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王绍祥

王绍祥 副研究员,讲师

药理学

药学院

0755-26912152

wsx@szu.edu.cn

深圳大学西丽校区A1-511

1、抗肿瘤药物的发现及药理机制研究

2、癌症昼夜节律和时辰治疗的研究

暨南大学医学博士、博士后,硕士生导师,于2014年10月入职深圳大学,2021年深圳市级人才,2022年法国巴斯德研究所访问学者,已获副研究员任职资格。主要业绩包括:(1)作为负责人共主持11个国家、省、市级科研项目,包括1项国家自然基金青年基金、1项中国博士后基金面上项目、1项中国博士后基金特别资助项目、3项广东省自然基金项目、5项深圳市科研项目,参与国家重点、“863”等6个国家项目;(2)已在Cancer letters、Autophagy、mBio、Mol Cancer、Organic Chemistry Frontiers等知名期刊上发表50余篇SCI论文,其中30篇为第一、通讯作者;(3)已授权5项第一发明人专利;(4)作为导师已培养12名本科毕业生,其中10名获得“优秀毕业论文”。在项目开展、课题设计、专利转化及学生培养等方面,积累了一定经验。

主持项目(市级以上项目):

[1] 深圳市科技计划项目,JCYJ20210324093602007,灵芝活性成分抑制食管癌细胞自噬及增强顺铂敏感性的作用及其机制研究,起止时间,2021.10.28-2024.10.31,60万元,在研,主持

[2] 深圳市科技计划项目,JCYJ20180305163658916,内质网应激在多靶点激酶抑制剂抗食管癌作用中的机制研究,起止时间,2019.03.31-2021.03.31,45万元,在研,主持

[3] 广东省自然科学基金自由申请项目,2018A030313122,调节PERK通路增强索拉非尼抗食管癌敏感性中的作用机制,起止时间,2018.05.01-2021.04.30,10万元,在研,主持

[4] 深圳市科技计划项目,JCYJ20170302145059926,PERK/eIF2α通路调节食管癌化疗耐药的作用机制,起止时间,2017.06.01 - 2019.05.31,40万元,在研,主持

[5] 广东省省级科技计划项目,2017A010105013,抑制IRE1增强食管癌干细胞药物敏感性的作用机制,起止时间,2017.1.1 – 2018.12.31,30万元,正在结题,主持

[6] 深圳市科技计划项目,JCYJ20150324141711568,内质网应激通路调控食管癌干细胞药物敏感性的作用机制,起止时间,2015.06.01 - 2017.08.31,30万元,已结题,主持

[7] 中国博士后科学基金面上项目,2012M511882,内质网应激在SNX-2112诱导食管癌细胞死亡中的作用,起止时间,2012.01 – 2013.12,5万元,已结题,主持

[8] 广东省自然科学基金博士启动项目,S2012040006873,SNX-2112阻断内质网应激在食管癌细胞死亡中的作用,起止时间,2012.10 – 2014.10,3万元,已结题,主持

[9] 国家自然科学基金青年基金,81201727,内质网应激在SNX-2112诱导食管癌细胞死亡中的作用,起止时间,2013.01 – 2015.12,23万元,已结题,主持

[10] 中国博士后科学基金特别资助,2013T60827,内质网应激抑制剂增强SNX-2112抗食管癌的作用机制,起止时间,2013.10 – 2014.10,15万元,已结题,主持


代表性论文(近五年第一及通讯作者论文):

[1] Ou, L., X. Wang, S. Cheng, M. Zhang, R. Cui, C. Hu, S. Liu, Q. Tang, Y. Peng, R. Chai, S. Xie, Shaoxiang Wang*, W. Huang*, and X. Wang*, Verdinexor, a Selective Inhibitor of Nuclear Exportin 1, Inhibits the Proliferation and Migration of Esophageal Cancer via XPO1/c-Myc/FOSL1 Axis. Int J Biol Sci, 2022. 18(1): p. 276-291. (IF:10.075, Corresponding author)

