong Xie*, Cheng Gao*. Intracellularly Gelated Macrophages Loaded with Probiotics for Therapy of Colitis. Nano Letters, 2024, 24, 13504-13512.

4. Mian Tang, Tianshun Duan, Yunfeng Lu, Jinwei Liu, Cheng Gao*, Ruibing Wang*. Tyrosinase‐Woven Melanin Nets for Melanoma Therapy through Targeted Mitochondrial Tethering and Enhanced Photothermal Treatment. Advanced Materials, 2024, 2411906.

5. Ruifeng Luo, Jinwei Liu, Qian Cheng, Mitsuhiko Shionoya, Cheng Gao*, Ruibing Wang*. Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis. Science Advances, 2024, 10, eado6798.

6. Cheng Gao, Qingfu Wang, Yuanfu Ding, Cheryl H.T. Kwong, Beibei Xie, Jianwen Wei, Simon M. Y. Lee, Greta S. P. Mok, Ruibing Wang. Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats. Nature Communications, 2024, 15, 328.

7. Cheng Gao, Cheryl H.T. Kwong, Mian Tang, Jinwei Liu, Hiotong Kam, Shengke Li, Simon M. Y. Lee, Chunhai Fan, Ruibing Wang. A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection. Matter, 2023, 6, 3889-3911. Highlighted by Matter, 2023, 6, 3695-3698.

8. Cheng Gao, Qingfu Wang, Junyan Li, Cheryl H.T. Kwong, Jianwen Wei, Beibei Xie, Simon M. Y. Lee, Ruibing Wang. In vivo hitchhiking of immune cells by intracellular self-assembly of bacteria-mimetic nanomedicine for targeted therapy of melanoma. Science Advances,2022, 8, eabn1805. Selected as Science Advances feature article (with artworks showcased online).

9. Cheng Gao, Qiaoxian Huang, Conghui Liu, Cheryl H.T Kwong, Ludan Yue, Jianbo Wan, Simon M. Y. Lee, Ruibing Wang. Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines. Nature Communications, 2020, 11, 2622 (ESI highly cited paper). Highlighted by Nature Review Cardiology, 2020, 17, 454. 

10. Cheng Gao, Qiaoxian Huang, Qingping Lan, Yu Feng, Fan Tang, Maggie P.M. Hoi, Jianxiang Zhang, Simon M. Y. Lee, Ruibing Wang. A user-friendly herbicide derived from photoresponsive supramolecular vesicles. Nature Communications, 2018, 9, 2967.

11. Cheng Gao, Cheryl H.T. Kwong, Qingfu Wang, Hiotong Kam, Beibei Xie, Guosong Chen, Simon M. Y. Lee, Ruibing Wang. Macrophage-mimetic microalgae mediated hitchhiking delivery of liposome for enhanced antitumor sonodynamic immunotherapy via hypoxia alleviation and autophagy inhibition. ACS Nano, 2023, 17, 4034-4049. 

12. Cheng Gao, Cheryl H.T. Kwong, Qingfu Wang, Hiotong Kam, Jianwen Wei, Qian Chen, Jian Zhang, Simon M. Y. Lee, Dayong Gu, Ruibing Wang. Surface-engineered chlorella alleviated hypoxic tumor microenvironment for enhanced chemotherapy and immunotherapy of first-line drugs. Materials Today, 2022, 58, 57-70.

13. Cheng Gao, Qian Cheng, Junyan Li, Jia Chen, Qingfu Wang, Jianwen Wei, Qiaoxian Huang, Simon M. Y. Lee, Dayong Gu, Ruibing Wang. Supramolecular macrophage-liposome marriage for cell-hitchhiking delivery and immunotherapy of acute pneumonia and melanoma. Advanced Functional Materials, 2021, 2102440.

14. Cheng Gao, Qian Cheng, Jianwen Wei, Chen Sun, Siyu Lu, Cheryl H.T Kwong, Simon M. Y. Lee, Zhiyuan Zhong, Ruibing Wang. Bioorthogonal supramolecular conjugation for targeted cell-hitchhiking delivery. Materials Today, 2020, 40, 9-17.

15. Jingzhe Wang, Tonggong Liu, Siyao Gu, Hui-hui Yang, Weidong Xie, Cheng Gao*, Dayong Gu*. Cytoplasm Hydrogelation-Mediated Cardiomyocyte Sponge Alleviated Coxsackievirus B3 Infection. Nano Letters, 2023, 23, 8881-8890.

16. Cheng Gao, Conghui Liu, Qian Chen, Yan Wang, Cheryl HT Kwong, Qingfu Wang, Beibei Xie, Simon MY Lee, Ruibing Wang. Cyclodextrin-mediated conjugation of macrophage and liposomes for treatment of atherosclerosis. Journal of Controlled Release, 2022, 349, 2-15. 


(1)工程化细菌及其制备方法和应用。专利号:ZL202310362292.2,授权日:202.08.29。

(2)载药系统及其制备方法、药物组合物,专利号: ZL202110498872.5,授权日:2022.08.29。

(3)一种超分子细胞载体、载药体系及其制备方法,专利号:ZL202010677793.6,授权日:2021.11.23。

(4)一种太阳光敏感型除草剂纳米囊及其制备方法和应用,专利号:ZL201810700314.0,授权日:2021.09.03。

(5)一种脲酶纳米反应器及其制备方法,专利号:ZL201310112299.5,授权日:2015.09.30。


(1)澳门科学技术奖-自然科学二等奖(2022年),“超分子细胞”药物递送体系的构建及用于炎症和肿瘤的靶向治疗。

(2)澳门科学技术奖-技术发明三等奖(2020年),环境友好百草枯新剂型的开发。


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