1. Wang, R.^#; Wang, X.-D.^#; Hu, M.-H.* Novel tetrahydroxanthylium-based ligands targeting mitochondrial DNA G-quadruplex structures for concurrent induction of apoptosis and inhibition of autophagy in liver cancer. J. Med. Chem., 2026, 69, 2685−2702.

2. Hu, M.-H.*; Lin, J.-H. New dibenzoquinoxalines inhibit triple-negative breast cancer growth by dual targeting of topoisomerase 1 and the c‑MYC G‑quadruplex. J. Med. Chem., 2021, 64, 6720–6729.

3. Wang, X.-D.^#; Lin, J.-H.^#; Hu, M.-H.* Discovery of a tribenzophenazine analog for binding to the KRAS mRNA G-quadruplex structures in the cisplatin-resistant non-small cell lung cancer. J. Biol. Chem., 2025, 301 (2), 108164.

4. Wang, X.-D.^#; Nie, Q.-W. ^#; Hu, M.-H.* A small-size imidazole-derived ligand binds to the KRAS promoter G-quadruplex and inhibits cancer growth with enhanced immunomodulation. J. Biol. Chem., 2025, 301 (10), 110647.

5. Wang, X.-D.; Lin, J.-H.; Hu, M.-H.* Photodynamic activation of a KRAS RNA G-quadruplex–targeted photosensitizer induces ferroptosis in cisplatin-resistant non-small cell lung cancer. J. Biol. Chem., 2026, 302 (3), 111181.

6. Hu, M.-H.*; Wu, T.-Y.; Huang, Q.; Jin, G.* New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription. Nucleic Acids Res., 2019, 47, 10529–10542.

7. Wang, R.; Hu, M.-H.* AIE and UIA-featured fluorescent ligands for G-quadruplex: the impact of linker rigidity between recognition moiety and fluorophore. Chem. Commun., 2025, 61, 4991–4994.

8. Dong, Y.; Hu, M.-H.* Discovery of an asymmetric triphenylamine-based onium salt as a G-quadruplex-targeted fluorescent ligand for potential triple-negative breast cancer treatment. Eur. J. Med. Chem., 2026, 302, 118292.

9. Zhou, Z.-L.; Hu, M.-H.* Photooxidation of biomolecules in cancer cells with a viscosity-dependent fluorescent Rhodamine derivative decorated with a naphthoimidazole rotor. Eur. J. Med. Chem., 2026, 301, 118200.

10. Wang, X.-D.^#; Liu, Y.-S.^#; Liang, Z.-L.; Hu, M.-H.* Mitochondrial DNA-targeted triphenylamine-thiophene (TPATP)-derived ligands boost type-I/II photodynamic therapy for triple-negative breast cancer. Eur. J. Med. Chem., 2025, 289, 117489.

11. Wang, J.-X.^#; Wang, X.-D.^#; Hu, M.-H.* Novel quinoxaline analogs as telomeric G-quadruplex ligands exert antitumor effects related to enhanced immunomodulation. Eur. J. Med. Chem., 2024, 274, 116536.

12. Wang, X.-D.; Liu, Y.-S.; Chen, M.-D.; Hu, M.-H.* Discovery of a triphenylamine-based ligand that targets mitochondrial DNA G-quadruplexes and activates the cGAS-STING immunomodulatory pathway. Eur. J. Med. Chem., 2024, 269, 116361.

13. Wang, Z.^#; Zhou, J.^#; Lin, L.; Hu, M.-H.* Discovery of a far-red carbazole-benzoindolium fluorescent ligand that selectively targets mitochondrial DNA and suppresses breast cancer growth. Eur. J. Med. Chem., 2024, 264, 116046.

14. Wang, X.-D.^#; Liu, X.-Z.^#; Hu, M.-H.* A lysosome-targeted benzene-imidazole-coumarin derivative boosts photodynamic therapy via induction of ferroptosis and G-quadruplex-mediated transcriptional regulation. Sens. Actuators B Chem., 2026, 464, 140158.

15. Wang, R.^#; Zhou, J.-R.^#; Hu, M.-H.* A carbazole-benzothiazolium conjugated photosensitive ligand exerts dual-targeting anticancer activity via c-Myc inhibition and mitochondrial dysregulation. Sens. Actuators B Chem., 2026, 458, 139799.

16. Wang, X.-D.^#; Li, Z.-M.^#; Liu, X.-Z.; Hu, M.-H.* Dicationic π-conjugated triphenylamine fluorescent ligands target mitochondrial DNA G‑quadruplexes and inhibit triple-negative breast cancer growth. Sens. Actuators B Chem., 2026, 446, 138696.

17. Zhou, Z.-L.^#; Zhang, X.^#; Hu, M.-H.* Enhanced ferroptosis in triple-negative cancer cells achieved by a type-I cell membrane-targeted tetrabenzophenazine photosensitizer. Sens. Actuators B Chem., 2025, 441, 137978.

18. Zhang, X.; Hu, M.-H.* Slight modification of a G-quadruplex-targeted quinoxaline may boost type-1 photodynamic therapy for triple-negative breast cancer. Sens. Actuators B Chem., 2025, 425, 136952.

19. Wang, X.-D.^#; Liu, Y.-S.^#; Hu, M.-H.* A highly emissive near infrared thiophene-benzoindolium ligand binding to mitochondrial G-quadruplexes triggers triple-negative breast cancer cell death. Sens. Actuators B Chem., 2024, 418, 136350.

20. Zhang, X.; Hu, M.-H.* Promising G-quadruplex-targeted dibenzoquinoxaline type-1 photosensitizer triggers DNA damage in triple-negative breast cancer cells. ACS Pharmacol. Transl. Sci., 2024, 7, 2174–2184.