[2] Qian Tang#, Yue Wang#, Ling Ou, Jieling Li, Kai Zheng, Hui Zhan, Jiayu Gu, Guibao Zhou, Shouxia Xie, Jianping Zhang, Wei Huang*, Shaoxiang Wang* and Xiao Wang*, Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation. Int J Biol Sci. 2021; 17(8): 1925–1939. (IF:10.075, Corresponding author)

[3] Nan Li#, Kaisheng Liu#, Shaowei Dong, Ling Ou, Jieling Li, Minshan Lai, Yue Wang, Yucheng Bao, Huijie Shi, Xiao Wang*, Shaoxiang Wang*, Identification of CHRNB4 as a Diagnostic/Prognostic Indicator and Therapeutic Target in Human Esophageal Squamous Cell Carcinoma, Front Oncol, 2020 Nov 16;10:571167. (IF: 6.244, Corresponding author)

[4] Liu, S., Y. Cheng, Shaoxiang Wang*, and H. Liu, Circadian Clock Genes Modulate Immune, Cell Cycle and Apoptosis in the Diagnosis and Prognosis of Pan-Renal Cell Carcinoma. Front Mol Biosci, 2021. 8: p. 747629. (IF:6.113, Corresponding author)

[5] Jieling Li#, Liyuan Zhou#, Ying Liu, Lingzhi Yang, Dayi Jiang, Kuan Li, Shouxia Xie, Xiao Wang*, Shaoxiang Wang*, Comprehensive Analysis of Cyclin Family Gene Expression in Colon Cancer. Front Oncol, 2021 Apr 29;11:674394. (IF:6.244, Corresponding author)

[6] BinYuan Hu#, ShaoXiang Wang#, YongMing Yan, JiaWang Liu, DaPeng Qina, YongXian Cheng*, Spiromyrrhenes A–D: unprecedented diterpene–sesquiterpene heterodimers as intermolecular [4 + 2] cycloaddition products from Resina Commiphora that inhibit tumor stemness in esophageal cancer. Organic Chemistry Frontiers, 2020,7, 2710-2718. (IF:5.281, Co-first author)

[7] Liang, Y. #Shaoxiang Wang#, X. Huang, R. Chai, Q. Tang, R. Yang, X. Huang, X. Wang, and K. Zheng, Dysregulation of Circadian Clock Genes as Significant Clinic Factor in the Tumorigenesis of Hepatocellular Carcinoma. Comput Math Methods Med, 2021. 2021: p. 8238833. (IF:2.238, Co-first author)

[8] Guifeng Xu#, Ling Ou#, Ying Liu#, Xiao Wang, Kaisheng Liu, Jieling Li, Junjun Li, Shaoqi Wang, Dane Huang, Kai Zheng*, Shaoxiang Wang*, Upregulated expression of MMP family genes is associated with poor survival in patients with esophageal squamous cell carcinoma via regulation of proliferation and epithelial‑mesenchymal transition, Oncology Reports, 2020, 44(1): 29-42. (IF: 3.906, Corresponding author)

[9] Jieling Li#, Xiao Wang#, Kai Zheng, Ying Liu, Junjun. Li, Shaoqi Wang, Kaisheng Liu, Xun Song, Nan Li, Shouxia Xie*, Shaoxiang Wang*, The clinical significance of collagen family gene expression for esophageal squamous cell carcinoma, PeerJ, 2019 Oct 4;7:e7705.(IF:2.984, Corresponding author)

[10] Wing-Fu Lai#, Chengshen Hu#, Guoxing Deng, Kwok-Ho Lui, Xiao Wang, Tik-Hung Tsoi, Shaoxiang Wang*, Wing-Tak Wong*, A Biocompatible and Easy-to-make Polyelectrolyte Dressing with Tunable Drug Delivery Properties for Wound Care, International Journal of Pharmaceutics, 2019, 16(566): 101-110. (IF:5.875, Corresponding author)

[11] Jixian Xiong#Shaoxiang Wang#, Tie Chen, Xingsheng Shu, Xianming Mo, Gang Chang, Jiajie Chen, Chenyuang Li, Hui Luo, Jiing Dwan Lee*, Verteporfin blocks Clusterin which is required for survival of gastric cancer stem cell by modulating HSP90 function, International Journal of Biological Sciences, 2019, 15(2): 312-324. (IF: 6.580, Co-first author)

[12] Shaoxiang Wang#, Kaisheng Liu, Yifei Lou, Shaoqi Wang, Yongbo Peng, Jianping Chen, Jiahao Huang,  Shouxia Xie*, Liang Cui*,  Xiao Wang*, RNase H meets molecular beacons: an ultrasensitive fluorometric assay for nucleic acids, Microchimica Acta, 2018, 185:375. (IF: 5.833, First author)

[13] Jiwei Ma#, Xiao Wang#, Lei Chang, Xueyun Zhong, Haiyan Jing, Xiaolong Zhu, Shaoxiang Wang*, Weiwei Xiao*, CD44 collaborates with ERBB2 mediate radiation resistance via p38 phosphorylation and DNA homologous recombination pathway in prostate cancer, Experimental Cell Research, 2018, 370(1): 58-67. (IF: 3.905, Co-corresponding author)

[14] Yong Zhang#, Yulin Wen, Jiwei Ma, Jiecheng Ye, Xiao Wang, Jianxian Huang, Chaoyue Meng, Xiaoze Xu, Shaoxiang Wang*, Xueyun Zhong*, Tetrandrine inhibits glioma stem-like cells by repressing beta-catenin expression. International journal of oncology, 2017, 50: 101-110. (IF: 3.0789, Co-corresponding author)

[15] Shaoqi Wang#, Xiao Wang#, Kai Zheng, Kaisheng Liu, Shaoxiang Wang*, Conghua Xie*, Simultaneous targeting PI3K and PERK pathways promotes cell death and improves the clinical prognosis in esophageal squamous carcinoma, Biochemical and Biophysical Research Communications, 2017, 493(1): 534-541. (IF: 2.4660, Co-corresponding author)

[16] Ru Li#, Haiying Li#Shaoxiang Wang#, Jiwei Ma, Yong Zhang, Jiecheng Ye, Yulin Wen, Xiao Wang, Xueyun Zhong*, Weiwei Xiao*. Novel prognostic value of nuclear lactate dehydrogenase-A in esophageal squamous cell carcinoma,  International Journal of Clinical and Experimental Pathology, 2016, 9(3): 3708-3716.  (IF: 1.7059, Co-first author)

[17] Shaoxiang Wang#, Zhan Du#, Jie Luo, Xiao Wang, Haiying Li, Yuting Liu, Yong Zhang, Jiwei Ma, Weiwei Xiao, Yifei Wang*, Xueyun Zhong*, Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer, Journal of Cancer Research and Clinical Oncology, 2015, 141 (8): 1405-16. (IF: 3.5024, First author)


代表性专利(已授权的第一发明人专利):

[1] 王绍祥#, 王晓, 王一飞, 徐海朋, 王绍其, 胡超智, 含有HDAC抑制剂和IRE1抑制剂的药物组合物及用途, 申请号:201710121669.X, 专利证书号:ZL201710121669.X, 授权日期: 2019.11.12.

[2] 王绍祥#, 王晓, 王一飞, 胡超智, 王绍其, 徐海朋, 含AKT抑制剂和IRE1抑制剂的药物组合物及其应用, 申请号:201710135038.3, 专利证书号:ZL201710135038.3, 授权日期:2019.10.25

[3] 王绍祥#, 王晓, 钟雪云, 张勇, 王一飞, 王绍其, 一种治疗食管癌的药物组合物及用途, 申请号:201710134282.8, 专利证书号:ZL201710134282.8, 授权日期:2019.11.15.

[4] 王绍祥#, 王绍其, 王晓, 陈家杰, 常港, 王艳, 王熙昊, 含索拉非尼和GSK2656157的药物组合物及用途, 申请号: 201710121670.2, 专利证书号:ZL201710121670.2,授权日期: 2019.11.12.

[5] 王绍祥#, 王绍其, 王晓, 王艳, 王熙昊, 常港, 陈家杰,  含PI3K抑制剂和PERK抑制剂的药物组合物及其应用, 申请号:201710123267.3, 专利证书号:ZL201710123267.3,授权日期: 2019.10.25.


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